TY  - JOUR
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical  Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Backes, Michael
A1  - Balenderan, Shangkari
A1  - Balzer, Arnim
A1  - Barnacka, Anna
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Biteau, Jonathan
A1  - Boettcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Carrigan, Svenja
A1  - Casanova, Sabrina
A1  - Chadwick, Paula M.
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Dalton, M.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, C.
A1  - deWilt, P.
A1  - Djannati-Ataï, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dubus, G.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Espigat, P.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Feinstein, F.
A1  - Fernandes, M. V.
A1  - Fernandez, D.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Goudelis, A.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadsch, D.
A1  - Haeffner, S.
A1  - Hahn, J.
A1  - Harris, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hervet, O.
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hofverberg, P.
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Jacholkowska, A.
A1  - Jahn, C.
A1  - Jamrozy, M.
A1  - Janiak, M.
A1  - Jankowsky, F.
A1  - Jung, I.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Kaufmann, S.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Krayzel, F.
A1  - Krueger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Lohse, T.
A1  - Lopatin, A.
A1  - Lu, C. -C.
A1  - Marandon, V.
A1  - Marcowith, Alexandre
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, M.
A1  - McComb, T. J. L.
A1  - Mehault, J.
A1  - Meintjes, P. J.
A1  - Menzler, U.
A1  - Meyer, M.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - de Naurois, M.
A1  - Niemiec, J.
A1  - Nolan, S. J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Opitz, B.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Perez, J.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reichardt, I.
A1  - Reimer, A.
A1  - Reimer, Olaf
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, F.
A1  - Rob, L.
A1  - Romoli, C.
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, Andrea
A1  - Schlickeiser, R.
A1  - Schuessler, Fabian
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwarzburg, S.
A1  - Schwemmer, S.
A1  - Serpico, P.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spiess, F.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Valerius, K.
A1  - van Eldik, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voelk, H. J.
A1  - Volpe, F.
A1  - Vorster, M.
A1  - Vuillaume, T.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - Ward, M.
A1  - Weidinger, M.
A1  - Weitzel, Q.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zabalza, V.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zechlin, H. -S.
T1  - Search for dark matter annihilation signatures in HESS observations of
dwarf spheroidal galaxies
JF  - Physical review : D, Particles, fields, gravitation, and cosmology
N2  - Dwarf spheroidal galaxies of the Local Group are close satellites of the Milky Way characterized by a large mass-to-light ratio and are not expected to be the site of nonthermal high-energy gamma-ray emission or intense star formation. Therefore they are among the most promising candidates for indirect dark matter searches. During the last years the High Energy Stereoscopic System (H.E.S.S.) of imaging atmospheric Cherenkov telescopes observed five of these dwarf galaxies for more than 140 hours in total, searching for TeV gamma-ray emission from annihilation of dark matter particles. The new results of the deep exposure of the Sagittarius dwarf spheroidal galaxy, the first observations of the Coma Berenices and Fornax dwarves and the reanalysis of two more dwarf spheroidal galaxies already published by the H.E.S.S. Collaboration, Carina and Sculptor, are presented. In the absence of a significant signal new constraints on the annihilation cross section applicable to weakly interacting massive particles (WIMPs) are derived by combining the observations of the five dwarf galaxies. The combined exclusion limit depends on the WIMP mass and the best constraint is reached at 1-2 TeV masses with a cross-section upper bound of similar to 3.9 x 10(-24) cm(3) s(-1) at a 95% confidence level.
Y1  - 2014
U6  - https://doi.org/10.1103/PhysRevD.90.112012
SN  - 1550-7998
SN  - 1550-2368
VL  - 90
IS  - 11
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Abramowski, Attila
A1  - Aharonian, Felix A.
A1  - Benkhali, Faical  Ait
A1  - Akhperjanian, A. G.
A1  - Angüner, Ekrem Oǧuzhan
A1  - Backes, Michael
A1  - Balenderan, Shangkari
A1  - Balzer, Arnim
A1  - Barnacka, Anna
A1  - Becherini, Yvonne
A1  - Tjus, J. Becker
A1  - Berge, David
A1  - Bernhard, Sabrina
A1  - Bernlöhr, K.
A1  - Birsin, E.
A1  - Biteau, Jonathan
A1  - Boettcher, Markus
A1  - Boisson, Catherine
A1  - Bolmont, J.
A1  - Bordas, Pol
A1  - Bregeon, Johan
A1  - Brun, Francois
A1  - Brun, Pierre
A1  - Bryan, Mark
A1  - Bulik, Tomasz
A1  - Carrigan, Svenja
A1  - Casanova, Sabrina
A1  - Chadwick, Paula M.
A1  - Chakraborty, N.
A1  - Chalme-Calvet, R.
A1  - Chaves, Ryan C. G.
A1  - Chretien, M.
A1  - Colafrancesco, Sergio
A1  - Cologna, Gabriele
A1  - Conrad, Jan
A1  - Couturier, C.
A1  - Cui, Y.
A1  - Davids, I. D.
A1  - Degrange, B.
A1  - Deil, C.
A1  - dewilt, P.
A1  - Djannati-Ataï, A.
A1  - Domainko, W.
A1  - Donath, A.
A1  - Dubus, G.
A1  - Dutson, K.
A1  - Dyks, J.
A1  - Dyrda, M.
A1  - Edwards, T.
A1  - Egberts, Kathrin
A1  - Eger, P.
A1  - Espigat, P.
A1  - Farnier, C.
A1  - Fegan, S.
A1  - Feinstein, F.
A1  - Fernandes, M. V.
A1  - Fernandez, D.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Foerster, A.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gajdus, M.
A1  - Gallant, Y. A.
A1  - Garrigoux, T.
A1  - Giavitto, G.
A1  - Giebels, B.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M. -H.
A1  - Grudzinska, M.
A1  - Hadasch, D.
A1  - Haeffner, S.
A1  - Hahn, J.
A1  - Harris, J.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hervet, O.
A1  - Hillert, A.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hofverberg, P.
A1  - Holler, M.
A1  - Horns, D.
A1  - Ivascenko, A.
A1  - Jacholkowska, A.
A1  - Jahn, C.
A1  - Jamrozy, Marek
A1  - Janiak, M.
A1  - Jankowsky, F.
A1  - Jung-Richardt, I.
A1  - Kastendieck, M. A.
A1  - Katarzynski, Krzysztof
A1  - Katz, Uli
A1  - Kaufmann, S.
A1  - Khelifi, B.
A1  - Kieffer, M.
A1  - Klepser, S.
A1  - Klochkov, D.
A1  - Kluzniak, W.
A1  - Kolitzus, D.
A1  - Komin, Nu.
A1  - Kosack, K.
A1  - Krakau, S.
A1  - Krayzel, F.
A1  - Krueger, P. P.
A1  - Laffon, H.
A1  - Lamanna, G.
A1  - Lefaucheur, J.
A1  - Lefranc, V.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Lohse, T.
A1  - Lopatin, A.
A1  - Lu, C. -C.
A1  - Marandon, V.
A1  - Marcowith, Alexandre
A1  - Marx, R.
A1  - Maurin, G.
A1  - Maxted, N.
A1  - Mayer, M.
A1  - McComb, T. J. L.
A1  - Mehault, J.
A1  - Meintjes, P. J.
A1  - Menzler, U.
A1  - Meyer, M.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mora, K.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - de Naurois, M.
A1  - Niemiec, J.
A1  - Nolan, S. J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Opitz, B.
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Arribas, M. Paz
A1  - Pekeur, N. W.
A1  - Pelletier, G.
A1  - Petrucci, P. -O.
A1  - Peyaud, B.
A1  - Pita, S.
A1  - Poon, H.
A1  - Puehlhofer, G.
A1  - Punch, Michael
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Reichardt, I.
A1  - Reimer, A.
A1  - Reimer, Olaf
A1  - Renaud, M.
A1  - de los Reyes, R.
A1  - Rieger, F.
A1  - Romoli, C.
A1  - Rosier-Lees, S.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Rulten, C. B.
A1  - Sahakian, V.
A1  - Salek, D.
A1  - Sanchez, David M.
A1  - Santangelo, Andrea
A1  - Schlickeiser, R.
A1  - Schuessler, Fabian
A1  - Schulz, A.
A1  - Schwanke, U.
A1  - Schwarzburg, S.
A1  - Schwemmer, S.
A1  - Sol, H.
A1  - Spanier, F.
A1  - Spengler, G.
A1  - Spies, F.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Stinzing, F.
A1  - Stycz, K.
A1  - Sushch, Iurii
A1  - Tavernet, J. -P.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Valerius, K.
A1  - van Eldik, Christopher
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Viana, A.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voelk, H. J.
A1  - Volpe, F.
A1  - Vorster, M.
A1  - Vuillaume, T.
A1  - Wagner, S. J.
A1  - Wagner, P.
A1  - Wagner, R. M.
A1  - Ward, M.
A1  - Weidinger, M.
A1  - Weitzel, Q.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Willmann, P.
A1  - Woernlein, A.
A1  - Wouters, D.
A1  - Yang, R.
A1  - Zabalza, V.
A1  - Zaborov, D.
A1  - Zacharias, M.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zechlin, H. -S.
A1  - Fukui, Y.
T1  - Diffuse Galactic gamma-ray emission with HESS
JF  - Physical review : D, Particles, fields, gravitation, and cosmology
N2  - Diffuse gamma-ray emission is the most prominent observable signature of celestial cosmic-ray interactions at high energies. While already being investigated at GeVenergies over several decades, assessments of diffuse gamma-ray emission at TeVenergies remain sparse. After completion of the systematic survey of the inner Galaxy, the H.E.S.S. experiment is in a prime position to observe large-scale diffuse emission at TeVenergies. Data of the H.E.S.S. Galactic Plane Survey are investigated in regions off known gamma-ray sources. Corresponding gamma-ray flux measurements were made over an extensive grid of celestial locations. Longitudinal and latitudinal profiles of the observed gamma-ray fluxes show characteristic excess emission not attributable to known gamma-ray sources. For the first time large-scale gamma-ray emission along the Galactic plane using imaging atmospheric Cherenkov telescopes has been observed. While the background subtraction technique limits the ability to recover modest variation on the scale of the H.E.S.S. field of view or larger, which is characteristic of the inverse Compton scatter-induced Galactic diffuse emission, contributions of neutral pion decay as well as emission from unresolved gamma-ray sources can be recovered in the observed signal to a large fraction. Calculations show that the minimum gamma-ray emission from pi(0) decay represents a significant contribution to the total signal. This detection is interpreted as a mix of diffuse Galactic gamma-ray emission and unresolved sources.
Y1  - 2014
U6  - https://doi.org/10.1103/PhysRevD.90.122007
SN  - 1550-7998
SN  - 1550-2368
VL  - 90
IS  - 12
PB  - American Physical Society
CY  - College Park
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - van der Plas, Fons
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Renner, Swen C.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Boch, Steffen
A1  - Böhm, Stefan
A1  - Börschig, Carmen
A1  - Buscot, Francois
A1  - Diekötter, Tim
A1  - Heinze, Johannes
A1  - Hölzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Müller, Jörg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schöning, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Türke, Manfred
A1  - Venter, Paul C.
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality
JF  - Nature : the international weekly journal of science
Y1  - 2016
U6  - https://doi.org/10.1038/nature19092
SN  - 0028-0836
SN  - 1476-4687
VL  - 536
SP  - 456
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Morel, T.
A1  - Castro, Norberto
A1  - Fossati, Luca
A1  - Hubrig, Swetlana
A1  - Langer, N.
A1  - Przybilla, Norbert
A1  - Schöller, Markus
A1  - Carroll, Thorsten Anthony
A1  - Ilyin, Ilya
A1  - Irrgang, Andreas
A1  - Oskinova, Lida
A1  - Schneider, Fabian R. N.
A1  - Simon Díaz, Sergio
A1  - Briquet, Maryline
A1  - González, Jean-Francois
A1  - Kharchenko, Nina
A1  - Nieva, M.-F.
A1  - Scholz, Ralf-Dieter
A1  - de Koter, Alexander
A1  - Hamann, Wolf-Rainer
A1  - Herrero, Artemio
A1  - Maíz Apellániz, Jesus
A1  - Sana, Hugues
A1  - Arlt, Rainer
A1  - Barbá, Rodolfo H.
A1  - Dufton, Polly
A1  - Kholtygin, Alexander
A1  - Mathys, Gautier
A1  - Piskunov, Anatoly E.
A1  - Reisenegger, Andreas
A1  - Spruit, H.
A1  - Yoon, S.-C.
T1  - The B fields in OB stars (BOB) survey
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The B fields in OB stars (BOB) survey is an ESO large programme collecting spectropolarimetric observations for a large number of early-type stars in order to study the occurrence rate, properties, and ultimately the origin of magnetic fields in massive stars. As of July 2014, a total of 98 objects were observed over 20 nights with FORS2 and HARPSpol. Our preliminary results indicate that the fraction of magnetic OB stars with an organised, detectable field is low. This conclusion, now independently reached by two different surveys, has profound implications for any theoretical model attempting to explain the field formation in these objects. We discuss in this contribution some important issues addressed by our observations (e.g., the lower bound of the field strength) and the discovery of some remarkable objects.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 821 
KW  - magnetic fields
KW  - stars: early-type
KW  - stars: magnetic fields
KW  - stars: individual (HD 164492C, CPD –57 ◦ 3509, HD 54879, β CMa, ε CMa)
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-415238
SN  - 1866-8372
IS  - 821
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Bluethgen, Nico
A1  - Boch, Steffen
A1  - Boehm, Stefan
A1  - Boerschig, Carmen
A1  - Buscot, Francois
A1  - Diekoetter, Tim
A1  - Heinze, Johannes
A1  - Hoelzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Klein, Alexandra-Maria
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Mueller, Joerg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Renner, Swen C.
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schoening, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Tuerke, Manfred
A1  - Venter, Paul
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Locally rare species influence grassland ecosystem multifunctionality
JF  - Philosophical transactions of the Royal Society of London : B, Biological sciences
N2  - Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land use intensity (LUI) gradient. The diversity of above- and below-ground rare species had opposite effects, with rare above-ground species being associated with high levels of multifunctionality, probably because their effects on different functions did not trade off against each other. Conversely, common species were only related to average, not high, levels of multifunctionality, and their functional effects declined with LUI. Apart from the community level effects of diversity, we found significant positive associations between the abundance of individual species and multifunctionality in 6% of the species tested. Species specific functional effects were best predicted by their response to LUI: species that declined in abundance with land use intensification were those associated with higher levels of multifunctionality. Our results highlight the importance of rare species for ecosystem multifunctionality and help guiding future conservation priorities.
KW  - biodiversity
KW  - common species
KW  - ecosystem function
KW  - identity hypothesis
KW  - land use
KW  - multitrophic
Y1  - 2016
U6  - https://doi.org/10.1098/rstb.2015.0269
SN  - 0962-8436
SN  - 1471-2970
VL  - 371
SP  - 3175
EP  - 3185
PB  - Royal Society
CY  - London
ER  - 
TY  - GEN
A1  - Send, T. S.
A1  - Gilles, M.
A1  - Codd, V.
A1  - Wolf, I. A. C.
A1  - Bardtke, S.
A1  - Streit, Fabian
A1  - Strohmaier, Jana
A1  - Frank, Josef
A1  - Schendel, D.
A1  - Sutterlin, M. W.
A1  - Denniff, M.
A1  - Laucht, Manfred
A1  - Samani, N. J.
A1  - Deuschle, Michael
A1  - Rietschel, Marcella
A1  - Witt, Stephanie H.
T1  - Telomere length in newborns is related to maternal stress during pregnancy Response
T2  - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
KW  - Predictive markers
KW  - Risk factors
Y1  - 2018
U6  - https://doi.org/10.1038/s41386-018-0079-8
SN  - 0893-133X
SN  - 1740-634X
VL  - 43
IS  - 11
SP  - 2164
EP  - 2164
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Witt, Stephanie H.
A1  - Frank, Josef
A1  - Gilles, Maria
A1  - Lang, Maren
A1  - Treutlein, Jens
A1  - Streit, Fabian
A1  - Wolf, Isabell A. C.
A1  - Peus, Verena
A1  - Scharnholz, Barbara
A1  - Send, Tabea S.
A1  - Heilmann-Heimbach, Stefanie
A1  - Sivalingam, Sugirthan
A1  - Dukal, Helene
A1  - Strohmaier, Jana
A1  - Sütterlin, Marc
A1  - Arloth, Janine
A1  - Laucht, Manfred
A1  - Nöthen, Markus M.
A1  - Deuschle, Michael
A1  - Rietschel, Marcella
T1  - Impact on birth weight of maternal smoking throughout pregnancy mediated by DNA methylation
JF  - BMC genomics
N2  - Background: Cigarette smoking has severe adverse health consequences in adults and in the offspring of mothers who smoke during pregnancy. One of the most widely reported effects of smoking during pregnancy is reduced birth weight which is in turn associated with chronic disease in adulthood. Epigenome-wide association studies have revealed that smokers show a characteristic "smoking methylation pattern", and recent authors have proposed that DNA methylation mediates the impact of maternal smoking on birth weight. The aims of the present study were to replicate previous reports that methylation mediates the effect of maternal smoking on birth weight, and for the first time to investigate whether the observed mediation effects are sex-specific in order to account for known sex-specific differences in methylation levels. Methods: Methylation levels in the cord blood of 313 newborns were determined using the Illumina HumanMethylation450K Beadchip. A total of 5,527 CpG sites selected on the basis of evidence from the literature were tested. To determine whether the observed association between maternal smoking and birth weight was attributable to methylation, mediation analyses were performed for significant CpG sites. Separate analyses were then performed in males and females. Results: Following quality control, 282 newborns eventually remained in the analysis. A total of 25 mothers had smoked consistently throughout the pregnancy. The birthweigt of newborns whose mothers had smoked throughout pregnancy was reduced by >200g. After correction for multiple testing, 30 CpGs showed differential methylation in the maternal smoking subgroup including top "smoking methylation pattern" genes AHRR, MYO1G, GFI1, CYP1A1, and CNTNAP2. The effect of maternal smoking on birth weight was partly mediated by the methylation of cg25325512 (PIM1); cg25949550 (CNTNAP2); and cg08699196 (ITGB7). Sex-specific analyses revealed a mediating effect for cg25949550 (CNTNAP2) in male newborns. Conclusion: The present data replicate previous findings that methylation can mediate the effect of maternal smoking on birth weight. The analysis of sex-dependent mediation effects suggests that the sex of the newborn may have an influence. Larger studies are warranted to investigate the role of both the identified differentially methylated loci and the sex of the newborn in mediating the association between maternal smoking during pregnancy and birth weight.
KW  - DNA methylation
KW  - Smoking
KW  - Birth weight
KW  - Mediation analysis
Y1  - 2018
U6  - https://doi.org/10.1186/s12864-018-4652-7
SN  - 1471-2164
VL  - 19
PB  - BMC
CY  - London
ER  - 
TY  - JOUR
A1  - Fabian, H.
A1  - Gast, Klaus
A1  - Filimonov, Vladimir V.
A1  - Zamyatkin, D. F.
A1  - Rogov, V. V.
T1  - Thermal unfolding of two designed monomeric lambda Cro repressor variants
N2  - The thermal unfolding of the wild-type lambda Cro repressor and of two designed variants, Cro K56-[DGEVK] and Cro K56-[DGEVK] Q16L, was studied by Fourier transform infrared spectroscopy and dynamic light scattering. The engineered Cro K56-[DGEVK] monomer has five additional amino acids inserted after position 56 of the wild-type sequence, while the K56-[DGEVK] Q16L variant differs only in one position (Gln-16 to Leu substitution) from the Cro K56-[DGEVK] sequence. The temperature dependence of selected protein backbone infrared `marker' bands revealed that Cro K56- [DGEVK] is slightly more stable than the wild-type protein, while the replacement of Gln-16 by Leu increases the thermal transition temperature by similar to 20 degrees C. Moreover, thermal unfolding of the two Cro variants was found to proceed through equilibrium unfolding intermediates and to involve the formation of oligomers. The first thermal transition of Cro K56-[DGEVK] involves the melting of major parts of its native secondary structure and is accompanied by the formation of dinners and non-native beta-sheet structures. These structures unfold during a second transition at higher temperatures, accompanied by the dissociation of the dimers. In contrast to the Cro K56-[DGEVK] protein, the intermediate state of the Cro K56-[DGEVK] Q16L variant is less well defined, and involves the formation of oligomers of different size. (c) 2005 Elsevier B.V. All rights reserved
Y1  - 2005
SN  - 0924-2031
ER  - 
TY  - JOUR
A1  - Allen, S. W.
A1  - Schmidt, Robert W.
A1  - Ebeling, H.
A1  - Fabian, A. C.
A1  - van Speybroeck, L.
T1  - Constraints on dark energy from Chandra observations of the largest relaxed galaxy clusters
N2  - We present constraints on the mean dark energy density, Omega(X) and dark energy equation of state parameter, w(X), based on Chandra measurements of the X-ray gas mass fraction in 26 X-ray luminous, dynamically relaxed galaxy clusters spanning the redshift range 0.07 < z < 0.9. Under the assumption that the X-ray gas mass fraction measured within r(2500) is constant with redshift and using only weak priors on the Hubble constant and mean baryon density of the Universe, we obtain a clear detection of the effects of dark energy on the distances to the clusters, confirming (at comparable significance) previous results from Type la supernovae studies. For a standard Lambda cold dark matter (CDM) cosmology with the curvature Omega(K) included as a free parameter, we find Omega(Lambda) = 0.94(-0.23)(+0.21) (68 per cent confidence limits). We also examine extended XCDM dark energy models. Combining the Chandra data with independent constraints from cosmic microwave background experiments, we find Omega(X) = 0.75 +/- 0.04, Omega(m) = 0.26(- 0.04)(+0.06) and w(X) =-1.26 +/- 0.24. Imposing the prior constraint w(X) > -1, the same data require w(X) < -0.7 at 95 per cent confidence. Similar results on the mean matter density and dark energy equation of state parameter, &UOmega;(m) = 0.24 ± 0.04 and w(X) 1.20(-0.28)(+0.24), are obtained by replacing the cosmic microwave background data with standard priors on the Hubble constant and mean baryon density and assuming a flat geometry
Y1  - 2004
SN  - 0035-8711
ER  - 
TY  - JOUR
A1  - Modler, Andreas Johannes
A1  - Fabian, H.
A1  - Sokolowski, F.
A1  - Lutsch, G.
A1  - Gast, Klaus
A1  - Damaschun, Gregor
T1  - Polymerization of proteins into amyloid protofibrils shares common critical oligomeric states but differs in the mechanisms of their formation
N2  - Amyloid protofibril formation of phosphoglycerate kinase (PGK) and Syrian hamster prion protein (SHaPrP(90- 232)) were investigated by static and dynamic light scattering, size exclusion chromatography and electron microscopy. Changes in secondary structure were monitored by Fourier transform infrared spectroscopy and by circular dichroism. Protofibril formation of the two proteins is found to be a two-stage process. At the beginning, an ensemble of critical oligomers is built lip. These critical oligomeric states possess a predominant beta-sheet structure and do not interact considerably with monomers. Initial oligomerization and transition to beta-sheet structure are coupled events differing in their details for both proteins. Intermediate oligomeric states (dimers, trimers, etc.) are populated in case of PGK, whereas SHaPrP(90-232) behaves according to oil apparent two-state reaction between monomers and octamers rich in beta- structure with a reaction order varying between 2 and 4. All oligomers coalesce to PGK protofibrils in the second stage, while SHaPrP(90-232) protofibrils are only formed by a subpopulation. The rates of both growth stages can be tuned in case of PGK by different salts preserving the underlying generalized diffusion-collision mechanism. The different kinetics of the early misfolding and oligomerization events of the two proteins argue against a common mechanism of protofibril formation. A classification scheme for misassembly, mechanisms of proteins based on energy landscapes is presented. It includes scenarios of downhill polymerization to which protofibril formation of PGK and SHaPrP(90-232) belong
Y1  - 2004
ER  - 
TY  - JOUR
A1  - Send, Tabea
A1  - Bardtke, S.
A1  - Gilles, M.
A1  - Wolf, I. A. C.
A1  - Sütterlin, Marc Wolf
A1  - Wudy, S. A.
A1  - Wang, R.
A1  - Laucht, Manfred
A1  - Witt, Stephanie H.
A1  - Rietschel, Marcella
A1  - Streit, Fabian
A1  - Deuschle, Michael
T1  - Prenatal maternal stress is associated with lower cortisol and cortisone levels in the first morning urine of 45-month-old children
JF  - Psychoneuroendocrinology
N2  - Prenatal stress (PS) has been related to altered hypothalamic-pituitary-adrenal (HPA) axis activity later in life. So far, studies in children assessing HPA axis functioning have focused on salivary cortisol, reflecting daytime activity. The present work is part of a prospective study and aims to extend knowledge about the association between PS and HPA axis regulation in children. To do so, we investigated cortisol, cortisone, and the ratio cortisone/(cortisone + cortisol) in the first morning urine of 45-month-old children in relation to several measures of maternal stress during pregnancy. Urinary cortisol and cortisone were measured by online turbulent flow chromatography coupled with high performance liquid chromatography-tandem mass spectrometry. PS was defined as: perceived stress for aim 1 (Perceived Stress Scale; n = 280); presence of self-reported (n = 371) and expert-rated psychopathology for aim 2 (Mini International Neuropsychiatric Interview; n = 281); continuous measures of anxiety and depression for exploratory aim 3 (State-Trait Anxiety Inventory and Edinburgh Postnatal Depression Scale; n = 280). The ratio cortisone/(cortisone + cortisol) as a global marker for the balance between the enzymes metabolizing cortisol to cortisone and vice versa (11 beta-hydroxysteroid dehydrogenases type 1 and 2; 11 beta-HSD1 and 2) was not associated with any measure of maternal PS (aims 1-3). The present study provides insight into possible programming effects of PS on nocturnal HPA axis activity and a proxy of 11 beta-HSD in a large sample. The results suggest that the nocturnal rate of cortisol production is lower in children exposed to PS, but do not support the hypothesis of divergent 11 beta-HSD activity.
KW  - Prenatal stress
KW  - Cortisol
KW  - Cortisone
KW  - HPA axis
KW  - Perceived stress
KW  - Psychopathology
Y1  - 2019
U6  - https://doi.org/10.1016/j.psyneuen.2019.01.017
SN  - 0306-4530
VL  - 103
SP  - 219
EP  - 224
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Send, Tabea Sarah
A1  - Bardtke, Svenja
A1  - Gilles, Maria
A1  - Wolf, Isabella Germaine
A1  - Sütterlin, Marc W.
A1  - Kirschbaum, Clemens
A1  - Laucht, Manfred
A1  - Witt, Stephanie H.
A1  - Rietschel, Marcella
A1  - Streit, Fabian
A1  - Deuschle, Michael
T1  - Stress reactivity in preschool-aged children
BT  - Evaluation of a social stress paradigm and investigation of the impact of prenatal maternal stress
JF  - Psychoneuroendocrinology
N2  - Prenatal maternal stress is an established risk factor for somatic and psychological health of the offspring. A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in offspring has been suggested as an important mechanism. However, the impact of prenatal stress on stress reactivity in preschool-aged children is not yet well understood. This is partly due to the fact that for this age group there is no stress test as well established as for older children and adults. In the present work a previously published stress test (Kryski et al., 2011) was evaluated in a large sample of 45-month-old children (n = 339). Furthermore, the relation between measures of prenatal maternal stress and cortisol reactivity was investigated. Prenatal stress was defined as psychopathology (self-report available for n = 339; expert-rating available for a subsample of n = 246) and perceived stress (n = 244) during pregnancy. The stress paradigm elicited significant increases in salivary cortisol 30 and 40 min after the test, and 60.8% of the children were classified as responders. Lower cortisol levels after the stress test were observed in the group of children with prenatal stress defined as maternal psychopathology (both self-reported and expert-rated). Maternal perceived stress as a continuous measure was not significantly associated with cortisol levels. However, when comparing children in the highest quartile of maternal perceived stress to all other children, significantly lower cortisol values were observed in the prenatally stressed group. The present study confirms the paradigm by Kryski et al. as an effective stress test for preschool-aged children. Moreover, it provides further evidence that prenatal stress impacts HPA axis reactivity. Future studies should target the timing, nature, and intensity of prenatal stressors and their effect on the stress response in offspring at different developmental stages.
KW  - Stress test
KW  - Children
KW  - Prenatal stress
KW  - Cortisol
KW  - HPA axis reactivity
KW  - Psychopathology
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.11.002
SN  - 0306-4530
VL  - 101
SP  - 223
EP  - 231
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Bauer, Christian G.
A1  - Eremenko, A. V.
A1  - Ehrentreich-Förster, Eva
A1  - Bier, Frank Fabian
A1  - Makower, Alexander
A1  - Halsall, H. B.
A1  - Heineman, W. R.
A1  - Scheller, Frieder W.
T1  - Zeptomole-detecting biosensor for alkaline phosphatase in an electroche mical immunoassay for 2,4- dichlorophenoacetic acid
Y1  - 1996
ER  - 
TY  - JOUR
A1  - Scheller, Frieder W.
A1  - Makower, Alexander
A1  - Ghindilis, A. L.
A1  - Bier, Frank Fabian
A1  - Ehrentreich-Förster, Eva
A1  - Wollenberger, Ursula
A1  - Bauer, Christian G.
A1  - Micheel, Burkhard
A1  - Pfeiffer, Dorothea
A1  - Szeponik, Jan
A1  - Michael, N.
A1  - Kaden, H.
T1  - Enzyme sensors for subnanomolar concentrations
Y1  - 1995
ER  - 
TY  - JOUR
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Alt, Fabian
A1  - Boch, Steffen
A1  - Gockel, Sonja
A1  - Hemp, Andreas
A1  - Lange, Markus
A1  - Müller, Jörg
A1  - Oelmann, Yvonne
A1  - Pasalic, Esther
A1  - Renner, Swen C.
A1  - Socher, Stephanie A.
A1  - Türke, Manfred
A1  - Weisser, Wolfgang W.
A1  - Fischer, Markus
A1  - Hölzel, Norbert
T1  - Does organic grassland farming benefit plant and arthropod diversity at the expense of yield and soil fertility?
JF  - Agriculture, ecosystems & environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere
N2  - Organic management is one of the most popular strategies to reduce negative environmental impacts of intensive agriculture. However, little is known about benefits for biodiversity and potential worsening of yield under organic grasslands management across different grassland types, i.e. meadow, pasture and mown pasture. Therefore, we studied the diversity of vascular plants and foliage-living arthropods (Coleoptera, Araneae, Heteroptera, Auchenorrhyncha), yield, fodder quality, soil phosphorus concentrations and land-use intensity of organic and conventional grasslands across three study regions in Germany. Furthermore, all variables were related to the time since conversion to organic management in order to assess temporal developments reaching up to 18 years. Arthropod diversity was significantly higher under organic than conventional management, although this was not the case for Araneae, Heteroptera and Auchenorrhyncha when analyzed separately. On the contrary, arthropod abundance, vascular plant diversity and also yield and fodder quality did not considerably differ between organic and conventional grasslands. Analyses did not reveal differences in the effect of organic management among grassland types. None of the recorded abiotic and biotic parameters showed a significant trend with time since transition to organic management, except soil organic phosphorus concentrations which decreased with time. This implies that permanent grasslands respond slower and probably weaker to organic management than crop fields do. However, as land-use intensity and inorganic soil phosphorus concentrations were significantly lower in organic grasslands, overcoming seed and dispersal limitation by re-introducing plant species might be needed to exploit the full ecological potential of organic grassland management. We conclude that although organic management did not automatically increase the diversity of all studied taxa, it is a reasonable and useful way to support agro-biodiversity.
KW  - Agri-environmental schemes
KW  - Fertilization
KW  - Fodder quality
KW  - Land-use intensity
KW  - Nitrogen
KW  - Biomass nutrient concentrations
KW  - Organic farming
KW  - Phosphorus
KW  - Species richness
KW  - Nutrient availability
Y1  - 2013
U6  - https://doi.org/10.1016/j.agee.2013.05.019
SN  - 0167-8809
VL  - 177
IS  - 3
SP  - 1
EP  - 9
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Blüthgen, Nico
A1  - Dormann, Carsten F.
A1  - Prati, Daniel
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Hoelzel, Norbert
A1  - Alt, Fabian
A1  - Boch, Steffen
A1  - Gockel, Sonja
A1  - Hemp, Andreas
A1  - Müller, Jörg
A1  - Nieschulze, Jens
A1  - Renner, Swen C.
A1  - Schöning, Ingo
A1  - Schumacher, Uta
A1  - Socher, Stephanie A.
A1  - Wells, Konstans
A1  - Birkhofer, Klaus
A1  - Buscot, Francois
A1  - Oelmann, Yvonne
A1  - Rothenwöhrer, Christoph
A1  - Scherber, Christoph
A1  - Tscharntke, Teja
A1  - Weiner, Christiane N.
A1  - Fischer, Markus
A1  - Kalko, Elisabeth K. V.
A1  - Linsenmair, Karl Eduard
A1  - Schulze, Ernst-Detlef
A1  - Weisser, Wolfgang W.
T1  - A quantitative index of land-use intensity in grasslands integrating mowing, grazing and fertilization
JF  - Basic and applied ecology : Journal of the Gesellschaft für Ökologie
N2  - Land use is increasingly recognized as a major driver of biodiversity and ecosystem functioning in many current research projects. In grasslands, land use is often classified by categorical descriptors such as pastures versus meadows or fertilized versus unfertilized sites. However, to account for the quantitative variation of multiple land-use types in heterogeneous landscapes, a quantitative, continuous index of land-use intensity (LUI) is desirable. Here we define such a compound, additive LUI index for managed grasslands including meadows and pastures. The LUI index summarizes the standardized intensity of three components of land use, namely fertilization, mowing, and livestock grazing at each site. We examined the performance of the LUI index to predict selected response variables on up to 150 grassland sites in the Biodiversity Exploratories in three regions in Germany(Alb, Hainich, Schorlheide). We tested the average Ellenberg nitrogen indicator values of the plant community, nitrogen and phosphorus concentration in the aboveground plant biomass, plant-available phosphorus concentration in the top soil, and soil C/N ratio, and the first principle component of these five response variables.
 The LUI index significantly predicted the principal component of all five response variables, as well as some of the individual responses. Moreover, vascular plant diversity decreased significantly with LUI in two regions (Alb and Hainich).
 Inter-annual changes in management practice were pronounced from 2006 to 2008, particularly due to variation in grazing intensity. This rendered the selection of the appropriate reference year(s) an important decision for analyses of land-use effects, whereas details in the standardization of the index were of minor importance. We also tested several alternative calculations of a LUI index, but all are strongly linearly correlated to the proposed index.
 The proposed LUI index reduces the complexity of agricultural practices to a single dimension and may serve as a baseline to test how different groups of organisms and processes respond to land use. In combination with more detailed analyses, this index may help to unravel whether and how land-use intensities, associated disturbance levels or other local or regional influences drive ecological processes.
KW  - Agro-ecosystems
KW  - Biodiversity exploratories
KW  - Grassland management
KW  - Land-use impacts
KW  - Livestock density
KW  - Meadows
KW  - Nitrogen
KW  - Pastures
Y1  - 2012
U6  - https://doi.org/10.1016/j.baae.2012.04.001
SN  - 1439-1791
VL  - 13
IS  - 3
SP  - 207
EP  - 220
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Allan, Eric
A1  - Manning, Pete
A1  - Alt, Fabian
A1  - Binkenstein, Julia
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Böhm, Stefan
A1  - Grassein, Fabrice
A1  - Hölzel, Norbert
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Morris, E. Kathryn
A1  - Oelmann, Yvonne
A1  - Prati, Daniel
A1  - Renner, Swen C.
A1  - Rillig, Matthias C.
A1  - Schaefer, Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schöning, Ingo
A1  - Schrumpf, Marion
A1  - Solly, Emily
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffen-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Fischer, Markus
T1  - Land use intensification alters ecosystem multifunctionality via loss of biodiversity and changes to functional composition
JF  - Ecology letters
N2  - Global change, especially land-use intensification, affects human well-being by impacting the delivery of multiple ecosystem services (multifunctionality). However, whether biodiversity loss is a major component of global change effects on multifunctionality in real-world ecosystems, as in experimental ones, remains unclear. Therefore, we assessed biodiversity, functional composition and 14 ecosystem services on 150 agricultural grasslands differing in land-use intensity. We also introduce five multifunctionality measures in which ecosystem services were weighted according to realistic land-use objectives. We found that indirect land-use effects, i.e. those mediated by biodiversity loss and by changes to functional composition, were as strong as direct effects on average. Their strength varied with land-use objectives and regional context. Biodiversity loss explained indirect effects in a region of intermediate productivity and was most damaging when land-use objectives favoured supporting and cultural services. In contrast, functional composition shifts, towards fast-growing plant species, strongly increased provisioning services in more inherently unproductive grasslands.
KW  - Biodiversity-ecosystem functioning
KW  - ecosystem services
KW  - global change
KW  - land use
KW  - multifunctionality
Y1  - 2015
U6  - https://doi.org/10.1111/ele.12469
SN  - 1461-023X
SN  - 1461-0248
VL  - 18
IS  - 8
SP  - 834
EP  - 843
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Wolf, Thomas J. A.
A1  - Holzmeier, Fabian
A1  - Wagner, Isabella
A1  - Berrah, Nora
A1  - Bostedt, Christoph
A1  - Bozek, John
A1  - Bucksbaum, Philip H.
A1  - Coffee, Ryan
A1  - Cryan, James
A1  - Farrell, Joe
A1  - Feifel, Raimund
A1  - Martinez, Todd J.
A1  - McFarland, Brian
A1  - Mucke, Melanie
A1  - Nandi, Saikat
A1  - Tarantelli, Francesco
A1  - Fischer, Ingo
A1  - Gühr, Markus
T1  - Observing Femtosecond Fragmentation Using Ultrafast X-ray-Induced Auger Spectra
JF  - Applied Sciences
N2  - Molecules often fragment after photoionization in the gas phase. Usually, this process can only be investigated spectroscopically as long as there exists electron correlation between the photofragments. Important parameters, like their kinetic energy after separation, cannot be investigated. We are reporting on a femtosecond time-resolved Auger electron spectroscopy study concerning the photofragmentation dynamics of thymine. We observe the appearance of clearly distinguishable signatures from thymine′s neutral photofragment isocyanic acid. Furthermore, we observe a time-dependent shift of its spectrum, which we can attribute to the influence of the charged fragment on the Auger electron. This allows us to map our time-dependent dataset onto the fragmentation coordinate. The time dependence of the shift supports efficient transformation of the excess energy gained from photoionization into kinetic energy of the fragments. Our method is broadly applicable to the investigation of photofragmentation processes.
KW  - ultrafast dynamics
KW  - Auger electron spectroscopy
KW  - photofragmentation
KW  - photochemistry
Y1  - 2017
U6  - https://doi.org/10.3390/app7070681
SN  - 2076-3417
VL  - 7
IS  - 7
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Wolf, Thomas J. A.
A1  - Holzmeier, Fabian
A1  - Wagner, Isabella
A1  - Berrah, Nora
A1  - Bostedt, Christoph
A1  - Bozek, John
A1  - Bucksbaum, Philip H.
A1  - Coffee, Ryan
A1  - Cryan, James
A1  - Farrell, Joe
A1  - Feifel, Raimund
A1  - Martinez, Todd J.
A1  - McFarland, Brian
A1  - Mucke, Melanie
A1  - Nandi, Saikat
A1  - Tarantelli, Francesco
A1  - Fischer, Ingo
A1  - Gühr, Markus
T1  - Observing Femtosecond Fragmentation Using Ultrafast X-ray-Induced Auger Spectra
N2  - Molecules often fragment after photoionization in the gas phase. Usually, this process can only be investigated spectroscopically as long as there exists electron correlation between the photofragments. Important parameters, like their kinetic energy after separation, cannot be investigated. We are reporting on a femtosecond time-resolved Auger electron spectroscopy study concerning the photofragmentation dynamics of thymine. We observe the appearance of clearly distinguishable signatures from thymine′s neutral photofragment isocyanic acid. Furthermore, we observe a time-dependent shift of its spectrum, which we can attribute to the influence of the charged fragment on the Auger electron. This allows us to map our time-dependent dataset onto the fragmentation coordinate. The time dependence of the shift supports efficient transformation of the excess energy gained from photoionization into kinetic energy of the fragments. Our method is broadly applicable to the investigation of photofragmentation processes.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 386 
KW  - Auger electron spectroscopy
KW  - photochemistry
KW  - photofragmentation
KW  - ultrafast dynamics
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-402692
ER  - 
TY  - JOUR
A1  - Send, Tabea Sarah
A1  - Gilles, Maria
A1  - Codd, Veryan
A1  - Wolf, Isabell
A1  - Bardtke, Svenja
A1  - Streit, Fabian
A1  - Strohmaier, Jana
A1  - Frank, Josef
A1  - Schendel, Darja
A1  - Suetterlin, Mark W.
A1  - Denniff, Matthew
A1  - Laucht, Manfred
A1  - Samani, Nilesh J.
A1  - Deuschle, Michael
A1  - Rietschel, Marcella
A1  - Witt, Stephanie H.
T1  - Telomere Length in Newborns is Related to Maternal Stress During Pregnancy
JF  - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
N2  - Telomere length (TL) is a marker of biological aging, and numerous studies have shown associations between TL and somatic or psychiatric disorders. Research also indicates an association between maternal stress during pregnancy and TL in the offspring. The present study investigated possible associations between TL and: (1) maternal perceived stress during pregnancy; (2) a maternal lifetime history of psychiatric disorder (lifetime PD); and (3) paternal age. TL was analyzed in 319 newborns and 318 mothers from a predominantly Caucasian sample (n= 273 Caucasian newborns and n= 274 Caucasian mothers). Two key findings were observed. First, maternal perceived stress during pregnancy was associated with shorter telomeres in newborns but not with maternal TL. Second, maternal lifetime PD was associated with shorter maternal telomeres, but not with TL in newborns. Paternal age was not associated with TL in newborns. The finding that maternal stress during pregnancy is associated with shorter telomeres in newborns supports the results of smaller previous studies. The fact that a relation between maternal prenatal stress and TL was observed in the offspring but not in mothers may be attributable to a high vulnerability to stress during intrauterine development of a maturing organism. To our knowledge, this is the largest study to date to show that maternal stress during pregnancy but not maternal lifetime PD is associated with shorter telomeres in the offspring.
Y1  - 2017
U6  - https://doi.org/10.1038/npp.2017.73
SN  - 0893-133X
SN  - 1740-634X
VL  - 42
SP  - 2407
EP  - 2413
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Samaha, Doaa
A1  - Hamdo, Housam H.
A1  - Cong, Xiaojing
A1  - Schumacher, Fabian
A1  - Banhart, Sebastian
A1  - Aglar, Öznur
A1  - Möller, Heiko Michael
A1  - Heuer, Dagmar
A1  - Kleuser, Burkhard
A1  - Saied, Essa M.
A1  - Arenz, Christoph
T1  - Liposomal FRET assay identifies potent drug-like inhibitors of the Ceramide Transport Protein (CERT)
JF  - Chemistry - a European journal
N2  - Ceramide transfer protein (CERT) mediates non-vesicular transfer of ceramide from endoplasmic reticulum to Golgi apparatus and thus catalyzes the rate-limiting step of sphingomyelin biosynthesis. Usually, CERT ligands are evaluated in tedious binding assays or non-homogenous transfer assays using radiolabeled ceramides. Herein, a facile and sensitive assay for CERT, based on Forster resonance energy transfer (FRET), is presented. To this end, we mixed donor and acceptor vesicles, each containing a different fluorescent ceramide species. By CERT-mediated transfer of fluorescent ceramide, a FRET system was established, which allows readout in 96-well plate format, despite the high hydrophobicity of the components. Screening of a 2 000 compound library resulted in two new potent CERT inhibitors. One is approved for use in humans and one is approved for use in animals. Evaluation of cellular activity by quantitative mass spectrometry and confocal microscopy showed inhibition of ceramide trafficking and sphingomyelin biosynthesis.
KW  - enzyme assays
KW  - Forster resonance energy transfer (FRET)
KW  - liposomes
KW  - sphingolipids
KW  - transport proteins
Y1  - 2020
U6  - https://doi.org/10.1002/chem.202003283
SN  - 0947-6539
SN  - 1521-3765
VL  - 26
IS  - 70
SP  - 16616
EP  - 16621
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - GEN
A1  - Naser, Eyad
A1  - Kadow, Stephanie
A1  - Schumacher, Fabian
A1  - Mohamed, Zainelabdeen H.
A1  - Kappe, Christian
A1  - Hessler, Gabriele
A1  - Pollmeier, Barbara
A1  - Kleuser, Burkhard
A1  - Arenz, Christoph
A1  - Becker, Katrin Anne
A1  - Gulbins, Erich
A1  - Carpinteiro, Alexander
T1  - Characterization of the small molecule ARC39
BT  - a direct and specific inhibitor of acid sphingomyelinase in vitro[S]
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently characterized. Here, we found that 1-aminodecylidene bis-phosphonic acid (ARC39) specifically and efficiently (>90%) inhibits both lysosomal and secretory ASM in vitro. Results from investigating sphingomyelin phosphodiesterase 1 (SMPD1/Smpd1) mRNA and ASM protein levels suggested that ARC39 directly inhibits ASM's catalytic activity in cultured cells, a mechanism that differs from that of functional inhibitors of ASM. We further provide evidence that ARC39 dose- and time-dependently inhibits lysosomal ASM in intact cells, and we show that ARC39 also reduces platelet- and ASM-promoted adhesion of tumor cells. The observed toxicity of ARC39 is low at concentrations relevant for ASM inhibition in vitro, and it does not strongly alter the lysosomal compartment or induce phospholipidosis in vitro. When applied intraperitoneally in vivo, even subtoxic high doses administered short-term induced sphingomyelin accumulation only locally in the peritoneal lavage without significant accumulation in plasma, liver, spleen, or brain. These findings require further investigation with other possible chemical modifications. In conclusion, our results indicate that ARC39 potently and selectively inhibits ASM in vitro and highlight the need for developing compounds that can reach tissue concentrations sufficient for ASM inhibition in vivo.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1407 
KW  - sphingolipids
KW  - sphingomyelin
KW  - cerami-des
KW  - lipid metabolism
KW  - enzymology
KW  - lysosome
KW  - lysosomal hydrolases
KW  - acid ceramidase
KW  - bisphosphonates
KW  - functional inhibitors of acid sphin-gomyelinase
KW  - 1-aminodecylidene bis-phosphonic acid
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516635
SN  - 1866-8372
IS  - 6
ER  - 
TY  - JOUR
A1  - Naser, Eyad
A1  - Kadow, Stephanie
A1  - Schumacher, Fabian
A1  - Mohamed, Zainelabdeen H.
A1  - Kappe, Christian
A1  - Hessler, Gabriele
A1  - Pollmeier, Barbara
A1  - Kleuser, Burkhard
A1  - Arenz, Christoph
A1  - Becker, Katrin Anne
A1  - Gulbins, Erich
A1  - Carpinteiro, Alexander
T1  - Characterization of the small molecule ARC39
BT  - a direct and specific inhibitor of acid sphingomyelinase in vitro[S]
JF  - Journal of Lipid Research
N2  - Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases. Specific ASM inhibitors are currently not sufficiently characterized. Here, we found that 1-aminodecylidene bis-phosphonic acid (ARC39) specifically and efficiently (>90%) inhibits both lysosomal and secretory ASM in vitro. Results from investigating sphingomyelin phosphodiesterase 1 (SMPD1/Smpd1) mRNA and ASM protein levels suggested that ARC39 directly inhibits ASM's catalytic activity in cultured cells, a mechanism that differs from that of functional inhibitors of ASM. We further provide evidence that ARC39 dose- and time-dependently inhibits lysosomal ASM in intact cells, and we show that ARC39 also reduces platelet- and ASM-promoted adhesion of tumor cells. The observed toxicity of ARC39 is low at concentrations relevant for ASM inhibition in vitro, and it does not strongly alter the lysosomal compartment or induce phospholipidosis in vitro. When applied intraperitoneally in vivo, even subtoxic high doses administered short-term induced sphingomyelin accumulation only locally in the peritoneal lavage without significant accumulation in plasma, liver, spleen, or brain. These findings require further investigation with other possible chemical modifications. In conclusion, our results indicate that ARC39 potently and selectively inhibits ASM in vitro and highlight the need for developing compounds that can reach tissue concentrations sufficient for ASM inhibition in vivo.
KW  - sphingolipids
KW  - sphingomyelin
KW  - cerami-des
KW  - lipid metabolism
KW  - enzymology
KW  - lysosome
KW  - lysosomal hydrolases
KW  - acid ceramidase
KW  - bisphosphonates
KW  - functional inhibitors of acid sphin-gomyelinase
KW  - 1-aminodecylidene bis-phosphonic acid
Y1  - 2021
U6  - https://doi.org/10.1194/jlr.RA120000682
SN  - 1539-7262
SN  - 0022-2275
VL  - 61
IS  - 6
SP  - 896
EP  - 910
PB  - American Society for Biochemistry and Molecular Biology
CY  - Bethesda
ER  - 
TY  - CHAP
A1  - Kurbel, Karl
A1  - Nowak, Dawid
A1  - Azodi, Amir
A1  - Jaeger, David
A1  - Meinel, Christoph
A1  - Cheng, Feng
A1  - Sapegin, Andrey
A1  - Gawron, Marian
A1  - Morelli, Frank
A1  - Stahl, Lukas
A1  - Kerl, Stefan
A1  - Janz, Mariska
A1  - Hadaya, Abdulmasih
A1  - Ivanov, Ivaylo
A1  - Wiese, Lena
A1  - Neves, Mariana
A1  - Schapranow, Matthieu-Patrick
A1  - Fähnrich, Cindy
A1  - Feinbube, Frank
A1  - Eberhardt, Felix
A1  - Hagen, Wieland
A1  - Plauth, Max
A1  - Herscheid, Lena
A1  - Polze, Andreas
A1  - Barkowsky, Matthias
A1  - Dinger, Henriette
A1  - Faber, Lukas
A1  - Montenegro, Felix
A1  - Czachórski, Tadeusz
A1  - Nycz, Monika
A1  - Nycz, Tomasz
A1  - Baader, Galina
A1  - Besner, Veronika
A1  - Hecht, Sonja
A1  - Schermann, Michael
A1  - Krcmar, Helmut
A1  - Wiradarma, Timur Pratama
A1  - Hentschel, Christian
A1  - Sack, Harald
A1  - Abramowicz, Witold
A1  - Sokolowska, Wioletta
A1  - Hossa, Tymoteusz
A1  - Opalka, Jakub
A1  - Fabisz, Karol
A1  - Kubaczyk, Mateusz
A1  - Cmil, Milena
A1  - Meng, Tianhui
A1  - Dadashnia, Sharam
A1  - Niesen, Tim
A1  - Fettke, Peter
A1  - Loos, Peter
A1  - Perscheid, Cindy
A1  - Schwarz, Christian
A1  - Schmidt, Christopher
A1  - Scholz, Matthias
A1  - Bock, Nikolai
A1  - Piller, Gunther
A1  - Böhm, Klaus
A1  - Norkus, Oliver
A1  - Clark, Brian
A1  - Friedrich, Björn
A1  - Izadpanah, Babak
A1  - Merkel, Florian
A1  - Schweer, Ilias
A1  - Zimak, Alexander
A1  - Sauer, Jürgen
A1  - Fabian, Benjamin
A1  - Tilch, Georg
A1  - Müller, David
A1  - Plöger, Sabrina
A1  - Friedrich, Christoph M.
A1  - Engels, Christoph
A1  - Amirkhanyan, Aragats
A1  - van der Walt, Estée
A1  - Eloff, J. H. P.
A1  - Scheuermann, Bernd
A1  - Weinknecht, Elisa
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Oswald, Gerhard
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Schulzki, Bernhard
T1  - HPI Future SOC Lab
BT  - Proceedings 2015
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor.
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - künstliche Intelligenz
Y1  - 2017
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516
ER  - 
TY  - JOUR
A1  - Schenk, Matthew
A1  - Eichelmann, Fabian
A1  - Schulze, Matthias Bernd
A1  - Rudovich, Natalia
A1  - Pfeiffer, Andreas F. H.
A1  - di Giuseppe, Romina
A1  - Böing, Heiner
A1  - Aleksandrova, Krasimira
T1  - Reproducibility of novel immune-inflammatory biomarkers over 4 months
BT  - an analysis with repeated measures design
JF  - Biomarkers in medicine
N2  - Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-beta (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research.
KW  - clusterin
KW  - immune-inflammatory biomarkers
KW  - MMF
KW  - repeated measures design
KW  - reproducibility
KW  - suPAR
KW  - TGF-beta
Y1  - 2019
U6  - https://doi.org/10.2217/bmm-2018-0351
SN  - 1752-0363
SN  - 1752-0371
VL  - 13
IS  - 8
SP  - 639
EP  - 648
PB  - Future Medicine
CY  - London
ER  - 
TY  - BOOK
A1  - Zhang, Shuhao
A1  - Plauth, Max
A1  - Eberhardt, Felix
A1  - Polze, Andreas
A1  - Lehmann, Jens
A1  - Sejdiu, Gezim
A1  - Jabeen, Hajira
A1  - Servadei, Lorenzo
A1  - Möstl, Christian
A1  - Bär, Florian
A1  - Netzeband, André
A1  - Schmidt, Rainer
A1  - Knigge, Marlene
A1  - Hecht, Sonja
A1  - Prifti, Loina
A1  - Krcmar, Helmut
A1  - Sapegin, Andrey
A1  - Jaeger, David
A1  - Cheng, Feng
A1  - Meinel, Christoph
A1  - Friedrich, Tobias
A1  - Rothenberger, Ralf
A1  - Sutton, Andrew M.
A1  - Sidorova, Julia A.
A1  - Lundberg, Lars
A1  - Rosander, Oliver
A1  - Sköld, Lars
A1  - Di Varano, Igor
A1  - van der Walt, Estée
A1  - Eloff, Jan H. P.
A1  - Fabian, Benjamin
A1  - Baumann, Annika
A1  - Ermakova, Tatiana
A1  - Kelkel, Stefan
A1  - Choudhary, Yash
A1  - Cooray, Thilini
A1  - Rodríguez, Jorge
A1  - Medina-Pérez, Miguel Angel
A1  - Trejo, Luis A.
A1  - Barrera-Animas, Ari Yair
A1  - Monroy-Borja, Raúl
A1  - López-Cuevas, Armando
A1  - Ramírez-Márquez, José Emmanuel
A1  - Grohmann, Maria
A1  - Niederleithinger, Ernst
A1  - Podapati, Sasidhar
A1  - Schmidt, Christopher
A1  - Huegle, Johannes
A1  - de Oliveira, Roberto C. L.
A1  - Soares, Fábio Mendes
A1  - van Hoorn, André
A1  - Neumer, Tamas
A1  - Willnecker, Felix
A1  - Wilhelm, Mathias
A1  - Kuster, Bernhard
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Beins, Karsten
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Rödszus, Kurt
ED  - Müller, Jürgen
T1  - HPI Future SOC Lab – Proceedings 2017
T1  - HPI Future SOC Lab – Proceedings 2017
N2  - The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners.
  The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies.
  This technical report presents results of research projects executed in 2017. Selected projects have presented their results on April 25th and November 15th 2017 at the Future SOC Lab Day events.
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
  Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
  In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2017 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 25. April und 15. November 2017 im Rahmen der Future SOC Lab Tag Veranstaltungen vor.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 130 
KW  - Future SOC Lab
KW  - research projects
KW  - multicore architectures
KW  - In-Memory technology
KW  - cloud computing
KW  - machine learning
KW  - artifical intelligence
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - Künstliche Intelligenz
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-433100
SN  - 978-3-86956-475-3
SN  - 1613-5652
SN  - 2191-1665
IS  - 130
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - BOOK
A1  - Rana, Kaushik
A1  - Mohapatra, Durga Prasad
A1  - Sidorova, Julia
A1  - Lundberg, Lars
A1  - Sköld, Lars
A1  - Lopes Grim, Luís Fernando
A1  - Sampaio Gradvohl, André Leon
A1  - Cremerius, Jonas
A1  - Siegert, Simon
A1  - Weltzien, Anton von
A1  - Baldi, Annika
A1  - Klessascheck, Finn
A1  - Kalancha, Svitlana
A1  - Lichtenstein, Tom
A1  - Shaabani, Nuhad
A1  - Meinel, Christoph
A1  - Friedrich, Tobias
A1  - Lenzner, Pascal
A1  - Schumann, David
A1  - Wiese, Ingmar
A1  - Sarna, Nicole
A1  - Wiese, Lena
A1  - Tashkandi, Araek Sami
A1  - van der Walt, Estée
A1  - Eloff, Jan H. P.
A1  - Schmidt, Christopher
A1  - Hügle, Johannes
A1  - Horschig, Siegfried
A1  - Uflacker, Matthias
A1  - Najafi, Pejman
A1  - Sapegin, Andrey
A1  - Cheng, Feng
A1  - Stojanovic, Dragan
A1  - Stojnev Ilić, Aleksandra
A1  - Djordjevic, Igor
A1  - Stojanovic, Natalija
A1  - Predic, Bratislav
A1  - González-Jiménez, Mario
A1  - de Lara, Juan
A1  - Mischkewitz, Sven
A1  - Kainz, Bernhard
A1  - van Hoorn, André
A1  - Ferme, Vincenzo
A1  - Schulz, Henning
A1  - Knigge, Marlene
A1  - Hecht, Sonja
A1  - Prifti, Loina
A1  - Krcmar, Helmut
A1  - Fabian, Benjamin
A1  - Ermakova, Tatiana
A1  - Kelkel, Stefan
A1  - Baumann, Annika
A1  - Morgenstern, Laura
A1  - Plauth, Max
A1  - Eberhard, Felix
A1  - Wolff, Felix
A1  - Polze, Andreas
A1  - Cech, Tim
A1  - Danz, Noel
A1  - Noack, Nele Sina
A1  - Pirl, Lukas
A1  - Beilharz, Jossekin Jakob
A1  - De Oliveira, Roberto C. L.
A1  - Soares, Fábio Mendes
A1  - Juiz, Carlos
A1  - Bermejo, Belen
A1  - Mühle, Alexander
A1  - Grüner, Andreas
A1  - Saxena, Vageesh
A1  - Gayvoronskaya, Tatiana
A1  - Weyand, Christopher
A1  - Krause, Mirko
A1  - Frank, Markus
A1  - Bischoff, Sebastian
A1  - Behrens, Freya
A1  - Rückin, Julius
A1  - Ziegler, Adrian
A1  - Vogel, Thomas
A1  - Tran, Chinh
A1  - Moser, Irene
A1  - Grunske, Lars
A1  - Szárnyas, Gábor
A1  - Marton, József
A1  - Maginecz, János
A1  - Varró, Dániel
A1  - Antal, János Benjamin
ED  - Meinel, Christoph
ED  - Polze, Andreas
ED  - Beins, Karsten
ED  - Strotmann, Rolf
ED  - Seibold, Ulrich
ED  - Rödszus, Kurt
ED  - Müller, Jürgen
T1  - HPI Future SOC Lab – Proceedings 2018
N2  - The “HPI Future SOC Lab” is a cooperation of the Hasso Plattner Institute (HPI) and industry partners. Its mission is to enable and promote exchange and interaction between the research community and the industry partners.
  The HPI Future SOC Lab provides researchers with free of charge access to a complete infrastructure of state of the art hard and software. This infrastructure includes components, which might be too expensive for an ordinary research environment, such as servers with up to 64 cores and 2 TB main memory. The offerings address researchers particularly from but not limited to the areas of computer science and business information systems. Main areas of research include cloud computing, parallelization, and In-Memory technologies.
  This technical report presents results of research projects executed in 2018. Selected projects have presented their results on April 17th and November 14th 2017 at the Future SOC Lab Day events.
N2  - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie.
  Am Lab wird interessierten Wissenschaftler:innen eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen Systeme, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler:innen in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. 
  In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2018 vorgestellt.  Ausgewählte Projekte stellten ihre Ergebnisse am 17. April und 14. November 2018 im Rahmen des Future SOC Lab Tags vor.
T3  - Technische Berichte des Hasso-Plattner-Instituts für Digital Engineering an der Universität Potsdam - 151 
KW  - Future SOC Lab
KW  - research projects
KW  - multicore architectures
KW  - in-memory technology
KW  - cloud computing
KW  - machine learning
KW  - artifical intelligence
KW  - Future SOC Lab
KW  - Forschungsprojekte
KW  - Multicore Architekturen
KW  - In-Memory Technologie
KW  - Cloud Computing
KW  - maschinelles Lernen
KW  - künstliche Intelligenz
Y1  - 2022
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-563712
SN  - 978-3-86956-547-7
SN  - 1613-5652
SN  - 2191-1665
IS  - 151
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  -