TY  - GEN
A1  - Doriti, Afroditi
A1  - Brosnan, Sarah M.
A1  - Weidner, Steffen M.
A1  - Schlaad, Helmut
T1  - Synthesis of polysarcosine from air and moisture stable N-phenoxycarbonyl-N-methylglycine assisted by tertiary amine base
N2  - Polysarcosine (Mn = 3650–20 000 g mol−1, Đ ∼ 1.1) was synthesized from the air and moisture stable N-phenoxycarbonyl-N-methylglycine. Polymerization was achieved by in situ transformation of the urethane precursor into the corresponding N-methylglycine-N-carboxyanhydride, when in the presence of a non-nucleophilic tertiary amine base and a primary amine initiator.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 255 
KW  - acids
KW  - activated urethane derivatives
KW  - carboxyanhydrides
KW  - copolymers
KW  - phosgene-free synthesis
KW  - polypeptides
KW  - ring-opening polymerization
Y1  - 2016
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-95852
SP  - 3067
EP  - 3070
ER  - 
TY  - JOUR
A1  - Secker, Christian
A1  - Brosnan, Sarah M.
A1  - Luxenhofer, Robert
A1  - Schlaad, Helmut
T1  - Poly(alpha-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial
JF  - Macromolecular bioscience
N2  - Polypeptoids have been of great interest in the polymer science community since the early half of the last century; however, they had been basically forgotten materials until the last decades in which they have enjoyed an exciting revival. In this mini-review, we focus on the recent developments in polypeptoid chemistry, with particular focus on polymers synthesized by the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs). Specifically, we will review traditional monomer synthesis (such as Leuchs, Katchalski, and Kricheldorf) and recent advances in polymerization methods to yield both linear, cyclic, and functional polymers, solution and bulk thermal properties, and preliminary results on the use of polypeptoids as biomaterials (i.e immunogenicity, biodistribution, degradability, and drug delivery).
KW  - amino acid N-carboxyanhydride (NCA)
KW  - biomaterials
KW  - peptides
KW  - properties
KW  - ring-opening polymerization
Y1  - 2015
U6  - https://doi.org/10.1002/mabi.201500023
SN  - 1616-5187
SN  - 1616-5195
VL  - 15
IS  - 7
SP  - 881
EP  - 891
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Doriti, Afroditi
A1  - Brosnan, Sarah M.
A1  - Weidner, Steffen M.
A1  - Schlaad, Helmut
T1  - Synthesis of polysarcosine from air and moisture stable N-phenoxycarbonyl-N-methylglycine assisted by tertiary amine base
JF  - Polymer Chemistry
N2  - Polysarcosine (Mn = 3650–20 000 g mol−1, Đ ∼ 1.1) was synthesized from the air and moisture stable N-phenoxycarbonyl-N-methylglycine. Polymerization was achieved by in situ transformation of the urethane precursor into the corresponding N-methylglycine-N-carboxyanhydride, when in the presence of a non-nucleophilic tertiary amine base and a primary amine initiator.
KW  - ring-opening polymerization
KW  - activated urethane derivatives
KW  - phosgene-free synthesis
KW  - carboxyanhydrides
KW  - polypeptides
KW  - acids
KW  - copolymers
Y1  - 2016
U6  - https://doi.org/10.1039/C6PY00221H
SN  - 1759-9954
SN  - 1759-9962
VL  - 7
SP  - 3067
EP  - 3070
PB  - RSC Publ.
CY  - Cambridge
ER  -