TY  - JOUR
A1  - Evans, C. J.
A1  - Smartt, S. J.
A1  - Lee, J. K.
A1  - Lennon, D. J.
A1  - Kaufer, A.
A1  - Dufton, P. L.
A1  - Trundle, C.
A1  - Herrero, A.
A1  - Simon Díaz, Sergio
A1  - de Koter, A.
A1  - Hamann, Wolf-Rainer
A1  - Hendry, M. A.
A1  - Hunter, I.
A1  - Irwin, M. J.
A1  - Korn, A. J.
A1  - Kudritzki, R. P.
A1  - Langer, Norbert
A1  - Mokiem, M. R.
A1  - Najarro, F.
A1  - Pauldrach, A. W. A.
A1  - Przybilla, Norbert
A1  - Puls, J.
A1  - Ryans, R. S. I.
A1  - Urbaneja, M. A.
A1  - Venn, K. A.
A1  - Villamariz, M. R.
T1  - The VLT-FLAMES survey of massive stars : Observations in the Galactic clusters NGC3293, NGC4755 and NGC6611
N2  - We introduce a new survey of massive stars in the Galaxy and the Magellanic Clouds using the Fibre Large Array Multi- Element Spectrograph ( FLAMES) instrument at the Very Large Telescope ( VLT). Here we present observations of 269 Galactic stars with the FLAMES- Giraffe Spectrograph ( R similar or equal to 25 000), in fields centered on the open clusters NGC3293, NGC4755 and NGC6611. These data are supplemented by a further 50 targets observed with the Fibre- Fed Extended Range Optical Spectrograph ( FEROS, R = 48 000). Following a description of our scientific motivations and target selection criteria, the data reduction methods are described; of critical importance the FLAMES reduction pipeline is found to yield spectra that are in excellent agreement with less automated methods. Spectral classifications and radial velocity measurements are presented for each star, with particular attention paid to morphological peculiarities and evidence of binarity. These observations represent a significant increase in the known spectral content of NGC3293 and NGC4755, and will serve as standards against which our subsequent FLAMES observations in the Magellanic Clouds will be compared
Y1  - 2005
ER  - 
TY  - JOUR
A1  - Chipman, Ariel D.
A1  - Ferrier, David E. K.
A1  - Brena, Carlo
A1  - Qu, Jiaxin
A1  - Hughes, Daniel S. T.
A1  - Schroeder, Reinhard
A1  - Torres-Oliva, Montserrat
A1  - Znassi, Nadia
A1  - Jiang, Huaiyang
A1  - Almeida, Francisca C.
A1  - Alonso, Claudio R.
A1  - Apostolou, Zivkos
A1  - Aqrawi, Peshtewani
A1  - Arthur, Wallace
A1  - Barna, Jennifer C. J.
A1  - Blankenburg, Kerstin P.
A1  - Brites, Daniela
A1  - Capella-Gutierrez, Salvador
A1  - Coyle, Marcus
A1  - Dearden, Peter K.
A1  - Du Pasquier, Louis
A1  - Duncan, Elizabeth J.
A1  - Ebert, Dieter
A1  - Eibner, Cornelius
A1  - Erikson, Galina
A1  - Evans, Peter D.
A1  - Extavour, Cassandra G.
A1  - Francisco, Liezl
A1  - Gabaldon, Toni
A1  - Gillis, William J.
A1  - Goodwin-Horn, Elizabeth A.
A1  - Green, Jack E.
A1  - Griffiths-Jones, Sam
A1  - Grimmelikhuijzen, Cornelis J. P.
A1  - Gubbala, Sai
A1  - Guigo, Roderic
A1  - Han, Yi
A1  - Hauser, Frank
A1  - Havlak, Paul
A1  - Hayden, Luke
A1  - Helbing, Sophie
A1  - Holder, Michael
A1  - Hui, Jerome H. L.
A1  - Hunn, Julia P.
A1  - Hunnekuhl, Vera S.
A1  - Jackson, LaRonda
A1  - Javaid, Mehwish
A1  - Jhangiani, Shalini N.
A1  - Jiggins, Francis M.
A1  - Jones, Tamsin E.
A1  - Kaiser, Tobias S.
A1  - Kalra, Divya
A1  - Kenny, Nathan J.
A1  - Korchina, Viktoriya
A1  - Kovar, Christie L.
A1  - Kraus, F. Bernhard
A1  - Lapraz, Francois
A1  - Lee, Sandra L.
A1  - Lv, Jie
A1  - Mandapat, Christigale
A1  - Manning, Gerard
A1  - Mariotti, Marco
A1  - Mata, Robert
A1  - Mathew, Tittu
A1  - Neumann, Tobias
A1  - Newsham, Irene
A1  - Ngo, Dinh N.
A1  - Ninova, Maria
A1  - Okwuonu, Geoffrey
A1  - Ongeri, Fiona
A1  - Palmer, William J.
A1  - Patil, Shobha
A1  - Patraquim, Pedro
A1  - Pham, Christopher
A1  - Pu, Ling-Ling
A1  - Putman, Nicholas H.
A1  - Rabouille, Catherine
A1  - Ramos, Olivia Mendivil
A1  - Rhodes, Adelaide C.
A1  - Robertson, Helen E.
A1  - Robertson, Hugh M.
A1  - Ronshaugen, Matthew
A1  - Rozas, Julio
A1  - Saada, Nehad
A1  - Sanchez-Gracia, Alejandro
A1  - Scherer, Steven E.
A1  - Schurko, Andrew M.
A1  - Siggens, Kenneth W.
A1  - Simmons, DeNard
A1  - Stief, Anna
A1  - Stolle, Eckart
A1  - Telford, Maximilian J.
A1  - Tessmar-Raible, Kristin
A1  - Thornton, Rebecca
A1  - van der Zee, Maurijn
A1  - von Haeseler, Arndt
A1  - Williams, James M.
A1  - Willis, Judith H.
A1  - Wu, Yuanqing
A1  - Zou, Xiaoyan
A1  - Lawson, Daniel
A1  - Muzny, Donna M.
A1  - Worley, Kim C.
A1  - Gibbs, Richard A.
A1  - Akam, Michael
A1  - Richards, Stephen
T1  - The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
JF  - PLoS biology
N2  - Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pbio.1002005
SN  - 1545-7885
VL  - 12
IS  - 11
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Vaid, Akhil
A1  - Somani, Sulaiman
A1  - Russak, Adam J.
A1  - De Freitas, Jessica K.
A1  - Chaudhry, Fayzan F.
A1  - Paranjpe, Ishan
A1  - Johnson, Kipp W.
A1  - Lee, Samuel J.
A1  - Miotto, Riccardo
A1  - Richter, Felix
A1  - Zhao, Shan
A1  - Beckmann, Noam D.
A1  - Naik, Nidhi
A1  - Kia, Arash
A1  - Timsina, Prem
A1  - Lala, Anuradha
A1  - Paranjpe, Manish
A1  - Golden, Eddye
A1  - Danieletto, Matteo
A1  - Singh, Manbir
A1  - Meyer, Dara
A1  - O'Reilly, Paul F.
A1  - Huckins, Laura
A1  - Kovatch, Patricia
A1  - Finkelstein, Joseph
A1  - Freeman, Robert M.
A1  - Argulian, Edgar
A1  - Kasarskis, Andrew
A1  - Percha, Bethany
A1  - Aberg, Judith A.
A1  - Bagiella, Emilia
A1  - Horowitz, Carol R.
A1  - Murphy, Barbara
A1  - Nestler, Eric J.
A1  - Schadt, Eric E.
A1  - Cho, Judy H.
A1  - Cordon-Cardo, Carlos
A1  - Fuster, Valentin
A1  - Charney, Dennis S.
A1  - Reich, David L.
A1  - Böttinger, Erwin
A1  - Levin, Matthew A.
A1  - Narula, Jagat
A1  - Fayad, Zahi A.
A1  - Just, Allan C.
A1  - Charney, Alexander W.
A1  - Nadkarni, Girish N.
A1  - Glicksberg, Benjamin S.
T1  - Machine learning to predict mortality and critical events in a cohort of patients with COVID-19 in New York City: model development and validation
JF  - Journal of medical internet research : international scientific journal for medical research, information and communication on the internet ; JMIR
N2  - Background:
COVID-19 has infected millions of people worldwide and is responsible for several hundred thousand fatalities. The COVID-19 pandemic has necessitated thoughtful resource allocation and early identification of high-risk patients. However, effective methods to meet these needs are lacking.

Objective:
The aims of this study were to analyze the electronic health records (EHRs) of patients who tested positive for COVID-19 and were admitted to hospitals in the Mount Sinai Health System in New York City; to develop machine learning models for making predictions about the hospital course of the patients over clinically meaningful time horizons based on patient characteristics at admission; and to assess the performance of these models at multiple hospitals and time points. 

Methods:
We used Extreme Gradient Boosting (XGBoost) and baseline comparator models to predict in-hospital mortality and critical events at time windows of 3, 5, 7, and 10 days from admission. Our study population included harmonized EHR data from five hospitals in New York City for 4098 COVID-19-positive patients admitted from March 15 to May 22, 2020. The models were first trained on patients from a single hospital (n=1514) before or on May 1, externally validated on patients from four other hospitals (n=2201) before or on May 1, and prospectively validated on all patients after May 1 (n=383). Finally, we established model interpretability to identify and rank variables that drive model predictions.

Results:
Upon cross-validation, the XGBoost classifier outperformed baseline models, with an area under the receiver operating characteristic curve (AUC-ROC) for mortality of 0.89 at 3 days, 0.85 at 5 and 7 days, and 0.84 at 10 days. XGBoost also performed well for critical event prediction, with an AUC-ROC of 0.80 at 3 days, 0.79 at 5 days, 0.80 at 7 days, and 0.81 at 10 days. In external validation, XGBoost achieved an AUC-ROC of 0.88 at 3 days, 0.86 at 5 days, 0.86 at 7 days, and 0.84 at 10 days for mortality prediction. Similarly, the unimputed XGBoost model achieved an AUC-ROC of 0.78 at 3 days, 0.79 at 5 days, 0.80 at 7 days, and 0.81 at 10 days. Trends in performance on prospective validation sets were similar. At 7 days, acute kidney injury on admission, elevated LDH, tachypnea, and hyperglycemia were the strongest drivers of critical event prediction, while higher age, anion gap, and C-reactive protein were the strongest drivers of mortality prediction. 

Conclusions:
We externally and prospectively trained and validated machine learning models for mortality and critical events for patients with COVID-19 at different time horizons. These models identified at-risk patients and uncovered underlying relationships that predicted outcomes.
KW  - machine learning
KW  - COVID-19
KW  - electronic health record
KW  - TRIPOD
KW  - clinical
KW  - informatics
KW  - prediction
KW  - mortality
KW  - EHR
KW  - cohort
KW  - hospital
KW  - performance
Y1  - 2020
U6  - https://doi.org/10.2196/24018
SN  - 1439-4456
SN  - 1438-8871
VL  - 22
IS  - 11
PB  - Healthcare World
CY  - Richmond, Va.
ER  - 
TY  - GEN
A1  - Sadovnichii, V. A.
A1  - Panasyuk, M. I.
A1  - Amelyushkin, A. M.
A1  - Benghin, V. V.
A1  - Garipov, G. K.
A1  - Kalegaev, V. V.
A1  - Klimov, P. A.
A1  - Khrenov, B. A.
A1  - Petrov, V. L.
A1  - Sharakin, S. A.
A1  - Shirokov, A. V.
A1  - Svertilov, S. I.
A1  - Zotov, M. Y.
A1  - Yashin, I. V.
A1  - Gorbovskoy, E. S.
A1  - Lipunov, V. M.
A1  - Park, I. H.
A1  - Lee, J.
A1  - Jeong, S.
A1  - Kim, M. B.
A1  - Jeong, H. M.
A1  - Shprits, Yuri Y.
A1  - Angelopoulos, V.
A1  - Russell, C. T.
A1  - Runov, A.
A1  - Turner, D.
A1  - Strangeway, R. J.
A1  - Caron, R.
A1  - Biktemerova, S.
A1  - Grinyuk, A.
A1  - Lavrova, M.
A1  - Tkachev, L.
A1  - Tkachenko, A.
A1  - Martinez, O.
A1  - Salazar, H.
A1  - Ponce, E.
T1  - "Lomonosov" satellite-space observatory to study extreme phenomena in space
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study:

-Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff;

-Ultraviolet (UV) transient luminous events in the upper atmosphere;

-Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays;

-Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances;

-Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects;

-Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight.

This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 959 
KW  - gamma-ray bursts
KW  - ultra-high energy cosmic rays
KW  - radiation belts
KW  - space mission
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-428185
SN  - 1866-8372
IS  - 959
SP  - 1705
EP  - 1738
ER  - 
TY  - JOUR
A1  - Sadovnichii, V. A.
A1  - Panasyuk, M. I.
A1  - Amelyushkin, A. M.
A1  - Bogomolov, V. V.
A1  - Benghin, V. V.
A1  - Garipov, G. K.
A1  - Kalegaev, V. V.
A1  - Klimov, P. A.
A1  - Khrenov, B. A.
A1  - Petrov, V. L.
A1  - Sharakin, S. A.
A1  - Shirokov, A. V.
A1  - Svertilov, S. I.
A1  - Zotov, M. Y.
A1  - Yashin, I. V.
A1  - Gorbovskoy, E. S.
A1  - Lipunov, V. M.
A1  - Park, I. H.
A1  - Lee, J.
A1  - Jeong, S.
A1  - Kim, M. B.
A1  - Jeong, H. M.
A1  - Shprits, Yuri Y.
A1  - Angelopoulos, V.
A1  - Russell, C. T.
A1  - Runov, A.
A1  - Turner, D.
A1  - Strangeway, R. J.
A1  - Caron, R.
A1  - Biktemerova, S.
A1  - Grinyuk, A.
A1  - Lavrova, M.
A1  - Tkachev, L.
A1  - Tkachenko, A.
A1  - Martinez, O.
A1  - Salazar, H.
A1  - Ponce, E.
T1  - "Lomonosov" Satellite-Space Observatory to Study Extreme Phenomena in Space
JF  - Space science reviews
N2  - The "Lomonosov" space project is lead by Lomonosov Moscow State University in collaboration with the following key partners: Joint Institute for Nuclear Research, Russia, University of California, Los Angeles (USA), University of Pueblo (Mexico), Sungkyunkwan University (Republic of Korea) and with Russian space industry organi-zations to study some of extreme phenomena in space related to astrophysics, astroparticle physics, space physics, and space biology. The primary goals of this experiment are to study: -Ultra-high energy cosmic rays (UHECR) in the energy range of the Greizen-ZatsepinKuzmin (GZK) cutoff; -Ultraviolet (UV) transient luminous events in the upper atmosphere; -Multi-wavelength study of gamma-ray bursts in visible, UV, gamma, and X-rays; -Energetic trapped and precipitated radiation (electrons and protons) at low-Earth orbit (LEO) in connection with global geomagnetic disturbances; -Multicomponent radiation doses along the orbit of spacecraft under different geomagnetic conditions and testing of space segments of optical observations of space-debris and other space objects; -Instrumental vestibular-sensor conflict of zero-gravity phenomena during space flight. This paper is directed towards the general description of both scientific goals of the project and scientific equipment on board the satellite. The following papers of this issue are devoted to detailed descriptions of scientific instruments.
KW  - Gamma-ray bursts
KW  - Ultra-high energy cosmic rays
KW  - Radiation belts
KW  - Space mission
Y1  - 2017
U6  - https://doi.org/10.1007/s11214-017-0425-x
SN  - 0038-6308
SN  - 1572-9672
VL  - 212
SP  - 1705
EP  - 1738
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Friedrich, A. M.
A1  - Lee, J.
A1  - Wernicke, B. P.
A1  - Sieh, K.
T1  - Geologic context of geodetic data across a Basin and Range normal fault, Crescent Valley, Nevada
N2  - [1] Geodetic strain and late Quaternary faulting in the Basin and Range province is distributed over a region much wider than historic seismicity, which is localized near the margins of the province. In the relatively aseismic interior, both the magnitude and direction of geodetic strain may be inconsistent with the Holocene faulting record. We document the best example of such a disagreement across the NE striking, similar to55degrees NW dipping Crescent normal fault, where a NW oriented, 70 km geodetic baseline records contemporary shortening of similar to2 mm/yr orthogonal to the fault trace. In contrast, our geomorphic, paleoseismic, and geochronologic analyses of the Crescent fault suggest that a large extensional rupture occurred during the late Holocene epoch. An excavation across the fault at Fourmile Canyon reveals that the most recent event occurred at 2.8 +/- 0.1 ka, with net vertical tectonic displacement of 4.6 +/- 0.4 m at this location, corresponding to the release of similar to3 m of accumulated NW-SE extension. Measured alluvial scarp profiles suggest a minimum rupture length of 30 km along the range front for the event, implying a moment magnitude M-w of at least 6.6. No prior event occurred between similar to2.8 ka and similar to6.4 +/- 0.1 ka, the C-14 calender age of strata near the base of the exposed section. Assuming typical slip rates for Basin and Range faults (similar to0.3 mm/yr), these results imply that up to one third, or similar to1 m, of the extensional strain released in the previous earthquake could have reaccumulated across the fault since similar to2.8 ka. However, the contemporary shortening implies that the fault is unloading due to a transient process, whose duration is limited to between 6 years ( geodetic recording time) and 2.8 ka ( the age of the most recent event). These results emphasize the importance of providing accurate geologic data on the timescale of the earthquake cycle in order to evaluate geodetic measurements
Y1  - 2004
SN  - 0278-7407
ER  - 
TY  - JOUR
A1  - Lee, Hui-Chun
A1  - Hwang, Jongkook
A1  - Schilde, Uwe
A1  - Antonietti, Markus
A1  - Matyjaszewski, Krzysztof
A1  - Schmidt, Bernhard V. K. J.
T1  - Toward ultimate control of radical polymerization
BT  - functionalized metal-organic frameworks as a robust environment for Metal-Catalyzed Polymerizations
JF  - Chemistry of materials : a publication of the American Chemical Society
N2  - Herein, an approach via combination of confined porous textures and reversible deactivation radical polymerization techniques is proposed to advance synthetic polymer chemistry, i.e., a connection of metal-organic frameworks (MOFs) and activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP). Zn-2(benzene-1,4-dicarboxylate)2(1,4-diazabicyclo[2.2.2]-octane) [Zn-2(bdc)(2)(dabco)] is utilized as a reaction environment for polymerization of various methacrylate monomers (methyl, ethyl, benzyl, and isobornyl methacrylate) in a confined nanochannel, resulting in polymers with control over dispersity, end functionalities, and tacticity with respect to distinct molecular size. To refine and reconsolidate the compartmentation effect on polymer regularity, initiator-functionalized Zn MOF was synthesized via cocrystallization with an initiator-functionalized ligand, 2-(2-bromo-2-methylpropanamido)-1,4-benzenedicarboxylate (Brbdc), in different ratios (10%, 20%, and 50%). Through the embedded initiator, surface-initiated ARGET ATRP was directly initiated from the walls of the nanochannels. The obtained polymers had a high molecular weight up to 392 000. Moreover, a significant improvement in end-group functionality and stereocontrol was observed, entailing polymers with obvious increments in isotacticity. The results highlight a combination of MOFs and ATRP that is a promising and universal methodology to prepare various polymers with high molecular weight exhibiting well-defined uniformity in chain length and microstructure as well as the preserved chain-end functionality.
Y1  - 2018
U6  - https://doi.org/10.1021/acs.chemmater.8b00546
SN  - 0897-4756
SN  - 1520-5002
VL  - 30
IS  - 9
SP  - 2983
EP  - 2994
PB  - American Chemical Society
CY  - Washington
ER  -