TY - JOUR A1 - König, Carolin A1 - Freudenreich, Johannes A1 - Ranft, Florian A1 - Gréciano, Philippe A1 - Weiß, Norman A1 - Bruchmüller, Silke A1 - Pickny, Linda A1 - Dieter, Anne A1 - Foith, Anne A1 - Dau, Corinna A1 - Meyer, Gunda A1 - Dietz, Alexander A1 - Brunn, Frank Martin A1 - Vespermann, Julia A1 - Giesen, Stefan A1 - Peek, Markus A1 - Schmahl, Stefanie T1 - MenschenRechtsMagazin : Informationen | Meinungen | Analysen N2 - Editorial: Wir greifen im vorliegenden Heft eine Reihe von eher praxisorientierten Fragestellungen auf, behandeln aber auch grundlegende Themen. Carolin König widmet sich in ihrem Beitrag über das TRIPS-Übereinkommen menschenrechtlichen Implikationen des geistigen Eigentums, wie sie vor allem für den Handel mit und die Entwicklung von Medikamenten von Bedeutung sind. Johannes Freudenreich und Florian Ranft liefern eine statistische Analyse der 29 Wahrheitskommissionen, die ihre Arbeit beendet haben. Dabei werden Variablen zu Ressourcen, Mandat, Inhalt und Ergebnis von Wahrheitskommissionen untersucht. Die Autoren wollten herausfinden, ob es ein Standardmodell für Wahrheitskommissionen gibt, kommen aber zu dem Ergebnis, dass sich ein solches noch nicht erkennbar herausgebildet hat. Unter dem Titel „Rechtsstaatlichkeit in Europa: Dogmatik im (Kon)text“ beschäftigen sich Philippe Gréciano und Norman Weiß mit dem diesbezüglichen Entwicklungsstand der Europäischen Union und versuchen, aus rechtsvergleichender Perspektive Anregungen für die weitere Entwicklung zu gewinnen. Silke Bruchmüller untersucht in ihrem Beitrag die Aktivitäten des Deutschen Bundestages im Zusammenhang mit der „Terrorismusbekämpfung in der 14. und 15. Legislaturperiode“. Der Beitrag „Menschsein als Teilhabe an innerer und äußerer Würde“ von Linda Pickny behandelt das Thema Menschenwürde aus rechtsphilosophischer Sicht. Anne Dieter ruft dazu auf, die „Menschenrechte leben [zu] lernen“, und erinnert so daran, den wohlweislich bereits in der Präambel der Allgemeinen Erklärung der Menschenrechte geforderten fortschreitenden Prozess der Anerkennung und Verwirklichung von Menschenrechten voranzutreiben. Der Dokumentationsteil enthält den traditionellen Bericht über die Arbeit des Menschenrechtsausschusses der Vereinten Nationen im Jahre 2008. Der erste Teil, verfasst von Anne Foith, behandelt vorrangig das Staatenberichtsverfahren. Corinna Dau und Gunda Meyer führen die Reihe „Mitgliedstaaten des Europarates“ mit einem Artikel über Lettland fort. Alexander Dietz und Frank Martin Brunn beschreiben Inhalte und Strukturen der „Interdisziplinäre[n] Forschung zum Thema Menschenwürde an der Universität Heidelberg“. Dem Problem der „Zirkulären Migration“ ist schließlich der Bericht von Julia Vespermann gewidmet. Buchbesprechungen runden das Heft ab, bei dessen Herstellung uns Jutta Wickenhäuser und Tim Reiß redaktionell unterstützt haben. Gunda Meyer scheidet mit diesem Heft aus der Redaktion aus, um sich ganz auf das Referendariat zu konzentrieren. Ihre Nachfolgerin, Anne Foith, gehört bereits zum Kreis unserer Autorinnen und Autoren. Wir wünschen unseren Lesern eine anregende Lektüre. T3 - MenschenRechtsMagazin : MRM ; Informationen, Meinungen, Analysen - 14.2009/1 Y1 - 2009 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-30747 SN - 1434-2820 VL - 14 IS - 1 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Schutkowski, Alexandra A1 - König, Bettina A1 - Kluge, Holger A1 - Hirche, Frank A1 - Henze, Andrea A1 - Schwerdtle, Tanja A1 - Lorkowski, Stefan A1 - Dawczynski, Christine A1 - Gabel, Alexander A1 - Grosse, Ivo A1 - Stangl, Gabriele I. T1 - Metabolic footprint and intestinal microbial changes in response to dietary proteins in a pig model JF - The journal of nutritional biochemistry N2 - Epidemiological studies revealed that dietary proteins can contribute to the modulation of the cardiovascular disease risk. Still, direct effects of dietary proteins on serum metabolites and other health-modulating factors have not been fully explored. Here, we compared the effects of dietary lupin protein with the effects of beef protein and casein on the serum metabolite profile, cardiovascular risk markers and the fecal microbiome. Pigs were fed diets containing 15% of the respective proteins for 4 weeks. A classification analysis of the serum metabolites revealed six biomarker sets of two metabolites each that discriminated between the intake of lupin protein, lean beef or casein. These biomarker sets included 1- and 3-methylhistidine, betaine, carnitine, homoarginine and methionine. The study revealed differences in the serum levels of the metabolites 1- and 3- methylhistidine, homoarginine, methionine and homocysteine, which are involved in the one-carbon cycle. However, these changes were not associated with differences in the methylation capacity or the histone methylation pattern. With the exception of serum homocysteine and homoarginine levels, other cardiovascular risk markers, such as the homeostatic model assessment index, trimethylamine-N-oxide and lipids, were not influenced by the dietary protein source. However, the composition of the fecal microorganisms was markedly changed by the dietary protein source. Lupin-protein-fed pigs exhibited more species from the phyla Bacteroidetes and Firmicutes than the other two groups. In conclusion, different dietary protein sources induce distinct serum metabolic fingerprints, have an impact on the cardiovascular risk and modulate the composition of the fecal microbiome. (C) 2019 Elsevier Inc. All rights reserved. KW - Lupin KW - Beef KW - Casein KW - Pig KW - Biomarker KW - Microbiome Y1 - 2019 U6 - https://doi.org/10.1016/j.jnutbio.2019.02.004 SN - 0955-2863 SN - 1873-4847 VL - 67 SP - 149 EP - 160 PB - Elsevier CY - New York ER - TY - JOUR A1 - Eckel, Nathalie A1 - Li, Yanping A1 - Kuxhaus, Olga A1 - Stefan, Norbert A1 - Hu, Frank B. A1 - Schulze, Matthias Bernd T1 - Transition from metabolic healthy to unhealthy phenotypes and association with cardiovascular disease risk across BMI categories in 90 257 women (the Nurses' Health Study) BT - 30 year follow-up from a prospective cohort study JF - The lancet diabetes & endocrinology N2 - Background Cardiovascular disease risk among individuals across different categories of BMI might depend on their metabolic health. It remains unclear to what extent metabolic health status changes over time and whether this affects cardiovascular disease risk. In this study, we aimed to examine the association between metabolic health and its change over time and cardiovascular disease risk across BMI categories. Findings During 2 127 391 person-years of follow-up with a median follow-up of 24 years, we documented 6306 cases of cardiovascular disease including 3304 myocardial infarction cases and 3080 strokes. Cardiovascular disease risk of women with metabolically healthy obesity was increased compared with women with metabolically healthy normal weight (HR 1.39, 95% CI 1.15-1.68), but risk was considerably higher in women with metabolically unhealthy normal weight (2.43, 2.19-2.68), overweight (2.61, 2.36-2.89) and obesity (3.15, 2.83-3.50). The majority of metabolically healthy women converted to unhealthy phenotypes (2555 [84%] of 3027 women with obesity, 22 215 [68%] of 32 882 women with normal-weight after 20 years). Women who maintained metabolically healthy obesity during follow-up were still at a higher cardiovascular disease risk compared with women with stable healthy normal weight (HR 1.57, 1.03-2.38), yet this risk was lower than for initially metabolically healthy women who converted to an unhealthy phenotype (normal-weight 1.90, 1.66-2.17 vs obesity 2.74, 2.30-3.27). Particularly incident diabetes and hypertension increased the risk among women with initial metabolic health. Interpretation Even when metabolic health is maintained during long periods of time, obesity remains a risk factor for cardiovascular disease. However, risks are highest for metabolically unhealthy women across all BMI categories. A large proportion of metabolically healthy women converted to an unhealthy phenotype over time across all BMI categories, which is associated with an increased cardiovascular disease risk. Copyright (C) 2018 Elsevier Ltd. All rights reserved. Y1 - 2018 U6 - https://doi.org/10.1016/S2213-8587(18)30137-2 SN - 2213-8587 VL - 6 IS - 9 SP - 714 EP - 724 PB - Elsevier CY - New York ER - TY - JOUR A1 - Stech, Marlitt A1 - Merk, Helmut A1 - Schenk, Jörg A. A1 - Stöcklein, Walter F. M. A1 - Wüstenhagen, Doreen Anja A1 - Micheel, Burkhard A1 - Duschl, Claus A1 - Bier, Frank Fabian A1 - Kubick, Stefan T1 - Production of functional antibody fragments in a vesicle-based eukaryotic cell-free translation system JF - Journal of biotechnology N2 - Cell-free protein synthesis is of increasing interest for the rapid and high-throughput synthesis of many proteins, in particular also antibody fragments. In this study, we present a novel strategy for the production of single chain antibody fragments (scFv) in a eukaryotic in vitro translation system. This strategy comprises the cell-free expression, isolation and label-free interaction analysis of a model antibody fragment synthesized in two differently prepared insect cell lysates. These lysates contain translocationally active microsomal structures derived from the endoplasmic reticulum (ER), allowing for posttranslational modifications of cell-free synthesized proteins. Both types of these insect cell lysates enable the synthesis and translocation of scFv into ER-derived vesicles. However, only the one that has a specifically adapted redox potential yields functional active antibody fragments. We have developed a new methodology for the isolation of functional target proteins based on the translocation of cell-free produced scFv into microsomal structures and subsequent collection of protein-enriched vesicles. Antibody fragments that have been released from these vesicles are shown to be well suited for label-free binding studies. Altogether, these results show the potential of insect cell lysates for the production, purification and selection of antibody fragments in an easy-to-handle and time-saving manner. KW - Cell-free KW - In vitro translation KW - Single chain antibody (scFv) KW - Insect lysate KW - Surface plasmon resonance Y1 - 2012 U6 - https://doi.org/10.1016/j.jbiotec.2012.08.020 SN - 0168-1656 VL - 164 IS - 2 SP - 220 EP - 231 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Broedel, A. K. A1 - Raymond, J. A. A1 - Duman, J. G. A1 - Bier, Frank Fabian A1 - Kubick, Stefan T1 - Functional evaluation of candidate ice structuring proteins using cell-free expression systems JF - JOURNAL OF BIOTECHNOLOGY N2 - Ice structuring proteins (ISPs) protect organisms from damage or death by freezing. They depress the non-equilibrium freezing point of water and prevent recrystallization, probably by binding to the surface of ice crystals. Many ISPs have been described and it is likely that many more exist in nature that have not yet been identified. ISPs come in many forms and thus cannot be reliably identified by their structure or consensus ice-binding motifs. Recombinant protein expression is the gold standard for proving the activity of a candidate ISP. Among existing expression systems, cell-free protein expression is the simplest and gives the fastest access to the protein of interest, but selection of the appropriate cell-free expression system is crucial for functionality. Here we describe cell-free expression methods for three ISPs that differ widely in structure and glycosylation status from three organisms: a fish (Macrozoarces americanus), an insect (Dendroides canadensis) and an alga (Chlamydomonas sp. CCMP681). We use both prokaryotic and eukaryotic expression systems for the production of ISPs. An ice recrystallization inhibition assay is used to test functionality. The techniques described here should improve the success of cell-free expression of ISPs in future applications. (C) 2012 Elsevier B.V. All rights reserved. KW - Ice structuring protein KW - Antifreeze protein KW - Ice binding protein KW - Cell-free protein synthesis KW - In vitro translation Y1 - 2013 U6 - https://doi.org/10.1016/j.jbiotec.2012.11.001 SN - 0168-1656 VL - 163 IS - 3 SP - 301 EP - 310 PB - ELSEVIER SCIENCE BV CY - AMSTERDAM ER - TY - JOUR A1 - Tiegs, Scott D. A1 - Costello, David M. A1 - Isken, Mark W. A1 - Woodward, Guy A1 - McIntyre, Peter B. A1 - Gessner, Mark O. A1 - Chauvet, Eric A1 - Griffiths, Natalie A. A1 - Flecker, Alex S. A1 - Acuna, Vicenc A1 - Albarino, Ricardo A1 - Allen, Daniel C. A1 - Alonso, Cecilia A1 - Andino, Patricio A1 - Arango, Clay A1 - Aroviita, Jukka A1 - Barbosa, Marcus V. M. A1 - Barmuta, Leon A. A1 - Baxter, Colden V. A1 - Bell, Thomas D. C. A1 - Bellinger, Brent A1 - Boyero, Luz A1 - Brown, Lee E. A1 - Bruder, Andreas A1 - Bruesewitz, Denise A. A1 - Burdon, Francis J. A1 - Callisto, Marcos A1 - Canhoto, Cristina A1 - Capps, Krista A. A1 - Castillo, Maria M. A1 - Clapcott, Joanne A1 - Colas, Fanny A1 - Colon-Gaud, Checo A1 - Cornut, Julien A1 - Crespo-Perez, Veronica A1 - Cross, Wyatt F. A1 - Culp, Joseph M. A1 - Danger, Michael A1 - Dangles, Olivier A1 - de Eyto, Elvira A1 - Derry, Alison M. A1 - Diaz Villanueva, Veronica A1 - Douglas, Michael M. A1 - Elosegi, Arturo A1 - Encalada, Andrea C. A1 - Entrekin, Sally A1 - Espinosa, Rodrigo A1 - Ethaiya, Diana A1 - Ferreira, Veronica A1 - Ferriol, Carmen A1 - Flanagan, Kyla M. A1 - Fleituch, Tadeusz A1 - Shah, Jennifer J. Follstad A1 - Frainer, Andre A1 - Friberg, Nikolai A1 - Frost, Paul C. A1 - Garcia, Erica A. A1 - Lago, Liliana Garcia A1 - Garcia Soto, Pavel Ernesto A1 - Ghate, Sudeep A1 - Giling, Darren P. A1 - Gilmer, Alan A1 - Goncalves, Jose Francisco A1 - Gonzales, Rosario Karina A1 - Graca, Manuel A. S. A1 - Grace, Mike A1 - Grossart, Hans-Peter A1 - Guerold, Francois A1 - Gulis, Vlad A1 - Hepp, Luiz U. A1 - Higgins, Scott A1 - Hishi, Takuo A1 - Huddart, Joseph A1 - Hudson, John A1 - Imberger, Samantha A1 - Iniguez-Armijos, Carlos A1 - Iwata, Tomoya A1 - Janetski, David J. A1 - Jennings, Eleanor A1 - Kirkwood, Andrea E. A1 - Koning, Aaron A. A1 - Kosten, Sarian A1 - Kuehn, Kevin A. A1 - Laudon, Hjalmar A1 - Leavitt, Peter R. A1 - Lemes da Silva, Aurea L. A1 - Leroux, Shawn J. A1 - Leroy, Carri J. A1 - Lisi, Peter J. A1 - MacKenzie, Richard A1 - Marcarelli, Amy M. A1 - Masese, Frank O. A1 - Mckie, Brendan G. A1 - Oliveira Medeiros, Adriana A1 - Meissner, Kristian A1 - Milisa, Marko A1 - Mishra, Shailendra A1 - Miyake, Yo A1 - Moerke, Ashley A1 - Mombrikotb, Shorok A1 - Mooney, Rob A1 - Moulton, Tim A1 - Muotka, Timo A1 - Negishi, Junjiro N. A1 - Neres-Lima, Vinicius A1 - Nieminen, Mika L. A1 - Nimptsch, Jorge A1 - Ondruch, Jakub A1 - Paavola, Riku A1 - Pardo, Isabel A1 - Patrick, Christopher J. A1 - Peeters, Edwin T. H. M. A1 - Pozo, Jesus A1 - Pringle, Catherine A1 - Prussian, Aaron A1 - Quenta, Estefania A1 - Quesada, Antonio A1 - Reid, Brian A1 - Richardson, John S. A1 - Rigosi, Anna A1 - Rincon, Jose A1 - Risnoveanu, Geta A1 - Robinson, Christopher T. A1 - Rodriguez-Gallego, Lorena A1 - Royer, Todd V. A1 - Rusak, James A. A1 - Santamans, Anna C. A1 - Selmeczy, Geza B. A1 - Simiyu, Gelas A1 - Skuja, Agnija A1 - Smykla, Jerzy A1 - Sridhar, Kandikere R. A1 - Sponseller, Ryan A1 - Stoler, Aaron A1 - Swan, Christopher M. A1 - Szlag, David A1 - Teixeira-de Mello, Franco A1 - Tonkin, Jonathan D. A1 - Uusheimo, Sari A1 - Veach, Allison M. A1 - Vilbaste, Sirje A1 - Vought, Lena B. M. A1 - Wang, Chiao-Ping A1 - Webster, Jackson R. A1 - Wilson, Paul B. A1 - Woelfl, Stefan A1 - Xenopoulos, Marguerite A. A1 - Yates, Adam G. A1 - Yoshimura, Chihiro A1 - Yule, Catherine M. A1 - Zhang, Yixin X. A1 - Zwart, Jacob A. T1 - Global patterns and drivers of ecosystem functioning in rivers and riparian zones JF - Science Advances N2 - River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale. Y1 - 2019 U6 - https://doi.org/10.1126/sciadv.aav0486 SN - 2375-2548 VL - 5 IS - 1 PB - American Assoc. for the Advancement of Science CY - Washington ER - TY - BOOK A1 - Rana, Kaushik A1 - Mohapatra, Durga Prasad A1 - Sidorova, Julia A1 - Lundberg, Lars A1 - Sköld, Lars A1 - Lopes Grim, Luís Fernando A1 - Sampaio Gradvohl, André Leon A1 - Cremerius, Jonas A1 - Siegert, Simon A1 - Weltzien, Anton von A1 - Baldi, Annika A1 - Klessascheck, Finn A1 - Kalancha, Svitlana A1 - Lichtenstein, Tom A1 - Shaabani, Nuhad A1 - Meinel, Christoph A1 - Friedrich, Tobias A1 - Lenzner, Pascal A1 - Schumann, David A1 - Wiese, Ingmar A1 - Sarna, Nicole A1 - Wiese, Lena A1 - Tashkandi, Araek Sami A1 - van der Walt, Estée A1 - Eloff, Jan H. P. A1 - Schmidt, Christopher A1 - Hügle, Johannes A1 - Horschig, Siegfried A1 - Uflacker, Matthias A1 - Najafi, Pejman A1 - Sapegin, Andrey A1 - Cheng, Feng A1 - Stojanovic, Dragan A1 - Stojnev Ilić, Aleksandra A1 - Djordjevic, Igor A1 - Stojanovic, Natalija A1 - Predic, Bratislav A1 - González-Jiménez, Mario A1 - de Lara, Juan A1 - Mischkewitz, Sven A1 - Kainz, Bernhard A1 - van Hoorn, André A1 - Ferme, Vincenzo A1 - Schulz, Henning A1 - Knigge, Marlene A1 - Hecht, Sonja A1 - Prifti, Loina A1 - Krcmar, Helmut A1 - Fabian, Benjamin A1 - Ermakova, Tatiana A1 - Kelkel, Stefan A1 - Baumann, Annika A1 - Morgenstern, Laura A1 - Plauth, Max A1 - Eberhard, Felix A1 - Wolff, Felix A1 - Polze, Andreas A1 - Cech, Tim A1 - Danz, Noel A1 - Noack, Nele Sina A1 - Pirl, Lukas A1 - Beilharz, Jossekin Jakob A1 - De Oliveira, Roberto C. L. A1 - Soares, Fábio Mendes A1 - Juiz, Carlos A1 - Bermejo, Belen A1 - Mühle, Alexander A1 - Grüner, Andreas A1 - Saxena, Vageesh A1 - Gayvoronskaya, Tatiana A1 - Weyand, Christopher A1 - Krause, Mirko A1 - Frank, Markus A1 - Bischoff, Sebastian A1 - Behrens, Freya A1 - Rückin, Julius A1 - Ziegler, Adrian A1 - Vogel, Thomas A1 - Tran, Chinh A1 - Moser, Irene A1 - Grunske, Lars A1 - Szárnyas, Gábor A1 - Marton, József A1 - Maginecz, János A1 - Varró, Dániel A1 - Antal, János Benjamin ED - Meinel, Christoph ED - Polze, Andreas ED - Beins, Karsten ED - Strotmann, Rolf ED - Seibold, Ulrich ED - Rödszus, Kurt ED - Müller, Jürgen T1 - HPI Future SOC Lab – Proceedings 2018 N2 - The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners. The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies. This technical report presents results of research projects executed in 2018. Selected projects have presented their results on April 17th and November 14th 2017 at the Future SOC Lab Day events. N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie. Am Lab wird interessierten Wissenschaftler:innen eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen Systeme, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler:innen in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2018 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 17. April und 14. November 2018 im Rahmen des Future SOC Lab Tags vor. T3 - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 151 KW - Future SOC Lab KW - research projects KW - multicore architectures KW - in-memory technology KW - cloud computing KW - machine learning KW - artifical intelligence KW - Future SOC Lab KW - Forschungsprojekte KW - Multicore Architekturen KW - In-Memory Technologie KW - Cloud Computing KW - maschinelles Lernen KW - künstliche Intelligenz Y1 - 2022 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-563712 SN - 978-3-86956-547-7 SN - 1613-5652 SN - 2191-1665 IS - 151 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Kamali, Bahareh A1 - Lorite, Ignacio J. A1 - Webber, Heidi A. A1 - Rezaei, Ehsan Eyshi A1 - Gabaldon-Leal, Clara A1 - Nendel, Claas A1 - Siebert, Stefan A1 - Ramirez-Cuesta, Juan Miguel A1 - Ewert, Frank A1 - Ojeda, Jonathan J. T1 - Uncertainty in climate change impact studies for irrigated maize cropping systems in southern Spain JF - Scientific reports N2 - This study investigates the main drivers of uncertainties in simulated irrigated maize yield under historical conditions as well as scenarios of increased temperatures and altered irrigation water availability. Using APSIM, MONICA, and SIMPLACE crop models, we quantified the relative contributions of three irrigation water allocation strategies, three sowing dates, and three maize cultivars to the uncertainty in simulated yields. The water allocation strategies were derived from historical records of farmer's allocation patterns in drip-irrigation scheme of the Genil-Cabra region, Spain (2014-2017). By considering combinations of allocation strategies, the adjusted R-2 values (showing the degree of agreement between simulated and observed yields) increased by 29% compared to unrealistic assumptions of considering only near optimal or deficit irrigation scheduling. The factor decomposition analysis based on historic climate showed that irrigation strategies was the main driver of uncertainty in simulated yields (66%). However, under temperature increase scenarios, the contribution of crop model and cultivar choice to uncertainty in simulated yields were as important as irrigation strategy. This was partially due to different model structure in processes related to the temperature responses. Our study calls for including information on irrigation strategies conducted by farmers to reduce the uncertainty in simulated yields at field scale. Y1 - 2022 U6 - https://doi.org/10.1038/s41598-022-08056-9 SN - 2045-2322 VL - 12 IS - 1 PB - Macmillan Publishers Limited, CY - London ER - TY - JOUR A1 - Li, Tian-yi A1 - Benduhn, Johannes A1 - Qiao, Zhi A1 - Liu, Yuan A1 - Li, Yue A1 - Shivhare, Rishi A1 - Jaiser, Frank A1 - Wang, Pei A1 - Ma, Jie A1 - Zeika, Olaf A1 - Neher, Dieter A1 - Mannsfeld, Stefan C. B. A1 - Ma, Zaifei A1 - Vandewal, Koen A1 - Leo, Karl T1 - Effect of H- and J-Aggregation on the Photophysical and Voltage Loss of Boron Dipyrromethene Small Molecules in Vacuum-Deposited Organic Solar Cells JF - The journal of physical chemistry letters N2 - An understanding of the factors limiting the open-circuit voltage (V-oc) and related photon energy loss mechanisms is critical to increase the power conversion efficiency (PCE) of small-molecule organic solar cells (OSCs), especially those with near-infrared (NIR) absorbers. In this work, two NIR boron dipyrromethene (BODIPY) molecules are characterized for application in planar (PHJ) and bulk (BHJ) heterojunction OSCs. When two H atoms are substituted by F atoms on the peripheral phenyl rings of the molecules, the molecular aggregation type in the thin film changes from the H-type to J-type. For PHJ devices, the nonradiative voltage loss of 0.35 V in the J-aggregated BODIPY is lower than that of 0.49 V in the H-aggregated device. In BHJ devices with a nonradiative voltage loss of 0.35 V, a PCE of 5.5% is achieved with an external quantum efficiency (EQE) maximum of 68% at 700 nm. Y1 - 2019 U6 - https://doi.org/10.1021/acs.jpclett.9b01222 SN - 1948-7185 VL - 10 IS - 11 SP - 2684 EP - 2691 PB - American Chemical Society CY - Washington ER - TY - CHAP A1 - Scharhag-Rosenberger, Friederike A1 - Carlsohn, Anja A1 - Schüler, Stefan A1 - Lundby, Carsten A1 - Mayer, Frank A1 - Scharhag, Jürgen T1 - Physiological changes over four maximal incremental cycling tests within one day T2 - Medicine and science in sports and exercise : official journal of the American College of Sports Medicine Y1 - 2012 SN - 0195-9131 VL - 44 SP - 933 EP - 934 PB - Lippincott Williams & Wilkins CY - Philadelphia ER - TY - JOUR A1 - Scharhag-Rosenberger, Friederike A1 - Carlsohn, Anja A1 - Lundby, Carsten A1 - Schueler, Stefan A1 - Mayer, Frank A1 - Scharhag, Jürgen T1 - Can more than one incremental cycling test be performed within one day? JF - European journal of sport science : official journal of the European College of Sport Science N2 - Changes in performance parameters over four consecutive maximal incremental cycling tests were investigated to determine how many tests can be performed within one single day without negatively affecting performance. Sixteen male and female subjects (eight trained (T): 25 +/- 3 yr, BMI 22.6 +/- 2.5 kg center dot m(-2), maximal power output (P-max) 4.6 +/- 0.5 W center dot kg(-1); eight untrained (UT): 27 +/- 3 yr, BMI 22.3 +/- 1.2 kg center dot m(-2), P-max 2.9 +/- 0.3 W center dot kg(-1)) performed four successive maximal incremental cycling tests separated by 1.5 h of passive rest. Individual energy requirements were covered by standardised meals between trials. Maximal oxygen uptake (VO2max) remained unchanged over the four tests in both groups (P = 0.20 and P = 0.33, respectively). P-max did not change in the T group (P = 0.32), but decreased from the third test in the UT group (P < 0.01). Heart rate responses to submaximal exercise were elevated from the third test in the T group and from the second test in the UT group (P < 0.05). The increase in blood lactate shifted rightward over the four tests in both groups (P < 0.001 and P < 0.01, respectively). Exercise-induced net increases in epinephrine and norepinephrine were not different between the tests in either group (P 0.15). If VO2max is the main parameter of interest, trained and untrained individuals can perform at least four maximal incremental cycling tests per day. However, because other parameters changed after the first and second test, respectively, no more than one test per day should be performed if parameters other than VO2max are the prime focus. KW - Maximal oxygen uptake KW - cardiopulmonary exercise testing KW - consecutive tests KW - study design KW - exhaustion KW - fatigue Y1 - 2014 U6 - https://doi.org/10.1080/17461391.2013.853208 SN - 1746-1391 SN - 1536-7290 VL - 14 IS - 5 SP - 459 EP - 467 PB - Routledge, Taylor & Francis Group CY - Abingdon ER - TY - JOUR A1 - Dunker, Susanne A1 - Boyd, Matthew A1 - Durka, Walter A1 - Erler, Silvio A1 - Harpole, W. Stanley A1 - Henning, Silvia A1 - Herzschuh, Ulrike A1 - Hornick, Thomas A1 - Knight, Tiffany A1 - Lips, Stefan A1 - Mäder, Patrick A1 - Švara, Elena Motivans A1 - Mozarowski, Steven A1 - Rakosy, Demetra A1 - Römermann, Christine A1 - Schmitt-Jansen, Mechthild A1 - Stoof-Leichsenring, Kathleen A1 - Stratmann, Frank A1 - Treudler, Regina A1 - Virtanen, Risto A1 - Wendt-Potthoff, Katrin A1 - Wilhelm, Christian T1 - The potential of multispectral imaging flow cytometry for environmental monitoring JF - Cytometry part A N2 - Environmental monitoring involves the quantification of microscopic cells and particles such as algae, plant cells, pollen, or fungal spores. Traditional methods using conventional microscopy require expert knowledge, are time-intensive and not well-suited for automated high throughput. Multispectral imaging flow cytometry (MIFC) allows measurement of up to 5000 particles per second from a fluid suspension and can simultaneously capture up to 12 images of every single particle for brightfield and different spectral ranges, with up to 60x magnification. The high throughput of MIFC has high potential for increasing the amount and accuracy of environmental monitoring, such as for plant-pollinator interactions, fossil samples, air, water or food quality that currently rely on manual microscopic methods. Automated recognition of particles and cells is also possible, when MIFC is combined with deep-learning computational techniques. Furthermore, various fluorescence dyes can be used to stain specific parts of the cell to highlight physiological and chemical features including: vitality of pollen or algae, allergen content of individual pollen, surface chemical composition (carbohydrate coating) of cells, DNA- or enzyme-activity staining. Here, we outline the great potential for MIFC in environmental research for a variety of research fields and focal organisms. In addition, we provide best practice recommendations. KW - environmental monitoring KW - imaging flow cytometry KW - plant traits Y1 - 2022 U6 - https://doi.org/10.1002/cyto.a.24658 SN - 1552-4922 SN - 1552-4930 VL - 101 IS - 9 SP - 782 EP - 799 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Svenning, Jens-Christian A1 - Gravel, Dominique A1 - Holt, Robert D. A1 - Schurr, Frank Martin A1 - Thuiller, Wilfried A1 - Muenkemueller, Tamara A1 - Schiffers, Katja H. A1 - Dullinger, Stefan A1 - Edwards, Thomas C. A1 - Hickler, Thomas A1 - Higgins, Steven I. A1 - Nabel, Julia E. M. S. A1 - Pagel, Jörn A1 - Normand, Signe T1 - The influence of interspecific interactions on species range expansion rates JF - Ecography : pattern and diversity in ecology ; research papers forum Y1 - 2014 U6 - https://doi.org/10.1111/j.1600-0587.2013.00574.x SN - 0906-7590 SN - 1600-0587 VL - 37 IS - 12 SP - 1198 EP - 1209 PB - Wiley-Blackwell CY - Hoboken ER -