TY - JOUR A1 - Abdalla, Hassan E. A1 - Abramowski, Attila A1 - Aharonian, Felix A. A1 - Benkhali, Faiçal Ait A1 - Akhperjanian, A. G. A1 - Angüner, Ekrem Oǧuzhan A1 - Arrieta, M. A1 - Aubert, Pierre A1 - Backes, Michael A1 - Balzer, Arnim A1 - Barnard, Michelle A1 - Becherini, Yvonne A1 - Tjus, Julia Becker A1 - Berge, David A1 - Bernhard, Sabrina A1 - Bernlöhr, K. A1 - Birsin, E. A1 - Blackwell, R. A1 - Bottcher, Markus A1 - Boisson, Catherine A1 - Bolmont, J. A1 - Bordas, Pol A1 - Bregeon, Johan A1 - Brun, Francois A1 - Brun, Pierre A1 - Bryan, Mark A1 - Bulik, Tomasz A1 - Capasso, M. A1 - Carr, John A1 - Casanova, Sabrina A1 - Chakraborty, N. A1 - Chalme-Calvet, R. A1 - Chaves, Ryan C. G. A1 - Chen, Andrew A1 - Chevalier, J. A1 - Chretien, M. A1 - Colafrancesco, Sergio A1 - Cologna, Gabriele A1 - Condon, B. A1 - Conrad, Jan A1 - Couturier, C. A1 - Cui, Y. A1 - Davids, I. D. A1 - Degrange, B. A1 - Deil, Christoph A1 - deWilt, P. A1 - Djannati-Atai, Arache A1 - Domainko, Wilfried A1 - Donath, Axel A1 - Dubus, Guillaume A1 - Dutson, Kate A1 - Dyks, J. A1 - Dyrda, M. A1 - Edwards, T. A1 - Egberts, Kathrin A1 - Eger, P. A1 - Ernenwein, J. -P. A1 - Eschbach, S. A1 - Farnier, C. A1 - Fegan, Stuart A1 - Fernandes, M. V. A1 - Fiasson, A. A1 - Fontaine, G. A1 - Foerster, A. A1 - Funk, S. A1 - Füßling, Matthias A1 - Gabici, Stefano A1 - Gajdus, M. A1 - Gallant, Y. A. A1 - Garrigoux, T. A1 - Giavitto, Gianluca A1 - Giebels, B. A1 - Glicenstein, J. F. A1 - Gottschall, Daniel A1 - Goyal, A. A1 - Grondin, M. -H. A1 - Grudzinska, M. A1 - Hadasch, Daniela A1 - Hahn, J. A1 - Hawkes, J. A1 - Heinzelmann, G. A1 - Henri, Gilles A1 - Hermann, G. A1 - Hervet, Olivier A1 - Hillert, A. A1 - Hinton, James Anthony A1 - Hofmann, Werner A1 - Hoischen, Clemens A1 - Holler, M. A1 - Horns, D. A1 - Ivascenko, Alex A1 - Jacholkowska, A. A1 - Jamrozy, Marek A1 - Janiak, M. A1 - Jankowsky, D. A1 - Jankowsky, Felix A1 - Jingo, M. A1 - Jogler, Tobias A1 - Jouvin, Lea A1 - Jung-Richardt, Ira A1 - Kastendieck, M. A. A1 - Katarzynski, Krzysztof A1 - Katz, Uli A1 - Kerszberg, D. A1 - Khelifi, B. A1 - Kieffer, M. A1 - King, J. A1 - Klepser, S. A1 - Klochkov, Dmitry A1 - Kluzniak, W. A1 - Kolitzus, D. A1 - Komin, Nu. A1 - Kosack, K. A1 - Krakau, S. A1 - Kraus, Michael A1 - Krayzel, F. A1 - Kruger, P. P. A1 - Laffon, H. A1 - Lamanna, G. A1 - Lau, Jeanie A1 - Lees, J. -P. A1 - Lefaucheur, J. A1 - Lefranc, V. A1 - Lemiere, A. A1 - Lemoine-Goumard, M. A1 - Lenain, J. -P. A1 - Leser, Eva A1 - Lohse, Thomas A1 - Lorentz, M. A1 - Lui, R. A1 - Lypova, Iryna A1 - Marandon, Vincent A1 - Marcowith, Alexandre A1 - Mariaud, C. A1 - Marx, R. A1 - Maurin, G. A1 - Maxted, N. A1 - Mayer, Michael A1 - Meintjes, Petrus Johannes A1 - Menzler, U. A1 - Meyer, Manuel A1 - Mitchell, A. M. W. A1 - Moderski, R. A1 - Mohamed, M. A1 - Mora, K. A1 - Moulin, Emmanuel A1 - Murach, T. A1 - de Naurois, Mathieu A1 - Niederwanger, F. A1 - Niemiec, J. A1 - Oakes, L. A1 - Odaka, Hirokazu A1 - Ohm, Stefan A1 - Oettl, S. A1 - Ostrowski, M. A1 - Oya, I. A1 - Padovani, Marco A1 - Panter, M. A1 - Parsons, R. D. A1 - Arribas, M. Paz A1 - Pekeur, N. W. A1 - Pelletier, G. A1 - Petrucci, P. -O. A1 - Peyaud, B. A1 - Pita, S. A1 - Poon, Helen A1 - Prokhorov, Dmitry A1 - Prokoph, Heike A1 - Puehlhofer, Gerd A1 - Punch, Michael A1 - Quirrenbach, Andreas A1 - Raab, S. A1 - Reimer, Anita A1 - Reimer, Olaf A1 - Renaud, M. A1 - de los Reyes, R. A1 - Rieger, Frank A1 - Romoli, Carlo A1 - Rosier-Lees, S. A1 - Rowell, G. A1 - Rudak, B. A1 - Rulten, C. B. A1 - Sahakian, V. A1 - Salek, David A1 - Sanchez, David A. A1 - Santangelo, Andrea A1 - Sasaki, Manami A1 - Schlickeiser, Reinhard A1 - Schussler, F. A1 - Schulz, Andreas A1 - Schwanke, U. A1 - Schwemmer, S. A1 - Seyffert, A. S. A1 - Shafi, N. A1 - Simoni, R. A1 - Sol, H. A1 - Spanier, Felix A1 - Spengler, G. A1 - Spiess, F. A1 - Stawarz, Lukasz A1 - Steenkamp, R. A1 - Stegmann, Christian A1 - Stinzing, F. A1 - Stycz, K. A1 - Sushch, Iurii A1 - Tavernet, J. -P. A1 - Tavernier, T. A1 - Taylor, A. M. A1 - Terrier, R. A1 - Tluczykont, Martin A1 - Trichard, C. A1 - Tuffs, R. A1 - van der Walt, Johan A1 - van Eldik, Christopher A1 - van Soelen, Brian A1 - Vasileiadis, Georges A1 - Veh, J. A1 - Venter, C. A1 - Viana, A. A1 - Vincent, P. A1 - Vink, Jacco A1 - Voisin, F. A1 - Voelk, Heinrich J. A1 - Vuillaume, Thomas A1 - Wadiasingh, Z. A1 - Wagner, Stefan J. A1 - Wagner, P. A1 - Wagner, R. M. A1 - White, R. A1 - Wierzcholska, Alicja A1 - Willmann, P. A1 - Woernlein, A. A1 - Wouters, Denis A1 - Yang, R. A1 - Zabalza, Victor A1 - Zaborov, D. A1 - Zacharias, M. A1 - Zdziarski, A. A. A1 - Zech, Andreas A1 - Zefi, F. A1 - Ziegler, A. A1 - Zywucka, Natalia T1 - Search for Dark Matter Annihilations towards the Inner Galactic Halo from 10 Years of Observations with HESS JF - Physical review letters N2 - The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section . These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe values expected from the thermal relic density for TeV DM particles. Y1 - 2016 U6 - https://doi.org/10.1103/PhysRevLett.117.111301 SN - 0031-9007 SN - 1079-7114 VL - 117 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Reiche, Jürgen A1 - Janietz, Dietmar A1 - Barberka, Thomas Andreas A1 - Hofmann, Dieter A1 - Brehmer, Ludwig T1 - Comprehensive structure investigation of Langmuir-Blodgett films of disc-shaped molecules N2 - The structure of mono- and multilayers of amphiphilic disc-shaped pentaynes wa inbestigated by Brewsterangle microscopy, X-ray specular reflection and grazing incidence diffraction (GID). X-ray specular reflection experiments confirm the "edge on" arrangement of the molecular discs. The molecular modelling of the Langmuir-Blodgett (LB)- multilayers predicts a columnar in-plane packing of the molecules. A GID experiment with monochromatic synchrotron radiation was used to verify the predicted multilayer structure on molecular level, while the Brewsterangle microscopy gave a deeper insight in the monolayer in-plane structure on micron scale. Y1 - 1995 ER - TY - JOUR A1 - Reiche, Jürgen A1 - Barberka, Thomas Andreas A1 - Janietz, Dietmar A1 - Hofmann, Dieter A1 - Pietsch, Ullrich A1 - Brehmer, Ludwig T1 - X-ray structure investigation and computer modelling of Langmuir-Blodgett films formed from disc-shaped pentaalkines Y1 - 1994 ER - TY - JOUR A1 - Behrens, Maik A1 - Frank, Oliver A1 - Rawel, Harshadrai Manilal A1 - Ahuja, Gaurav A1 - Potting, Christoph A1 - Hofmann, Thomas A1 - Meyerhof, Wolfgang A1 - Korsching, Sigrun T1 - ORA1, a Zebrafish Olfactory Receptor Ancestral to All Mammalian V1R Genes, Recognizes 4-Hydroxyphenylacetic Acid, a Putative Reproductive Pheromone JF - The journal of biological chemistry N2 - The teleost v1r-related ora genes are a small, highly conserved olfactory receptor gene family of only six genes, whose direct orthologues can be identified in lineages as far as that of cartilaginous fish. However, no ligands for fish olfactory receptor class A related genes (ORA) had been uncovered so far. Here we have deorphanized the ORA1 receptor using heterologous expression and calcium imaging. We report that zebrafish ORA1 recognizes with high specificity and sensitivity 4-hydroxyphenylacetic acid. The carboxyl group of this compound is required in a particular distance from the aromatic ring, whereas the hydroxyl group in the para-position is not essential, but strongly enhances the binding efficacy. Low concentrations of 4-hydroxyphenylacetic acid elicit increases in oviposition frequency in zebrafish mating pairs. This effect is abolished by naris closure. We hypothesize that 4-hydroxyphenylacetic acid might function as a pheromone for reproductive behavior in zebrafish. ORA1 is ancestral to mammalian V1Rs, and its putative function as pheromone receptor is reminiscent of the role of several mammalian V1Rs as pheromone receptors. Y1 - 2014 U6 - https://doi.org/10.1074/jbc.M114.573162 SN - 0021-9258 SN - 1083-351X VL - 289 IS - 28 SP - 19778 EP - 19788 PB - American Society for Biochemistry and Molecular Biology CY - Bethesda ER - TY - JOUR A1 - Moser, Othmar A1 - Tschakert, Gerhard A1 - Müller, Alexander A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Obermayer-Pietsch, Barbara A1 - Köhler, Gerd A1 - Hofmann, Peter T1 - Effects of High-Intensity Interval Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin JF - PLoS one N2 - Introduction We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM). Material and Methods Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system. Results BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C. Conclusion Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM. Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0136489 SN - 1932-6203 VL - 10 IS - 8 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Marom, Noa A1 - Caruso, Fabio A1 - Ren, Xinguo A1 - Hofmann, Oliver T. A1 - Körzdörfer, Thomas A1 - Chelikowsky, James R. A1 - Rubio, Angel A1 - Scheffler, Matthias A1 - Rinke, Patrick T1 - Benchmark of GW methods for azabenzenes JF - Physical review : B, Condensed matter and materials physics N2 - Many-body perturbation theory in the GW approximation is a useful method for describing electronic properties associated with charged excitations. A hierarchy of GW methods exists, starting from non-self-consistent G(0)W(0), through partial self-consistency in the eigenvalues and in the Green's function (scGW(0)), to fully self-consistent GW (scGW). Here, we assess the performance of these methods for benzene, pyridine, and the diazines. The quasiparticle spectra are compared to photoemission spectroscopy (PES) experiments with respect to all measured particle removal energies and the ordering of the frontier orbitals. We find that the accuracy of the calculated spectra does not match the expectations based on their level of self-consistency. In particular, for certain starting points G(0)W(0) and scGW(0) provide spectra in better agreement with the PES than scGW. Y1 - 2012 U6 - https://doi.org/10.1103/PhysRevB.86.245127 SN - 1098-0121 VL - 86 IS - 24 PB - American Physical Society CY - College Park ER - TY - JOUR A1 - Fritz, Joerg A1 - Tagle, Roald A1 - Ashworth, Luisa A1 - Schmitt, Ralf Thomas A1 - Hofmann, Axel A1 - Luais, Beatrice A1 - Harris, Phillip D. A1 - Hoehnel, Desiree A1 - Özdemir, Seda A1 - Mohr-Westheide, Tanja A1 - Koeberl, Christian T1 - Nondestructive spectroscopic and petrochemical investigations of Paleoarchean spherule layers from the ICDP drill core BARB5, Barberton Mountain Land, South Africa JF - Quaestiones geographicae N2 - A Paleoarchean impact spherule-bearing interval of the 763 m long International Continental Scientific Drilling Program (ICDP) drill core BARB5 from the lower Mapepe Formation of the Fig Tree Group, Barberton Mountain Land (South Africa) was investigated using nondestructive analytical techniques. The results of visual observation, infrared (IR) spectroscopic imaging, and micro-X-ray fluorescence (lXRF) of drill cores are presented. Petrographic and sedimentary features, as well as major and trace element compositions of lithologies from the micrometer to kilometer-scale, assisted in the localization and characterization of eight spherule-bearing intervals between 512.6 and 510.5 m depth. The spherule layers occur in a strongly deformed section between 517 and 503 m, and the rocks in the core above and below are clearly less disturbed. The lXRF element maps show that spherule layers have similar petrographic and geochemical characteristics but differences in (1) sorting of two types of spherules and (2) occurrence of primary minerals (Ni-Cr spinel and zircon). We favor a single impact scenario followed by postimpact reworking, and subsequent alteration. The spherule layers are Al2O3-rich and can be distinguished from the Al2O3-poor marine sediments by distinct Al-OH absorption features in the short wave infrared (SWIR) region of the electromagnetic spectrum. Infrared images can cover tens to hundreds of square meters of lithologies and, thus, may be used to search for Al-OH-rich spherule layers in Al2O3-poor sediments, such as Eoarchean metasediments, where the textural characteristics of the spherule layers are obscured by metamorphism. Y1 - 2016 U6 - https://doi.org/10.1111/maps.12736 SN - 1086-9379 SN - 1945-5100 VL - 51 SP - 2441 EP - 2458 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Moser, Othmar A1 - Mader, Julia K. A1 - Tschakert, Gerhard A1 - Mueller, Alexander A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Koehler, Gerd A1 - Messerschmidt, Janin A1 - Hofmann, Peter T1 - Accuracy of Continuous Glucose Monitoring (CGM) during Continuous and High-Intensity Interval Exercise in Patients with Type 1 Diabetes Mellitus JF - Nutrients N2 - Continuous exercise (CON) and high-intensity interval exercise (HIIE) can be safely performed with type 1 diabetes mellitus (T1DM). Additionally, continuous glucose monitoring (CGM) systems may serve as a tool to reduce the risk of exercise-induced hypoglycemia. It is unclear if CGM is accurate during CON and HIIE at different mean workloads. Seven T1DM patients performed CON and HIIE at 5% below (L) and above (M) the first lactate turn point (LTP1), and 5% below the second lactate turn point (LTP2) (H) on a cycle ergometer. Glucose was measured via CGM and in capillary blood (BG). Differences were found in comparison of CGM vs. BG in three out of the six tests (p < 0.05). In CON, bias and levels of agreement for L, M, and H were found at: 0.85 (-3.44, 5.15) mmol.L-1, -0.45 (-3.95, 3.05) mmol.L-1, -0.31 (-8.83, 8.20) mmol.L-1 and at 1.17 (-2.06, 4.40) mmol.L-1, 0.11 (-5.79, 6.01) mmol.L-1, 1.48 (-2.60, 5.57) mmol.L-1 in HIIE for the same intensities. Clinically-acceptable results (except for CON H) were found. CGM estimated BG to be clinically acceptable, except for CON H. Additionally, using CGM may increase avoidance of exercise-induced hypoglycemia, but usual BG control should be performed during intense exercise. KW - continuous glucose monitoring KW - exercise KW - diabetes KW - blood glucose Y1 - 2016 U6 - https://doi.org/10.3390/nu8080489 SN - 2072-6643 VL - 8 PB - MDPI CY - Basel ER - TY - JOUR A1 - Moser, Othmar A1 - Tschakert, Gerhard A1 - Müller, Alexander A1 - Groeschl, Werner A1 - Pieber, Thomas R. A1 - Obermayer-Pietsch, Barbara A1 - Koehler, Gerd A1 - Hofmann, Peter T1 - Exercise versus Moderate Continuous Exercise on Glucose Homeostasis and Hormone Response in Patients with Type 1 Diabetes Mellitus Using Novel Ultra-Long-Acting Insulin JF - PLoS one N2 - Introduction We investigated blood glucose (BG) and hormone response to aerobic high-intensity interval exercise (HIIE) and moderate continuous exercise (CON) matched for mean load and duration in type 1 diabetes mellitus (T1DM). Material and Methods Seven trained male subjects with T1DM performed a maximal incremental exercise test and HIIE and CON at 3 different mean intensities below (A) and above (B) the first lactate turn point and below the second lactate turn point (C) on a cycle ergometer. Subjects were adjusted to ultra-long-acting insulin Degludec (Tresiba/ Novo Nordisk, Denmark). Before exercise, standardized meals were administered, and short-acting insulin dose was reduced by 25% (A), 50% (B), and 75% (C) dependent on mean exercise intensity. During exercise, BG, adrenaline, noradrenaline, dopamine, cortisol, glucagon, and insulin-like growth factor-1, blood lactate, heart rate, and gas exchange variables were measured. For 24 h after exercise, interstitial glucose was measured by continuous glucose monitoring system. Results BG decrease during HIIE was significantly smaller for B (p = 0.024) and tended to be smaller for A and C compared to CON. No differences were found for post-exercise interstitial glucose, acute hormone response, and carbohydrate utilization between HIIE and CON for A, B, and C. In HIIE, blood lactate for A (p = 0.006) and B (p = 0.004) and respiratory exchange ratio for A (p = 0.003) and B (p = 0.003) were significantly higher compared to CON but not for C. Conclusion Hypoglycemia did not occur during or after HIIE and CON when using ultra-long-acting insulin and applying our methodological approach for exercise prescription. HIIE led to a smaller BG decrease compared to CON, although both exercises modes were matched for mean load and duration, even despite markedly higher peak workloads applied in HIIE. Therefore, HIIE and CON could be safely performed in T1DM. KW - Insulin KW - Exercise KW - Glucose KW - Hypoglycemia KW - Carbohydrates KW - Blood KW - Blood sugar KW - Heart rate Y1 - 2015 U6 - https://doi.org/10.1371/journal.pone.0136489 SN - 1932-6203 VL - 10 IS - 8 PB - Public Library of Science CY - Lawrence ER -