TY  - JOUR
A1  - Tino, G. M.
A1  - Cacciapuoti, L.
A1  - Bongs, K.
A1  - Bordé, Ch. J.
A1  - Bouyer, P.
A1  - Dittus, H.
A1  - Ertmer, W.
A1  - Görlitz, A.
A1  - Inguscio, M.
A1  - Landragin, A.
A1  - Lemonde, P.
A1  - Lämmerzahl, C.
A1  - Peters, A.
A1  - Rasel, E.
A1  - Reichel, J.
A1  - Salomon, C.
A1  - Schiller, S.
A1  - Schleich, W.
A1  - Sengstock, K.
A1  - Sterr, U.
A1  - Wilkens, Martin
T1  - Atom interferometers and optical atomic clocks : new quantum sensors for fundamental physics experiments in space
N2  - We present projects for future space missions using new quantum devices based on ultracold atoms. They will enable fundamental physics experiments testing quantum physics, physics beyond the standard model of fundamental particles and interactions, special relativity, gravitation and general relativity.
Y1  - 2007
ER  - 
TY  - JOUR
A1  - Kachler, Katerina
A1  - Bailer, Maximilian
A1  - Heim, Lisanne
A1  - Schumacher, Fabian
A1  - Reichel, Martin
A1  - Holzinger, Corinna D.
A1  - Trump, Sonja
A1  - Mittler, Susanne
A1  - Monti, Juliana
A1  - Trufa, Denis I.
A1  - Rieker, Ralf J.
A1  - Hartmann, Arndt
A1  - Sirbu, Horia
A1  - Kleuser, Burkhard
A1  - Kornhuber, Johannes
A1  - Finotto, Susetta
T1  - Enhanced acid sphingomyelinase activity drives immune evasion and tumor growth in non-small cell lung carcinoma
JF  - Cancer research
N2  - The lipid hydrolase enzyme acid sphingomyelinase (ASM) is required for the conversion of the lipid cell membrane component sphingomyelin into ceramide. In cancer cells, ASM-mediated ceramide production is important for apoptosis, cell proliferation, and immune modulation, highlighting ASM as a potential multimodal therapeutic target. In this study, we demonstrate elevated ASM activity in the lung tumor environment and blood serum of patients with non-small cell lung cancer (NSCLC). RNAi-mediated attenuation of SMPD1 in human NSCLC cells rendered them resistant to serum starvation-induced apoptosis. In a murine model of lung adenocarcinoma, ASM deficiency reduced tumor development in a manner associated with significant enhancement of Th1-mediated and cytotoxic T-cell-mediated antitumor immunity. Our findings indicate that targeting ASM in NSCLC can act by tumor cell-intrinsic and-extrinsic mechanisms to suppress tumor cell growth, most notably by enabling an effective antitumor immune response by the host. (C) 2017 AACR.
Y1  - 2017
U6  - https://doi.org/10.1158/0008-5472.CAN-16-3313
SN  - 0008-5472
SN  - 1538-7445
VL  - 77
IS  - 21
SP  - 5963
EP  - 5976
PB  - American Association for Cancer Research
CY  - Philadelphia
ER  -