TY - JOUR A1 - Titze, Karl A1 - Koch, Sabine A1 - Helge, Hans A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Steinhausen, Hans-Christoph T1 - Prenatal and familial risks of children born by epileptic mothers : long term effects on the cognitive development Y1 - 2008 UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1469-8749.2007.02020.x/pdf U6 - https://doi.org/10.1111/j.1469-8749.2007.02020.x ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Zimmer, Ulrike A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Helge, Hans T1 - Wachstum von Kindern nach Antiepileptikaexpositon während der Schwangerschaft Y1 - 2004 UR - http://www.springerlink.com/(yvnzjbnfgnyul545naopdtrh)/media/MM8XD75N4G1KTGD93ECN/Contributions/M/E/J/3/ MEJ3UXAT3PLU3R0T.pdf U6 - https://doi.org/10.1007/s00112-003-0837-4 SN - 0026-9298 ER - TY - JOUR A1 - Koch, Sabine A1 - Titze, Karl A1 - Zimmer, Ulrike A1 - Lehmkuhl, Ulrike A1 - Rauh, Hellgard A1 - Helge, Hans T1 - Growth of children exposed to antiepileptic medications in the womb N2 - Antiepileptic drugs are suspected of being weakly teratogenic in humans. In a prospective longitudinal study, we assessed growth parameters of children from birth to adolescence who had been prenatally exposed to various antiepileptic drugs and compared them to non-exposed control children matched for parental body length, social status, and maternal nicotine consumption during pregnancy as well as for parity. While no differences in mean head circumferences could be ascertained in the group of exposed children at 1, 6, and 14 years, differences were measured in body length at I year. The differences were more pronounced for both measurements when therapy forms and types of drugs were considered: polytherapy and phenobarbitone therapy (which was usually part of polytherapy) of the mother appeared to have an influence on the children's growth. Children exposed to polytherapy and phenobarbitone (as single drug or as part of polytherapy) had smaller head circumferences and were shorter. We assume an influence of polytherapy and phenobarbitone therapy taken by the epileptic woman during pregnancy on the growth of the child into adolescence Y1 - 2004 SN - 0026-9298 ER - TY - JOUR A1 - Reiche, Jürgen A1 - Pietsch, Ullrich A1 - Fink, Hans-Peter A1 - Lemmetyinen, Helge T1 - A comparison fo x-ray methods for structure refinement of Langmuir-Blodgett multilayers N2 - The possibilities and limits of structure refinement of Langmuir-Blodgett films by means of symmetrical reflection of X- rays are described using the example of a stearic acid multilayer. Three different techniques for the determiantion of the electron density profile from reflectivity data are compared; a Fourier method, a Patterson method, and model calculations. The important role of the a priori information for finding the besft structure model is outlined. Y1 - 1992 ER - TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Schmidt, Helge A1 - Prehn, Kristin A1 - Schwintowski, Hans-Peter A1 - Villringer, Arno T1 - Influence of bodily harm on neural correlates of semantic and moral decision-making N2 - Moral decision-making is central to everyday social life because the evaluation of the actions of another agent or our own actions made with respect to the norms and values guides our behavior in a community. There is previous evidence that the presence of bodily harm-even if irrelevant for a decision-may affect the decision-making, process. While recent neuroimaging studies found a common neural substrate of moral decision-making, the role of bodily harm has not been systematically studied so far. Here we used event-related functional magnetic resonance imaging (fMRI) to investigate how behavioral and neural correlates of semantic and moral decision-making processes are modulated by the presence of direct bodily harm or violence in the stimuli. Twelve participants made moral and semantic decisions about sentences describing actions of agents that either contained bodily harm or not and that could easily be judged as being good or bad or correct/incorrect, respectively. During moral and semantic decision-making, the presence of bodily harm resulted in faster response times (RT) and weaker activity in the temporal poles relative to trials devoid of bodily harm/violence, indicating a processing advantage and reduced processing depth for violence-related linguistic stimuli. Notably, there was no increase in activity in the amygdala and the posterior cingulate cortex (PCC) in response to trials containing bodily harm. These findings might be a correlate of limited generation of the semantic and emotional context in the anterior temporal poles during the evaluation of actions of another agent related to violence that is made with respect to the norms and values guiding our behavior in a community. (C) 2004 Elsevier Inc. All rights reserved Y1 - 2005 SN - 1053-8119 ER - TY - JOUR A1 - Heekeren, Hauke R. A1 - Wartenburger, Isabell A1 - Schmidt, Helge A1 - Schwintowski, Hans-Peter A1 - Villringer, Arno T1 - An fMRI study of simple ethical decision-making Y1 - 2003 UR - http://gateway.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=toc&SEARCH=00001756-000000000- 00000.kc&LINKTYPE=asBody&LINKPOS=1&D=yrovft SN - 0959-4965 ER - TY - BOOK A1 - Albers, Marion A1 - Appel, Ivo A1 - Bauer, Hartmut A1 - von Bogdandy, Armin A1 - Britz, Gabriele A1 - Bumke, Wolfgang A1 - Fehling, Michael A1 - Gusy, Christoph A1 - Hermes, Georg A1 - Hill, Hermann A1 - Hoffmann-Riem, Wolfgang A1 - Holznagel, Bernd A1 - Köck, Wolfgang A1 - Ladeur, Karl-Heinz A1 - Michael, Lothar A1 - Pitschas, Rainer A1 - Röhl, Hans Christian A1 - Rossen-Stahlfeld, Helge A1 - Sachs, Michael A1 - Sachsofsky, Ute A1 - Schmidt-Aßmann, Eberhard A1 - Schneider, Jens-Peter A1 - Vesting, Thomas ED - Hoffmann-Riem, Wolfgang ED - Schmidt-Aßmann, Eberhard ED - Voßkuhle, Andreas T1 - Grundlagen des Verwaltungsrechts : Bd. II Informationsordnung, Verwaltungsverfahren, Handlungsformen Y1 - 2008 SN - 978-3-406-54718-8 VL - 2 PB - Beck CY - München ER - TY - JOUR A1 - Breuer, Lutz A1 - Willems, Patrick A1 - Bormann, Helge A1 - Bronstert, Axel A1 - Croke, Barry A1 - Frede, Hans Georg A1 - Gräff, Thomas A1 - Hubrechts, Lode A1 - Kite, Geoffrey A1 - Lanini, Jordan A1 - Leavesley, George A1 - Lettenmaier, Dennis P. A1 - Lindstroem, Goeran A1 - Seibert, Jan A1 - Sivapalan, Mayuran A1 - Viney, Neil R. T1 - Assessing the impact of land use change on hydrology by ensemble modeling (LUCHEM) : I: model intercomparison with current land use N2 - This paper introduces the project on 'Assessing the impact of land use change on hydrology by ensemble modeling (LUCHEM)' that aims at investigating the envelope of predictions on changes in hydrological fluxes due to land use change. As part of a series of four papers, this paper outlines the motivation and setup of LUCHEM, and presents a model intercomparison for the present-day simulation results. Such an intercomparison provides a valuable basis to investigate the effects of different model structures on model predictions and paves the ground for the analysis of the performance of multi-model ensembles and the reliability of the scenario predictions in companion papers. in this study, we applied a set of 10 lumped, semi-lumped and fully distributed hydrological models that have been previously used in land use change studies to the low mountainous Dill catchment. Germany. Substantial differences in model performance were observed with Nash-Sutcliffe efficiencies ranging from 0.53 to 0.92. Differences in model performance were attributed to (1) model input data, (2) model calibration and (3) the physical basis of the models. The models were applied with two sets of input data: an original and a homogenized data set. This homogenization of precipitation, temperature and leaf area index was performed to reduce the variation between the models. Homogenization improved the comparability of model simulations and resulted in a reduced average bias, although some variation in model data input remained. The effect of the physical differences between models on the long-term water balance was mainly attributed to differences in how models represent evapotranspiration. Semi-lumped and lumped conceptual models slightly outperformed the fully distributed and physically based models. This was attributed to the automatic model calibration typically used for this type of models. Overall, however, we conclude that there was no superior model if several measures of model performance are considered and that all models are suitable to participate in further multi-model ensemble set-ups and land use change scenario investigations. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/03091708 U6 - https://doi.org/10.1016/j.advwatres.2008.10.003 SN - 0309-1708 ER - TY - JOUR A1 - Breuer, Lutz A1 - Bormann, Helge A1 - Bronstert, Axel A1 - Croke, Barry F. W. A1 - Frede, Hans-Georg A1 - Gräff, Thomas A1 - Hubrechts, Lode A1 - Kite, Geoffrey A1 - Lanini, Jordan A1 - Leavesley, George A1 - Lettenmaier, Dennis P. A1 - Lindstroem, Goeran A1 - Seibert, Jan A1 - Sivapalan, Mayuran A1 - Viney, Neil R. A1 - Willems, Patrick T1 - Assessing the impact of land use change on hydrology by ensemble modeling (LUCHEM) III : scenario analysis N2 - An ensemble of 10 hydrological models was applied to the same set of land use change scenarios. There was general agreement about the direction of changes in the mean annual discharge and 90% discharge percentile predicted by the ensemble members, although a considerable range in the magnitude of predictions for the scenarios and catchments under consideration was obvious. Differences in the magnitude of the increase were attributed to the different mean annual actual evapotranspiration rates for each land use type. The ensemble of model runs was further analyzed with deterministic and probabilistic ensemble methods. The deterministic ensemble method based on a trimmed mean resulted in a single somewhat more reliable scenario prediction. The probabilistic reliability ensemble averaging (REA) method allowed a quantification of the model structure uncertainty in the scenario predictions. It was concluded that the use of a model ensemble has greatly increased our confidence in the reliability of the model predictions. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/03091708 U6 - https://doi.org/10.1016/j.advwatres.2008.06.009 SN - 0309-1708 ER - TY - JOUR A1 - Viney, Neil R. A1 - Bormann, Helge A1 - Breuer, Lutz A1 - Bronstert, Axel A1 - Croke, Barry F. W. A1 - Frede, Hans-Georg A1 - Gräff, Thomas A1 - Hubrechts, Lode A1 - Huisman, Johan A. A1 - Jakeman, Anthony J. A1 - Kite, Geoffrey W. A1 - Lanini, Jordan A1 - Leavesley, George A1 - Lettenmaier, Dennis P. A1 - Lindstroem, Goeran A1 - Seibert, Jan A1 - Sivapalan, Murugesu A1 - Willems, Patrick T1 - Assessing the impact of land use change on hydrology by ensemble modelling (LUCHEM) II : ensemble combinations and predictions N2 - This paper reports on a project to compare predictions from a range of catchment models applied to a mesoscale river basin in central Germany and to assess various ensemble predictions of catchment streamflow. The models encompass a large range in inherent complexity and input requirements. In approximate order of decreasing complexity, they are DHSVM, MIKE-SHE, TOPLATS, WASIM-ETH, SWAT, PRMS, SLURP, HBV, LASCAM and IHACRES. The models are calibrated twice using different sets of input data. The two predictions from each model are then combined by simple averaging to produce a single-model ensemble. The 10 resulting single-model ensembles are combined in various ways to produce multi-model ensemble predictions. Both the single-model ensembles and the multi-model ensembles are shown to give predictions that are generally superior to those of their respective constituent models, both during a 7-year calibration period and a 9- year validation period. This occurs despite a considerable disparity in performance of the individual models. Even the weakest of models is shown to contribute useful information to the ensembles they are part of. The best model combination methods are a trimmed mean (constructed using the central four or six predictions each day) and a weighted mean ensemble (with weights calculated from calibration performance) that places relatively large weights on the better performing models. Conditional ensembles. in which separate model weights are used in different system states (e.g. summer and winter, high and low flows) generally yield little improvement over the weighted mean ensemble. However a conditional ensemble that discriminates between rising and receding flows shows moderate improvement. An analysis of ensemble predictions shows that the best ensembles are not necessarily those containing the best individual models. Conversely, it appears that some models that predict well individually do not necessarily combine well with other models in multi-model ensembles. The reasons behind these observations may relate to the effects of the weighting schemes, non- stationarity of the climate series and possible cross-correlations between models. Y1 - 2009 UR - http://www.sciencedirect.com/science/journal/03091708 U6 - https://doi.org/10.1016/j.advwatres.2008.05.006 SN - 0309-1708 ER -