TY  - JOUR
A1  - Risch, Lucie
A1  - Stoll, Josefine
A1  - Schomöller, Anne
A1  - Engel, Tilman
A1  - Mayer, Frank
A1  - Cassel, Michael
T1  - Intraindividual Doppler Flow Response to Exercise Differs Between Symptomatic and Asymptomatic Achilles Tendons
JF  - Frontiers in physiology
N2  - Objective: This study investigated intraindividual differences of intratendinous blood flow (IBF) in response to running exercise in participants with Achilles tendinopathy.

Design: This is a cross-sectional study.

Setting: The study was conducted at the University Outpatient Clinic.

Participants: Sonographic detectable intratendinous blood flow was examined in symptomatic and contralateral asymptomatic Achilles tendons of 19 participants (42 ± 13 years, 178 ± 10 cm, 76 ± 12 kg, VISA-A 75 ± 16) with clinically diagnosed unilateral Achilles tendinopathy and sonographic evident tendinosis.

Intervention: IBF was assessed using Doppler ultrasound “Advanced Dynamic Flow” before (Upre) and 5, 30, 60, and 120 min (U5–U120) after a standardized submaximal constant load run.

Main Outcome Measure: IBF was quantified by counting the number (n) of vessels in each tendon.

Results: At Upre, IBF was higher in symptomatic compared with asymptomatic tendons [mean 6.3 (95% CI: 2.8–9.9) and 1.7 (0.4–2.9), p < 0.01]. Overall, 63% of symptomatic and 47% of asymptomatic Achilles tendons responded to exercise, whereas 16 and 11% showed persisting IBF and 21 and 42% remained avascular throughout the investigation. At U5, IBF increased in both symptomatic and asymptomatic tendons [difference to baseline: 2.4 (0.3–4.5) and 0.9 (0.5–1.4), p = 0.05]. At U30 to U120, IBF was still increased in symptomatic but not in asymptomatic tendons [mean difference to baseline: 1.9 (0.8–2.9) and 0.1 (-0.9 to 1.2), p < 0.01].

Conclusion: Irrespective of pathology, 47–63% of Achilles tendons responded to exercise with an immediate acute physiological IBF increase by an average of one to two vessels (“responders”). A higher amount of baseline IBF (approximately five vessels) and a prolonged exercise-induced IBF response found in symptomatic ATs indicate a pain-associated altered intratendinous “neovascularization.”
KW  - achilles tendinopathy
KW  - tendinosis
KW  - neovascularization
KW  - ultrasound
KW  - advanced dynamic flow
KW  - sonography
Y1  - 2021
U6  - https://doi.org/10.3389/fphys.2021.617497
SN  - 1664-042X
VL  - 12
SP  - 1
EP  - 8
PB  - Frontiers Research Foundation
CY  - Lausanne, Schweiz
ER  -