TY  - JOUR
A1  - Abeysekara, A. U.
A1  - Benbow, Wystan
A1  - Bird, Ralph
A1  - Brill, A.
A1  - Brose, Robert
A1  - Buckley, J. H.
A1  - Chromey, A. J.
A1  - Daniel, M. K.
A1  - Falcone, A.
A1  - Finley, J. P.
A1  - Fortson, L.
A1  - Furniss, Amy
A1  - Gent, A.
A1  - Gillanders, Gerald H.
A1  - Hanna, David
A1  - Hassan, T.
A1  - Hervet, O.
A1  - Holder, J.
A1  - Hughes, G.
A1  - Humensky, T. B.
A1  - Kaaret, Philip
A1  - Kar, P.
A1  - Kertzman, M.
A1  - Kieda, David
A1  - Krause, Maria
A1  - Krennrich, F.
A1  - Kumar, S.
A1  - Lang, M. J.
A1  - Lin, T. T. Y.
A1  - Maier, Gernot
A1  - Moriarty, P.
A1  - Mukherjee, Reshmi
A1  - Ong, R. A.
A1  - Otte, Adam Nepomuk
A1  - Park, Nahee
A1  - Petrashyk, A.
A1  - Pohl, Martin
A1  - Pueschel, Elisa
A1  - Quinn, J.
A1  - Ragan, K.
A1  - Richards, Gregory T.
A1  - Roache, E.
A1  - Sadeh, I.
A1  - Santander, Marcos
A1  - Schlenstedt, S.
A1  - Sembroski, G. H.
A1  - Sushch, Iurii
A1  - Tyler, J.
A1  - Vassiliev, V. V.
A1  - Wakely, S. P.
A1  - Weinstein, A.
A1  - Wells, R. M.
A1  - Wilcox, P.
A1  - Wilhelm, Alina
A1  - Williams, David A.
A1  - Williamson, T. J.
A1  - Zitzer, B.
A1  - Acciari, V. A.
A1  - Ansoldi, S.
A1  - Antonelli, L. A.
A1  - Engels, A. Arbet
A1  - Baack, D.
A1  - Babic, A.
A1  - Banerjee, B.
A1  - de Almeida, U. Barres
A1  - Barrio, J. A.
A1  - Becerra Gonzalez, Josefa
A1  - Bednarek, Wlodek
A1  - Bernardini, Elisa
A1  - Berti, A.
A1  - Besenrieder, J.
A1  - Bhattacharyya, W.
A1  - Bigongiari, C.
A1  - Biland, A.
A1  - Blanch, O.
A1  - Bonnoli, G.
A1  - Busetto, G.
A1  - Carosi, R.
A1  - Ceribella, G.
A1  - Cikota, S.
A1  - Colak, S. M.
A1  - Colin, P.
A1  - Colombo, E.
A1  - Contreras, J. L.
A1  - Cortina, J.
A1  - Covino, S.
A1  - Da Vela, P.
A1  - Dazzi, F.
A1  - De Angelis, A.
A1  - De Lotto, B.
A1  - Delfino, M.
A1  - Delgado, J.
A1  - Di Pierro, F.
A1  - Do Souto Espinera, E.
A1  - Dominguez, A.
A1  - Prester, D. Dominis
A1  - Dorner, D.
A1  - Doro, M.
A1  - Einecke, S.
A1  - Elsaesser, D.
A1  - Ramazani, V. Fallah
A1  - Fattorini, A.
A1  - Fernandez-Barral, A.
A1  - Ferrara, G.
A1  - Fidalgo, D.
A1  - Foffano, L.
A1  - Fonseca, M. V.
A1  - Font, L.
A1  - Fruck, C.
A1  - Galindo, D.
A1  - Gallozzi, S.
A1  - Lopez, R. J. Garcia
A1  - Garczarczyk, M.
A1  - Gasparyan, S.
A1  - Gaug, Markus
A1  - Giammaria, P.
A1  - Godinovic, N.
A1  - Guberman, D.
A1  - Hadasch, D.
A1  - Hahn, A.
A1  - Herrera, J.
A1  - Hoang, J.
A1  - Hrupec, D.
A1  - Inoue, S.
A1  - Ishio, K.
A1  - Iwamura, Y.
A1  - Kubo, H.
A1  - Kushida, J.
A1  - Kuvezdic, D.
A1  - Lamastra, A.
A1  - Lelas, D.
A1  - Leone, Francesco
A1  - Lindfors, E.
A1  - Lombardi, S.
A1  - Longo, Francesco
A1  - Lopez, M.
A1  - Lopez-Oramas, A.
A1  - Machado de Oliveira Fraga, B.
A1  - Maggio, C.
A1  - Majumdar, P.
A1  - Makariev, M.
A1  - Mallamaci, M.
A1  - Maneva, G.
A1  - Manganaro, M.
A1  - Mannheim, K.
A1  - Maraschi, L.
A1  - Mariotti, M.
A1  - Martinez, M.
A1  - Masuda, S.
A1  - Mazin, D.
A1  - Minev, M.
A1  - Miranda, J. M.
A1  - Mirzoyan, R.
A1  - Molina, E.
A1  - Moralejo, A.
A1  - Moreno, V.
A1  - Moretti, E.
A1  - Munar-Adrover, Pere
A1  - Neustroev, V.
A1  - Niedzwiecki, Andrzej
A1  - Rosillo, Mireia Nievas
A1  - Nigro, C.
A1  - Nilsson, Kari
A1  - Ninci, D.
A1  - Nishijima, K.
A1  - Noda, K.
A1  - Nogues, L.
A1  - Noethe, M.
A1  - Paiano, Simona
A1  - Palacio, J.
A1  - Paneque, D.
A1  - Paoletti, R.
A1  - Paredes, J. M.
A1  - Pedaletti, G.
A1  - Penil, P.
A1  - Peresano, M.
A1  - Persic, M.
A1  - Moroni, P. G. Prada
A1  - Prandini, E.
A1  - Puljak, I.
A1  - Garcia, J. R.
A1  - Rhode, W.
A1  - Ribo, Marc
A1  - Rico, J.
A1  - Righi, C.
A1  - Rugliancich, A.
A1  - Saha, Lab
A1  - Sahakyan, Narek
A1  - Saito, T.
A1  - Satalecka, K.
A1  - Schweizer, T.
A1  - Sitarek, J.
A1  - Snidaric, I.
A1  - Sobczynska, D.
A1  - Somero, A.
A1  - Stamerra, A.
A1  - Strzys, M.
A1  - Suric, T.
A1  - Tavecchio, Fabrizio
A1  - Temnikov, P.
A1  - Terzic, T.
A1  - Teshima, M.
A1  - Torres-Alba, N.
A1  - Tsujimoto, S.
A1  - van Scherpenberg, J.
A1  - Vanzo, G.
A1  - Vazquez Acosta, M.
A1  - Vovk, I.
A1  - Will, M.
A1  - Zaric, D.
T1  - Periastron Observations of TeV Gamma-Ray Emission from a Binary System with a 50-year Period
JF  - The astrophysical journal : an international review of spectroscopy and astronomical physics ; Part 2, Letters
N2  - We report on observations of the pulsar/Be star binary system PSR J2032+4127/MT91 213 in the energy range between 100 GeV and 20 TeV with the Very Energetic Radiation Imaging Telescope Array and Major Atmospheric Gamma Imaging Cherenkov telescope arrays. The binary orbit has a period of approximately 50 years, with the most recent periastron occurring on 2017 November 13. Our observations span from 18 months prior to periastron to one month after. A new point-like gamma-ray source is detected, coincident with the location of PSR J2032+4127/MT91 213. The gamma-ray light curve and spectrum are well characterized over the periastron passage. The flux is variable over at least an order of magnitude, peaking at periastron, thus providing a firm association of the TeV source with the pulsar/Be star system. Observations prior to periastron show a cutoff in the spectrum at an energy around 0.5 TeV. This result adds a new member to the small population of known TeV binaries, and it identifies only the second source of this class in which the nature and properties of the compact object are firmly established. We compare the gamma-ray results with the light curve measured with the X-ray Telescope on board the Neil Gehrels Swift Observatory and with the predictions of recent theoretical models of the system. We conclude that significant revision of the models is required to explain the details of the emission that we have observed, and we discuss the relationship between the binary system and the overlapping steady extended source, TeV J2032+4130.
KW  - gamma rays: general
KW  - pulsars: individual (PSR J2032+4127, VER J2032+414, MAGIC J2032+4127)
KW  - stars: individual (MT91 213)
KW  - X-rays: binaries
Y1  - 2018
U6  - https://doi.org/10.3847/2041-8213/aae70e
SN  - 2041-8205
SN  - 2041-8213
VL  - 867
IS  - 1
PB  - IOP Publ. Ltd.
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Meyer, Susann
A1  - Schroeter, M. -A.
A1  - Hahn, Marc B.
A1  - Solomun, T.
A1  - Sturm, Heinz
A1  - Kunte, H. J.
T1  - Ectoine can enhance structural changes in DNA in vitro
JF  - Scientific reports
N2  - Strand breaks and conformational changes of DNA have consequences for the physiological role of DNA. The natural protecting molecule ectoine is beneficial to entire bacterial cells and biomolecules such as proteins by mitigating detrimental effects of environmental stresses. It was postulated that ectoine-like molecules bind to negatively charged spheres that mimic DNA surfaces. We investigated the effect of ectoine on DNA and whether ectoine is able to protect DNA from damages caused by ultraviolet radiation (UV-A). In order to determine different isoforms of DNA, agarose gel electrophoresis and atomic force microscopy experiments were carried out with plasmid pUC19 DNA. Our quantitative results revealed that a prolonged incubation of DNA with ectoine leads to an increase in transitions from supercoiled (undamaged) to open circular (single-strand break) conformation at pH 6.6. The effect is pH dependent and no significant changes were observed at physiological pH of 7.5. After UV-A irradiation in ectoine solution, changes in DNA conformation were even more pronounced and this effect was pH dependent. We hypothesize that ectoine is attracted to the negatively charge surface of DNA at lower pH and therefore fails to act as a stabilizing agent for DNA in our in vitro experiments.
Y1  - 2017
U6  - https://doi.org/10.1038/s41598-017-07441-z
SN  - 2045-2322
VL  - 7
PB  - Nature Publ. Group
CY  - London
ER  -