TY  - JOUR
A1  - Chapman, Eric M.
A1  - Lant, Benjamin
A1  - Ohashi, Yota
A1  - Yu, Bin
A1  - Schertzberg, Michael
A1  - Go, Christopher
A1  - Dogra, Deepika
A1  - Koskimaki, Janne
A1  - Girard, Romuald
A1  - Li, Yan
A1  - Fraser, Andrew G.
A1  - Awad, Issam A.
A1  - Abdelilah-Seyfried, Salim
A1  - Gingras, Anne-Claude
A1  - Derry, William Brent
T1  - A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis
JF  - Nature Communications
N2  - Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.
Y1  - 2019
U6  - https://doi.org/10.1038/s41467-019-09829-z
SN  - 2041-1723
VL  - 10
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Scheller, Frieder W.
A1  - Makower, Alexander
A1  - Ghindilis, A. L.
A1  - Bier, Frank Fabian
A1  - Ehrentreich-Förster, Eva
A1  - Wollenberger, Ursula
A1  - Bauer, Christian G.
A1  - Micheel, Burkhard
A1  - Pfeiffer, Dorothea
A1  - Szeponik, Jan
A1  - Michael, N.
A1  - Kaden, H.
T1  - Enzyme sensors for subnanomolar concentrations
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Correia, Marcia A. S.
A1  - Otrelo-Cardoso, Ana Rita
A1  - Schwuchow, Viola
A1  - Clauss, Kajsa G. V. Sigfridsson
A1  - Haumann, Michael
A1  - Romao, Maria Joao
A1  - Leimkühler, Silke
A1  - Santos-Silva, Teresa
T1  - The Escherichia coli Periplasmic Aldehyde Oxidoreductase Is an Exceptional Member of the Xanthine Oxidase Family of Molybdoenzymes
JF  - ACS chemical biology
N2  - The xanthine oxidase (XO) family comprises molybdenum-dependent enzymes that usually form homodimers (or dimers of heterodimers/trimers) organized in three domains that harbor two [2Fe-2S] clusters, one FAD, and a Mo cofactor. In this work, we crystallized an unusual member of the family, the periplasmic aldehyde oxidoreductase PaoABC from Escherichia coli. This is the first example of an E. coli protein containing a molybdopterin-cytosine-dinucleotide cofactor and is the only heterotrimer of the XO family so far structurally characterized. The crystal structure revealed the presence of an unexpected [4Fe-4S] cluster, anchored to an additional 40 residues subdomain. According to phylogenetic analysis, proteins containing this cluster are widely spread in many bacteria phyla, putatively through repeated gene transfer events. The active site of PaoABC is highly exposed to the surface with no aromatic residues and an arginine (PaoC-R440) making a direct interaction with PaoC-E692, which acts as a base catalyst. In order to understand the importance of R440, kinetic assays were carried out, and the crystal structure of the PaoC-R440H variant was also determined.
Y1  - 2016
U6  - https://doi.org/10.1021/acschembio.6b00572
SN  - 1554-8929
SN  - 1554-8937
VL  - 11
SP  - 2923
EP  - 2935
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Kutsuradēs, Achilleas G.
A1  - Sonnentag, Michael
T1  - Die außergerichtliche einvernehmliche Scheidung nach griechischem Recht und ihre Anerkennung in Deutschland
JF  - Zeitschrift für das gesamte Familienrecht
N2  - Bereits seit 2017 ist die außergerichtliche einvernehmliche Scheidung vor dem Notar in Griechenland zulässig. Es wird dazu ein Gesetz aus dem Jahr 2020 mit einigen Änderungen vorgestellt, die Anlass zu einem Gesamtüberblick der griechischen einvernehmlichen Scheidung geben. Einleitend wird auf die Historie des Gesetzes erklärend eingegangen. Folgende Themen- und Regelungsbereiche werden vertiefend erläuternd erörtert: Die außergerichtliche einvernehmliche Scheidung nach griechischem Recht (Vereinbarung der Ehegatten über die Auflösung ihrer Ehe - Bestätigung der Eheauflösung und Beurkundung durch den Notar - Eintragung der Scheidung in das Eheregister des zuständigen Standesamts); Schutz der Ehegatten und der gemeinsamen minderjährigen Kinder; Anerkennung der griechischen einvernehmlichen Scheidung in Deutschland (Geltung der Brüssel IIa-VO - Geltung der Brüssel IIb-VO); Geltung der Rom III-VO). Abschließend wird festgestellt: Die in Griechenland 2017 eingeführte einvernehmliche Scheidung unterliege mit Ausnahme des Konsenses der Ehegatten keinen weiteren materiellen Voraussetzungen. Allerdings sei es erforderlich, dass die Ehegatten Regelungen über die elterliche Sorge, den Umgang und den Unterhalt der gemeinsamen minderjährigen Kinder treffen. Dabei sei nicht immer sicher, dass zur Ermöglichung einer schnellen Scheidung das Wohl der Kinder stets bestmöglichst berücksichtigt werde. Auch berge die einvernehmliche Scheidung vor dem Notar familien-verögensrechtliche Gefahren. Hierzu wird näher ausgeführt.
Y1  - 2022
SN  - 0044-2410
VL  - 69
IS  - 18
SP  - 1430
EP  - 1436
PB  - Gieseking
CY  - Bielefeld
ER  - 
TY  - JOUR
A1  - Beye, Martin
A1  - Öberg, Henrik
A1  - Xin, Hongliang
A1  - Dakovski, Georgi L.
A1  - Föhlisch, Alexander
A1  - Gladh, Jorgen
A1  - Hantschmann, Markus
A1  - Hieke, Florian
A1  - Kaya, Sarp
A1  - Kühn, Danilo
A1  - LaRue, Jerry
A1  - Mercurio, Giuseppe
A1  - Minitti, Michael P.
A1  - Mitra, Ankush
A1  - Moeller, Stefan P.
A1  - Ng, May Ling
A1  - Nilsson, Anders
A1  - Nordlund, Dennis
A1  - Norskov, Jens
A1  - Öström, Henrik
A1  - Ogasawara, Hirohito
A1  - Persson, Mats
A1  - Schlotter, William F.
A1  - Sellberg, Jonas A.
A1  - Wolf, Martin
A1  - Abild-Pedersen, Frank
A1  - Pettersson, Lars G. M.
A1  - Wurth, Wilfried
T1  - Chemical Bond Activation Observed with an X-ray Laser
JF  - The journal of physical chemistry letters
N2  - The concept of bonding and antibonding orbitals is fundamental in chemistry. The population of those orbitals and the energetic difference between the two reflect the strength of the bonding interaction. Weakening the bond is expected to reduce this energetic splitting, but the transient character of bond-activation has so far prohibited direct experimental access. Here we apply time-resolved soft X-ray spectroscopy at a free electron laser to directly observe the decreased bonding antibonding splitting following bond-activation using an ultrashort optical laser pulse.
Y1  - 2016
U6  - https://doi.org/10.1021/acs.jpclett.6b01543
SN  - 1948-7185
VL  - 7
SP  - 3647
EP  - 3651
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Mallonn, Matthias
A1  - Poppenhäger, Katja
A1  - Granzer, Thomas
A1  - Weber, Michael
A1  - Strassmeier, Klaus G.
T1  - Detection capability of ground-based meter-sized telescopes for shallow exoplanet transits
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Meter-sized ground-based telescopes are frequently used today for the follow-up of extrasolar planet candidates. While the transit signal of a Jupiter-sized object can typically be detected to a high level of confidence with small telescope apertures as well, the shallow transit dips of planets with the size of Neptune and smaller are more challenging to reveal. We employ new observational data to illustrate the photometric follow-up capabilities of meter-sized telescopes for shallow exoplanet transits. We describe in detail the capability of distinguishing the photometric signal of an exoplanet transit from an underlying trend in the light curve. The transit depths of the six targets we observed, Kepler-94b, Kepler-63b, K2-100b, K2-138b, K2-138c, and K2-138e, range from 3.9 ppt down to 0.3 ppt. For five targets of this sample, we provide the first ground-based photometric follow-up. The timing of three targets is precisely known from previous observations, and the timing of the other three targets is uncertain and we aim to constrain it. We detect or rule out the transit features significantly in single observations for the targets that show transits of 1.3 ppt or deeper. The shallower transit depths of two targets of 0.6 and 0.8 ppt were detected tentatively in single light curves, and were detected significantly by repeated observations. Only for the target of the shallowest transit depth of 0.3 ppt were we unable to draw a significant conclusion despite combining five individual light curves. An injection-recovery test on our real data shows that we detect transits of 1.3 ppt depth significantly in single light curves if the transit is fully covered, including out-of-transit data toward both sides, in some cases down to 0.7 ppt depth. For Kepler-94b, Kepler-63b, and K2-100b, we were able to verify the ephemeris. In the case of K2-138c with a 0.6 ppt deep transit, we were able to refine it, and in the case of K2-138e, we ruled out the transit in the time interval of more than ±1.5 σ of its current literature ephemeris.
KW  - methods: observational
KW  - techniques: photometric
KW  - planets and satellites: fundamental parameters
Y1  - 2022
U6  - https://doi.org/10.1051/0004-6361/202140599
SN  - 0004-6361
SN  - 1432-0746
VL  - 657
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Zhang, Hucai
A1  - Paijmans, Johanna L. A.
A1  - Chang, Fengqin
A1  - Wu, Xiaohong
A1  - Chen, Guangjie
A1  - Lei, Chuzhao
A1  - Yang, Xiujuan
A1  - Wei, Zhenyi
A1  - Bradley, Daniel G.
A1  - Orlando, Ludovic
A1  - O'Connor, Terry
A1  - Hofreiter, Michael
T1  - Morphological and genetic evidence for early Holocene cattle management in northeastern China
JF  - Nature Communications
N2  - The domestication of cattle is generally accepted to have taken place in two independent centres: around 10,500 years ago in the Near East, giving rise to modern taurine cattle, and two millennia later in southern Asia, giving rise to zebu cattle. Here we provide firmly dated morphological and genetic evidence for early Holocene management of taurine cattle in northeastern China. We describe conjoining mandibles from this region that show evidence of oral stereotypy, dated to the early Holocene by two independent C-14 dates. Using Illumina high-throughput sequencing coupled with DNA hybridization capture, we characterize 15,406 bp of the mitogenome with on average 16.7-fold coverage. Phylogenetic analyses reveal a hitherto unknown mitochondrial haplogroup that falls outside the known taurine diversity. Our data suggest that the first attempts to manage cattle in northern China predate the introduction of domestic cattle that gave rise to the current stock by several thousand years.
Y1  - 2013
U6  - https://doi.org/10.1038/ncomms3755
SN  - 2041-1723
VL  - 4
IS  - 6
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Baier, Frank W.
A1  - Lima-Neto, G. B.
A1  - Wipper, H.
A1  - Braun, Michael
T1  - Optical and X-ray structures of galaxy clusters I
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Abercrombie, Laura Good
A1  - Anderson, Cynthia M.
A1  - Baldwin, Bruce G.
A1  - Bang, In-Chul
A1  - Beldade, Ricardo
A1  - Bernardi, Giacomo
A1  - Boubou, Angham
A1  - Branca, Antoine
A1  - Bretagnolle, Francois
A1  - Bruford, Michael W.
A1  - Buonamici, Anna
A1  - Burnett, Robert K.
A1  - Canal, D.
A1  - Cardenas, H.
A1  - Caullet, Coraline
A1  - Chen, S. Y.
A1  - Chun, Y. J.
A1  - Cossu, C.
A1  - Crane, Charles F.
A1  - Cros-Arteil, Sandrine
A1  - Cudney-Bueno, Richard
A1  - Danti, Roberto
A1  - Davila, José Antonio
A1  - Della Rocca, Gianni
A1  - Dobata, Shigeto
A1  - Dunkle, Larry D.
A1  - Dupas, Stephane and others
T1  - Permanent genetic resources added to molecular ecology resources database 1 January 2009-30 April 2009
N2  - This article documents the addition of 283 microsatellite marker loci to the Molecular Ecology Resources Database. Loci were developed for the following species: Agalinis acuta; Ambrosia artemisiifolia; Berula erecta; Casuarius casuarius; Cercospora zeae-maydis; Chorthippus parallelus; Conyza canadensis; Cotesia sesamiae; Epinephelus acanthistius; Ficedula hypoleuca; Grindelia hirsutula; Guadua angustifolia; Leucadendron rubrum; Maritrema novaezealandensis; Meretrix meretrix; Nilaparvata lugens; Oxyeleotris marmoratus; Phoxinus neogaeus; Pristomyrmex punctatus; Pseudobagrus brevicorpus; Seiridium cardinale; Stenopsyche marmorata; Tetranychus evansi and Xerus inauris. These loci were cross-tested on the following species: Agalinis decemloba; Agalinis tenella; Agalinis obtusifolia; Agalinis setacea; Agalinis skinneriana; Cercospora zeina; Cercospora kikuchii; Cercospora sorghi; Mycosphaerella graminicola; Setosphaeria turcica; Magnaporthe oryzae; Cotesia flavipes; Cotesia marginiventris; Grindelia Xpaludosa; Grindelia chiloensis; Grindelia fastigiata; Grindelia lanceolata; Grindelia squarrosa; Leucadendron coniferum; Leucadendron salicifolium; Leucadendron tinctum; Leucadendron meridianum; Laodelphax striatellus; Sogatella furcifera; Phoxinus eos; Phoxinus rigidus; Phoxinus brevispinosus; Phoxinus bicolor; Tetranychus urticae; Tetranychus turkestani; Tetranychus ludeni; Tetranychus neocaledonicus; Tetranychus amicus; Amphitetranychus viennensis; Eotetranychus rubiphilus; Eotetranychus tiliarium; Oligonychus perseae; Panonychus citri; Bryobia rubrioculus; Schizonobia bundi; Petrobia harti; Xerus princeps; Spermophilus tridecemlineatus and Sciurus carolinensis.
Y1  - 2009
UR  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291755-0998
U6  - https://doi.org/10.1111/j.1755-0998.2009.02746.x
SN  - 1755-098X
ER  - 
TY  - JOUR
A1  - Kucian, Karin
A1  - Kohn, Juliane
A1  - Hannula-Sormunen, Minna M.
A1  - Richtmann, Verena
A1  - Grond, Ursin
A1  - Käser, Tanja
A1  - Esser, Günter
A1  - von Aster, Michael G.
T1  - Kinder mit Dyskalkulie fokussieren spontan weniger auf Anzahligkeit
Y1  - 2012
ER  - 
TY  - JOUR
A1  - Hofmann, Ch.
A1  - Sandig, V.
A1  - Kirillova, I.
A1  - Jennings, G.
A1  - Rudolph, Michael
A1  - Schlag, Peter M.
A1  - Strauss, M.
T1  - Hepatocyte- specific binding of L/S-HBV protein particles expressed in insect cells
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Hofmann, Ch.
A1  - Sandig, V.
A1  - Jennings, G.
A1  - Rudolph, Michael
A1  - Schlag, Peter M.
A1  - Strauss, M.
T1  - Efficient gene transfer into human hepatocytes by baculovirus vectors
Y1  - 1995
ER  - 
TY  - THES
A1  - Noll, Michael G.
T1  - Understanding and leveraging the social web for information retrieval
Y1  - 2010
CY  - Potsdam
ER  - 
TY  - INPR
A1  - Kaufmann, Liane
A1  - Mazzocco, Michele M.
A1  - Dowker, Ann
A1  - von Aster, Michael G.
A1  - Goebel, Silke M.
A1  - Grabner, Roland H.
A1  - Henik, Avishai
A1  - Jordan, Nancy C.
A1  - Karmiloff-Smith, Annette D.
A1  - Kucian, Karin
A1  - Rubinsten, Orly
A1  - Szucs, Denes
A1  - Shalev, Ruth
A1  - Nuerk, Hans-Christoph
T1  - Dyscalculia from a developmental and differential perspective
T2  - Frontiers in psychology
Y1  - 2013
U6  - https://doi.org/10.3389/fpsyg.2013.00516
SN  - 1664-1078
VL  - 4
IS  - 2
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Reschke, Stefan
A1  - Sigfridsson, Kajsa G. V.
A1  - Kaufmann, Paul
A1  - Leidel, Nils
A1  - Horn, Sebastian
A1  - Gast, Klaus
A1  - Schulzke, Carola
A1  - Haumann, Michael
A1  - Leimkühler, Silke
T1  - Identification of a bis-molybdopterin intermediate in molybdenum cofactor biosynthesis in escherichia coli
JF  - The journal of biological chemistry
N2  - The molybdenum cofactor is an important cofactor, and its biosynthesis is essential for many organisms, including humans. Its basic form comprises a single molybdopterin (MPT) unit, which binds a molybdenum ion bearing three oxygen ligands via a dithiolene function, thus forming Mo-MPT. In bacteria, this form is modified to form the bis-MPT guanine dinucleotide cofactor with two MPT units coordinated at one molybdenum atom, which additionally contains GMPs bound to the terminal phosphate group of the MPTs (bis-MGD). The MobA protein catalyzes the nucleotide addition to MPT, but the mechanism of the biosynthesis of the bis-MGD cofactor has remained enigmatic. We have established an in vitro system for studying bis-MGD assembly using purified compounds. Quantification of the MPT/molybdenum and molybdenum/phosphorus ratios, time-dependent assays for MPT and MGD detection, and determination of the numbers and lengths of Mo-S and Mo-O bonds by X-ray absorption spectroscopy enabled identification of a novel bis-Mo-MPT intermediate on MobA prior to nucleotide attachment. The addition of Mg-GTP to MobA loaded with bis-Mo-MPT resulted in formation and release of the final bis-MGD product. This cofactor was fully functional and reconstituted the catalytic activity of apo-TMAO reductase (TorA). We propose a reaction sequence for bis-MGD formation, which involves 1) the formation of bis-Mo-MPT, 2) the addition of two GMP units to form bis-MGD on MobA, and 3) the release and transfer of the mature cofactor to the target protein TorA, in a reaction that is supported by the specific chaperone TorD, resulting in an active molybdoenzyme.
Y1  - 2013
U6  - https://doi.org/10.1074/jbc.M113.497453
SN  - 0021-9258
SN  - 1083-351X
VL  - 288
IS  - 41
SP  - 29736
EP  - 29745
PB  - American Society for Biochemistry and Molecular Biology
CY  - Bethesda
ER  - 
TY  - JOUR
A1  - Schorck, Torben
A1  - Christlieb, Norbert
A1  - Cohen, Judy G.
A1  - Beers, Timothy C.
A1  - Shectman, Steve
A1  - Thompson, Ian
A1  - McWilliam, Andrew
A1  - Bessell, Michael S.
A1  - Norris, John E.
A1  - Meléndez, Jorge
A1  - Ramïrez, Solange
A1  - Haynes, D.
A1  - Cass, Paul
A1  - Hartley, Malcolm
A1  - Russell, Ken
A1  - Watson, Fred
A1  - Zickgraf, Franz-Josef
A1  - Behnke, Berit
A1  - Fechner, Cora
A1  - Fuhrmeister, Birgit
A1  - Barklem, Paul S.
A1  - Edvardsson, Bengt
A1  - Frebel, Anna
A1  - Wisotzki, Lutz
A1  - Reimers, Dieter
T1  - The stellar content of the Hamburg/ESO survey : V. the metallicity distribution function of the Galactic halo
N2  - We determine the metallicity distribution function (MDF) of the Galactic halo by means of a sample of 1638 metal-poor stars selected from the Hamburg/ESO objective-prism survey (HES). The sample was corrected for minor biases introduced by the strategy for spectroscopic follow-up observations of the metal-poor candidates, namely "best and brightest stars first". Comparison of the metallicities [Fe/H] of the stars determined from moderate-resolution (i.e., R similar to 2000) follow-up spectra with results derived from abundance analyses based on high-resolution spectra (i.e., R > 20 000) shows that the [Fe/H] estimates used for the determination of the halo MDF are accurate to within 0.3 dex, once highly C-rich stars are eliminated. We determined the selection function of the HES, which must be taken into account for a proper comparison between the HES MDF with MDFs of other stellar populations or those predicted by models of Galactic chemical evolution. The latter show a reasonable agreement with the overall shape of the HES MDF for [Fe/H] > -3.6, but only a model of Salvadori et al. (2007) with a critical metallicity for low-mass star formation of Z(cr) = 10(-3.4) Z(circle dot) reproduces the sharp drop at [Fe/H] similar to -3.6 present in the HES MDF. Although currently about ten stars at [Fe/H] < -3.6 are known, the evidence for the existence of a tail of the halo MDF extending to [Fe/H] similar to -5.5 is weak from the sample considered in this paper, because it only includes two stars [Fe/H] < -3.6. Therefore, a comparison with theoretical models has to await larger statistically complete and unbiased samples. A comparison of the MDF of Galactic globular clusters and of dSph satellites to the Galaxy shows qualitative agreement with the halo MDF, derived from the HES, once the selection function of the latter is included. However, statistical tests show that the differences between these are still highly significant.
Y1  - 2009
UR  - http://www.aanda.org/
U6  - https://doi.org/10.1051/0004-6361/200810925
SN  - 0004-6361
ER  - 
TY  - JOUR
A1  - Reschke, Stefan
A1  - Niks, Dimitri
A1  - Wilson, Heather
A1  - Sigfridsson, Kajsa G. V.
A1  - Haumann, Michael
A1  - Rajagopalan, K. V.
A1  - Hine, Russ
A1  - Leimkühler, Silke
T1  - Effect of exchange of the cysteine molybdenum ligand with selenocysteine on the structure and function of the active site in human sulfite oxidase
JF  - Biochemistry
N2  - Sulfite oxidase (SO) is an essential molybdoenzyme for humans, catalyzing the final step in the degradation of sulfur-containing amino acids and lipids, which is the oxidation of sulfite to sulfate. The catalytic site of SO consists of a molybdenum ion bound to the dithiolene sulfurs of one molybdopterin (MPT) molecule, carrying two oxygen ligands, and is further coordinated by the thiol sulfur of a conserved cysteine residue. We have exchanged four non-active site cysteines in the molybdenum cofactor (Moco) binding domain of human SO (SOMD) with serine using site-directed mutagenesis. This facilitated the specific replacement of the active site Cys207 with selenocysteine during protein expression in Escherichia coli. The sulfite oxidizing activity (k(cat)/K-M) of SeSOMD4Ser was increased at least 1.5-fold, and the pH optimum was shifted to a more acidic value compared to those of SOMD4Ser and SOMD4Cys(wt) X-ray absorption spectroscopy revealed a Mow Se bond length of 2.51 A, likely caused by the specific binding of Sec207 to the molybdenum, and otherwise rather similar square-pyramidal S/Se(Cys)(O2MoS2)-S-VI(MPT) site structures in the three constructs. The low-pH form of the Mo(V) electron paramagnetic resonance (EPR) signal of SeSOM4Ser was altered compared to those of SOMD4Ser and SOMD4cy,(,), with g, in particular shifted to a lower magnetic field, due to the Se ligation at the molybdenum. In contrast, the Mo(V) EPR signal of the high-pH form was unchanged. The substantially stronger effect of substituting selenocysteine for cysteine at low pH as compared to high pH is most likely due to the decreased covalency of the Mo Se bond.
Y1  - 2013
U6  - https://doi.org/10.1021/bi4008512
SN  - 0006-2960
VL  - 52
IS  - 46
SP  - 8295
EP  - 8303
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - INPR
A1  - Kucian, Karin
A1  - Plangger, Fabienne
A1  - O'Gorman, Ruth
A1  - von Aster, Michael G.
T1  - Operational momentum effect in children with and without developmental dyscalculia
T2  - Frontiers in psychology
KW  - developmental dyscalculia
KW  - operational momentum
KW  - children
KW  - learning disability
KW  - numerical cognition
KW  - mental number line
KW  - symbolic calculation
KW  - attention
Y1  - 2013
U6  - https://doi.org/10.3389/fpsyg.2013.00847
SN  - 1664-1078
VL  - 4
IS  - 45
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - De Frenne, Pieter
A1  - Rodriguez-Sanchez, Francisco
A1  - Coomes, David Anthony
A1  - Bäten, Lander
A1  - Versträten, Gorik
A1  - Vellend, Mark
A1  - Bernhardt-Römermann, Markus
A1  - Brown, Carissa D.
A1  - Brunet, Jörg
A1  - Cornelis, Johnny
A1  - Decocq, Guillaume M.
A1  - Dierschke, Hartmut
A1  - Eriksson, Ove
A1  - Gilliam, Frank S.
A1  - Hedl, Radim
A1  - Heinken, Thilo
A1  - Hermy, Martin
A1  - Hommel, Patrick
A1  - Jenkins, Michael A.
A1  - Kelly, Daniel L.
A1  - Kirby, Keith J.
A1  - Mitchell, Fraser J. G.
A1  - Naaf, Tobias
A1  - Newman, Miles
A1  - Peterken, George
A1  - Petrik, Petr
A1  - Schultz, Jan
A1  - Sonnier, Gregory
A1  - Van Calster, Hans
A1  - Waller, Donald M.
A1  - Walther, Gian-Reto
A1  - White, Peter S.
A1  - Woods, Kerry D.
A1  - Wulf, Monika
A1  - Graae, Bente Jessen
A1  - Verheyen, Kris
T1  - Microclimate moderates plant responses to macroclimate warming
JF  - Proceedings of the National Academy of Sciences of the United States of America
N2  - Recent global warming is acting across marine, freshwater, and terrestrial ecosystems to favor species adapted to warmer conditions and/or reduce the abundance of cold-adapted organisms (i.e., "thermophilization" of communities). Lack of community responses to increased temperature, however, has also been reported for several taxa and regions, suggesting that "climatic lags" may be frequent. Here we show that microclimatic effects brought about by forest canopy closure can buffer biotic responses to macroclimate warming, thus explaining an apparent climatic lag. Using data from 1,409 vegetation plots in European and North American temperate forests, each surveyed at least twice over an interval of 12-67 y, we document significant thermophilization of ground-layer plant communities. These changes reflect concurrent declines in species adapted to cooler conditions and increases in species adapted to warmer conditions. However, thermophilization, particularly the increase of warm-adapted species, is attenuated in forests whose canopies have become denser, probably reflecting cooler growing-season ground temperatures via increased shading. As standing stocks of trees have increased in many temperate forests in recent decades, local microclimatic effects may commonly be moderating the impacts of macroclimate warming on forest understories. Conversely, increases in harvesting woody biomass-e.g., for bioenergy-may open forest canopies and accelerate thermophilization of temperate forest biodiversity.
KW  - climate change
KW  - forest management
KW  - understory
KW  - climatic debt
KW  - range shifts
Y1  - 2013
U6  - https://doi.org/10.1073/pnas.1311190110
SN  - 0027-8424
VL  - 110
IS  - 46
SP  - 18561
EP  - 18565
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Käser, Tanja
A1  - Baschera, Gian-Marco
A1  - Kohn, Juliane
A1  - Kucian, Karin
A1  - Richtmann, Verena
A1  - Grond, Ursina
A1  - Gross, Markus
A1  - von Aster, Michael G.
T1  - Design and evaluation of the computer-based training program Calcularis for enhancing numerical cognition
JF  - Frontiers in psychology
N2  - This article presents the design and a first pilot evaluation of the computer-based training program Calcularis for children with developmental dyscalculia (DD) or difficulties in learning mathematics. The program has been designed according to insights on the typical and atypical development of mathematical abilities. The learning process is supported through multimodal cues, which encode different properties of numbers. To offer optimal learning conditions, a user model completes the program and allows flexible adaptation to a child's individual learning and knowledge profile. Thirty-two children with difficulties in learning mathematics completed the 6-12-weeks computer training. The children played the game for 20 min per day for 5 days a week. The training effects were evaluated using neuropsychological tests. Generally, children benefited significantly from the training regarding number representation and arithmetic operations. Furthermore, children liked to play with the program and reported that the training improved their mathematical abilities.
KW  - learning
KW  - intervention
KW  - optimization
KW  - calculation
KW  - spatial representation
KW  - interactive learning environment
Y1  - 2013
U6  - https://doi.org/10.3389/fpsyg.2013.00489
SN  - 1664-1078
VL  - 4
IS  - 31
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -