TY  - JOUR
A1  - Hesse, Julia
A1  - Klier, Dennis Tobias
A1  - Sgarzi, Massimo
A1  - Nsubuga, Anne
A1  - Bauer, Christoph
A1  - Grenzer, Joerg
A1  - Hübner, Rene
A1  - Wislicenus, Marcus
A1  - Joshi, Tanmaya
A1  - Kumke, Michael Uwe
A1  - Stephan, Holger
T1  - Rapid Synthesis of Sub-10nm Hexagonal NaYF4-Based Upconverting Nanoparticles using Therminol((R))66
JF  - ChemistryOpen : including thesis treasury
N2  - We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.
KW  - core-shell materials
KW  - lanthanides
KW  - nanostructures
KW  - photoluminescence
KW  - upconversion
Y1  - 2018
U6  - https://doi.org/10.1002/open.201700186
SN  - 2191-1363
VL  - 7
IS  - 2
SP  - 159
EP  - 168
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Hoffmann, Mathias
A1  - Wirth, Stephan J.
A1  - Bessler, Holger
A1  - Engels, Christof
A1  - Jochheim, Hubert
A1  - Sommer, Michael
A1  - Augustin, Jürgen
T1  - Combining a root exclusion technique with continuous chamber and porous tube measurements for a pin-point separation of ecosystem respiration in croplands
JF  - Journal of plant nutrition and soil science = Zeitschrift für Pflanzenernährung und Bodenkunde
N2  - To better assess ecosystem C budgets of croplands and understand their potential response to climate and management changes, detailed information on the mechanisms and environmental controls driving the individual C flux components are needed. This accounts in particular for the ecosystem respiration (R-eco) and its components, the autotrophic (R-a) and heterotrophic respiration (R-h) which vary tremendously in time and space. This study presents a method to separate R-eco into R-a [as the sum of R-a (shoot) and R-a (root)] and R-h in order to detect temporal and small-scale spatial dynamics within their relative contribution to overall R-eco. Thus, predominant environmental drivers and underlying mechanisms can be revealed. R-eco was derived during nighttime by automatic chamber CO2 flux measurements on plant covered plots. R-h was derived from CO2 efflux measurements, which were performed in parallel to R-eco measurements on a fallow plot using CO2 sampling tubes in 10 cm soil depth. R-a (root) was calculated as the difference between sampling tube CO2 efflux measurements on a plant covered plot and R-h. R-a (shoot) was calculated as R-eco - R-a (root) - R-h. Measurements were carried out for winter wheat (Triticum aestivum L.) during the crop season 2015 at an experimental plot located in the hummocky ground moraine landscape of NE Germany. R-eco varied seasonally from < 1 to 9.5 g C m(-2) d(-1), and was higher in adult (a) and reproductive (r) than juvenile (j) stands (gC m(-2) d(-1): j = 1.2, a = 4.6, r = 5.3). Observed R-a and R-h were in general smaller compared to the independently measured R-eco, contributing in average 58% and 42% to R-eco. However, both varied strongly regarding their environmental drivers and particular contribution throughout the study period, following the seasonal development of soil temperature and moisture (R-h) as well as crop development (R-a). Thus, our results consistently revealed temporal dynamics regarding the relative contribution of R-a (root) and R-a (shoot) to R-a, as well as of R-a and R-h to R-eco. Based on the observed results, implications for partitioning of R-eco in croplands are given.
KW  - automatic chambers
KW  - autotrophic respiration
KW  - heterotrophic respiration
KW  - soil CO2 sampling tubes
Y1  - 2017
U6  - https://doi.org/10.1002/jpln.201600489
SN  - 1436-8730
SN  - 1522-2624
VL  - 181
IS  - 1
SP  - 41
EP  - 50
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - BOOK
A1  - Giese, Holger
A1  - Hildebrandt, Stephan
A1  - Neumann, Stefan
A1  - Wätzoldt, Sebastian
T1  - Industrial case study on the integration of SysML and AUTOSAR with triple graph grammars
N2  - During the overall development of complex engineering systems different modeling notations are employed. For example, in the domain of automotive systems system engineering models are employed quite early to capture the requirements and basic structuring of the entire system, while software engineering models are used later on to describe the concrete software architecture. Each model helps in addressing the specific design issue with appropriate notations and at a suitable level of abstraction. However, when we step forward from system design to the software design, the engineers have to ensure that all decisions captured in the system design model are correctly transferred to the software engineering model. Even worse, when changes occur later on in either model, today the consistency has to be reestablished in a cumbersome manual step. In this report, we present in an extended version of [Holger Giese, Stefan Neumann, and Stephan Hildebrandt. Model Synchronization at Work: Keeping SysML and AUTOSAR Models Consistent. In Gregor Engels, Claus Lewerentz, Wilhelm Schäfer, Andy Schürr, and B. Westfechtel, editors, Graph Transformations and Model Driven Enginering - Essays Dedicated to Manfred Nagl on the Occasion of his 65th Birthday, volume 5765 of Lecture Notes in Computer Science, pages 555–579. Springer Berlin / Heidelberg, 2010.] how model synchronization and consistency rules can be applied to automate this task and ensure that the different models are kept consistent. We also introduce a general approach for model synchronization. Besides synchronization, the approach consists of tool adapters as well as consistency rules covering the overlap between the synchronized parts of a model and the rest. We present the model synchronization algorithm based on triple graph grammars in detail and further exemplify the general approach by means of a model synchronization solution between system engineering models in SysML and software engineering models in AUTOSAR which has been developed for an industrial partner. In the appendix as extension to [19] the meta-models and all TGG rules for the SysML to AUTOSAR model synchronization are documented.
N2  - Bei der Entwicklung komplexer technischer Systeme werden verschiedene Modellierungssprachen verwendet. Zum Beispiel werden bei der Entwicklung von Systemen in der Automobilindustrie bereits früh im Entwicklungsprozess Systemmodelle verwendet, um die Anforderungen und die grobe Struktur des Gesamtsystems darzustellen. Später werden Softwaremodelle verwendet, um die konkrete Softwarearchitektur zu modellieren. Jedes Modell stellt spezifische Entwurfsaspekte mit Hilfe passender Notationen auf einem angemessenen Abstraktionsniveau dar. Wenn jedoch vom Systementwurf zum Softwareentwurf übergegangen wird, müssen die Entwicklungsingenieure sicherstellen, dass alle Entwurfsentscheidungen, die im Systemmodell enthalten sind, korrekt auf das Softwaremodell übertragen werden. Sobald danach auch noch Änderungen auftreten, muss die Konsistenz zwischen den Modellen in einem aufwändigen manuellen Schritt wiederhergestellt werden. In diesem Bericht zeigen wir, wie Modellsynchronisation und Konsistenzregeln zur Automatisierung dieses Arbeitsschrittes verwendet und die Konsistenz zwischen den Modellen sichergestellt werden können. Außerdem stellen wir einen allgemeinen Ansatz zur Modellsynchronisation vor. Neben der reinen Synchronisation umfasst unsere Lösung weiterhin Tool-Adapter, sowie Konsistenzregeln, die sowohl die Teile der Modelle abdecken, die synchronisiert werden können, als auch die restlichen Teile. Der Modellsynchronisationsalgorithmus basiert auf Tripel-Graph-Grammatiken und wird im Detail erläutert. An Hand einer konkreten Transformation zwischen SysML- und AUTOSAR-Modellen, die im Rahmen eines Industrieprojektes entwickelt wurde, wird der Ansatz demonstriert. Im Anhang des Berichts sind alle TGG-Regeln für die SysML-zu-AUTOSAR-Transformation dokumentiert.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 57 
KW  - Model Transformation
KW  - Model Synchronisation
KW  - SysML
KW  - AUTOSAR
KW  - Tripel-Graph-Grammatik
KW  - Model Transformation
KW  - Model Synchronization
KW  - SysML
KW  - AUTOSAR
KW  - Triple Graph Grammar
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-60184
SN  - 978-3-86956-191-2
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Giese, Holger
A1  - Hildebrandt, Stephan
A1  - Lambers, Leen
T1  - Toward bridging the gap between formal semantics and implementation of triple graph grammars
N2  - The correctness of model transformations is a crucial element for the model-driven engineering of high quality software. A prerequisite to verify model transformations at the level of the model transformation specification is that an unambiguous formal semantics exists and that the employed implementation of the model transformation language adheres to this semantics. However, for existing relational model transformation approaches it is usually not really clear under which constraints particular implementations are really conform to the formal semantics. In this paper, we will bridge this gap for the formal semantics of triple graph grammars (TGG) and an existing efficient implementation. Whereas the formal semantics assumes backtracking and ignores non-determinism, practical implementations do not support backtracking, require rule sets that ensure determinism, and include further optimizations. Therefore, we capture how the considered TGG implementation realizes the transformation by means of operational rules, define required criteria and show conformance to the formal semantics if these criteria are fulfilled. We further outline how static analysis can be employed to guarantee these criteria.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 37 
Y1  - 2010
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-45219
SN  - 978-3-86956-078-6
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Giese, Holger
A1  - Hildebrandt, Stephan
T1  - Efficient model synchronization of large-scale models
N2  - Model-driven software development requires techniques to consistently propagate modifications between different related models to realize its full potential. For large-scale models, efficiency is essential in this respect. In this paper, we present an improved model synchronization algorithm based on triple graph grammars that is highly efficient and, therefore, can also synchronize large-scale models sufficiently fast. We can show, that the overall algorithm has optimal complexity if it is dominating the rule matching and further present extensive measurements that show the efficiency of the presented model transformation and synchronization technique.
N2  - Die Model-getriebene Softwareentwicklung benötigt Techniken zur Übertragung von Änderungen zwischen verschiedenen zusammenhängenden Modellen, um vollständig nutzbar zu sein. Bei großen Modellen spielt hier die Effizienz eine entscheidende Rolle. In diesem Bericht stellen wir einen verbesserten Modellsynchronisationsalgorithmus vor, der auf Tripel-Graph-Grammatiken basiert. Dieser arbeitet sehr effizient und kann auch sehr große Modelle schnell synchronisieren. Wir können zeigen, dass der Gesamtalgortihmus eine optimale Komplexität aufweist, sofern er die Ausführung dominiert. Die Effizient des Algorithmus' wird durch einige Benchmarkergebnisse belegt.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 28 
KW  - Model Transformation
KW  - Model Synchronisation
KW  - Tripel-Graph-Grammatik
KW  - Modell-getriebene Softwareentwicklung
KW  - Model Transformation
KW  - Model Synchronization
KW  - Triple Graph Grammars
KW  - Model-Driven Engineering
Y1  - 2009
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-29281
SN  - 978-3-940793-84-3
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Uhlemann, Erhard
A1  - Gloe, Karsten
A1  - Stephan, Holger
A1  - Heitzsch, Olaf
A1  - Bukowsky, Heinz
A1  - Pollex, Rolf
A1  - Weber, Erwin
T1  - Preorganized endo-dicarboxylic host macrocycles having superior extraction selectivity for small alkaline earth metal ions
Y1  - 1994
ER  - 
TY  - JOUR
A1  - Giese, Holger
A1  - Hildebrandt, Stephan
A1  - Lambers, Leen
T1  - Bridging the gap between formal semantics and implementation of triple graph grammars
JF  - Software and systems modeling
N2  - The correctness of model transformations is a crucial element for model-driven engineering of high-quality software. A prerequisite to verify model transformations at the level of the model transformation specification is that an unambiguous formal semantics exists and that the implementation of the model transformation language adheres to this semantics. However, for existing relational model transformation approaches, it is usually not really clear under which constraints particular implementations really conform to the formal semantics. In this paper, we will bridge this gap for the formal semantics of triple graph grammars (TGG) and an existing efficient implementation. While the formal semantics assumes backtracking and ignores non-determinism, practical implementations do not support backtracking, require rule sets that ensure determinism, and include further optimizations. Therefore, we capture how the considered TGG implementation realizes the transformation by means of operational rules, define required criteria, and show conformance to the formal semantics if these criteria are fulfilled. We further outline how static and runtime checks can be employed to guarantee these criteria.
Y1  - 2014
U6  - https://doi.org/10.1007/s10270-012-0247-y
SN  - 1619-1366
SN  - 1619-1374
VL  - 13
IS  - 1
SP  - 273
EP  - 299
PB  - Springer
CY  - Heidelberg
ER  - 
TY  - GEN
A1  - Hesse, Julia
A1  - Klier, Dennis Tobias
A1  - Sgarzi, Massimo
A1  - Nsubuga, Anne
A1  - Bauer, Christoph
A1  - Grenzer, Jörg
A1  - Hübner, René
A1  - Wislicenus, Marcus
A1  - Joshi, Tanmaya
A1  - Kumke, Michael Uwe
A1  - Stephan, Holger
T1  - Rapid synthesis of sub-10 nm hexagonal NaYF4-based upconverting nanoparticles using Therminol® 66
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - We report a simple one-pot method for the rapid preparation of sub-10nm pure hexagonal (-phase) NaYF4-based upconverting nanoparticles (UCNPs). Using Therminol((R))66 as a co-solvent, monodisperse UCNPs could be obtained in unusually short reaction times. By varying the reaction time and reaction temperature, it was possible to control precisely the particle size and crystalline phase of the UCNPs. The upconversion (UC) luminescence properties of the nanocrystals were tuned by varying the concentrations of the dopants (Nd3+ and Yb3+ sensitizer ions and Er3+ activator ions). The size and phase-purity of the as-synthesized core and core-shell nanocrystals were assessed by using complementary transmission electron microscopy, dynamic light scattering, X-ray diffraction, and small-angle X-ray scattering studies. In-depth photophysical evaluation of the UCNPs was pursued by using steady-state and time-resolved luminescence spectroscopy. An enhancement in the UC intensity was observed if the nanocrystals, doped with optimized concentrations of lanthanide sensitizer/activator ions, were further coated with an inert/active shell. This was attributed to the suppression of surface-related luminescence quenching effects.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 613 
KW  - core-shell materials
KW  - lanthanides
KW  - nanostructures
KW  - photoluminescence
KW  - upconversion
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-423515
SN  - 1866-8372
IS  - 613
ER  - 
TY  - JOUR
A1  - Petersen, Sven
A1  - Fabian, Steffi
A1  - Meier, Martin
A1  - Oldach, Robert
A1  - Giersch, Stephan
A1  - Gräf, Holger
A1  - Süß, Karsten
T1  - Militär und Gesellschaft in der Frühen Neuzeit
N2  - Der Arbeitskreis Militär und Gesellschaft in der Frühen Neuzeit e. V. wurde im Frühjahr 1995 gegründet. Er hat es sich zur Aufgabe gemacht, die Erforschung des Militärs im Rahmen der frühneuzeitlichen Geschichte zu befördern und zugleich das Bewusstsein der Frühneuzeit-HistorikerInnen für die Bedeutung des Militärs in all seinen Funktionen zu wecken. Das Militär steht somit als soziale Gruppe selbst im Mittelpunkt der Aktivitäten des Arbeitskreises, wird aber auch in seinen Wirkungen und Repräsentationen thematisiert. Ziel ist es, die Rolle des Militärs als Teil der frühneuzeitlichen Gesellschaft umfassend herauszuarbeiten und zu würdigen. Insofern versteht der AMG seine Arbeit nicht nur als Beitrag zur Militärgeschichte, sondern vor allem als Beitrag zur Geschichte der Frühen Neuzeit insgesamt. Der Arbeitskreis bietet ein Diskussions- und Informationsforum durch die Organisation von Tagungen, die Herausgabe der Schriftenreihe ‚Herrschaft und soziale Systeme in der Frühen Neuzeit‘, die Zeitschrift ‚Militär und Gesellschaft in der Frühen Neuzeit‘ und die Mailingliste mil-fnz.
T3  - Militär und Gesellschaft in der frühen Neuzeit - 16, Heft 2 
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62068
SN  - 1617-9722
SN  - 1861-910X
VL  - 16
IS  - 2
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Giersch, Stephan
A1  - Gräf, Holger
T1  - Hessische Truppen im Amerikanischen  Unabhängigkeitskrieg
BT  - ein neues Datenbankprojekt
JF  - Militär und Gesellschaft in der frühen Neuzeit
Y1  - 2012
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-63765
SN  - 1617-9722
SN  - 1861-910X
VL  - 16
IS  - 2
SP  - 257
EP  - 263
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Scherber, Christoph
A1  - Eisenhauer, Nico
A1  - Weisser, Wolfgang W.
A1  - Schmid, Bernhard
A1  - Voigt, Winfried
A1  - Fischer, Markus
A1  - Schukze, Ernst-Detlef
A1  - Roscher, Christiane
A1  - Weigelt, Alexandra
A1  - Allan, Eric
A1  - Beßler, Holger
A1  - Bonkowski, Michael
A1  - Buchmann, Nina
A1  - Buscot, François
A1  - Clement, Lars W.
A1  - Ebeling, Anne
A1  - Engels, Christof
A1  - Halle, Stefan
A1  - Kertscher, Ilona
A1  - Klein, Alexandra-Maria
A1  - Koller, Robert
A1  - König, Stephan
A1  - Kowalski, Esther
A1  - Kummer, Volker
A1  - Kuu, Annely
A1  - Lange, Markus
A1  - Lauterbach, Dirk
T1  - Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment
Y1  - 2010
UR  - http://www.nature.com/nature/journal/v468/n7323/full/nature09492.html
SN  - 0028-0836
ER  - 
TY  - JOUR
A1  - Wuttke, Matthias
A1  - Li, Yong
A1  - Li, Man
A1  - Sieber, Karsten B.
A1  - Feitosa, Mary F.
A1  - Gorski, Mathias
A1  - Tin, Adrienne
A1  - Wang, Lihua
A1  - Chu, Audrey Y.
A1  - Hoppmann, Anselm
A1  - Kirsten, Holger
A1  - Giri, Ayush
A1  - Chai, Jin-Fang
A1  - Sveinbjornsson, Gardar
A1  - Tayo, Bamidele O.
A1  - Nutile, Teresa
A1  - Fuchsberger, Christian
A1  - Marten, Jonathan
A1  - Cocca, Massimiliano
A1  - Ghasemi, Sahar
A1  - Xu, Yizhe
A1  - Horn, Katrin
A1  - Noce, Damia
A1  - Van der Most, Peter J.
A1  - Sedaghat, Sanaz
A1  - Yu, Zhi
A1  - Akiyama, Masato
A1  - Afaq, Saima
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Amin, Najaf
A1  - Arnlov, Johan
A1  - Bakker, Stephan J. L.
A1  - Bansal, Nisha
A1  - Baptista, Daniela
A1  - Bergmann, Sven
A1  - Biggs, Mary L.
A1  - Biino, Ginevra
A1  - Boehnke, Michael
A1  - Boerwinkle, Eric
A1  - Boissel, Mathilde
A1  - Böttinger, Erwin
A1  - Boutin, Thibaud S.
A1  - Brenner, Hermann
A1  - Brumat, Marco
A1  - Burkhardt, Ralph
A1  - Butterworth, Adam S.
A1  - Campana, Eric
A1  - Campbell, Archie
A1  - Campbell, Harry
A1  - Canouil, Mickael
A1  - Carroll, Robert J.
A1  - Catamo, Eulalia
A1  - Chambers, John C.
A1  - Chee, Miao-Ling
A1  - Chee, Miao-Li
A1  - Chen, Xu
A1  - Cheng, Ching-Yu
A1  - Cheng, Yurong
A1  - Christensen, Kaare
A1  - Cifkova, Renata
A1  - Ciullo, Marina
A1  - Concas, Maria Pina
A1  - Cook, James P.
A1  - Coresh, Josef
A1  - Corre, Tanguy
A1  - Sala, Cinzia Felicita
A1  - Cusi, Daniele
A1  - Danesh, John
A1  - Daw, E. Warwick
A1  - De Borst, Martin H.
A1  - De Grandi, Alessandro
A1  - De Mutsert, Renee
A1  - De Vries, Aiko P. J.
A1  - Degenhardt, Frauke
A1  - Delgado, Graciela
A1  - Demirkan, Ayse
A1  - Di Angelantonio, Emanuele
A1  - Dittrich, Katalin
A1  - Divers, Jasmin
A1  - Dorajoo, Rajkumar
A1  - Eckardt, Kai-Uwe
A1  - Ehret, Georg
A1  - Elliott, Paul
A1  - Endlich, Karlhans
A1  - Evans, Michele K.
A1  - Felix, Janine F.
A1  - Foo, Valencia Hui Xian
A1  - Franco, Oscar H.
A1  - Franke, Andre
A1  - Freedman, Barry I.
A1  - Freitag-Wolf, Sandra
A1  - Friedlander, Yechiel
A1  - Froguel, Philippe
A1  - Gansevoort, Ron T.
A1  - Gao, He
A1  - Gasparini, Paolo
A1  - Gaziano, J. Michael
A1  - Giedraitis, Vilmantas
A1  - Gieger, Christian
A1  - Girotto, Giorgia
A1  - Giulianini, Franco
A1  - Gogele, Martin
A1  - Gordon, Scott D.
A1  - Gudbjartsson, Daniel F.
A1  - Gudnason, Vilmundur
A1  - Haller, Toomas
A1  - Hamet, Pavel
A1  - Harris, Tamara B.
A1  - Hartman, Catharina A.
A1  - Hayward, Caroline
A1  - Hellwege, Jacklyn N.
A1  - Heng, Chew-Kiat
A1  - Hicks, Andrew A.
A1  - Hofer, Edith
A1  - Huang, Wei
A1  - Hutri-Kahonen, Nina
A1  - Hwang, Shih-Jen
A1  - Ikram, M. Arfan
A1  - Indridason, Olafur S.
A1  - Ingelsson, Erik
A1  - Ising, Marcus
A1  - Jaddoe, Vincent W. V.
A1  - Jakobsdottir, Johanna
A1  - Jonas, Jost B.
A1  - Joshi, Peter K.
A1  - Josyula, Navya Shilpa
A1  - Jung, Bettina
A1  - Kahonen, Mika
A1  - Kamatani, Yoichiro
A1  - Kammerer, Candace M.
A1  - Kanai, Masahiro
A1  - Kastarinen, Mika
A1  - Kerr, Shona M.
A1  - Khor, Chiea-Chuen
A1  - Kiess, Wieland
A1  - Kleber, Marcus E.
A1  - Koenig, Wolfgang
A1  - Kooner, Jaspal S.
A1  - Korner, Antje
A1  - Kovacs, Peter
A1  - Kraja, Aldi T.
A1  - Krajcoviechova, Alena
A1  - Kramer, Holly
A1  - Kramer, Bernhard K.
A1  - Kronenberg, Florian
A1  - Kubo, Michiaki
A1  - Kuhnel, Brigitte
A1  - Kuokkanen, Mikko
A1  - Kuusisto, Johanna
A1  - La Bianca, Martina
A1  - Laakso, Markku
A1  - Lange, Leslie A.
A1  - Langefeld, Carl D.
A1  - Lee, Jeannette Jen-Mai
A1  - Lehne, Benjamin
A1  - Lehtimaki, Terho
A1  - Lieb, Wolfgang
A1  - Lim, Su-Chi
A1  - Lind, Lars
A1  - Lindgren, Cecilia M.
A1  - Liu, Jun
A1  - Liu, Jianjun
A1  - Loeffler, Markus
A1  - Loos, Ruth J. F.
A1  - Lucae, Susanne
A1  - Lukas, Mary Ann
A1  - Lyytikainen, Leo-Pekka
A1  - Magi, Reedik
A1  - Magnusson, Patrik K. E.
A1  - Mahajan, Anubha
A1  - Martin, Nicholas G.
A1  - Martins, Jade
A1  - Marz, Winfried
A1  - Mascalzoni, Deborah
A1  - Matsuda, Koichi
A1  - Meisinger, Christa
A1  - Meitinger, Thomas
A1  - Melander, Olle
A1  - Metspalu, Andres
A1  - Mikaelsdottir, Evgenia K.
A1  - Milaneschi, Yuri
A1  - Miliku, Kozeta
A1  - Mishra, Pashupati P.
A1  - Program, V. A. Million Veteran
A1  - Mohlke, Karen L.
A1  - Mononen, Nina
A1  - Montgomery, Grant W.
A1  - Mook-Kanamori, Dennis O.
A1  - Mychaleckyj, Josyf C.
A1  - Nadkarni, Girish N.
A1  - Nalls, Mike A.
A1  - Nauck, Matthias
A1  - Nikus, Kjell
A1  - Ning, Boting
A1  - Nolte, Ilja M.
A1  - Noordam, Raymond
A1  - Olafsson, Isleifur
A1  - Oldehinkel, Albertine J.
A1  - Orho-Melander, Marju
A1  - Ouwehand, Willem H.
A1  - Padmanabhan, Sandosh
A1  - Palmer, Nicholette D.
A1  - Palsson, Runolfur
A1  - Penninx, Brenda W. J. H.
A1  - Perls, Thomas
A1  - Perola, Markus
A1  - Pirastu, Mario
A1  - Pirastu, Nicola
A1  - Pistis, Giorgio
A1  - Podgornaia, Anna I.
A1  - Polasek, Ozren
A1  - Ponte, Belen
A1  - Porteous, David J.
A1  - Poulain, Tanja
A1  - Pramstaller, Peter P.
A1  - Preuss, Michael H.
A1  - Prins, Bram P.
A1  - Province, Michael A.
A1  - Rabelink, Ton J.
A1  - Raffield, Laura M.
A1  - Raitakari, Olli T.
A1  - Reilly, Dermot F.
A1  - Rettig, Rainer
A1  - Rheinberger, Myriam
A1  - Rice, Kenneth M.
A1  - Ridker, Paul M.
A1  - Rivadeneira, Fernando
A1  - Rizzi, Federica
A1  - Roberts, David J.
A1  - Robino, Antonietta
A1  - Rossing, Peter
A1  - Rudan, Igor
A1  - Rueedi, Rico
A1  - Ruggiero, Daniela
A1  - Ryan, Kathleen A.
A1  - Saba, Yasaman
A1  - Sabanayagam, Charumathi
A1  - Salomaa, Veikko
A1  - Salvi, Erika
A1  - Saum, Kai-Uwe
A1  - Schmidt, Helena
A1  - Schmidt, Reinhold
A1  - Ben Schottker, 
A1  - Schulz, Christina-Alexandra
A1  - Schupf, Nicole
A1  - Shaffer, Christian M.
A1  - Shi, Yuan
A1  - Smith, Albert V.
A1  - Smith, Blair H.
A1  - Soranzo, Nicole
A1  - Spracklen, Cassandra N.
A1  - Strauch, Konstantin
A1  - Stringham, Heather M.
A1  - Stumvoll, Michael
A1  - Svensson, Per O.
A1  - Szymczak, Silke
A1  - Tai, E-Shyong
A1  - Tajuddin, Salman M.
A1  - Tan, Nicholas Y. Q.
A1  - Taylor, Kent D.
A1  - Teren, Andrej
A1  - Tham, Yih-Chung
A1  - Thiery, Joachim
A1  - Thio, Chris H. L.
A1  - Thomsen, Hauke
A1  - Thorleifsson, Gudmar
A1  - Toniolo, Daniela
A1  - Tonjes, Anke
A1  - Tremblay, Johanne
A1  - Tzoulaki, Ioanna
A1  - Uitterlinden, Andre G.
A1  - Vaccargiu, Simona
A1  - Van Dam, Rob M.
A1  - Van der Harst, Pim
A1  - Van Duijn, Cornelia M.
A1  - Edward, Digna R. Velez
A1  - Verweij, Niek
A1  - Vogelezang, Suzanne
A1  - Volker, Uwe
A1  - Vollenweider, Peter
A1  - Waeber, Gerard
A1  - Waldenberger, Melanie
A1  - Wallentin, Lars
A1  - Wang, Ya Xing
A1  - Wang, Chaolong
A1  - Waterworth, Dawn M.
A1  - Bin Wei, Wen
A1  - White, Harvey
A1  - Whitfield, John B.
A1  - Wild, Sarah H.
A1  - Wilson, James F.
A1  - Wojczynski, Mary K.
A1  - Wong, Charlene
A1  - Wong, Tien-Yin
A1  - Xu, Liang
A1  - Yang, Qiong
A1  - Yasuda, Masayuki
A1  - Yerges-Armstrong, Laura M.
A1  - Zhang, Weihua
A1  - Zonderman, Alan B.
A1  - Rotter, Jerome I.
A1  - Bochud, Murielle
A1  - Psaty, Bruce M.
A1  - Vitart, Veronique
A1  - Wilson, James G.
A1  - Dehghan, Abbas
A1  - Parsa, Afshin
A1  - Chasman, Daniel I.
A1  - Ho, Kevin
A1  - Morris, Andrew P.
A1  - Devuyst, Olivier
A1  - Akilesh, Shreeram
A1  - Pendergrass, Sarah A.
A1  - Sim, Xueling
A1  - Boger, Carsten A.
A1  - Okada, Yukinori
A1  - Edwards, Todd L.
A1  - Snieder, Harold
A1  - Stefansson, Kari
A1  - Hung, Adriana M.
A1  - Heid, Iris M.
A1  - Scholz, Markus
A1  - Teumer, Alexander
A1  - Kottgen, Anna
A1  - Pattaro, Cristian
T1  - A catalog of genetic loci associated with kidney function from analyses of a million individuals
JF  - Nature genetics
N2  - Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through transancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these,147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
Y1  - 2019
U6  - https://doi.org/10.1038/s41588-019-0407-x
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 6
SP  - 957
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  -