TY  - JOUR
A1  - Bauer, Christian G.
A1  - Eremenko, A. V.
A1  - Ehrentreich-Förster, Eva
A1  - Bier, Frank Fabian
A1  - Makower, Alexander
A1  - Halsall, H. B.
A1  - Heineman, W. R.
A1  - Scheller, Frieder W.
T1  - Zeptomole-detecting biosensor for alkaline phosphatase in an electroche mical immunoassay for 2,4- dichlorophenoacetic acid
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Rajasundaram, Dhivyaa
A1  - Runavot, Jean-Luc
A1  - Guo, Xiaoyuan
A1  - Willats, William G. T.
A1  - Meulewaeter, Frank
A1  - Selbig, Joachim
T1  - Understanding the relationship between cotton fiber properties and non-cellulosic cell wall polysaccharides
JF  - PLoS one
N2  - A detailed knowledge of cell wall heterogeneity and complexity is crucial for understanding plant growth and development. One key challenge is to establish links between polysaccharide-rich cell walls and their phenotypic characteristics. It is of particular interest for some plant material, like cotton fibers, which are of both biological and industrial importance. To this end, we attempted to study cotton fiber characteristics together with glycan arrays using regression based approaches. Taking advantage of the comprehensive microarray polymer profiling technique (CoMPP), 32 cotton lines from different cotton species were studied. The glycan array was generated by sequential extraction of cell wall polysaccharides from mature cotton fibers and screening samples against eleven extensively characterized cell wall probes. Also, phenotypic characteristics of cotton fibers such as length, strength, elongation and micronaire were measured. The relationship between the two datasets was established in an integrative manner using linear regression methods. In the conducted analysis, we demonstrated the usefulness of regression based approaches in establishing a relationship between glycan measurements and phenotypic traits. In addition, the analysis also identified specific polysaccharides which may play a major role during fiber development for the final fiber characteristics. Three different regression methods identified a negative correlation between micronaire and the xyloglucan and homogalacturonan probes. Moreover, homogalacturonan and callose were shown to be significant predictors for fiber length. The role of these polysaccharides was already pointed out in previous cell wall elongation studies. Additional relationships were predicted for fiber strength and elongation which will need further experimental validation.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pone.0112168
SN  - 1932-6203
VL  - 9
IS  - 11
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Bier, Frank Fabian
A1  - Ehrentreich-Förster, Eva
A1  - Scheller, Frieder W.
A1  - Makower, Alexander
A1  - Eremenko, A. V.
A1  - Wollenberger, Ursula
A1  - Bauer, Christian G.
A1  - Pfeiffer, Dorothea
A1  - Micheel, Burkhard
T1  - Ultrasensitive biosensors
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Schulze-Makuch, Dirk
A1  - Wagner, Dirk
A1  - Kounaves, Samuel P.
A1  - Mangelsdorf, Kai
A1  - Devine, Kevin G.
A1  - de Vera, Jean-Pierre
A1  - Schmitt-Kopplin, Philippe
A1  - Grossart, Hans-Peter
A1  - Parro, Victor
A1  - Kaupenjohann, Martin
A1  - Galy, Albert
A1  - Schneider, Beate
A1  - Airo, Alessandro
A1  - Froesler, Jan
A1  - Davila, Alfonso F.
A1  - Arens, Felix L.
A1  - Caceres, Luis
A1  - Cornejo, Francisco Solis
A1  - Carrizo, Daniel
A1  - Dartnell, Lewis
A1  - DiRuggiero, Jocelyne
A1  - Flury, Markus
A1  - Ganzert, Lars
A1  - Gessner, Mark O.
A1  - Grathwohl, Peter
A1  - Guan, Lisa
A1  - Heinz, Jacob
A1  - Hess, Matthias
A1  - Keppler, Frank
A1  - Maus, Deborah
A1  - McKay, Christopher P.
A1  - Meckenstock, Rainer U.
A1  - Montgomery, Wren
A1  - Oberlin, Elizabeth A.
A1  - Probst, Alexander J.
A1  - Saenz, Johan S.
A1  - Sattler, Tobias
A1  - Schirmack, Janosch
A1  - Sephton, Mark A.
A1  - Schloter, Michael
A1  - Uhl, Jenny
A1  - Valenzuela, Bernardita
A1  - Vestergaard, Gisle
A1  - Woermer, Lars
A1  - Zamorano, Pedro
T1  - Transitory microbial habitat in the hyperarid Atacama Desert
JF  - Proceedings of the National Academy of Sciences of the United States of America
KW  - habitat
KW  - aridity
KW  - microbial activity
KW  - biomarker
KW  - Mars
Y1  - 2018
U6  - https://doi.org/10.1073/pnas.1714341115
SN  - 0027-8424
VL  - 115
IS  - 11
SP  - 2670
EP  - 2675
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Shenar, Tomer
A1  - Richardson, N. D.
A1  - Sablowski, Daniel P.
A1  - Hainich, Rainer
A1  - Sana, H.
A1  - Moffat, A. F. J.
A1  - Todt, Helge Tobias
A1  - Hamann, Wolf-Rainer
A1  - Oskinova, Lida
A1  - Sander, Andreas Alexander Christoph
A1  - Tramper, Frank
A1  - Langer, Norbert
A1  - Bonanos, Alceste Z.
A1  - de Mink, Selma E.
A1  - Gräfener, G.
A1  - Crowther, Paul
A1  - Vink, J. S.
A1  - Almeida, Leonardo A.
A1  - de Koter, A.
A1  - Barbá, Rodolfo
A1  - Herrero, A.
A1  - Ulaczyk, Krzysztof
T1  - The tarantula massive binary monitoring
BT  - II. First SB2 orbital and spectroscopic analysis for the Wolf-Rayet binary R145
JF  - Astronomy and astrophysics : an international weekly journal
N2  - We present the first SB2 orbital solution and disentanglement of the massive Wolf-Rayet binary R145 (P = 159 d) located in the Large Magellanic Cloud. The primary was claimed to have a stellar mass greater than 300 M-circle dot, making it a candidate for being the most massive star known to date. While the primary is a known late-type, H-rich Wolf-Rayet star (WN6h), the secondary has so far not been unambiguously detected. Using moderate-resolution spectra, we are able to derive accurate radial velocities for both components. By performing simultaneous orbital and polarimetric analyses, we derive the complete set of orbital parameters, including the inclination. The spectra are disentangled and spectroscopically analyzed, and an analysis of the wind-wind collision zone is conducted. The disentangled spectra and our models are consistent with a WN6h type for the primary and suggest that the secondary is an O3.5 If*/WN7 type star. We derive a high eccentricity of e = 0 : 78 and minimum masses of M-1 sin(3) i approximate to M-2 sin(3) i = 13 +/- 2 M-circle dot, with q = M-2/M-1 = 1.01 +/- 0.07. An analysis of emission excess stemming from a wind-wind collision yields an inclination similar to that obtained from polarimetry (i = 39 +/- 6 degrees). Our analysis thus implies M-1 = 53(-20)(+40) and M2 = 54(-20)(+40) M-circle dot, excluding M-1 > 300 M-circle dot. A detailed comparison with evolution tracks calculated for single and binary stars together with the high eccentricity suggests that the components of the system underwent quasi-homogeneous evolution and avoided mass-transfer. This scenario would suggest current masses of approximate to 80 M-circle dot and initial masses of M-i,M-1 approximate to 10(5) and M-i,M-2 approximate to 90 M-circle dot, consistent with the upper limits of our derived orbital masses, and would imply an age of approximate to 2.2 Myr.
KW  - binaries: spectroscopic
KW  - stars: Wolf-Rayet
KW  - stars: massive
KW  - Magellanic Clouds
KW  - stars: individual: R 145
KW  - stars: atmospheres
Y1  - 2017
U6  - https://doi.org/10.1051/0004-6361/201629621
SN  - 1432-0746
VL  - 598
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Arridge, Christopher S.
A1  - Achilleos, N.
A1  - Agarwal, Jessica
A1  - Agnor, C. B.
A1  - Ambrosi, R.
A1  - Andre, N.
A1  - Badman, S. V.
A1  - Baines, K.
A1  - Banfield, D.
A1  - Barthelemy, M.
A1  - Bisi, M. M.
A1  - Blum, J.
A1  - Bocanegra-Bahamon, T.
A1  - Bonfond, B.
A1  - Bracken, C.
A1  - Brandt, P.
A1  - Briand, C.
A1  - Briois, C.
A1  - Brooks, S.
A1  - Castillo-Rogez, J.
A1  - Cavalie, T.
A1  - Christophe, B.
A1  - Coates, Andrew J.
A1  - Collinson, G.
A1  - Cooper, J. F.
A1  - Costa-Sitja, M.
A1  - Courtin, R.
A1  - Daglis, I. A.
A1  - De Pater, Imke
A1  - Desai, M.
A1  - Dirkx, D.
A1  - Dougherty, M. K.
A1  - Ebert, R. W.
A1  - Filacchione, Gianrico
A1  - Fletcher, Leigh N.
A1  - Fortney, J.
A1  - Gerth, I.
A1  - Grassi, D.
A1  - Grodent, D.
A1  - Grün, Eberhard
A1  - Gustin, J.
A1  - Hedman, M.
A1  - Helled, R.
A1  - Henri, P.
A1  - Hess, Sebastien
A1  - Hillier, J. K.
A1  - Hofstadter, M. H.
A1  - Holme, R.
A1  - Horanyi, M.
A1  - Hospodarsky, George B.
A1  - Hsu, S.
A1  - Irwin, P.
A1  - Jackman, C. M.
A1  - Karatekin, O.
A1  - Kempf, Sascha
A1  - Khalisi, E.
A1  - Konstantinidis, K.
A1  - Kruger, H.
A1  - Kurth, William S.
A1  - Labrianidis, C.
A1  - Lainey, V.
A1  - Lamy, L. L.
A1  - Laneuville, Matthieu
A1  - Lucchesi, D.
A1  - Luntzer, A.
A1  - MacArthur, J.
A1  - Maier, A.
A1  - Masters, A.
A1  - McKenna-Lawlor, S.
A1  - Melin, H.
A1  - Milillo, A.
A1  - Moragas-Klostermeyer, Georg
A1  - Morschhauser, Achim
A1  - Moses, J. I.
A1  - Mousis, O.
A1  - Nettelmann, N.
A1  - Neubauer, F. M.
A1  - Nordheim, T.
A1  - Noyelles, B.
A1  - Orton, G. S.
A1  - Owens, Mathew
A1  - Peron, R.
A1  - Plainaki, C.
A1  - Postberg, F.
A1  - Rambaux, N.
A1  - Retherford, K.
A1  - Reynaud, Serge
A1  - Roussos, E.
A1  - Russell, C. T.
A1  - Rymer, Am.
A1  - Sallantin, R.
A1  - Sanchez-Lavega, A.
A1  - Santolik, O.
A1  - Saur, J.
A1  - Sayanagi, Km.
A1  - Schenk, P.
A1  - Schubert, J.
A1  - Sergis, N.
A1  - Sittler, E. C.
A1  - Smith, A.
A1  - Spahn, Frank
A1  - Srama, Ralf
A1  - Stallard, T.
A1  - Sterken, V.
A1  - Sternovsky, Zoltan
A1  - Tiscareno, M.
A1  - Tobie, G.
A1  - Tosi, F.
A1  - Trieloff, M.
A1  - Turrini, D.
A1  - Turtle, E. P.
A1  - Vinatier, S.
A1  - Wilson, R.
A1  - Zarkat, P.
T1  - The science case for an orbital mission to Uranus: Exploring the origins and evolution of ice giant planets
JF  - Planetary and space science
N2  - Giant planets helped to shape the conditions we see in the Solar System today and they account for more than 99% of the mass of the Sun's planetary system. They can be subdivided into the Ice Giants (Uranus and Neptune) and the Gas Giants (Jupiter and Saturn), which differ from each other in a number of fundamental ways. Uranus, in particular is the most challenging to our understanding of planetary formation and evolution, with its large obliquity, low self-luminosity, highly asymmetrical internal field, and puzzling internal structure. Uranus also has a rich planetary system consisting of a system of inner natural satellites and complex ring system, five major natural icy satellites, a system of irregular moons with varied dynamical histories, and a highly asymmetrical magnetosphere. Voyager 2 is the only spacecraft to have explored Uranus, with a flyby in 1986, and no mission is currently planned to this enigmatic system. However, a mission to the uranian system would open a new window on the origin and evolution of the Solar System and would provide crucial information on a wide variety of physicochemical processes in our Solar System. These have clear implications for understanding exoplanetary systems. In this paper we describe the science case for an orbital mission to Uranus with an atmospheric entry probe to sample the composition and atmospheric physics in Uranus' atmosphere. The characteristics of such an orbiter and a strawman scientific payload are described and we discuss the technical challenges for such a mission. This paper is based on a white paper submitted to the European Space Agency's call for science themes for its large-class mission programme in 2013.
KW  - Uranus
KW  - Magnetosphere
KW  - Atmosphere
KW  - Natural satellites
KW  - Rings
KW  - Planetary interior
Y1  - 2014
U6  - https://doi.org/10.1016/j.pss.2014.08.009
SN  - 0032-0633
VL  - 104
SP  - 122
EP  - 140
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Cohen, Andrew
A1  - Campisano, C.
A1  - Arrowsmith, J. Ramón
A1  - Asrat, Asfawossen
A1  - Behrensmeyer, A. K.
A1  - Deino, A.
A1  - Feibel, C.
A1  - Hill, A.
A1  - Johnson, R.
A1  - Kingston, J.
A1  - Lamb, Henry F.
A1  - Lowenstein, T.
A1  - Noren, A.
A1  - Olago, D.
A1  - Owen, R. B.
A1  - Potts, R.
A1  - Reed, Kate
A1  - Renaut, R.
A1  - Schäbitz, Frank
A1  - Tiercelin, J. -J.
A1  - Trauth, Martin H.
A1  - Wynn, J.
A1  - Ivory, S.
A1  - Brady, K.
A1  - Rodysill, J.
A1  - Githiri, J.
A1  - Russell, J.
A1  - Förster, Verena
A1  - Dommain, René
A1  - Rucina, S.
A1  - Deocampo, D.
A1  - Russell, J.
A1  - Billingsley, A.
A1  - Beck, C.
A1  - Dorenbeck, G.
A1  - Dullo, L.
A1  - Feary, D.
A1  - Garello, D.
A1  - Gromig, R.
A1  - Johnson, T.
A1  - Junginger, A.
A1  - Karanja, M.
A1  - Kimburi, E.
A1  - Mbuthia, A.
A1  - McCartney, T.
A1  - McNulty, E.
A1  - Muiruri, V.
A1  - Nambiro, E.
A1  - Negash, E. W.
A1  - Njagi, D.
A1  - Wilson, J. N.
A1  - Rabideaux, N.
A1  - Raub, T.
A1  - Sier, M. J.
A1  - Smith, P.
A1  - Urban, J.
A1  - Warren, M.
A1  - Yadeta, M.
A1  - Yost, C.
A1  - Zinaye, B.
T1  - The Hominin Sites and Paleolakes Drilling Project: inferring the environmental context of human evolution from eastern African rift lake deposits
JF  - Scientific Drilling
N2  - The role that climate and environmental history may have played in influencing human evolution has been the focus of considerable interest and controversy among paleoanthropologists for decades. Prior attempts to understand the environmental history side of this equation have centered around the study of outcrop sediments and fossils adjacent to where fossil hominins (ancestors or close relatives of modern humans) are found, or from the study of deep sea drill cores. However, outcrop sediments are often highly weathered and thus are unsuitable for some types of paleoclimatic records, and deep sea core records come from long distances away from the actual fossil and stone tool remains. The Hominin Sites and Paleolakes Drilling Project (HSPDP) was developed to address these issues. The project has focused its efforts on the eastern African Rift Valley, where much of the evidence for early hominins has been recovered. We have collected about 2 km of sediment drill core from six basins in Kenya and Ethiopia, in lake deposits immediately adjacent to important fossil hominin and archaeological sites. Collectively these cores cover in time many of the key transitions and critical intervals in human evolutionary history over the last 4 Ma, such as the earliest stone tools, the origin of our own genus Homo, and the earliest anatomically modern Homo sapiens. Here we document the initial field, physical property, and core description results of the 2012-2014 HSPDP coring campaign.
Y1  - 2016
U6  - https://doi.org/10.5194/sd-21-1-2016
SN  - 1816-8957
SN  - 1816-3459
VL  - 21
SP  - 1
EP  - 16
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Chipman, Ariel D.
A1  - Ferrier, David E. K.
A1  - Brena, Carlo
A1  - Qu, Jiaxin
A1  - Hughes, Daniel S. T.
A1  - Schroeder, Reinhard
A1  - Torres-Oliva, Montserrat
A1  - Znassi, Nadia
A1  - Jiang, Huaiyang
A1  - Almeida, Francisca C.
A1  - Alonso, Claudio R.
A1  - Apostolou, Zivkos
A1  - Aqrawi, Peshtewani
A1  - Arthur, Wallace
A1  - Barna, Jennifer C. J.
A1  - Blankenburg, Kerstin P.
A1  - Brites, Daniela
A1  - Capella-Gutierrez, Salvador
A1  - Coyle, Marcus
A1  - Dearden, Peter K.
A1  - Du Pasquier, Louis
A1  - Duncan, Elizabeth J.
A1  - Ebert, Dieter
A1  - Eibner, Cornelius
A1  - Erikson, Galina
A1  - Evans, Peter D.
A1  - Extavour, Cassandra G.
A1  - Francisco, Liezl
A1  - Gabaldon, Toni
A1  - Gillis, William J.
A1  - Goodwin-Horn, Elizabeth A.
A1  - Green, Jack E.
A1  - Griffiths-Jones, Sam
A1  - Grimmelikhuijzen, Cornelis J. P.
A1  - Gubbala, Sai
A1  - Guigo, Roderic
A1  - Han, Yi
A1  - Hauser, Frank
A1  - Havlak, Paul
A1  - Hayden, Luke
A1  - Helbing, Sophie
A1  - Holder, Michael
A1  - Hui, Jerome H. L.
A1  - Hunn, Julia P.
A1  - Hunnekuhl, Vera S.
A1  - Jackson, LaRonda
A1  - Javaid, Mehwish
A1  - Jhangiani, Shalini N.
A1  - Jiggins, Francis M.
A1  - Jones, Tamsin E.
A1  - Kaiser, Tobias S.
A1  - Kalra, Divya
A1  - Kenny, Nathan J.
A1  - Korchina, Viktoriya
A1  - Kovar, Christie L.
A1  - Kraus, F. Bernhard
A1  - Lapraz, Francois
A1  - Lee, Sandra L.
A1  - Lv, Jie
A1  - Mandapat, Christigale
A1  - Manning, Gerard
A1  - Mariotti, Marco
A1  - Mata, Robert
A1  - Mathew, Tittu
A1  - Neumann, Tobias
A1  - Newsham, Irene
A1  - Ngo, Dinh N.
A1  - Ninova, Maria
A1  - Okwuonu, Geoffrey
A1  - Ongeri, Fiona
A1  - Palmer, William J.
A1  - Patil, Shobha
A1  - Patraquim, Pedro
A1  - Pham, Christopher
A1  - Pu, Ling-Ling
A1  - Putman, Nicholas H.
A1  - Rabouille, Catherine
A1  - Ramos, Olivia Mendivil
A1  - Rhodes, Adelaide C.
A1  - Robertson, Helen E.
A1  - Robertson, Hugh M.
A1  - Ronshaugen, Matthew
A1  - Rozas, Julio
A1  - Saada, Nehad
A1  - Sanchez-Gracia, Alejandro
A1  - Scherer, Steven E.
A1  - Schurko, Andrew M.
A1  - Siggens, Kenneth W.
A1  - Simmons, DeNard
A1  - Stief, Anna
A1  - Stolle, Eckart
A1  - Telford, Maximilian J.
A1  - Tessmar-Raible, Kristin
A1  - Thornton, Rebecca
A1  - van der Zee, Maurijn
A1  - von Haeseler, Arndt
A1  - Williams, James M.
A1  - Willis, Judith H.
A1  - Wu, Yuanqing
A1  - Zou, Xiaoyan
A1  - Lawson, Daniel
A1  - Muzny, Donna M.
A1  - Worley, Kim C.
A1  - Gibbs, Richard A.
A1  - Akam, Michael
A1  - Richards, Stephen
T1  - The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima
JF  - PLoS biology
N2  - Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history.
Y1  - 2014
U6  - https://doi.org/10.1371/journal.pbio.1002005
SN  - 1545-7885
VL  - 12
IS  - 11
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Middeldorp, Christel M.
A1  - Mahajan, Anubha
A1  - Horikoshi, Momoko
A1  - Robertson, Neil R.
A1  - Beaumont, Robin N.
A1  - Bradfield, Jonathan P.
A1  - Bustamante, Mariona
A1  - Cousminer, Diana L.
A1  - Day, Felix R.
A1  - De Silva, N. Maneka
A1  - Guxens, Monica
A1  - Mook-Kanamori, Dennis O.
A1  - St Pourcain, Beate
A1  - Warrington, Nicole M.
A1  - Adair, Linda S.
A1  - Ahlqvist, Emma
A1  - Ahluwalia, Tarunveer Singh
A1  - Almgren, Peter
A1  - Ang, Wei
A1  - Atalay, Mustafa
A1  - Auvinen, Juha
A1  - Bartels, Meike
A1  - Beckmann, Jacques S.
A1  - Bilbao, Jose Ramon
A1  - Bond, Tom
A1  - Borja, Judith B.
A1  - Cavadino, Alana
A1  - Charoen, Pimphen
A1  - Chen, Zhanghua
A1  - Coin, Lachlan
A1  - Cooper, Cyrus
A1  - Curtin, John A.
A1  - Custovic, Adnan
A1  - Das, Shikta
A1  - Davies, Gareth E.
A1  - Dedoussis, George V.
A1  - Duijts, Liesbeth
A1  - Eastwood, Peter R.
A1  - Eliasen, Anders U.
A1  - Elliott, Paul
A1  - Eriksson, Johan G.
A1  - Estivill, Xavier
A1  - Fadista, Joao
A1  - Fedko, Iryna O.
A1  - Frayling, Timothy M.
A1  - Gaillard, Romy
A1  - Gauderman, W. James
A1  - Geller, Frank
A1  - Gilliland, Frank
A1  - Gilsanz, Vincente
A1  - Granell, Raquel
A1  - Grarup, Niels
A1  - Groop, Leif
A1  - Hadley, Dexter
A1  - Hakonarson, Hakon
A1  - Hansen, Torben
A1  - Hartman, Catharina A.
A1  - Hattersley, Andrew T.
A1  - Hayes, M. Geoffrey
A1  - Hebebrand, Johannes
A1  - Heinrich, Joachim
A1  - Helgeland, Oyvind
A1  - Henders, Anjali K.
A1  - Henderson, John
A1  - Henriksen, Tine B.
A1  - Hirschhorn, Joel N.
A1  - Hivert, Marie-France
A1  - Hocher, Berthold
A1  - Holloway, John W.
A1  - Holt, Patrick
A1  - Hottenga, Jouke-Jan
A1  - Hypponen, Elina
A1  - Iniguez, Carmen
A1  - Johansson, Stefan
A1  - Jugessur, Astanand
A1  - Kahonen, Mika
A1  - Kalkwarf, Heidi J.
A1  - Kaprio, Jaakko
A1  - Karhunen, Ville
A1  - Kemp, John P.
A1  - Kerkhof, Marjan
A1  - Koppelman, Gerard H.
A1  - Korner, Antje
A1  - Kotecha, Sailesh
A1  - Kreiner-Moller, Eskil
A1  - Kulohoma, Benard
A1  - Kumar, Ashish
A1  - Kutalik, Zoltan
A1  - Lahti, Jari
A1  - Lappe, Joan M.
A1  - Larsson, Henrik
A1  - Lehtimaki, Terho
A1  - Lewin, Alexandra M.
A1  - Li, Jin
A1  - Lichtenstein, Paul
A1  - Lindgren, Cecilia M.
A1  - Lindi, Virpi
A1  - Linneberg, Allan
A1  - Liu, Xueping
A1  - Liu, Jun
A1  - Lowe, William L.
A1  - Lundstrom, Sebastian
A1  - Lyytikainen, Leo-Pekka
A1  - Ma, Ronald C. W.
A1  - Mace, Aurelien
A1  - Magi, Reedik
A1  - Magnus, Per
A1  - Mamun, Abdullah A.
A1  - Mannikko, Minna
A1  - Martin, Nicholas G.
A1  - Mbarek, Hamdi
A1  - McCarthy, Nina S.
A1  - Medland, Sarah E.
A1  - Melbye, Mads
A1  - Melen, Erik
A1  - Mohlke, Karen L.
A1  - Monnereau, Claire
A1  - Morgen, Camilla S.
A1  - Morris, Andrew P.
A1  - Murray, Jeffrey C.
A1  - Myhre, Ronny
A1  - Najman, Jackob M.
A1  - Nivard, Michel G.
A1  - Nohr, Ellen A.
A1  - Nolte, Ilja M.
A1  - Ntalla, Ioanna
A1  - Oberfield, Sharon E.
A1  - Oken, Emily
A1  - Oldehinkel, Albertine J.
A1  - Pahkala, Katja
A1  - Palviainen, Teemu
A1  - Panoutsopoulou, Kalliope
A1  - Pedersen, Oluf
A1  - Pennell, Craig E.
A1  - Pershagen, Goran
A1  - Pitkanen, Niina
A1  - Plomin, Robert
A1  - Power, Christine
A1  - Prasad, Rashmi B.
A1  - Prokopenko, Inga
A1  - Pulkkinen, Lea
A1  - Raikkonen, Katri
A1  - Raitakari, Olli T.
A1  - Reynolds, Rebecca M.
A1  - Richmond, Rebecca C.
A1  - Rivadeneira, Fernando
A1  - Rodriguez, Alina
A1  - Rose, Richard J.
A1  - Salem, Rany
A1  - Santa-Marina, Loreto
A1  - Saw, Seang-Mei
A1  - Schnurr, Theresia M.
A1  - Scott, James G.
A1  - Selzam, Saskia
A1  - Shepherd, John A.
A1  - Simpson, Angela
A1  - Skotte, Line
A1  - Sleiman, Patrick M. A.
A1  - Snieder, Harold
A1  - Sorensen, Thorkild I. A.
A1  - Standl, Marie
A1  - Steegers, Eric A. P.
A1  - Strachan, David P.
A1  - Straker, Leon
A1  - Strandberg, Timo
A1  - Taylor, Michelle
A1  - Teo, Yik-Ying
A1  - Thiering, Elisabeth
A1  - Torrent, Maties
A1  - Tyrrell, Jessica
A1  - Uitterlinden, Andre G.
A1  - van Beijsterveldt, Toos
A1  - van der Most, Peter J.
A1  - van Duijn, Cornelia M.
A1  - Viikari, Jorma
A1  - Vilor-Tejedor, Natalia
A1  - Vogelezang, Suzanne
A1  - Vonk, Judith M.
A1  - Vrijkotte, Tanja G. M.
A1  - Vuoksimaa, Eero
A1  - Wang, Carol A.
A1  - Watkins, William J.
A1  - Wichmann, H-Erich
A1  - Willemsen, Gonneke
A1  - Williams, Gail M.
A1  - Wilson, James F.
A1  - Wray, Naomi R.
A1  - Xu, Shujing
A1  - Xu, Cheng-Jian
A1  - Yaghootkar, Hanieh
A1  - Yi, Lu
A1  - Zafarmand, Mohammad Hadi
A1  - Zeggini, Eleftheria
A1  - Zemel, Babette S.
A1  - Hinney, Anke
A1  - Lakka, Timo A.
A1  - Whitehouse, Andrew J. O.
A1  - Sunyer, Jordi
A1  - Widen, Elisabeth E.
A1  - Feenstra, Bjarke
A1  - Sebert, Sylvain
A1  - Jacobsson, Bo
A1  - Njolstad, Pal R.
A1  - Stoltenberg, Camilla
A1  - Smith, George Davey
A1  - Lawlor, Debbie A.
A1  - Paternoster, Lavinia
A1  - Timpson, Nicholas J.
A1  - Ong, Ken K.
A1  - Bisgaard, Hans
A1  - Bonnelykke, Klaus
A1  - Jaddoe, Vincent W. V.
A1  - Tiemeier, Henning
A1  - Jarvelin, Marjo-Riitta
A1  - Evans, David M.
A1  - Perry, John R. B.
A1  - Grant, Struan F. A.
A1  - Boomsma, Dorret I.
A1  - Freathy, Rachel M.
A1  - McCarthy, Mark I.
A1  - Felix, Janine F.
T1  - The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
BT  - design, results and future prospects
JF  - European journal of epidemiology
N2  - The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
KW  - Genetics
KW  - Consortium
KW  - Childhood traits and disorders
KW  - Longitudinal
Y1  - 2019
U6  - https://doi.org/10.1007/s10654-019-00502-9
SN  - 0393-2990
SN  - 1573-7284
VL  - 34
IS  - 3
SP  - 279
EP  - 300
PB  - Springer
CY  - Dordrecht
ER  - 
TY  - JOUR
A1  - Scherbaum, Frank
A1  - Weber, Michael H.
A1  - Borm, G.
T1  - The deep seismological lab in the KTB borehole: Status 1999
Y1  - 2000
ER  -