TY  - JOUR
A1  - Fages, Antoine
A1  - Hanghoj, Kristian
A1  - Khan, Naveed
A1  - Gaunitz, Charleen
A1  - Seguin-Orlando, Andaine
A1  - Leonardi, Michela
A1  - Constantz, Christian McCrory
A1  - Gamba, Cristina
A1  - Al-Rasheid, Khaled A. S.
A1  - Albizuri, Silvia
A1  - Alfarhan, Ahmed H.
A1  - Allentoft, Morten
A1  - Alquraishi, Saleh
A1  - Anthony, David
A1  - Baimukhanov, Nurbol
A1  - Barrett, James H.
A1  - Bayarsaikhan, Jamsranjav
A1  - Benecke, Norbert
A1  - Bernaldez-Sanchez, Eloisa
A1  - Berrocal-Rangel, Luis
A1  - Biglari, Fereidoun
A1  - Boessenkool, Sanne
A1  - Boldgiv, Bazartseren
A1  - Brem, Gottfried
A1  - Brown, Dorcas
A1  - Burger, Joachim
A1  - Crubezy, Eric
A1  - Daugnora, Linas
A1  - Davoudi, Hossein
A1  - Damgaard, Peter de Barros
A1  - de Chorro y de Villa-Ceballos, Maria de los Angeles
A1  - Deschler-Erb, Sabine
A1  - Detry, Cleia
A1  - Dill, Nadine
A1  - Oom, Maria do Mar
A1  - Dohr, Anna
A1  - Ellingvag, Sturla
A1  - Erdenebaatar, Diimaajav
A1  - Fathi, Homa
A1  - Felkel, Sabine
A1  - Fernandez-Rodriguez, Carlos
A1  - Garcia-Vinas, Esteban
A1  - Germonpre, Mietje
A1  - Granado, Jose D.
A1  - Hallsson, Jon H.
A1  - Hemmer, Helmut
A1  - Hofreiter, Michael
A1  - Kasparov, Aleksei
A1  - Khasanov, Mutalib
A1  - Khazaeli, Roya
A1  - Kosintsev, Pavel
A1  - Kristiansen, Kristian
A1  - Kubatbek, Tabaldiev
A1  - Kuderna, Lukas
A1  - Kuznetsov, Pavel
A1  - Laleh, Haeedeh
A1  - Leonard, Jennifer A.
A1  - Lhuillier, Johanna
A1  - von Lettow-Vorbeck, Corina Liesau
A1  - Logvin, Andrey
A1  - Lougas, Lembi
A1  - Ludwig, Arne
A1  - Luis, Cristina
A1  - Arruda, Ana Margarida
A1  - Marques-Bonet, Tomas
A1  - Silva, Raquel Matoso
A1  - Merz, Victor
A1  - Mijiddorj, Enkhbayar
A1  - Miller, Bryan K.
A1  - Monchalov, Oleg
A1  - Mohaseb, Fatemeh A.
A1  - Morales, Arturo
A1  - Nieto-Espinet, Ariadna
A1  - Nistelberger, Heidi
A1  - Onar, Vedat
A1  - Palsdottir, Albina H.
A1  - Pitulko, Vladimir
A1  - Pitskhelauri, Konstantin
A1  - Pruvost, Melanie
A1  - Sikanjic, Petra Rajic
A1  - Papesa, Anita Rapan
A1  - Roslyakova, Natalia
A1  - Sardari, Alireza
A1  - Sauer, Eberhard
A1  - Schafberg, Renate
A1  - Scheu, Amelie
A1  - Schibler, Jorg
A1  - Schlumbaum, Angela
A1  - Serrand, Nathalie
A1  - Serres-Armero, Aitor
A1  - Shapiro, Beth
A1  - Seno, Shiva Sheikhi
A1  - Shevnina, Irina
A1  - Shidrang, Sonia
A1  - Southon, John
A1  - Star, Bastiaan
A1  - Sykes, Naomi
A1  - Taheri, Kamal
A1  - Taylor, William
A1  - Teegen, Wolf-Rudiger
A1  - Vukicevic, Tajana Trbojevic
A1  - Trixl, Simon
A1  - Tumen, Dashzeveg
A1  - Undrakhbold, Sainbileg
A1  - Usmanova, Emma
A1  - Vahdati, Ali
A1  - Valenzuela-Lamas, Silvia
A1  - Viegas, Catarina
A1  - Wallner, Barbara
A1  - Weinstock, Jaco
A1  - Zaibert, Victor
A1  - Clavel, Benoit
A1  - Lepetz, Sebastien
A1  - Mashkour, Marjan
A1  - Helgason, Agnar
A1  - Stefansson, Kari
A1  - Barrey, Eric
A1  - Willerslev, Eske
A1  - Outram, Alan K.
A1  - Librado, Pablo
A1  - Orlando, Ludovic
T1  - Tracking five millennia of horse management with extensive ancient genome time series
JF  - Cell
N2  - Horse domestication revolutionized warfare and accelerated travel, trade, and the geographic expansion of languages. Here, we present the largest DNA time series for a non-human organism to date, including genome-scale data from 149 ancient animals and 129 ancient genomes (>= 1-fold coverage), 87 of which are new. This extensive dataset allows us to assess the modem legacy of past equestrian civilisations. We find that two extinct horse lineages existed during early domestication, one at the far western (Iberia) and the other at the far eastern range (Siberia) of Eurasia. None of these contributed significantly to modern diversity. We show that the influence of Persian-related horse lineages increased following the Islamic conquests in Europe and Asia. Multiple alleles associated with elite-racing, including at the MSTN "speed gene," only rose in popularity within the last millennium. Finally, the development of modem breeding impacted genetic diversity more dramatically than the previous millennia of human management.
Y1  - 2019
U6  - https://doi.org/10.1016/j.cell.2019.03.049
SN  - 0092-8674
SN  - 1097-4172
VL  - 177
IS  - 6
SP  - 1419
EP  - 1435
PB  - Cell Press
CY  - Cambridge
ER  - 
TY  - JOUR
A1  - Kihampa, Charles
A1  - Nkunya, Mayunga H. H.
A1  - Joseph, Cosam C.
A1  - Magesa, Stephen M.
A1  - Hassanali, Ahmed
A1  - Heydenreich, Matthias
A1  - Kleinpeter, Erich
T1  - Antimosquito and antimicrobial clerodanoids and a chlorobenzoid from Tessmannia species
N2  - The clerodane diterpenoids trans-kolavenolic acid, 18-oxocleroda-3,13(E)-dien-15-oic acid, ent-(18- hydroxycarbonyl)-cleroda- 3,13(E)-dien-15-oate, 2-oxo-ent-cleroda-3,13(Z)-dien-15-oic acid and trans-2-oxo-ent-cleroda- 13(Z)-en-15-oic acid, and the chlorobenzenoid O-(3-hydroxy-4-hydroxycarbonyl-5-pentylphenyl)-3-chloro-4-methoxy-6-pentyl- 2-oxybenzoic acid were isolated from Tessmannia martiniana var pauloi and T. martiniana var matiniana. Structures were established based on interpretation of spectroscopic data. Some of the compounds exhibited significant antimosquito, antifungal and antibacterial activities.
Y1  - 2010
UR  - http://www.naturalproduct.us/
SN  - 1934-578X
ER  - 
TY  - JOUR
A1  - Kihampa, Charles
A1  - Nkunya, Mayunga H. H.
A1  - Joseph, Cosam C.
A1  - Magesa, Stephen M.
A1  - Hassanali, Ahmed
A1  - Heydenreich, Matthias
A1  - Kleinpeter, Erich
T1  - Anti-mosquito and antimicrobial nor-halimanoids, isocoumarins and an anilinoid from Tessmannia densiflora
N2  - The nor-halimane diterpenoid tessmannic acid and its methyl, 2-methylisopropyl and 1-methylbutyl esters, the unusual isocoumarins 8-hydroxy-6-methoxy-3-pentylisocoumarin and 7-chloro-8-hydroxy-6-methoxy-3-pentylisocoumarin, and 5- pentyl-3-methoxy-N-butylaniline were isolated from the stem and root bark extracts of Tessmannia densiflora Harms (Caesalpiniaceae) that showed mosquito larvicidal activity. The structures were determined on interpretation of spectroscopic data. Tessmannic acid and its methyl ester exhibited antibacterial and antifungal activity. The compounds also caused high larvae and adult Anopheles gambiae mosquitoe mortality effects, and stronger mosquito repellency than that shown by the standard repellent DEET, hence indicating Tessmannia species to be potential sources of bioactive natural products.
Y1  - 2009
UR  - http://www.sciencedirect.com/science/journal/00319422
U6  - https://doi.org/10.1016/j.phytochem.2009.07.024
SN  - 0031-9422
ER  - 
TY  - JOUR
A1  - Abbas, Ioana M.
A1  - Vranic, Marija
A1  - Hoffmann, Holger
A1  - El-Khatib, Ahmed H.
A1  - Montes-Bayón, María
A1  - Möller, Heiko Michael
A1  - Weller, Michael G.
T1  - Investigations of the Copper Peptide Hepcidin-25 by
LC-MS/MS and NMR⁺
JF  - International Journal of Molecular Sciences
N2  - Hepcidin-25 was identified as themain iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that encompasses a small copper(II) binding site known as the ATCUN (amino-terminal Cu(II)- and Ni(II)-binding) motif. Interestingly, this copper-binding property is largely ignored in most papers dealing with hepcidin-25. In this context, detailed investigations of the complex formed between hepcidin-25 and copper could reveal insight into its biological role. The present work focuses on metal-bound hepcidin-25 that can be considered the biologically active form. The first part is devoted to the reversed-phase chromatographic separation of copper-bound and copper-free hepcidin-25 achieved by applying basic mobile phases containing 0.1% ammonia. Further, mass spectrometry (tandemmass spectrometry (MS/MS), high-resolutionmass spectrometry (HRMS)) and nuclear magnetic resonance (NMR) spectroscopy were employed to characterize the copper-peptide. Lastly, a three-dimensional (3D)model of hepcidin-25with bound copper(II) is presented. The identification of metal complexes and potential isoforms and isomers, from which the latter usually are left undetected by mass spectrometry, led to the conclusion that complementary analytical methods are needed to characterize a peptide calibrant or referencematerial comprehensively. Quantitative nuclear magnetic resonance (qNMR), inductively-coupled plasma mass spectrometry (ICP-MS), ion-mobility spectrometry (IMS) and chiral amino acid analysis (AAA) should be considered among others.
KW  - hepcidin-25
KW  - copper
KW  - nickel
KW  - copper complex
KW  - ATCUN motif
KW  - metal complex
KW  - MS
KW  - NMR structure
KW  - metal peptide
KW  - metalloprotein
KW  - metallopeptide
KW  - isomerization
KW  - racemization
KW  - purity
KW  - reference material
Y1  - 2018
U6  - https://doi.org/10.3390/ijms19082271
SN  - 1422-0067
SN  - 1661-6596
VL  - 19
IS  - 8
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  - 
TY  - GEN
A1  - Abbas, Ioana M.
A1  - Vranic, Marija
A1  - Hoffmann, Holger
A1  - El-Khatib, Ahmed H.
A1  - Montes-Bayón, María
A1  - Möller, Heiko Michael
A1  - Weller, Michael G.
T1  - Investigations of the Copper Peptide Hepcidin-25 by
LC-MS/MS and NMR⁺
T2  - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe
N2  - Hepcidin-25 was identified as themain iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that encompasses a small copper(II) binding site known as the ATCUN (amino-terminal Cu(II)- and Ni(II)-binding) motif. Interestingly, this copper-binding property is largely ignored in most papers dealing with hepcidin-25. In this context, detailed investigations of the complex formed between hepcidin-25 and copper could reveal insight into its biological role. The present work focuses on metal-bound hepcidin-25 that can be considered the biologically active form. The first part is devoted to the reversed-phase chromatographic separation of copper-bound and copper-free hepcidin-25 achieved by applying basic mobile phases containing 0.1% ammonia. Further, mass spectrometry (tandemmass spectrometry (MS/MS), high-resolutionmass spectrometry (HRMS)) and nuclear magnetic resonance (NMR) spectroscopy were employed to characterize the copper-peptide. Lastly, a three-dimensional (3D)model of hepcidin-25with bound copper(II) is presented. The identification of metal complexes and potential isoforms and isomers, from which the latter usually are left undetected by mass spectrometry, led to the conclusion that complementary analytical methods are needed to characterize a peptide calibrant or referencematerial comprehensively. Quantitative nuclear magnetic resonance (qNMR), inductively-coupled plasma mass spectrometry (ICP-MS), ion-mobility spectrometry (IMS) and chiral amino acid analysis (AAA) should be considered among others.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 701 
KW  - hepcidin-25
KW  - copper
KW  - nickel
KW  - copper complex
KW  - ATCUN motif
KW  - metal complex
KW  - MS
KW  - NMR structure
KW  - metal peptide
KW  - metalloprotein
KW  - metallopeptide
KW  - isomerization
KW  - racemization
KW  - purity
KW  - reference material
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-427926
SN  - 1866-8372
IS  - 701
ER  - 
TY  - JOUR
A1  - Schubert, Mikkel
A1  - Jonsson, Hakon
A1  - Chang, Dan
A1  - Sarkissian, Clio Der
A1  - Ermini, Luca
A1  - Ginolhac, Aurelien
A1  - Albrechtsen, Anders
A1  - Dupanloup, Isabelle
A1  - Foucal, Adrien
A1  - Petersen, Bent Larsen
A1  - Fumagalli, Matteo
A1  - Raghavan, Maanasa
A1  - Seguin-Orlando, Andaine
A1  - Korneliussen, Thorfinn S.
A1  - Velazquez, Amhed M. V.
A1  - Stenderup, Jesper
A1  - Hoover, Cindi A.
A1  - Rubin, Carl-Johan
A1  - Alfarhan, Ahmed H.
A1  - Alquraishi, Saleh A.
A1  - Al-Rasheid, Khaled A. S.
A1  - MacHugh, David E.
A1  - Kalbfleisch, Ted
A1  - MacLeod, James N.
A1  - Rubin, Edward M.
A1  - Sicheritz-Ponten, Thomas
A1  - Andersson, Leif
A1  - Hofreiter, Michael
A1  - Marques-Bonet, Tomas
A1  - Gilbert, M. Thomas P.
A1  - Nielsen, Rasmus
A1  - Excoffier, Laurent
A1  - Willerslev, Eske
A1  - Shapiro, Beth
A1  - Orlando, Ludovic
T1  - Prehistoric genomes reveal the genetic foundation and cost of horse domestication
JF  - Proceedings of the National Academy of Sciences of the United States of America
Y1  - 2014
U6  - https://doi.org/10.1073/pnas.1416991111
SN  - 0027-8424
VL  - 111
IS  - 52
SP  - E5661
EP  - E5669
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Librado, Pablo
A1  - Gamba, Cristina
A1  - Gaunitz, Charleen
A1  - Sarkissian, Clio Der
A1  - Pruvost, Melanie
A1  - Albrechtsen, Anders
A1  - Fages, Antoine
A1  - Khan, Naveed
A1  - Schubert, Mikkel
A1  - Jagannathan, Vidhya
A1  - Serres-Armero, Aitor
A1  - Kuderna, Lukas F. K.
A1  - Povolotskaya, Inna S.
A1  - Seguin-Orlando, Andaine
A1  - Lepetz, Sebastien
A1  - Neuditschko, Markus
A1  - Theves, Catherine
A1  - Alquraishi, Saleh A.
A1  - Alfarhan, Ahmed H.
A1  - Al-Rasheid, Khaled A. S.
A1  - Rieder, Stefan
A1  - Samashev, Zainolla
A1  - Francfort, Henri-Paul
A1  - Benecke, Norbert
A1  - Hofreiter, Michael
A1  - Ludwig, Arne
A1  - Keyser, Christine
A1  - Marques-Bonet, Tomas
A1  - Ludes, Bertrand
A1  - Crubezy, Eric
A1  - Leeb, Tosso
A1  - Willerslev, Eske
A1  - Orlando, Ludovic
T1  - Ancient genomic changes associated with domestication of the horse
JF  - Science
N2  - The genomic changes underlying both early and late stages of horse domestication remain largely unknown. We examined the genomes of 14 early domestic horses from the Bronze and Iron Ages, dating to between similar to 4.1 and 2.3 thousand years before present. We find early domestication selection patterns supporting the neural crest hypothesis, which provides a unified developmental origin for common domestic traits. Within the past 2.3 thousand years, horses lost genetic diversity and archaic DNA tracts introgressed from a now-extinct lineage. They accumulated deleterious mutations later than expected under the cost-of-domestication hypothesis, probably because of breeding from limited numbers of stallions. We also reveal that Iron Age Scythian steppe nomads implemented breeding strategies involving no detectable inbreeding and selection for coat-color variation and robust forelimbs.
Y1  - 2017
U6  - https://doi.org/10.1126/science.aam5298
SN  - 0036-8075
SN  - 1095-9203
VL  - 356
SP  - 442
EP  - 445
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Dieckmann, M. E.
A1  - Ahmed, H.
A1  - Sarri, G.
A1  - Doria, D.
A1  - Kourakis, I.
A1  - Romagnani, L.
A1  - Pohl, Martin
A1  - Borghesi, M.
T1  - Parametric study of non-relativistic electrostatic shocks and the structure of their transition layer
JF  - Physics of plasmas
N2  - Nonrelativistic electrostatic unmagnetized shocks are frequently observed in laboratory plasmas and they are likely to exist in astrophysical plasmas. Their maximum speed, expressed in units of the ion acoustic speed far upstream of the shock, depends only on the electron-to-ion temperature ratio if binary collisions are absent. The formation and evolution of such shocks is examined here for a wide range of shock speeds with particle-in-cell simulations. The initial temperatures of the electrons and the 400 times heavier ions are equal. Shocks form on electron time scales at Mach numbers between 1.7 and 2.2. Shocks with Mach numbers up to 2.5 form after tens of inverse ion plasma frequencies. The density of the shock-reflected ion beam increases and the number of ions crossing the shock thus decreases with an increasing Mach number, causing a slower expansion of the downstream region in its rest frame. The interval occupied by this ion beam is on a positive potential relative to the far upstream. This potential pre-heats the electrons ahead of the shock even in the absence of beam instabilities and decouples the electron temperature in the foreshock ahead of the shock from the one in the far upstream plasma. The effective Mach number of the shock is reduced by this electron heating. This effect can potentially stabilize nonrelativistic electrostatic shocks moving as fast as supernova remnant shocks.
Y1  - 2013
U6  - https://doi.org/10.1063/1.4801447
SN  - 1070-664X
VL  - 20
IS  - 4
PB  - American Institute of Physics
CY  - Melville
ER  - 
TY  - JOUR
A1  - Alqahtani, Obaid
A1  - Babics, Maxime
A1  - Gorenflot, Julien
A1  - Savikhin, Victoria
A1  - Ferron, Thomas
A1  - Balawi, Ahmed H.
A1  - Paulke, Andreas
A1  - Kan, Zhipeng
A1  - Pope, Michael
A1  - Clulow, Andrew J.
A1  - Wolf, Jannic
A1  - Burn, Paul L.
A1  - Gentle, Ian R.
A1  - Neher, Dieter
A1  - Toney, Michael F.
A1  - Laquai, Frederic
A1  - Beaujuge, Pierre M.
A1  - Collins, Brian A.
T1  - Mixed Domains Enhance Charge Generation and Extraction in Bulk-Heterojunction Solar Cells with Small-Molecule Donors
JF  - Advanced energy materials
N2  - The interplay between nanomorphology and efficiency of polymer-fullerene bulk-heterojunction (BHJ) solar cells has been the subject of intense research, but the generality of these concepts for small-molecule (SM) BHJs remains unclear. Here, the relation between performance; charge generation, recombination, and extraction dynamics; and nanomorphology achievable with two SM donors benzo[1,2-b:4,5-b]dithiophene-pyrido[3,4-b]-pyrazine BDT(PPTh2)(2), namely SM1 and SM2, differing by their side-chains, are examined as a function of solution additive composition. The results show that the additive 1,8-diiodooctane acts as a plasticizer in the blends, increases domain size, and promotes ordering/crystallinity. Surprisingly, the system with high domain purity (SM1) exhibits both poor exciton harvesting and severe charge trapping, alleviated only slightly with increased crystallinity. In contrast, the system consisting of mixed domains and lower crystallinity (SM2) shows both excellent exciton harvesting and low charge recombination losses. Importantly, the onset of large, pure crystallites in the latter (SM2) system reduces efficiency, pointing to possible differences in the ideal morphologies for SM-based BHJ solar cells compared with polymer-fullerene devices. In polymer-based systems, tie chains between pure polymer crystals establish a continuous charge transport network, whereas SM-based active layers may in some cases require mixed domains that enable both aggregation and charge percolation to the electrodes.
KW  - charge transport
KW  - domain purity
KW  - microscopy
KW  - mixed domains
KW  - organic solar cells
KW  - photovoltaic devices
KW  - resonant X-ray scattering
KW  - small molecules
KW  - transient spectroscopy
Y1  - 2018
U6  - https://doi.org/10.1002/aenm.201702941
SN  - 1614-6832
SN  - 1614-6840
VL  - 8
IS  - 19
PB  - Wiley-VCH
CY  - Weinheim
ER  -