TY  - JOUR
A1  - Knebel, Constanze
A1  - Neeb, Jannika
A1  - Zahn, Elisabeth
A1  - Schmidt, Flavia
A1  - Carazo, Alejandro
A1  - Holas, Ondej
A1  - Pavek, Petr
A1  - Püschel, Gerhard Paul
A1  - Zanger, Ulrich M.
A1  - Süssmuth, Roderich
A1  - Lampen, Alfonso
A1  - Marx-Stoelting, Philip
A1  - Braeuning, Albert
T1  - Unexpected Effects of Propiconazole, Tebuconazole, and Their Mixture on the Receptors CAR and PXR in Human Liver Cells
JF  - Toxicological sciences
N2  - Analyzing mixture toxicity requires an in-depth understanding of the mechanisms of action of its individual components. Substances with the same target organ, same toxic effect and same mode of action (MoA) are believed to cause additive effects, whereas substances with different MoAs are assumed to act independently. Here, we tested 2 triazole fungicides, propiconazole, and tebuconazole (Te), for individual and combined effects on liver toxicity-related endpoints. Both triazoles are proposed to belong to the same cumulative assessment group and are therefore thought to display similar and additive behavior. Our data show that Te is an antagonist of the constitutive androstane receptor (CAR) in rats and humans, while propiconazole is an agonist of this receptor. Both substances activate the pregnane X-receptor (PXR) and further induce mRNA expression of CYP3A4. CYP3A4 enzyme activity, however, is inhibited by propiconazole. For common targets of PXR and CAR, the activation of PXR by Te overrides CAR inhibition. In summary, propiconazole and Te affect different hepatotoxicity-relevant cellular targets and, depending on the individual endpoint analyzed, act via similar or dissimilar mechanisms. The use of molecular data based on research in human cell systems extends the picture to refine cumulative assessment group grouping and substantially contributes to the understanding of mixture effects of chemicals in biological systems.
KW  - triazole fungicides
KW  - constitutive androstane receptor
KW  - pregnane X-receptor
KW  - enzyme induction
KW  - liver toxicity
KW  - mixtures
Y1  - 2018
U6  - https://doi.org/10.1093/toxsci/kfy026
SN  - 1096-6080
SN  - 1096-0929
VL  - 163
IS  - 1
SP  - 170
EP  - 181
PB  - Oxford Univ. Press
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Schröder, Astrid
A1  - Grimm, Angela
A1  - Schulz, Petra
A1  - Heide, Judith
A1  - Frank, Ulrike
A1  - Wahl, Michael
A1  - Lampe, Leonie
A1  - Fieder, Nora
A1  - Krajenbrink, Trudy
A1  - Nickels, Lyndsey
A1  - Bykova, Ksenia
A1  - Wilzek, Alexa
A1  - van den Engl-Hoek, Lenie
A1  - Huckabee, Maggie-Lee
A1  - Balzer, Julia
A1  - Ebert, Susanne
A1  - Kaps, Hella
A1  - Matteschk, Maria
A1  - Tzschöckel, Katharina Andrea
A1  - Dressel, Katharina
A1  - Kröger, Bernd J.
A1  - Diwoky, Laura Cassandra
A1  - Breitenstein, Sarah
A1  - Bruno, Giulia
A1  - Lassotta, Romy
A1  - Adani, Flavia
A1  - Ferchland, Lisa
A1  - Baatz, Charlotte
A1  - Netzebandt, Jonka
A1  - Heyde, Cornelia J.
A1  - Cleland, Joanne
A1  - Scobbie, James M.
A1  - Roxburgh, Zoe
A1  - Schmidt, Jessica
ED  - Adelt, Anne
ED  - Yetim, Özlem
ED  - Otto, Constanze
ED  - Fritzsche, Tom
T1  - Spektrum Patholinguistik Band 10. Schwerpunktthema: Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie
N2  - Das 10. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Panorama Patholinguistik: Sprachwissenschaft trifft Sprachtherapie« fand am 19.11.2016 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die vier Hauptvorträge zum Schwerpunktthema sowie Beiträge zu den Kurzvorträgen »Patholinguistik im Fokus« und der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis.
N2  - The Tenth Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Panorama Patholinguistics: Linguistics meets speech/language therapy« took place in Potsdam on November 19 2016. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain the four keynote talks on the main topic as well as contributions from the short talks in the section »Patholinguistics in Focus« and from the poster session covering a broad range of areas in speech/language therapy research and practice.
T3  - Spektrum Patholinguistik - 10 
KW  - Patholinguistik
KW  - Sprachtherapie
KW  - Spracherwerb
KW  - Aphasie
KW  - Schluckstörungen
KW  - Lese-Rechtschreibschwierigkeiten
KW  - patholinguistics
KW  - speech/language therapy
KW  - language acquisition
KW  - ahasia
KW  - dysphagia
KW  - dyslexia
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-397019
SN  - 978-3-86956-404-3
SN  - 1866-9085
SN  - 1866-9433
IS  - 10
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Tucker, Marlee A.
A1  - Boehning-Gaese, Katrin
A1  - Fagan, William F.
A1  - Fryxell, John M.
A1  - Van Moorter, Bram
A1  - Alberts, Susan C.
A1  - Ali, Abdullahi H.
A1  - Allen, Andrew M.
A1  - Attias, Nina
A1  - Avgar, Tal
A1  - Bartlam-Brooks, Hattie
A1  - Bayarbaatar, Buuveibaatar
A1  - Belant, Jerrold L.
A1  - Bertassoni, Alessandra
A1  - Beyer, Dean
A1  - Bidner, Laura
A1  - van Beest, Floris M.
A1  - Blake, Stephen
A1  - Blaum, Niels
A1  - Bracis, Chloe
A1  - Brown, Danielle
A1  - de Bruyn, P. J. Nico
A1  - Cagnacci, Francesca
A1  - Calabrese, Justin M.
A1  - Camilo-Alves, Constanca
A1  - Chamaille-Jammes, Simon
A1  - Chiaradia, Andre
A1  - Davidson, Sarah C.
A1  - Dennis, Todd
A1  - DeStefano, Stephen
A1  - Diefenbach, Duane
A1  - Douglas-Hamilton, Iain
A1  - Fennessy, Julian
A1  - Fichtel, Claudia
A1  - Fiedler, Wolfgang
A1  - Fischer, Christina
A1  - Fischhoff, Ilya
A1  - Fleming, Christen H.
A1  - Ford, Adam T.
A1  - Fritz, Susanne A.
A1  - Gehr, Benedikt
A1  - Goheen, Jacob R.
A1  - Gurarie, Eliezer
A1  - Hebblewhite, Mark
A1  - Heurich, Marco
A1  - Hewison, A. J. Mark
A1  - Hof, Christian
A1  - Hurme, Edward
A1  - Isbell, Lynne A.
A1  - Janssen, Rene
A1  - Jeltsch, Florian
A1  - Kaczensky, Petra
A1  - Kane, Adam
A1  - Kappeler, Peter M.
A1  - Kauffman, Matthew
A1  - Kays, Roland
A1  - Kimuyu, Duncan
A1  - Koch, Flavia
A1  - Kranstauber, Bart
A1  - LaPoint, Scott
A1  - Leimgruber, Peter
A1  - Linnell, John D. C.
A1  - Lopez-Lopez, Pascual
A1  - Markham, A. Catherine
A1  - Mattisson, Jenny
A1  - Medici, Emilia Patricia
A1  - Mellone, Ugo
A1  - Merrill, Evelyn
A1  - Mourao, Guilherme de Miranda
A1  - Morato, Ronaldo G.
A1  - Morellet, Nicolas
A1  - Morrison, Thomas A.
A1  - Diaz-Munoz, Samuel L.
A1  - Mysterud, Atle
A1  - Nandintsetseg, Dejid
A1  - Nathan, Ran
A1  - Niamir, Aidin
A1  - Odden, John
A1  - Oliveira-Santos, Luiz Gustavo R.
A1  - Olson, Kirk A.
A1  - Patterson, Bruce D.
A1  - de Paula, Rogerio Cunha
A1  - Pedrotti, Luca
A1  - Reineking, Bjorn
A1  - Rimmler, Martin
A1  - Rogers, Tracey L.
A1  - Rolandsen, Christer Moe
A1  - Rosenberry, Christopher S.
A1  - Rubenstein, Daniel I.
A1  - Safi, Kamran
A1  - Said, Sonia
A1  - Sapir, Nir
A1  - Sawyer, Hall
A1  - Schmidt, Niels Martin
A1  - Selva, Nuria
A1  - Sergiel, Agnieszka
A1  - Shiilegdamba, Enkhtuvshin
A1  - Silva, Joao Paulo
A1  - Singh, Navinder
A1  - Solberg, Erling J.
A1  - Spiegel, Orr
A1  - Strand, Olav
A1  - Sundaresan, Siva
A1  - Ullmann, Wiebke
A1  - Voigt, Ulrich
A1  - Wall, Jake
A1  - Wattles, David
A1  - Wikelski, Martin
A1  - Wilmers, Christopher C.
A1  - Wilson, John W.
A1  - Wittemyer, George
A1  - Zieba, Filip
A1  - Zwijacz-Kozica, Tomasz
A1  - Mueller, Thomas
T1  - Moving in the Anthropocene
BT  - global reductions in terrestrial mammalian movements
JF  - Science
N2  - Animal movement is fundamental for ecosystem functioning and species survival, yet the effects of the anthropogenic footprint on animal movements have not been estimated across species. Using a unique GPS-tracking database of 803 individuals across 57 species, we found that movements of mammals in areas with a comparatively high human footprint were on average one-half to one-third the extent of their movements in areas with a low human footprint. We attribute this reduction to behavioral changes of individual animals and to the exclusion of species with long-range movements from areas with higher human impact. Global loss of vagility alters a key ecological trait of animals that affects not only population persistence but also ecosystem processes such as predator-prey interactions, nutrient cycling, and disease transmission.
Y1  - 2018
U6  - https://doi.org/10.1126/science.aam9712
SN  - 0036-8075
SN  - 1095-9203
VL  - 359
IS  - 6374
SP  - 466
EP  - 469
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  -