TY - GEN A1 - de Vera, Jean-Pierre Paul A1 - Alawi, Mashal A1 - Backhaus, Theresa A1 - Baque, Mickael A1 - Billi, Daniela A1 - Boettger, Ute A1 - Berger, Thomas A1 - Bohmeier, Maria A1 - Cockell, Charles A1 - Demets, Rene A1 - de la Torre Noetzel, Rosa A1 - Edwards, Howell A1 - Elsaesser, Andreas A1 - Fagliarone, Claudia A1 - Fiedler, Annelie A1 - Foing, Bernard A1 - Foucher, Frederic A1 - Fritz, Jörg A1 - Hanke, Franziska A1 - Herzog, Thomas A1 - Horneck, Gerda A1 - Hübers, Heinz-Wilhelm A1 - Huwe, Björn A1 - Joshi, Jasmin Radha A1 - Kozyrovska, Natalia A1 - Kruchten, Martha A1 - Lasch, Peter A1 - Lee, Natuschka A1 - Leuko, Stefan A1 - Leya, Thomas A1 - Lorek, Andreas A1 - Martinez-Frias, Jesus A1 - Meessen, Joachim A1 - Moritz, Sophie A1 - Moeller, Ralf A1 - Olsson-Francis, Karen A1 - Onofri, Silvano A1 - Ott, Sieglinde A1 - Pacelli, Claudia A1 - Podolich, Olga A1 - Rabbow, Elke A1 - Reitz, Günther A1 - Rettberg, Petra A1 - Reva, Oleg A1 - Rothschild, Lynn A1 - Garcia Sancho, Leo A1 - Schulze-Makuch, Dirk A1 - Selbmann, Laura A1 - Serrano, Paloma A1 - Szewzyk, Ulrich A1 - Verseux, Cyprien A1 - Wadsworth, Jennifer A1 - Wagner, Dirk A1 - Westall, Frances A1 - Wolter, David A1 - Zucconi, Laura T1 - Limits of life and the habitability of Mars BT - the ESA space experiment BIOMEX on the ISS T2 - Astrobiology N2 - BIOMEX (BIOlogy and Mars EXperiment) is an ESA/Roscosmos space exposure experiment housed within the exposure facility EXPOSE-R2 outside the Zvezda module on the International Space Station (ISS). The design of the multiuser facility supports-among others-the BIOMEX investigations into the stability and level of degradation of space-exposed biosignatures such as pigments, secondary metabolites, and cell surfaces in contact with a terrestrial and Mars analog mineral environment. In parallel, analysis on the viability of the investigated organisms has provided relevant data for evaluation of the habitability of Mars, for the limits of life, and for the likelihood of an interplanetary transfer of life (theory of lithopanspermia). In this project, lichens, archaea, bacteria, cyanobacteria, snow/permafrost algae, meristematic black fungi, and bryophytes from alpine and polar habitats were embedded, grown, and cultured on a mixture of martian and lunar regolith analogs or other terrestrial minerals. The organisms and regolith analogs and terrestrial mineral mixtures were then exposed to space and to simulated Mars-like conditions by way of the EXPOSE-R2 facility. In this special issue, we present the first set of data obtained in reference to our investigation into the habitability of Mars and limits of life. This project was initiated and implemented by the BIOMEX group, an international and interdisciplinary consortium of 30 institutes in 12 countries on 3 continents. Preflight tests for sample selection, results from ground-based simulation experiments, and the space experiments themselves are presented and include a complete overview of the scientific processes required for this space experiment and postflight analysis. The presented BIOMEX concept could be scaled up to future exposure experiments on the Moon and will serve as a pretest in low Earth orbit. KW - EXPOSE-R2 KW - BIOMEX KW - Habitability KW - Limits of life KW - Extremophiles KW - Mars Y1 - 2019 U6 - https://doi.org/10.1089/ast.2018.1897 SN - 1531-1074 SN - 1557-8070 VL - 19 IS - 2 SP - 145 EP - 157 PB - Liebert CY - New Rochelle ER - TY - GEN A1 - Hägele, Claudia A1 - Schlagenhauf, Florian A1 - Rapp, Michael A. A1 - Sterzer, Philipp A1 - Beck, Anne A1 - Bermpohl, Felix A1 - Stoy, Meline A1 - Ströhle, Andreas A1 - Wittchen, Hans-Ulrich A1 - Dolan, Raymond J. A1 - Heinz, Andreas T1 - Dimensional psychiatry BT - reward dysfunction and depressive mood across psychiatric disorders T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. We used functional magnetic resonance imaging (fMRI) and a monetary incentive delay (MID) task to study the functional correlates of reward anticipation across major psychiatric disorders in 184 subjects, with the diagnoses of alcohol dependence (n = 26), schizophrenia (n = 44), major depressive disorder (MDD, n = 24), bipolar disorder (acute manic episode, n = 13), attention deficit/hyperactivity disorder (ADHD, n = 23), and healthy controls (n = 54). Subjects' individual Beck Depression Inventory-and State-Trait Anxiety Inventory-scores were correlated with clusters showing significant activation during reward anticipation. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 653 KW - dimensional KW - fMRI KW - reward system KW - ventral striatum KW - monetary incentive delay task KW - depressive symptoms Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-431064 SN - 1866-8364 IS - 653 SP - 331 EP - 341 ER - TY - GEN A1 - Rapp, Michael A. A1 - Kluge, Ulrike A1 - Penka, Simone A1 - Vardar, Azra A1 - Aichberger, Marion Christina A1 - Mundt, Adrian P. A1 - Schouler-Ocak, Meryam A1 - Mösko, Mike A1 - Butler, Jeffrey A1 - Meyer-Lindenberg, Andreas A1 - Heinz, Andreas T1 - When local poverty is more important than your income: Mental health in minorities in inner cities T2 - World psychiatry Y1 - 2015 U6 - https://doi.org/10.1002/wps.20221 SN - 1723-8617 SN - 2051-5545 VL - 14 IS - 2 SP - 249 EP - 250 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Haegele, Claudia A1 - Schlagenhauf, Florian A1 - Rapp, Michael A. A1 - Sterzer, Philipp A1 - Beck, Anne A1 - Bermpohl, Felix A1 - Stoy, Meline A1 - Stroehle, Andreas A1 - Wittchen, Hans-Ulrich A1 - Dolan, Raymond J. A1 - Heinz, Andreas T1 - Dimensional psychiatry: reward dysfunction and depressive mood across psychiatric disorders JF - Psychopharmacology N2 - A dimensional approach in psychiatry aims to identify core mechanisms of mental disorders across nosological boundaries. We compared anticipation of reward between major psychiatric disorders, and investigated whether reward anticipation is impaired in several mental disorders and whether there is a common psychopathological correlate (negative mood) of such an impairment. During reward anticipation, we observed significant group differences in ventral striatal (VS) activation: patients with schizophrenia, alcohol dependence, and major depression showed significantly less ventral striatal activation compared to healthy controls. Depressive symptoms correlated with dysfunction in reward anticipation regardless of diagnostic entity. There was no significant correlation between anxiety symptoms and VS functional activation. Our findings demonstrate a neurobiological dysfunction related to reward prediction that transcended disorder categories and was related to measures of depressed mood. The findings underline the potential of a dimensional approach in psychiatry and strengthen the hypothesis that neurobiological research in psychiatric disorders can be targeted at core mechanisms that are likely to be implicated in a range of clinical entities. KW - Dimensional KW - fMRI KW - Reward system KW - Ventral striatum KW - Monetary incentive delay task KW - Depressive symptoms Y1 - 2015 U6 - https://doi.org/10.1007/s00213-014-3662-7 SN - 0033-3158 SN - 1432-2072 VL - 232 IS - 2 SP - 331 EP - 341 PB - Springer CY - New York ER - TY - JOUR A1 - Förstner, Bernd Rainer A1 - Böttger, Sarah Jane A1 - Moldavski, Alexander A1 - Bajbouj, Malek A1 - Pfennig, Andrea A1 - Manook, Andre A1 - Ising, Marcus A1 - Pittig, Andre A1 - Heinig, Ingmar A1 - Heinz, Andreas A1 - Mathiak, Klaus A1 - Schulze, Thomas G. A1 - Schneider, Frank A1 - Kamp-Becker, Inge A1 - Meyer-Lindenberg, Andreas A1 - Padberg, Frank A1 - Banaschewski, Tobias A1 - Bauer, Michael A1 - Rupprecht, Rainer A1 - Wittchen, Hans-Ulrich A1 - Rapp, Michael A. A1 - Tschorn, Mira T1 - The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders JF - Frontiers in psychiatry N2 - Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: & beta; = -0.35; NVS: & beta; = 0.39; CS: & beta; = -0.12; SP: & beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways. KW - Research Domain Criteria KW - depression KW - anxiety disoders KW - disease severity KW - transdiagnostic KW - RDoC Y1 - 2023 U6 - https://doi.org/10.3389/fpsyt.2023.1161097 SN - 1664-0640 VL - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - CHAP A1 - Haegele, Claudia A1 - Friedel, Eva A1 - Schlagenhauf, Florian A1 - Sterzer, Philipp A1 - Beck, Anne A1 - Bermpohl, Felix A1 - Rapp, Michael A. A1 - Stoy, Meline A1 - Stroehle, Andreas A1 - Dolan, Raymond J. A1 - Heinz, Andreas T1 - Reward expectation and affective responses across psychiatric disorders - A dimensional approach T2 - Biological psychiatry : a journal of psychiatric neuroscience and therapeutics ; a publication of the Society of Biological Psychiatry KW - dimensional KW - transdiagnostic KW - reward system KW - ventral striatum KW - fMRI Y1 - 2014 SN - 0006-3223 SN - 1873-2402 VL - 75 IS - 9 SP - 91S EP - 92S PB - Elsevier CY - New York ER - TY - JOUR A1 - Förstner, Bernd R. A1 - Tschorn, Mira A1 - Reinoso-Schiller, Nicolas A1 - Maričić, Lea Mascarell A1 - Röcher, Erik A1 - Kalman, Janos L. A1 - Stroth, Sanna A1 - Mayer, Annalina V. A1 - Schwarz, Kristina A1 - Kaiser, Anna A1 - Pfennig, Andrea A1 - Manook, André A1 - Ising, Marcus A1 - Heinig, Ingmar A1 - Pittig, Andre A1 - Heinz, Andreas A1 - Mathiak, Klaus A1 - Schulze, Thomas G. A1 - Schneider, Frank A1 - Kamp-Becker, Inge A1 - Meyer-Lindenberg, Andreas A1 - Padberg, Frank A1 - Banaschewski, Tobias A1 - Bauer, Michael A1 - Rupprecht, Rainer A1 - Wittchen, Hans-Ulrich A1 - Rapp, Michael A. T1 - Mapping research domain criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis JF - European archives of psychiatry and clinical neuroscience N2 - This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix. KW - Diagnosis and classification KW - Research Domain Criteria KW - PD-CAN KW - Confirmatory factor analysis CFA KW - RDoC KW - Transdiagnostic Y1 - 2022 U6 - https://doi.org/10.1007/s00406-022-01440-6 SN - 0940-1334 SN - 1433-8491 VL - 273 IS - 3 SP - 527 EP - 539 PB - Springer Nature CY - Heidelberg ER - TY - JOUR A1 - Braunß, Hans-Andreas A1 - Junek, Heinz T1 - Factorization of injective ideals by interpolation N2 - We construct a factorization of certain multilinear mappings through linear operators belonging to closed, injective operator ideals using interpolation technique. An extension of the duality theorem for interpolation spaces is also obtained. Y1 - 2004 SN - 0022-247x ER - TY - JOUR A1 - Hansen, Dominique A1 - Kraenkel, Nicolle A1 - Kemps, Hareld A1 - Wilhelm, Matthias A1 - Abreu, Ana A1 - Pfeiffer, Andreas F. H. A1 - Jordao, Alda A1 - Cornelissen, Veronique A1 - Völler, Heinz T1 - Management of patients with type 2 diabetes in cardiovascular rehabilitation JF - European journal of preventive cardiology : the official ESC journal for primary & secondary cardiovascular prevention, rehabilitation and sports cardiology N2 - The clinical benefits of rehabilitation in cardiovascular disease are well established. Among cardiovascular disease patients, however, patients with type 2 diabetes mellitus require a distinct approach. Specific challenges to clinicians and healthcare professionals in patients with type 2 diabetes include the prevalence of peripheral and autonomic neuropathy, retinopathy, nephropathy, but also the intake of glucose-lowering medication. In addition, the psychosocial wellbeing, driving ability and/or occupational status can be affected by type 2 diabetes. As a result, the target parameters of cardiovascular rehabilitation and the characteristics of the cardiovascular rehabilitation programme in patients with type 2 diabetes often require significant reconsideration and a multidisciplinary approach. This review explains how to deal with diabetes-associated comorbidities in the intake screening of patients with type 2 diabetes entering a cardiovascular rehabilitation programme. Furthermore, we discuss diabetes-specific target parameters and characteristics of cardiovascular rehabilitation programmes for patients with type 2 diabetes in a multidisciplinary context, including the implementation of guideline-directed medical therapy. KW - Diabetes KW - cardiovascular rehabilitation KW - intake screening KW - exercise Y1 - 2019 U6 - https://doi.org/10.1177/2047487319882820 SN - 2047-4873 SN - 2047-4881 VL - 26 IS - 2_SUPPL SP - 133 EP - 144 PB - Sage Publ. CY - London ER - TY - THES A1 - Heinz, Andreas T1 - Der Begriff psychischer Krankheiten Y1 - 2013 CY - Potsdam ER - TY - GEN A1 - Daig, Isolde A1 - Mahlberg, Richard A1 - Schroeder, Franziska A1 - Gudlowski, Yehonala A1 - Wrase, Jana A1 - Wertenauer, Florian A1 - Bschor, Tom A1 - Esser, Günter A1 - Heinz, Andreas A1 - Kienast, Thorsten T1 - Low effective organizational strategies in visual memory performance of unmedicated alcoholics during early abstinence Y1 - 2010 SN - 1860 - 5214 ER - TY - JOUR A1 - Daig, Isolde A1 - Mahlberg, Richard A1 - Stethin, Julia A1 - Shroeder, Franziska A1 - Wrase, Jana A1 - Knoll, Nina A1 - Bschor, Tom A1 - Esser, Günter A1 - Heinz, Andreas A1 - Kienast, Thorsten T1 - Decreased verbal learning but not recognition performance in alcohol-dependent individuals during early abstinence Y1 - 2012 ER - TY - JOUR A1 - Fabian, Heinz A1 - Gast, Klaus A1 - Laue, Michael A1 - Misselwitz, Rolf A1 - Uchanska-Ziegler, Barbara A1 - Ziegler, Andreas A1 - Naumann, Dieter T1 - Early stages of misfolding and association of beta2-microglobulin : insights from infrared spectroscopy and dynamic light scattering N2 - Conformational changes associated with the assembly of recombinant ;2-microglobulin in vitro under acidic conditions were investigated using infrared spectroscopy and static and dynamic light scattering. In parallel, the morphology of the different aggregated species obtained under defined conditions was characterized by electron microscopy. The initial salt-induced aggregate form of ;2-microglobulin, composed of small oligomers (dimers to tetramers), revealed the presence of ;-strands organized in an intramolecular-like fashion. Further particle growth was accompanied by the formation of intermolecular ;-sheet structure and led to short curved forms. An increase in temperature by only 25 °C was able to disaggregate these assemblies, followed by the formation of longer filamentous structures. In contrast, a rise in temperature up to 100 °C was associated with a reorganization of the short curved forms at the level of secondary structure and the state of assembly, leading to a species with a characteristic infrared spectrum different from those of all the other aggregates observed before, suggesting a unique overall structure. The infrared spectral features of this species were nearly identical to those of ;2-microglobulin assemblies formed at low ionic strength with agitation, indicating the presence of fibrils, which was confirmed by electron microscopy. The observed spectroscopic changes suggest that the heat-triggered conversion of the short curved assemblies into fibrils involves a reorganization of the ;-strands from an antiparallel arrangement to a parallel arrangement, with the latter being characteristic of amyloid fibrils of ;2-microglobulin. Y1 - 2008 UR - http://pubs.acs.org/doi/abs/10.1021/bi800279y ER - TY - JOUR A1 - Fabian, Heinz A1 - Gast, Klaus A1 - Laue, Michael A1 - Jetzschmann, Katharina J. A1 - Naumann, Dieter A1 - Ziegler, Andreas A1 - Uchanska-Ziegler, Barbara T1 - IR spectroscopic analyses of amyloid fibril formation of beta(2)-microglobulin using a simplified procedure for its in vitro generation at neutral pH JF - Biophysical chemistry : an international journal devoted to the physical chemistry of biological phenomena N2 - beta(2)-microglobulin (beta(2)m) is known to be the major component of fibrillar deposits in the joints of patients suffering from dialysis-related amyloidosis. We have developed a simplified procedure to convert monomeric recombinant beta(2)m into amyloid fibrils at physiological pH by a combination of stirring and heating, enabling us to follow conformational changes associated with the assembly by infrared spectroscopy and electron microscopy. Our studies reveal that fibrillogenesis begins with the formation of relatively large aggregates, with secondary structure not significantly altered by the stirring-induced association. In contrast, the conversion of the amorphous aggregates into amyloid fibrils is associated with a profound re-organization at the level of the secondary and tertiary structures, leading to non-native like parallel arrangements of the beta-strands in the fully formed amyloid structure of beta(2)m. This study highlights the power of an approach to investigate the formation of beta(2)m fibrils by a combination of biophysical techniques including IR spectroscopy. KW - Amyloid fibril KW - beta(2)-microglobulin KW - Amyloidogenesis KW - IR spectroscopy Y1 - 2013 U6 - https://doi.org/10.1016/j.bpc.2013.05.001 SN - 0301-4622 VL - 179 IS - 5 SP - 35 EP - 46 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Junek, Heinz A1 - Braunß, Hans-Andreas A1 - Botelho, Geraldo T1 - Almost p-summing polynomials and multilinear mappings N2 - For several applications it is very useful to classify the linear or non-linear mappings by their summability properties. Absolutely summing operators and polynomials are prominent and classical examples of such setting. Here we are interested in the larger class of almost summing polynomials and we investigate their connections to other related notions of summability. Y1 - 2001 ER - TY - JOUR A1 - Junek, Heinz A1 - Braunß, Hans-Andreas A1 - Plewnia, Eckart T1 - Approximation numbers for polynomials N2 - Approximation numbers of linear operators are a very useful tool in order to understand the structure and the numerical behaviour of the operators. In this paper, this concept is extended to polynomials on Banach spaces and the approximation numbers of diagonal polynomials are estimated. As a main tool the rank of polynomials as a graduation of finite type polynomials is introduced and studied. Y1 - 2000 ER - TY - JOUR A1 - Grimm, Volker A1 - Berger, Uta A1 - Bastiansen, Finn A1 - Eliassen, Sigrunn A1 - Ginot, Vincent A1 - Giske, Jarl A1 - Goss-Custard, John A1 - Grand, Tamara A1 - Heinz, Simone K. A1 - Huse, Geir A1 - Huth, Andreas A1 - Jepsen, Jane U. A1 - Jorgensen, Christian A1 - Mooij, Wolf M. A1 - Mueller, Birgit A1 - Piou, Cyril A1 - Railsback, Steven Floyd A1 - Robbins, Andrew M. A1 - Robbins, Martha M. A1 - Rossmanith, Eva A1 - Rueger, Nadja A1 - Strand, Espen A1 - Souissi, Sami A1 - Stillman, Richard A. A1 - Vabo, Rune A1 - Visser, Ute A1 - DeAngelis, Donald L. T1 - A standard protocol for describing individual-based and agent-based models JF - Ecological modelling : international journal on ecological modelling and engineering and systems ecolog N2 - Simulation models that describe autonomous individual organisms (individual based models, IBM) or agents (agent-based models, ABM) have become a widely used tool, not only in ecology, but also in many other disciplines dealing with complex systems made up of autonomous entities. However, there is no standard protocol for describing such simulation models, which can make them difficult to understand and to duplicate. This paper presents a proposed standard protocol, ODD, for describing IBMs and ABMs, developed and tested by 28 modellers who cover a wide range of fields within ecology. This protocol consists of three blocks (Overview, Design concepts, and Details), which are subdivided into seven elements: Purpose, State variables and scales, Process overview and scheduling, Design concepts, Initialization, Input, and Submodels. We explain which aspects of a model should be described in each element, and we present an example to illustrate the protocol in use. In addition, 19 examples are available in an Online Appendix. We consider ODD as a first step for establishing a more detailed common format of the description of IBMs and ABMs. Once initiated, the protocol will hopefully evolve as it becomes used by a sufficiently large proportion of modellers. (c) 2006 Elsevier B.V. All rights reserved. KW - individual-based model KW - agent-based model KW - model description KW - scientific communication KW - standardization Y1 - 2006 U6 - https://doi.org/10.1016/j.ecolmodel.2006.04.023 SN - 0304-3800 VL - 198 SP - 115 EP - 126 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Schirrmann, Michael A1 - Landwehr, Niels A1 - Giebel, Antje A1 - Garz, Andreas A1 - Dammer, Karl-Heinz T1 - Early detection of stripe rust in winter wheat using deep residual neural networks JF - Frontiers in plant science : FPLS N2 - Stripe rust (Pst) is a major disease of wheat crops leading untreated to severe yield losses. The use of fungicides is often essential to control Pst when sudden outbreaks are imminent. Sensors capable of detecting Pst in wheat crops could optimize the use of fungicides and improve disease monitoring in high-throughput field phenotyping. Now, deep learning provides new tools for image recognition and may pave the way for new camera based sensors that can identify symptoms in early stages of a disease outbreak within the field. The aim of this study was to teach an image classifier to detect Pst symptoms in winter wheat canopies based on a deep residual neural network (ResNet). For this purpose, a large annotation database was created from images taken by a standard RGB camera that was mounted on a platform at a height of 2 m. Images were acquired while the platform was moved over a randomized field experiment with Pst-inoculated and Pst-free plots of winter wheat. The image classifier was trained with 224 x 224 px patches tiled from the original, unprocessed camera images. The image classifier was tested on different stages of the disease outbreak. At patch level the image classifier reached a total accuracy of 90%. To test the image classifier on image level, the image classifier was evaluated with a sliding window using a large striding length of 224 px allowing for fast test performance. At image level, the image classifier reached a total accuracy of 77%. Even in a stage with very low disease spreading (0.5%) at the very beginning of the Pst outbreak, a detection accuracy of 57% was obtained. Still in the initial phase of the Pst outbreak with 2 to 4% of Pst disease spreading, detection accuracy with 76% could be attained. With further optimizations, the image classifier could be implemented in embedded systems and deployed on drones, vehicles or scanning systems for fast mapping of Pst outbreaks. KW - yellow rust KW - monitoring KW - deep learning KW - wheat crops KW - image recognition KW - camera sensor KW - ResNet KW - smart farming Y1 - 2021 U6 - https://doi.org/10.3389/fpls.2021.469689 SN - 1664-462X VL - 12 PB - Frontiers Media CY - Lausanne ER - TY - JOUR A1 - Lohwaßer, Roswitha A1 - Wendland, Mirko A1 - Reinhardt, Felix A1 - Halibrand, Katharina A1 - Deiseroth, Laura A1 - Jennek, Julia A1 - Strobel, Anne A1 - Hackel, Manuela A1 - Krüger, Sophie A1 - Fischer, Tom A1 - Bosse, Stefanie A1 - Florian, Lena A1 - Fabian, Melina A1 - Israel, Franziska A1 - Iffert, Mathias A1 - Hintze, Ksenia A1 - Wendland, Mirko A1 - Egbert, Björn A1 - Heinz, Sarah A1 - Bock, Sophia A1 - Mutschler, Tanja A1 - Burchard, Daniel A1 - Musil, Andreas T1 - Kentron : Journal zur Lehrerbildung = AHA Moment T3 - Kentron : Journal zur Lehrerbildung - 35 Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-590429 SN - 1867-4720 SN - 1867-4747 IS - 35 PB - Universität Potsdam, Zentrum für Lehrerbildung CY - Potsdam ER - TY - JOUR A1 - Merz, Bruno A1 - Kuhlicke, Christian A1 - Kunz, Michael A1 - Pittore, Massimiliano A1 - Babeyko, Andrey A1 - Bresch, David N. A1 - Domeisen, Daniela I. A1 - Feser, Frauke A1 - Koszalka, Inga A1 - Kreibich, Heidi A1 - Pantillon, Florian A1 - Parolai, Stefano A1 - Pinto, Joaquim G. A1 - Punge, Heinz Jürgen A1 - Rivalta, Eleonora A1 - Schröter, Kai A1 - Strehlow, Karen A1 - Weisse, Ralf A1 - Wurpts, Andreas T1 - Impact forecasting to support emergency management of natural hazards JF - Reviews of geophysics N2 - Forecasting and early warning systems are important investments to protect lives, properties, and livelihood. While early warning systems are frequently used to predict the magnitude, location, and timing of potentially damaging events, these systems rarely provide impact estimates, such as the expected amount and distribution of physical damage, human consequences, disruption of services, or financial loss. Complementing early warning systems with impact forecasts has a twofold advantage: It would provide decision makers with richer information to take informed decisions about emergency measures and focus the attention of different disciplines on a common target. This would allow capitalizing on synergies between different disciplines and boosting the development of multihazard early warning systems. This review discusses the state of the art in impact forecasting for a wide range of natural hazards. We outline the added value of impact-based warnings compared to hazard forecasting for the emergency phase, indicate challenges and pitfalls, and synthesize the review results across hazard types most relevant for Europe. KW - impact forecasting KW - natural hazards KW - early warning Y1 - 2020 U6 - https://doi.org/10.1029/2020RG000704 SN - 8755-1209 SN - 1944-9208 VL - 58 IS - 4 PB - American Geophysical Union CY - Washington ER -