TY - JOUR A1 - Buchmann, Arlette F. A1 - Zohsel, Katrin A1 - Blomeyer, Dorothea A1 - Hohm, Erika A1 - Hohmann, Sarah A1 - Jennen-Steinmetz, Christine A1 - Treutlein, Jens A1 - Becker, Katja A1 - Banaschewski, Tobias A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Brandeis, Daniel A1 - Poustka, Luise A1 - Zimmermann, Ulrich S. A1 - Laucht, Manfred T1 - Interaction between prenatal stress and dopamine D4 receptor genotype in predicting aggression and cortisol levels in young adults JF - Psychopharmacology N2 - Considerable evidence suggests that genetic factors combine with environmental influences to impact on the development of aggressive behavior. A genetic variant that has repeatedly been reported to render individuals more sensitive to the presence of adverse experiences, including stress exposure during fetal life, is the seven-repeat allele of the dopamine D4 receptor (DRD4) gene. The present investigation concentrated on the interplay of prenatal maternal stress and DRD4 genotype in predicting self-reported aggression in young adults. As disruption of the hypothalamic-pituitary-adrenal system has been discussed as a pathophysiological pathway to aggression, cortisol stress reactivity was additionally examined. As part of an epidemiological cohort study, prenatal maternal stress was assessed by maternal interview 3 months after childbirth. Between the ages of 19 and 23 years, 298 offspring (140 males, 158 females) completed the Young Adult Self-Report to measure aggressive behavior and were genotyped for the DRD4 gene. At 19 years, 219 participants additionally underwent the Trier Social Stress Test to determine cortisol reactivity. Extending earlier findings with respect to childhood antisocial behavior, the results revealed that, under conditions of higher prenatal maternal stress, carriers of the DRD4 seven-repeat allele displayed more aggression in adulthood (p = 0.032). Moreover, the same conditions which seemed to promote aggression were found to predict attenuated cortisol secretion (p = 0.028). This is the first study to indicate a long-term impact of prenatal stress exposure on the cortisol stress response depending on DRD4 genotype. KW - Prenatal stress KW - Aggression KW - Cortisol KW - DRD4 KW - Gene-environment interaction Y1 - 2014 U6 - https://doi.org/10.1007/s00213-014-3484-7 SN - 0033-3158 SN - 1432-2072 VL - 231 IS - 16 SP - 3089 EP - 3097 PB - Springer CY - New York ER - TY - JOUR A1 - Tobler, Michael A1 - Schlupp, Ingo A1 - Heubel, Katja U. A1 - Riesch, Rudiger A1 - Garcia de Leon, Francisco J. A1 - Giere, Olav A1 - Plath, Martin T1 - Life on the edge: hydrogen sulfide and the fish communities of a Mexican cave and surrounding waters JF - Extremophiles : life under extreme conditions N2 - Most eucaryotic organisms classified as living in an extreme habitat are invertebrates. Here we report of a fish living in a Mexican cave (Cueva del Azufre) that is rich in highly toxic H2S. We compared the water chemistry and fish communities of the cave and several nearby surface streams. Our study revealed high concentrations of H2S in the cave and its outflow (El Azufre). The concentrations of H2S reach more than 300 mu M inside the cave, which are acutely toxic for most fishes. In both sulfidic habitats, the diversity of fishes was heavily reduced, and Poecilia mexicana was the dominant species indicating that the presence of H2S has an all-or-none effect, permitting only few species to survive in sulfidic habitats. Compared to habitats without H2S, P. mexicana from the cave and the outflow have a significantly lower body condition. Although there are microhabitats with varying concentrations of H2S within the cave, we could not find a higher fish density in areas with lower concentrations of H2S. We discuss that P. mexicana is one of the few extremophile vertebrates. Our study supports the idea that extreme habitats lead to an impoverished species diversity. KW - extremophile teleosts KW - Poecilia mexicana KW - cave fish KW - hypoxia KW - chemoautotrophy KW - condition factor Y1 - 2006 U6 - https://doi.org/10.1007/s00792-006-0531-2 SN - 1431-0651 VL - 10 SP - 577 EP - 585 PB - Springer CY - Tokyo ER - TY - THES A1 - Martin, Katja T1 - Beerdigen oder verbrennen? BT - zur Beteiligung von Jüdinnen und Juden am Reformprojekt Feuerbestattung Y1 - 2024 SN - 978-3-944693-04-0 PB - arijeh-verlag CY - Potsdam ER - TY - JOUR A1 - Iven, Claudia A1 - Hansen, Bernd A1 - Anders, Kristina A1 - Starke, Andreas A1 - Richardt, Kirsten A1 - Prüß, Holger A1 - El Meskioui, Martina A1 - Haase, Tobias A1 - Mahlberg, Lea A1 - Wiehe, Lea A1 - de Beer, Carola A1 - Niepelt Karampamapa, Rebekka A1 - Hofmann, Andrea A1 - Stadie, Nicole A1 - Hanne, Sandra A1 - Thomson, Jenny A1 - Schäfer, Blanca A1 - Huttenlauch, Clara A1 - Wartenburger, Isabell A1 - Weiland, Katharina A1 - Wirsam, Anke A1 - Hartung, Julia A1 - Wahl, Michael A1 - Unger, Julia A1 - Buschmann, Anke A1 - Seefeld, Martin A1 - Bethge, Anita A1 - Fieder, Nora A1 - Rahman, Rasha Abdel A1 - Nousair, Iman A1 - Klassert, Annegret A1 - Wellmann, Caroline A1 - Verbree, Rahel A1 - van Rij, Jacolien A1 - Sprenger, Simone A1 - Mähl, Anna Luisa A1 - Schneider, Kathleen A1 - Kutz, Anne A1 - Kaps, Hella A1 - Frank, Ulrike A1 - Brekeller, Sophie A1 - Ryll, Katja ED - Breitenstein, Sarah ED - Burmester, Juliane ED - Yetim, Özlem ED - Fritzsche, Tom T1 - Spektrum Patholinguistik Band 12. Schwerpunktthema: Weg(e) mit dem Stottern: Therapie und Selbsthilfe für Kinder und Erwachsene T2 - Spektrum Patholinguistik N2 - Das 12. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Weg(e) mit dem Stottern: Therapie und Selbsthilfe für Kinder und Erwachsene« fand am 24.11.2018 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Vorträge zum Schwerpunktthema sowie Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Twelfth Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Away/A way with stuttering: Therapy and self-help for children and adults« took place in Potsdam on November 24 2018. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain all talks on the main topic as well as contributions from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 12 KW - Patholinguistik KW - Sprachtherapie KW - Stottern KW - Redeflussstörungen KW - Selbsthilfe KW - patholinguistics KW - speech/language therapy KW - stuttering KW - fluency disorder KW - self-help Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437002 SN - 978-3-86956-479-1 SN - 1866-9085 SN - 1866-9433 IS - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Buchmann, Arlette F. A1 - Schmid, Brigitte A1 - Blomeyer, Dorothea A1 - Becker, Katja A1 - Treutlein, Jens A1 - Zimmermann, Ulrich S. A1 - Jennen-Steinmetz, Christine A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Rietschel, Marcella A1 - Schumann, Gunter A1 - Laucht, Manfred T1 - Impact of age at first drink on vulnerability to alcohol-related problems : testing the marker hypothesis in a prospective study of young adults N2 - There is ample evidence that the early initiation of alcohol use is a risk factor for the development of later alcohol-related problems. The purpose of the current study was to examine whether this association can be explained by indicators of a common underlying susceptibility or whether age at drinking onset may be considered as an independent predictor of later drinking behavior, suggesting a potential causal relationship. Participants were drawn from a prospective cohort study of the long-term outcomes of early risk factors followed up from birth onwards. Structured interviews were administered to 304 participants to assess age at first drink and current drinking behavior. Data on risk factors, including early family adversity, parental alcohol use, childhood psychopathology and stressful life events, were repeatedly collected during childhood using standardized parent interviews. In addition, information on genotype was considered. Results confirmed previous work demonstrating that hazardous alcohol consumption is related to early-adolescent drinking onset. A younger age of first drink was significantly predicted by 5-HTTLPR genotype and the degree of preceding externalizing symptoms, and both factors were related to increased consumption or harmful alcohol use at age 19. However, even after controlling for these potential explanatory factors, earlier age at drinking onset remained a strong predictor of heavy alcohol consumption in young adulthood. The present longitudinal study adds to the current literature indicating that the early onset - adult hazardous drinking association cannot solely be attributed to shared genetic and psychopathologic risk factors as examined in this study. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/00223956 U6 - https://doi.org/10.1016/j.jpsychires.2009.02.006 SN - 0022-3956 ER - TY - JOUR A1 - Laucht, Manfred A1 - Becker, Katja A1 - Frank, Josef A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Treutlein, Jens A1 - Skowronek, Markus H. A1 - Schumann, Gunter T1 - Genetic variation in dopamine pathways differentially associated with smoking progression in adolescence N2 - Objective: To clarify the nature of the association between dopamine genes and smoking by examining whether genetic variability in components of the dopamine pathway could explain refined phenotypes in adolescent smoking progression. Method: Data are from an ongoing prospective study of the long-term outcome of early risk factors studied since birth. At age 15 years, 220 participants (108 males, 112 females) completed a self-report questionnaire measuring smoking behavior and were genotyped for five dopamine gene variants. Results: Smoking initiation was related to allelic variation in the dopamine D-4 receptor gene (DRD4), whereas smoking continuation and dependence showed association with the dopamine D-2 receptor gene (DRD2). Adolescents with the seven-repeat allele of the common DRD4 exon 3 polymorphism had rates of ever smoking that were significantly higher than in those with other genotypes. Once smoking started, carriers of the T allele of a single nucleotide polymorphism of DRD2 (rs4648317) reported higher rates of current smoking and scored higher on nicotine dependence than their allelic counterparts. Among current smokers, intention to quit was significantly lower in adolescents homozygous for the 10-repeat allele of the common dopamine transporter 3 untranslated region polymorphism. Conclusions: Our results provide preliminary evidence of genetic influences on different stages of smoking and suggest the importance of specific dopamine genes in smoking progression in adolescence. Y1 - 2008 U6 - https://doi.org/10.1097/Chi.0b013e31816bff77 SN - 0890-8567 ER - TY - JOUR A1 - Stoppenbrink, Katja A1 - Kalis, Michael A1 - Reeh, Greta A1 - Kaya, Gizem A1 - Kopshteyn, Georgy A1 - Nguyen, Martin A1 - Lingg, Rosana Teresa A1 - Carstens, Margret A1 - Lanzl, Theresa A1 - Li, Yao T1 - MenschenRechtsMagazin : Informationen | Meinungen | Analysen N2 - Aus dem Inhalt: Themenschwerpunkt: Pandemie und Menschenrechte - Prozeduralisierung gegen Diskriminierung? Menschen mit Behinderungen, das Bundesverfassungsgericht und das ‚Triage-Problem‘ in der Pandemie - Aus der Krise lernen – grund- und menschenrechtliche Erwägungen der Corona-Schutzmaßnahmen als Vorbild für einen ambitionierten Klimaschutz - Die Impfpflicht-Debatte auf dem philosophischen Prüfstand Bericht über die Tätigkeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2021 – Teil II: Individualbeschwerden T3 - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen - 27.2022/2 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-564937 SN - 1434-2820 VL - 27 IS - 2 SP - 63 EP - 161 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - GEN A1 - Bittlingmayer, Uwe H. A1 - Gerdes, Jürgen A1 - Pinheiro, Paulo A1 - Dege, Martin A1 - Bauer, Ullrich A1 - Jäntsch, Christian A1 - Kirchhoff, Sandra A1 - Knigge, Michael A1 - Köpfer, Andreas A1 - Markovic, Sandra A1 - Okcu, Gözde A1 - Scharenberg, Katja T1 - Health Promoting Schools (HPS) and the impact of inclusion BT - the StiEL-project T2 - The European Journal of Public Health N2 - Background: The overall goal of the project ‘StiEL’ is to contribute to the professional development of teachers and other educational staff working at German secondary schools. The aim is to develop an evidence-based training concept for the inclusion of students with diverse abilities. The project is organized as a collaborative research effort of three partnering institutions and funded by the German Federal Ministry of Education and Research from 2018-2021. Methods: To support the on-going transition towards inclusive school practices, a multi-stage approach is envisaged. The first phase aims at a scoping review of existing literature and programmes on inclusion. The overview is supplemented by interviews with school staff members. Training modules are developed in the second project phase. The third phase of StiEL puts the newly developed training program into practice. The knowledge and skills acquired by the participants through the training as well as the teaching and management of inclusive classrooms after the training are evaluated through longitudinal and ethnographic approaches. The final project phase creates a best practice manual and makes the modules available via open access databases. Results: The presentation will focus on the first phase and try to explore the health-related consequences of the transition towards an inclusive school system in Germany for different participants. We will present preliminary results of expert interviews as well as some results from the literature screening. Due to our findings the current practice on German schools towards the road to inclusion is very stressful for all participants. We will explore recommendations for health promoting schools under conditions of inclusion. Conclusions: In terms of health-related consequences for all participants, the road to inclusion is very ambitious but also very stressful. Regarding the development of an inclusive school system, we need to focus much more on health and health promotion. Y1 - 2018 SN - 1101-1262 SN - 1464-360X VL - 28 IS - Supp. 4 SP - 287 EP - 288 PB - Oxford Univ. Press CY - Oxford ER - TY - JOUR A1 - Burkart, Michael A1 - Alsleben, Katja A1 - Lachmuth, Susanne A1 - Schumacher, Juliane A1 - Hofmann, Ralf A1 - Jeltsch, Florian A1 - Schurr, Frank Martin T1 - Recruitment requirements of the rare and threatened Juncus atratus N2 - The long-term persistence of populations and species depends on the successful recruitment of individuals. The generative recruitment of plants may be limited by a lack of suitable germination and establishment conditions. Establishment limitation may especially be caused by the competitive effect of surrounding dense vegetation, which is believed to restrict the recruitment success of many plant species to small open patches ('safe sites'). We conducted experiments to clarify the roles of germination and seedling establishment as limiting processes in the recruitment of Juncus atratus Krock., a rare and threatened herbaceous perennial river corridor plant in Central Europe. Light intensity had a positive effect on germination. However, some seedlings emerged even in total darkness and the germination rate at 1% light intensity was more than half of that at 60% light intensity. Seedling establishment in the field after 10 weeks was 30% on bare ground, but it was close to zero in grassland. Establishment in the growth chamber after 8 weeks was close to 75% for seedlings that germinated underwater, but only about 35% for seedlings that germinated afloat. Furthermore, establishment decreased with flooding duration on bare ground, but increased with flooding duration in grassland. These data indicate that establishment, rather than germination, is a critical life stage in Central European populations off. atratus. They furthermore indicate that the competition of surrounding vegetation for water limits seedling establishment under field conditions without flooding, largely restricting establishment success to bare ground habitats. In contrast, grassland is more suitable for the recruitment off. atratus than bare ground under prolonged flooding. Grassland may facilitate the establishment off. atratus seedlings during long- lasting floods by supplying oxygen to the soil through aerenchyma. The shift from competition to facilitation in grassland occurred after 30 days of flooding, i.e. within the ontogeny of individual plants. The specific recruitment requirements off. arrows may be a main cause of its rarity in modern Central Europe. In order to prevent regional extinction off. atratus, we suggest maintaining or re-establishing natural hydrodynamics in the species' habitats. Y1 - 2010 UR - http://www.sciencedirect.com/science/journal/03672530 U6 - https://doi.org/10.1016/j.flora.2009.08.003 SN - 0367-2530 ER - TY - JOUR A1 - Winkelmann, Ricarda A1 - Levermann, Anders A1 - Martin, Maria A. A1 - Frieler, Katja T1 - Increased future ice discharge from Antarctica owing to higher snowfall JF - Nature : the international weekly journal of science N2 - Anthropogenic climate change is likely to cause continuing global sea level rise(1), but some processes within the Earth system may mitigate the magnitude of the projected effect. Regional and global climate models simulate enhanced snowfall over Antarctica, which would provide a direct offset of the future contribution to global sea level rise from cryospheric mass loss(2,3) and ocean expansion(4). Uncertainties exist in modelled snowfall(5), but even larger uncertainties exist in the potential changes of dynamic ice discharge from Antarctica(1,6) and thus in the ultimate fate of the precipitation-deposited ice mass. Here we show that snowfall and discharge are not independent, but that future ice discharge will increase by up to three times as a result of additional snowfall under global warming. Our results, based on an ice-sheet model(7) forced by climate simulations through to the end of 2500 (ref. 8), show that the enhanced discharge effect exceeds the effect of surface warming as well as that of basal ice-shelf melting, and is due to the difference in surface elevation change caused by snowfall on grounded versus floating ice. Although different underlying forcings drive ice loss from basal melting versus increased snowfall, similar ice dynamical processes are nonetheless at work in both; therefore results are relatively independent of the specific representation of the transition zone. In an ensemble of simulations designed to capture ice-physics uncertainty, the additional dynamic ice loss along the coastline compensates between 30 and 65 per cent of the ice gain due to enhanced snowfall over the entire continent. This results in a dynamic ice loss of up to 1.25 metres in the year 2500 for the strongest warming scenario. The reported effect thus strongly counters a potential negative contribution to global sea level by the Antarctic Ice Sheet. Y1 - 2012 U6 - https://doi.org/10.1038/nature11616 SN - 0028-0836 VL - 492 IS - 7428 SP - 239 EP - + PB - Nature Publ. Group CY - London ER -