TY  - JOUR
A1  - Fages, Antoine
A1  - Hanghoj, Kristian
A1  - Khan, Naveed
A1  - Gaunitz, Charleen
A1  - Seguin-Orlando, Andaine
A1  - Leonardi, Michela
A1  - Constantz, Christian McCrory
A1  - Gamba, Cristina
A1  - Al-Rasheid, Khaled A. S.
A1  - Albizuri, Silvia
A1  - Alfarhan, Ahmed H.
A1  - Allentoft, Morten
A1  - Alquraishi, Saleh
A1  - Anthony, David
A1  - Baimukhanov, Nurbol
A1  - Barrett, James H.
A1  - Bayarsaikhan, Jamsranjav
A1  - Benecke, Norbert
A1  - Bernaldez-Sanchez, Eloisa
A1  - Berrocal-Rangel, Luis
A1  - Biglari, Fereidoun
A1  - Boessenkool, Sanne
A1  - Boldgiv, Bazartseren
A1  - Brem, Gottfried
A1  - Brown, Dorcas
A1  - Burger, Joachim
A1  - Crubezy, Eric
A1  - Daugnora, Linas
A1  - Davoudi, Hossein
A1  - Damgaard, Peter de Barros
A1  - de Chorro y de Villa-Ceballos, Maria de los Angeles
A1  - Deschler-Erb, Sabine
A1  - Detry, Cleia
A1  - Dill, Nadine
A1  - Oom, Maria do Mar
A1  - Dohr, Anna
A1  - Ellingvag, Sturla
A1  - Erdenebaatar, Diimaajav
A1  - Fathi, Homa
A1  - Felkel, Sabine
A1  - Fernandez-Rodriguez, Carlos
A1  - Garcia-Vinas, Esteban
A1  - Germonpre, Mietje
A1  - Granado, Jose D.
A1  - Hallsson, Jon H.
A1  - Hemmer, Helmut
A1  - Hofreiter, Michael
A1  - Kasparov, Aleksei
A1  - Khasanov, Mutalib
A1  - Khazaeli, Roya
A1  - Kosintsev, Pavel
A1  - Kristiansen, Kristian
A1  - Kubatbek, Tabaldiev
A1  - Kuderna, Lukas
A1  - Kuznetsov, Pavel
A1  - Laleh, Haeedeh
A1  - Leonard, Jennifer A.
A1  - Lhuillier, Johanna
A1  - von Lettow-Vorbeck, Corina Liesau
A1  - Logvin, Andrey
A1  - Lougas, Lembi
A1  - Ludwig, Arne
A1  - Luis, Cristina
A1  - Arruda, Ana Margarida
A1  - Marques-Bonet, Tomas
A1  - Silva, Raquel Matoso
A1  - Merz, Victor
A1  - Mijiddorj, Enkhbayar
A1  - Miller, Bryan K.
A1  - Monchalov, Oleg
A1  - Mohaseb, Fatemeh A.
A1  - Morales, Arturo
A1  - Nieto-Espinet, Ariadna
A1  - Nistelberger, Heidi
A1  - Onar, Vedat
A1  - Palsdottir, Albina H.
A1  - Pitulko, Vladimir
A1  - Pitskhelauri, Konstantin
A1  - Pruvost, Melanie
A1  - Sikanjic, Petra Rajic
A1  - Papesa, Anita Rapan
A1  - Roslyakova, Natalia
A1  - Sardari, Alireza
A1  - Sauer, Eberhard
A1  - Schafberg, Renate
A1  - Scheu, Amelie
A1  - Schibler, Jorg
A1  - Schlumbaum, Angela
A1  - Serrand, Nathalie
A1  - Serres-Armero, Aitor
A1  - Shapiro, Beth
A1  - Seno, Shiva Sheikhi
A1  - Shevnina, Irina
A1  - Shidrang, Sonia
A1  - Southon, John
A1  - Star, Bastiaan
A1  - Sykes, Naomi
A1  - Taheri, Kamal
A1  - Taylor, William
A1  - Teegen, Wolf-Rudiger
A1  - Vukicevic, Tajana Trbojevic
A1  - Trixl, Simon
A1  - Tumen, Dashzeveg
A1  - Undrakhbold, Sainbileg
A1  - Usmanova, Emma
A1  - Vahdati, Ali
A1  - Valenzuela-Lamas, Silvia
A1  - Viegas, Catarina
A1  - Wallner, Barbara
A1  - Weinstock, Jaco
A1  - Zaibert, Victor
A1  - Clavel, Benoit
A1  - Lepetz, Sebastien
A1  - Mashkour, Marjan
A1  - Helgason, Agnar
A1  - Stefansson, Kari
A1  - Barrey, Eric
A1  - Willerslev, Eske
A1  - Outram, Alan K.
A1  - Librado, Pablo
A1  - Orlando, Ludovic
T1  - Tracking five millennia of horse management with extensive ancient genome time series
JF  - Cell
N2  - Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (>= 1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modem legacy of past equestrian civilisations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN "speed gene," only rose in popularity within the last millennium. Finally, the development of modem breeding impacted genetic diversity more dramatically than the previous millennia of human management.
Y1  - 2019
U6  - https://doi.org/10.1016/j.cell.2019.03.049
SN  - 0092-8674
SN  - 1097-4172
VL  - 177
IS  - 6
SP  - 1419
EP  - 1435
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Keller, S.
A1  - Sauer, I.
A1  - Strauss, H.
A1  - Gast, Klaus
A1  - Dathe, M.
A1  - Bienert, Michael C.
T1  - Membrane-mimetic nanocarriers formed by a dipalmitoylated cell-penetrating peptide
Y1  - 2005
ER  - 
TY  - JOUR
A1  - Na, L.
A1  - Wartenberg, Maria
A1  - Nau, H.
A1  - Hescheler, Jürgen
A1  - Sauer, Heinrich
T1  - Anticonvulsant valproic acid inhibits cardiomyocyte differentiation of embryonic stem cells by increasing intracellular levels of reactive oxygen species
Y1  - 2003
ER  - 
TY  - JOUR
A1  - Wartenberg, Maria
A1  - Schallenberg, M.
A1  - Hescheler, H.
A1  - Sauer, Heinrich
T1  - Reactive oxygen species-mediated regulation of eNOS and iNOS expression in multicellular prostate tumor spheroids
Y1  - 2003
ER  - 
TY  - JOUR
A1  - von Loeffelholz, Christian
A1  - Lieske, Stefanie
A1  - Neuschaefer-Rube, Frank
A1  - Willmes, Diana M.
A1  - Raschzok, Nathanael
A1  - Sauer, Igor M.
A1  - König, Jörg
A1  - Fromm, Martin F.
A1  - Horn, Paul
A1  - Chatzigeorgiou, Antonios
A1  - Pathe-Neuschaefer-Rube, Andrea
A1  - Jordan, Jens
A1  - Pfeiffer, Andreas F. H.
A1  - Mingrone, Geltrude
A1  - Bornstein, Stefan R.
A1  - Stroehle, Peter
A1  - Harms, Christoph
A1  - Wunderlich, F. Thomas
A1  - Helfand, Stephen L.
A1  - Bernier, Michel
A1  - de Cabo, Rafael
A1  - Shulman, Gerald I.
A1  - Chavakis, Triantafyllos
A1  - Püschel, Gerhard Paul
A1  - Birkenfeld, Andreas L.
T1  - The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism
BT  - official journal of the American Association for the Study of Liver Diseases
JF  - Hepatology
N2  - Reduced expression of the Indy ("I am Not Dead, Yet") gene in lower organisms promotes longevity in a manner akin to caloric restriction. Deletion of the mammalian homolog of Indy (mIndy, Slc13a5) encoding for a plasma membrane-associated citrate transporter expressed highly in the liver, protects mice from high-fat diet-induced and aging-induced obesity and hepatic fat accumulation through a mechanism resembling caloric restriction. We studied a possible role of mIndy in human hepatic fat metabolism. In obese, insulin-resistant patients with nonalcoholic fatty liver disease, hepatic mIndy expression was increased and mIndy expression was also independently associated with hepatic steatosis. In nonhuman primates, a 2-year high-fat, high-sucrose diet increased hepatic mIndy expression. Liver microarray analysis showed that high mIndy expression was associated with pathways involved in hepatic lipid metabolism and immunological processes. Interleukin-6 (IL-6) was identified as a regulator of mIndy by binding to its cognate receptor. Studies in human primary hepatocytes confirmed that IL-6 markedly induced mIndy transcription through the IL-6 receptor and activation of the transcription factor signal transducer and activator of transcription 3, and a putative start site of the human mIndy promoter was determined. Activation of the IL-6-signal transducer and activator of transcription 3 pathway stimulated mIndy expression, enhanced cytoplasmic citrate influx, and augmented hepatic lipogenesis in vivo. In contrast, deletion of mIndy completely prevented the stimulating effect of IL-6 on citrate uptake and reduced hepatic lipogenesis. These data show that mIndy is increased in liver of obese humans and nonhuman primates with NALFD. Moreover, our data identify mIndy as a target gene of IL-6 and determine novel functions of IL-6 through mINDY. Conclusion: Targeting human mINDY may have therapeutic potential in obese patients with nonalcoholic fatty liver disease. German Clinical Trials Register: DRKS00005450.
Y1  - 2017
U6  - https://doi.org/10.1002/hep.29089
SN  - 0270-9139
SN  - 1527-3350
VL  - 66
IS  - 2
SP  - 616
EP  - 630
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Ten Freyhaus, Henrik
A1  - Huntgeburth, Michael
A1  - Wingler, Kirstin
A1  - Baeumer, A. T.
A1  - Wartenberg, Maria
A1  - Sauer, H.
A1  - Bekhite, Mohamed M.
A1  - Rosenkranz, S.
T1  - Inhibition of ROS liberation by the novel nox inhibitor VAS2870 attenuates PDGF-dependent src activation and chemotaxis, but not proliferation in vascular smooth muscle cells
T2  - European heart journal
Y1  - 2006
SN  - 0195-668X
SN  - 1522-9645
VL  - 27
SP  - 965
EP  - 965
PB  - Oxford University Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Toy, Virginia Gail
A1  - Sutherland, Rupert
A1  - Townend, John
A1  - Allen, Michael J.
A1  - Becroft, Leeza
A1  - Boles, Austin
A1  - Boulton, Carolyn
A1  - Carpenter, Brett
A1  - Cooper, Alan
A1  - Cox, Simon C.
A1  - Daube, Christopher
A1  - Faulkner, D. R.
A1  - Halfpenny, Angela
A1  - Kato, Naoki
A1  - Keys, Stephen
A1  - Kirilova, Martina
A1  - Kometani, Yusuke
A1  - Little, Timothy
A1  - Mariani, Elisabetta
A1  - Melosh, Benjamin
A1  - Menzies, Catriona D.
A1  - Morales, Luiz
A1  - Morgan, Chance
A1  - Mori, Hiroshi
A1  - Niemeijer, Andre
A1  - Norris, Richard
A1  - Prior, David
A1  - Sauer, Katrina
A1  - Schleicher, Anja Maria
A1  - Shigematsu, Norio
A1  - Teagle, Damon A. H.
A1  - Tobin, Harold
A1  - Valdez, Robert
A1  - Williams, Jack
A1  - Yeo, Samantha
A1  - Baratin, Laura-May
A1  - Barth, Nicolas
A1  - Benson, Adrian
A1  - Boese, Carolin
A1  - Célérier, Bernard
A1  - Chamberlain, Calum J.
A1  - Conze, Ronald
A1  - Coussens, Jamie
A1  - Craw, Lisa
A1  - Doan, Mai-Linh
A1  - Eccles, Jennifer
A1  - Grieve, Jason
A1  - Grochowski, Julia
A1  - Gulley, Anton
A1  - Howarth, Jamie
A1  - Jacobs, Katrina
A1  - Janku-Capova, Lucie
A1  - Jeppson, Tamara
A1  - Langridge, Robert
A1  - Mallyon, Deirdre
A1  - Marx, Ray
A1  - Massiot, Cécile
A1  - Mathewson, Loren
A1  - Moore, Josephine
A1  - Nishikawa, Osamu
A1  - Pooley, Brent
A1  - Pyne, Alex
A1  - Savage, Martha K.
A1  - Schmitt, Doug
A1  - Taylor-Offord, Sam
A1  - Upton, Phaedra
A1  - Weaver, Konrad C.
A1  - Wiersberg, Thomas
A1  - Zimmer, Martin
T1  - Bedrock geology of DFDP-2B, central Alpine Fault, New Zealand
JF  - New Zealand journal of geology and geophysics : an international journal of the geoscience of New Zealand, the Pacific Rim, and Antarctica ; NZJG
N2  - During the second phase of the Alpine Fault, Deep Fault Drilling Project (DFDP) in the Whataroa River, South Westland, New Zealand, bedrock was encountered in the DFDP-2B borehole from 238.5–893.2 m Measured Depth (MD). Continuous sampling and meso- to microscale characterisation of whole rock cuttings established that, in sequence, the borehole sampled amphibolite facies, Torlesse Composite Terrane-derived schists, protomylonites and mylonites, terminating 200–400 m above an Alpine Fault Principal Slip Zone (PSZ) with a maximum dip of 62°. The most diagnostic structural features of increasing PSZ proximity were the occurrence of shear bands and reduction in mean quartz grain sizes. A change in composition to greater mica:quartz + feldspar, most markedly below c. 700 m MD, is inferred to result from either heterogeneous sampling or a change in lithology related to alteration. Major oxide variations suggest the fault-proximal Alpine Fault alteration zone, as previously defined in DFDP-1 core, was not sampled.
KW  - Alpine Fault
KW  - New Zealand
KW  - scientific drilling
KW  - mylonite
KW  - cataclasite
Y1  - 2017
U6  - https://doi.org/10.1080/00288306.2017.1375533
SN  - 0028-8306
SN  - 1175-8791
VL  - 60
IS  - 4
SP  - 497
EP  - 518
PB  - Taylor & Francis
CY  - Abingdon
ER  - 
TY  - CHAP
A1  - Kurbel, Karl
A1  - Nowak, Dawid
A1  - Azodi, Amir
A1  - Jaeger, David
A1  - Meinel, Christoph
A1  - Cheng, Feng
A1  - Sapegin, Andrey
A1  - Gawron, Marian
A1  - Morelli, Frank
A1  - Stahl, Lukas
A1  - Kerl, Stefan
A1  - Janz, Mariska
A1  - Hadaya, Abdulmasih
A1  - Ivanov, Ivaylo
A1  - Wiese, Lena
A1  - Neves, Mariana
A1  - Schapranow, Matthieu-Patrick
A1  - Fähnrich, Cindy
A1  - Feinbube, Frank
A1  - Eberhardt, Felix
A1  - Hagen, Wieland
A1  - Plauth, Max
A1  - Herscheid, Lena
A1  - Polze, Andreas
A1  - Barkowsky, Matthias
A1  - Dinger, Henriette
A1  - Faber, Lukas
A1  - Montenegro, Felix
A1  - Czachórski, Tadeusz
A1  - Nycz, Monika
A1  - Nycz, Tomasz
A1  - Baader, Galina
A1  - Besner, Veronika
A1  - Hecht, Sonja
A1  - Schermann, Michael
A1  - Krcmar, Helmut
A1  - Wiradarma, Timur Pratama
A1  - Hentschel, Christian
A1  - Sack, Harald
A1  - Abramowicz, Witold
A1  - Sokolowska, Wioletta
A1  - Hossa, Tymoteusz
A1  - Opalka, Jakub
A1  - Fabisz, Karol
A1  - Kubaczyk, Mateusz
A1  - Cmil, Milena
A1  - Meng, Tianhui
A1  - Dadashnia, Sharam
A1  - Niesen, Tim
A1  - Fettke, Peter
A1  - Loos, Peter
A1  - Perscheid, Cindy
A1  - Schwarz, Christian
A1  - Schmidt, Christopher
A1  - Scholz, Matthias
A1  - Bock, Nikolai
A1  - Piller, Gunther
A1  - Böhm, Klaus
A1  - Norkus, Oliver
A1  - Clark, Brian
A1  - Friedrich, Björn
A1  - Izadpanah, Babak
A1  - Merkel, Florian
A1  - Schweer, Ilias
A1  - Zimak, Alexander
A1  - Sauer, Jürgen
A1  - Fabian, Benjamin
A1  - Tilch, Georg
A1  - Müller, David
A1  - Plöger, Sabrina
A1  - Friedrich, Christoph M.
A1  - Engels, Christoph
A1  - Amirkhanyan, Aragats
A1  - van der Walt, Estée
A1  - Eloff, J. H. P.
A1  - Scheuermann, Bernd
A1  - Weinknecht, Elisa
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Oswald, Gerhard
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Schulzki, Bernhard
T1  - HPI Future SOC Lab
BT  - Proceedings 2015
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor.
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - künstliche Intelligenz
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516
ER  -