TY - JOUR A1 - Förstner, Bernd Rainer A1 - Böttger, Sarah Jane A1 - Moldavski, Alexander A1 - Bajbouj, Malek A1 - Pfennig, Andrea A1 - Manook, Andre A1 - Ising, Marcus A1 - Pittig, Andre A1 - Heinig, Ingmar A1 - Heinz, Andreas A1 - Mathiak, Klaus A1 - Schulze, Thomas G. A1 - Schneider, Frank A1 - Kamp-Becker, Inge A1 - Meyer-Lindenberg, Andreas A1 - Padberg, Frank A1 - Banaschewski, Tobias A1 - Bauer, Michael A1 - Rupprecht, Rainer A1 - Wittchen, Hans-Ulrich A1 - Rapp, Michael A. A1 - Tschorn, Mira T1 - The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders JF - Frontiers in psychiatry N2 - Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: & beta; = -0.35; NVS: & beta; = 0.39; CS: & beta; = -0.12; SP: & beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways. KW - Research Domain Criteria KW - depression KW - anxiety disoders KW - disease severity KW - transdiagnostic KW - RDoC Y1 - 2023 U6 - https://doi.org/10.3389/fpsyt.2023.1161097 SN - 1664-0640 VL - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Schneider, Kathleen A1 - Kutz, Anne A1 - Kaps, Hella A1 - Frank, Ulrike T1 - Dysarthria Impact Profile – D BT - Anwendbarkeit des Fragebogens und Selbsteinschätzung der Dysarthrie von ParkinsonpatientInnen im Bereich der Aktivität und Partizipation JF - Spektrum Patholinguistik Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469645 SN - 978-3-86956-479-1 SN - 1866-9085 SN - 1866-9433 IS - 12 SP - 241 EP - 246 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - BOOK A1 - Schneider, Frank T1 - Wohlfahrtsstaatlichkeit in Lateinamerika N2 - Inhalt 1. Einleitung 2. Die historische Entwicklung der Wohlfahrtsregime in Lateinamerika 3. Strukturen und zentrale Charakteristika lateinamerikanischer Wohlfahrtsproduktion 3.1 Ausgewählte Entwicklungspfade lateinamerikanischer Wohlfahrtsstaaten 3.2. Lateinamerika – ein Wohlfahrtsregime? 4. Exkurs: Wohlfahrtsregime und Geschlechterverhältnisse in Lateinamerika 5. Exkurs: Bildung in Lateinamerika und Wohlfahrtsregime 6. Zusammenfassung Literatur T3 - Potsdamer Beiträge zur Sozialforschung - 30 Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-49148 ER - TY - JOUR A1 - Wippert, Pia-Maria A1 - Arampatzis, Adamantios A1 - Banzer, Winfried A1 - Beck, Heidrun A1 - Hasenbring, Monika Ilona A1 - Schiltenwolf, Marcus A1 - Schneider, Christian A1 - Stengel, Dirk A1 - Platen, Petra A1 - Mayer, Frank T1 - Psychosoziale Risikofaktoren in der Entstehung von chronisch unspezifischen Rückenschmerzen BT - Auszug aus der methodischen Rationale der Multicenterstudien in MiSpEx JF - Zeitschrift für Sportpsychologie N2 - Chronisch unspezifische Rückenschmerzen (CURS) gehören international zu den häufigsten Schmerzphänomenen und können für Athletinnen und Athleten karrierelimitierend sein. Knapp ein Drittel der jährlichen Trainingsausfallzeiten werden auf CURS zurückgeführt. In der Entstehung von chronischen Schmerzen ist ein multifaktorielles Ätiologiemodell mit einem signifikanten Einfluss psychosozialer Risikofaktoren evident. Obwohl dies in der Allgemeinbevölkerung bereits gut erforscht ist, gibt es in der Sportwissenschaft vergleichsweise wenige Arbeiten darüber. Dieses Thema wird daher in drei Multicenterstudien und zahlreichen Teilstudien des MiSpEx-Netzwerks (Medicine in Spine-Exercise-Network, Förderzeitraum 2011 – 2018) aufgegriffen. Entsprechend der Empfehlung einer frühzeitigen Diagnostik von Chronifizierungsfaktoren in der „Nationalen Versorgungsleitlinie Kreuzschmerz“, beschäftigt sich das Netzwerk u. a. mit der Überprüfung, Entwicklung und Evaluation diagnostischer Möglichkeiten. Der vorliegende Beitrag beschreibt die Entwicklung einer Diagnostik von psychosozialen Risikofaktoren, die einerseits eine Einschätzung des Risikos der Entwicklung von CURS und andererseits eine individuelle Zuweisung zu (Trainings)Interventionen erlaubt. Es wird die Entwicklungsrationale beschrieben und dabei verschiedene methodische Herangehensweisen und Entscheidungssequenzen reflektiert. N2 - Chronic nonspecific low back pain (CLBP) is one of the most common pain syndromes globally. Attributing to one third of missed training days, CLBP can seriously affect athletes’ careers. Studies in the general population show a multifactorial etiology with significant influence of psychosocial risk factors in the development of CLBP. As less is known about this phenomenon in athletes, the MiSpEx Network (Medicine in Spine Exercise, funded from 2011 to 2018) has conducted three multicenter studies and numerous substudies investigating this topic. The network has been concerned with the testing, development, and evaluation of diagnostics, in accordance with the recommendation of the German National Treatment Guidelines for CLBP that risk factors be recognized and treated early. Our article describes the development of a diagnostic tool for psychosocial risk factors that allows (medical) practitioners to predict the occurrence of CLBP and to suggest individualized (trainings) interventions. We present the methodological approach and discuss various methodological issues. T2 - Psychosocial Risk Factors in the Development of Chronic Nonspecific Back Pain: On the Methodical Rationale of the Multicenter Studies in MiSpEx KW - CLBP KW - MiSpEx KW - yellow flags KW - diagnostics KW - PROGRESS Y1 - 2019 U6 - https://doi.org/10.1026/1612-5010/a000245 SN - 1612-5010 SN - 2190-6300 VL - 26 IS - 1 SP - 25 EP - 35 PB - Hogrefe CY - Göttingen ER - TY - GEN A1 - Wippert, Pia-Maria A1 - Puschmann, Anne-Katrin A1 - Drießlein, David A1 - Arampatzis, Adamantios A1 - Banzer, Winfried A1 - Beck, Heidrun A1 - Schiltenwolf, Marcus A1 - Schmidt, Hendrik A1 - Schneider, Christian A1 - Mayer, Frank T1 - Development of a risk stratification and prevention index for stratified care in chronic low back pain. Focus: yellow flags (MiSpEx network) N2 - Introduction: Chronic low back pain (LBP) is a major cause of disability; early diagnosis and stratification of care remain challenges. Objectives: This article describes the development of a screening tool for the 1-year prognosis of patients with high chronic LBP risk (risk stratification index) and for treatment allocation according to treatment-modifiable yellow flag indicators (risk prevention indices, RPI-S). Methods: Screening tools were derived from a multicentre longitudinal study (n = 1071, age >18, intermittent LBP). The greatest prognostic predictors of 4 flag domains ("pain," "distress," "social-environment," "medical care-environment") were determined using least absolute shrinkage and selection operator regression analysis. Internal validity and prognosis error were evaluated after 1-year follow-up. Receiver operating characteristic curves for discrimination (area under the curve) and cutoff values were determined. Results: The risk stratification index identified persons with increased risk of chronic LBP and accurately estimated expected pain intensity and disability on the Pain Grade Questionnaire (0-100 points) up to 1 year later with an average prognosis error of 15 points. In addition, 3-risk classes were discerned with an accuracy of area under the curve = 0.74 (95% confidence interval 0.63-0.85). The RPI-S also distinguished persons with potentially modifiable prognostic indicators from 4 flag domains and stratified allocation to biopsychosocial treatments accordingly. Conclusion: The screening tools, developed in compliance with the PROGRESS and TRIPOD statements, revealed good validation and prognostic strength. These tools improve on existing screening tools because of their utility for secondary preventions, incorporation of exercise effect modifiers, exact pain estimations, and personalized allocation to multimodal treatments. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 351 KW - Back pain prognosis KW - Back pain diagnosis KW - Pain screening KW - PROGRESS/TRIPOD KW - Prediction of disability/intensity KW - Yellow flags KW - Exercise Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-403424 ER - TY - JOUR A1 - v. Frankenberg, Jenny A1 - Seidl, Rainer Ottis A1 - Schultheiss, Corinna A1 - Frank, Ulrike A1 - Fuß, Sophia A1 - Stefke, Michaela A1 - Honekamp, Andrea A1 - Winkler, Silke A1 - Jäckel, Annemarie A1 - Schindler, Wencke A1 - Wenglarczyk, Anke A1 - Weise, Stefanie A1 - Heide, Judith A1 - Stadie, Nicole A1 - Schröder, Astrid A1 - Baer-Henney, Dinah A1 - van de Vijver, Ruben A1 - Sauerland, Uli A1 - Yatsushiro, Kazuko A1 - Schöppe, Doreen A1 - Blatter, Kristine A1 - Faust, Verena A1 - Jäger, Dana A1 - Artelt, Cordula A1 - Schneider, Wolfgang A1 - Stanat, Petra A1 - Bruchmüller, Wiebke A1 - Sjöström, Saana A1 - Schütz, Susann A1 - Swietza, Romy A1 - Zielina, Marie A1 - Freymann, Marie A1 - Hausmann, Nadin A1 - Köntopp, Isabelle A1 - Liebig, Johanna A1 - Schnell, Annemarie A1 - Wegener, Viktoria A1 - Heinemann, Steffi A1 - Haensel, Diana A1 - Mürbe, Dirk A1 - Pomnitz, Patricia A1 - Siegmüller, Julia ED - Heide, Judith ED - Fritzsche, Tom ED - Meyer, Corinna B. ED - Ott, Susan T1 - Spektrum Patholinguistik = Schwerpunktthema: Schluck für Schluck: Dysphagietherapie bei Kindern und Erwachsenen T1 - Spektrum Patholinguistik = Key issue: Sip by sip: Dysphagia therapy in children and adults N2 - Das Herbsttreffen Patholinguistik wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Die Jubiläumsveranstaltung am 19.11.2011 in Potsdam war nicht nur die 5. Auflage der Veranstaltung, sondern auch ein Fest zum 10jährigen Bestehen des Verbandes. Das Thema lautete "Schluck für Schluck: Dysphagietherapie bei Kindern und Erwachsenen". Im vorliegenden Tagungsband finden sich die Artikel der Hauptvorträge sowie die Abstracts der Posterpräsentationen. N2 - The 'Herbsttreffen Patholinguistik' is an annual conference organized by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl) since 2007. The anniversary event on November 19th, 2011 in Potsdam marked both the 5th edition of this conference series and the 10th birthday of the vpl. The main topic of the meeting was "Sip by sip: Dysphagia therapy in children and adults". These proceedings contain the papers from the invited talks and the abstracts of the poster presentations. T3 - Spektrum Patholinguistik - 5 KW - Patholinguistik KW - Sprachtherapie KW - Dysphagie KW - Schluckstörung KW - Schlucktherapie KW - patholinguistics KW - speech/language therapy KW - dysphagia KW - swallowing disorders KW - dysphagia therapy Y1 - 2012 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-59877 SN - 978-3-86956-199-8 SN - 1866-9433 SN - 1869-3822 IS - 5 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Zirafi, Onofrio A1 - Kim, Kyeong-Ae A1 - Ständker, Ludger A1 - Mohr, Katharina B. A1 - Sauter, Daniel A1 - Heigele, Anke A1 - Kluge, Silvia F. A1 - Wiercinska, Eliza A1 - Chudziak, Doreen A1 - Richter, Rudolf A1 - Möpps, Barbara A1 - Gierschik, Peter A1 - Vas, Virag A1 - Geiger, Hartmut A1 - Lamla, Markus A1 - Weil, Tanja A1 - Burster, Timo A1 - Zgraja, Andreas A1 - Daubeuf, Francois A1 - Frossard, Nelly A1 - Hachet-Haas, Muriel A1 - Heunisch, Fabian A1 - Reichetzeder, Christoph A1 - Galzi, Jean-Luc A1 - Perez-Castells, Javier A1 - Canales-Mayordomo, Angeles A1 - Jimenez-Barbero, Jesus A1 - Gimenez-Gallego, Guillermo A1 - Schneider, Marion A1 - Shorter, James A1 - Telenti, Amalio A1 - Hocher, Berthold A1 - Forssmann, Wolf-Georg A1 - Bonig, Halvard A1 - Kirchhoff, Frank A1 - Münch, Jan T1 - Discovery and Characterization of an Endogenous CXCR4 Antagonist JF - Cell reports N2 - CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived peptide library for inhibitors of CXCR4-tropic HIV-1 strains. This approach identified a 16 amino acid fragment of serum albumin as an effective and highly specific CXCR4 antagonist. The endogenous peptide, termed EPI-X4, is evolutionarily conserved and generated from the highly abundant albumin precursor by pH-regulated proteases. EPI-X4 forms an unusual lasso-like structure and antagonizes CXCL12-induced tumor cell migration, mobilizes stem cells, and suppresses inflammatory responses in mice. Furthermore, the peptide is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker. Our results identify EPI-X4 as a key regulator of CXCR4 signaling and introduce proteolysis of an abundant precursor protein as an alternative concept for chemokine receptor regulation. Y1 - 2015 U6 - https://doi.org/10.1016/j.celrep.2015.03.061 SN - 2211-1247 VL - 11 IS - 5 SP - 737 EP - 747 PB - Cell Press CY - Cambridge ER - TY - JOUR A1 - Szymanski, Kolja V. A1 - Tönnies, Mario A1 - Becher, Anne A1 - Fatykhova, Diana A1 - N'Guessan, Philippe D. A1 - Gutbier, Birgitt A1 - Klauschen, Frederick A1 - Neuschäfer-Rube, Frank A1 - Schneider, Paul A1 - Rückert, Jens A1 - Neudecker, Jens A1 - Bauer, Torsten T. A1 - Dalhoff, Klaus A1 - Droemann, Daniel A1 - Gruber, Achim D. A1 - Kershaw, Olivia A1 - Temmesfeld-Wollbrueck, Bettina A1 - Suttorp, Norbert A1 - Hippenstiel, Stefan A1 - Hocke, Andreas C. T1 - Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue JF - The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology N2 - The majority of cases of community-acquired pneumonia are caused by Streptococcus pneumoniae and most studies on pneumococcal host interaction are based on cell culture or animal experiments. Thus, little is known about infections in human lung tissue. Cyclooxygenase-2 and its metabolites play an important regulatory role in lung inflammation. Therefore, we established a pneumococcal infection model on human lung tissue demonstrating mitogen-activated protein kinase (MAPK)-dependent induction of cyclooxygenase-2 and its related metabolites. In addition to alveolar macrophages and the vascular endothelium, cyclooxygenase-2 was upregulated in alveolar type II but not type I epithelial cells, which was confirmed in lungs of patients suffering from acute pneumonia. Moreover, we demonstrated the expression profile of all four E prostanoid receptors at the mRNA level and showed functionality of the E prostanoid(4) receptor by cyclic adenosine monophosphate production. Additionally, in comparison to previous studies, cyclooxygenase-2/prostaglandin E-2 related pro- and anti-inflammatory mediator regulation was partly confirmed in human lung tissue after pneumococcal infection. Overall, cell type-specific and MAPK-dependent cyclooxygenase-2 expression and prostaglandin E-2 formation in human lung tissue may play an important role in the early phase of pneumococcal infections. KW - Alveolar epithelial cells KW - cytokines KW - inflammation KW - lung infection KW - pneumonia KW - prostaglandins Y1 - 2012 U6 - https://doi.org/10.1183/09031936.00186911 SN - 0903-1936 VL - 40 IS - 6 SP - 1458 EP - 1467 PB - European Respiratory Society CY - Sheffield ER - TY - JOUR A1 - Moenickes, Sylvia A1 - Schneider, Anne-Kathrin A1 - Muehle, Lesley A1 - Rohe, Lena A1 - Richter, Otto A1 - Suhling, Frank T1 - From population-level effects to individual response: modelling temperature dependence in Gammarus pulex JF - The journal of experimental biology N2 - Population-level effects of global warming result from concurrent direct and indirect processes. They are typically described by physiologically structured population models (PSPMs). Therefore, inverse modelling offers a tool to identify parameters of individual physiological processes through population-level data analysis, e. g. the temperature dependence of growth from size-frequency data of a field population. Here, we make use of experiments under laboratory conditions, in mesocosms and field monitoring to determine the temperature dependence of growth and mortality of Gammarus pulex. We found an optimum temperature for growth of approximately 17 degrees C and a related temperature coefficient, Q(10), of 1.5 degrees C(-1), irrespective of whether we classically fitted individual growth curves or applied inverse modelling based on PSPMs to laboratory data. From a comparison of underlying data sets we conclude that applying inverse modelling techniques to population-level data results in meaningful response parameters for physiological processes if additional temperature-driven effects, including within-population interaction, can be excluded or determined independently. If this is not the case, parameter estimates describe a cumulative response, e. g. comprising temperature-dependent resource dynamics. Finally, fluctuating temperatures in natural habitats increased the uncertainty in parameter values. Here, PSPM should be applied for virtual monitoring in order to determine a sampling scheme that comprises important dates to reduce parameter uncertainty. KW - temperature response KW - temperature coefficient KW - Q(10) KW - optimum temperature KW - parameter estimation KW - inverse modelling Y1 - 2011 U6 - https://doi.org/10.1242/jeb.061945 SN - 0022-0949 VL - 214 IS - 21 SP - 3678 EP - 3687 PB - Company of Biologists Limited CY - Cambridge ER - TY - JOUR A1 - Iven, Claudia A1 - Hansen, Bernd A1 - Anders, Kristina A1 - Starke, Andreas A1 - Richardt, Kirsten A1 - Prüß, Holger A1 - El Meskioui, Martina A1 - Haase, Tobias A1 - Mahlberg, Lea A1 - Wiehe, Lea A1 - de Beer, Carola A1 - Niepelt Karampamapa, Rebekka A1 - Hofmann, Andrea A1 - Stadie, Nicole A1 - Hanne, Sandra A1 - Thomson, Jenny A1 - Schäfer, Blanca A1 - Huttenlauch, Clara A1 - Wartenburger, Isabell A1 - Weiland, Katharina A1 - Wirsam, Anke A1 - Hartung, Julia A1 - Wahl, Michael A1 - Unger, Julia A1 - Buschmann, Anke A1 - Seefeld, Martin A1 - Bethge, Anita A1 - Fieder, Nora A1 - Rahman, Rasha Abdel A1 - Nousair, Iman A1 - Klassert, Annegret A1 - Wellmann, Caroline A1 - Verbree, Rahel A1 - van Rij, Jacolien A1 - Sprenger, Simone A1 - Mähl, Anna Luisa A1 - Schneider, Kathleen A1 - Kutz, Anne A1 - Kaps, Hella A1 - Frank, Ulrike A1 - Brekeller, Sophie A1 - Ryll, Katja ED - Breitenstein, Sarah ED - Burmester, Juliane ED - Yetim, Özlem ED - Fritzsche, Tom T1 - Spektrum Patholinguistik Band 12. Schwerpunktthema: Weg(e) mit dem Stottern: Therapie und Selbsthilfe für Kinder und Erwachsene T2 - Spektrum Patholinguistik N2 - Das 12. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Weg(e) mit dem Stottern: Therapie und Selbsthilfe für Kinder und Erwachsene« fand am 24.11.2018 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Vorträge zum Schwerpunktthema sowie Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Twelfth Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Away/A way with stuttering: Therapy and self-help for children and adults« took place in Potsdam on November 24 2018. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain all talks on the main topic as well as contributions from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 12 KW - Patholinguistik KW - Sprachtherapie KW - Stottern KW - Redeflussstörungen KW - Selbsthilfe KW - patholinguistics KW - speech/language therapy KW - stuttering KW - fluency disorder KW - self-help Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437002 SN - 978-3-86956-479-1 SN - 1866-9085 SN - 1866-9433 IS - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER -