TY  - JOUR
A1  - Jedrusik-Bode, Monika
A1  - Studencka, Maja
A1  - Smolka, Christian
A1  - Baumann, Tobias
A1  - Schmidt, Henning
A1  - Kampf, Jan
A1  - Paap, Franziska
A1  - Martin, Sophie
A1  - Tazi, Jamal
A1  - Müller, Kristian M.
A1  - Krüger, Marcus
A1  - Braun, Thomas
A1  - Bober, Eva
T1  - The sirtuin SIRT6 regulates stress granule formation in C. elegans and mammals
JF  - Journal of cell science
N2  - SIRT6 is a NAD(+)-dependent deacetylase that modulates chromatin structure and safeguards genomic stability. Until now, SIRT6 has been assigned to the nucleus and only nuclear targets of SIRT6 are known. Here, we demonstrate that in response to stress, C. elegans SIR-2.4 and its mammalian orthologue SIRT6 localize to cytoplasmic stress granules, interact with various stress granule components and induce their assembly. Loss of SIRT6 or inhibition of its catalytic activity in mouse embryonic fibroblasts impairs stress granule formation and delays disassembly during recovery, whereas deficiency of SIR-2.4 diminishes maintenance of P granules and decreases survival of C. elegans under stress conditions. Our findings uncover a novel, evolutionary conserved function of SIRT6 in the maintenance of stress granules in response to stress.
KW  - C. elegans
KW  - G3BP
KW  - SIRT6
KW  - Sirtuins
KW  - Stress
KW  - Stress granules
Y1  - 2013
U6  - https://doi.org/10.1242/jcs.130708
SN  - 0021-9533
SN  - 1477-9137
VL  - 126
IS  - 22
SP  - 5166
EP  - +
PB  - Company of Biologists Limited
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Lohwaßer, Roswitha
A1  - Wendland, Mirko
A1  - Reinhardt, Felix
A1  - Halibrand, Katharina
A1  - Deiseroth, Laura
A1  - Jennek, Julia
A1  - Strobel, Anne
A1  - Hackel, Manuela
A1  - Krüger, Sophie
A1  - Fischer, Tom
A1  - Bosse, Stefanie
A1  - Florian, Lena
A1  - Fabian, Melina
A1  - Israel, Franziska
A1  - Iffert, Mathias
A1  - Hintze, Ksenia
A1  - Wendland, Mirko
A1  - Egbert, Björn
A1  - Heinz, Sarah
A1  - Bock, Sophia
A1  - Mutschler, Tanja
A1  - Burchard, Daniel
A1  - Musil, Andreas
T1  - Kentron : Journal zur Lehrerbildung = AHA Moment
T3  - Kentron : Journal zur Lehrerbildung - 35 
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-590429
SN  - 1867-4720
SN  - 1867-4747
IS  - 35
PB  - Universität Potsdam, Zentrum für Lehrerbildung
CY  - Potsdam
ER  -