TY  - JOUR
A1  - Mueller, Carsten
A1  - Ullmann, Kristina
A1  - Wilkens, Andrea
A1  - Winterhalter, Peter
A1  - Toyokuni, Shinya
A1  - Steinberg, Pablo
T1  - Potent antioxidative activity of vineatrol (R) 30 grapevine-shoot extract
N2  - The health promoting effects of a grapevine-shoot extract named Vineatrol (R) 30, which contains resveratrol (Resv) as well as considerable amounts of Resv oligomers, have recently been investigated. In the present study, we analyzed the free radical scavenging capacity, the ability to inhibit lipid peroxidation, and the capacity to enhance the human glutathione peroxidase 1 (GPx) and the human superoxide dismutase 1 (SOD) gene promoter activities of Vineatrol (R) 30. Vineatrol (R) 30 was able to scavenge the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid radical cation and led to concentration-dependent inhibition of lipid peroxidation, Vineatrol (R) 30 not being superior to Resv alone in both cases. Vineatrol (R) 30 also enhanced the gene promoter activities of human GPx and SOD expressed in V79 cells, whereas this effect could not be demonstrated for Resv. In summary, the results presented in this study show that the Vineatrol (R) 30 grapevine-shoot extract is a free radical scavenger and potent antioxidant at non- eytotoxic concentrations.
Y1  - 2009
UR  - http://www.jstage.jst.go.jp/browse/bbb
U6  - https://doi.org/10.1271/Bbb.90213
SN  - 0916-8451
ER  - 
TY  - JOUR
A1  - Müller, Carsten
A1  - Ullmann, Kristina
A1  - Steinberg, Pablo
T1  - The grapevine-shoot extract Vineatrol30 Inhibits the chemically induced malignant transformation of BALB/c-3T3 Cells
JF  - Journal of medicinal food
N2  - Vineatrol (R) 30 (developed and produced jointly by Breko GmbH [Bremen, Germany] and Actichem [Montauban, France]) is a grapevine-shoot extract that contains resveratrol as well as considerable amounts of resveratrol oligomers. In the present study it is shown that Vineatrol30 at a noncytotoxic concentration of 2.3 mu g/mL significantly reduced the number of malignantly transformed foci induced by a sequential treatment of BALB/c-3T3 cells with 3-methylcholanthrene and 12-O-tetradecanoylphorbol 13-acetate in the so-called BALB/c-3T3 cell transformation assay. At a higher concentration Vineatrol30 drastically decreased the relative plating efficiency of the cells. Furthermore, the results suggest that the resveratrol oligomers present in Vineatrol30, independently from resveratrol itself, were indeed able to inhibit the formation of malignantly transformed BALB/c-3T3 foci.
KW  - BALB/c-3T3 cells
KW  - cell transformation assay
KW  - resveratrol
KW  - resveratrol oligomers
KW  - Vineatrol (R) 30
Y1  - 2011
U6  - https://doi.org/10.1089/jmf.2010.0022
SN  - 1096-620X
VL  - 14
IS  - 1-2
SP  - 34
EP  - 39
PB  - Liebert
CY  - New Rochelle
ER  -