TY  - BOOK
A1  - Andrae, Marianne
A1  - Ebert, Johannes
A1  - Garbe-von Kuczkowski, Angela
A1  - Garbe, Roland
A1  - Grabow, Christian
A1  - Klees-Wambach, Marie-Luise
A1  - Kofler, Rolf
A1  - Mittmann, Michael
A1  - Nickel, Michael
A1  - Nöthen, Thomas
A1  - Schrader-Kroschewski, Karen
A1  - Schramm, Barbara
A1  - Ulrich, Christoph
ED  - Garbe, Roland
T1  - Verfahren in Familiensachen : FamFG ; ZPO ; BGB
T3  - Nomos ProzessHandbuch
Y1  - 2009
SN  - 978-3-8329-3973-1
PB  - Nomos; Beck-Online
CY  - Baden-Baden; München
ER  - 
TY  - JOUR
A1  - Finke, Hannah
A1  - Winkelbeiner, Nicola Lisa
A1  - Lossow, Kristina
A1  - Hertel, Barbara
A1  - Wandt, Viktoria Klara Veronika
A1  - Schwarz, Maria
A1  - Pohl, Gabriele
A1  - Kopp, Johannes Florian
A1  - Ebert, Franziska
A1  - Kipp, Anna Patricia
A1  - Schwerdtle, Tanja
T1  - Effects of a Cumulative, Suboptimal Supply of Multiple Trace Elements in Mice
BT  - trace element status, genomic stability, inflammation, and epigenetics
JF  - Molecular nutrition & food research
N2  - Scope: Trace element (TE) deficiencies often occur accumulated, as nutritional intake is inadequate for several TEs, concurrently. Therefore, the impact of a suboptimal supply of iron, zinc, copper, iodine, and selenium on the TE status, health parameters, epigenetics, and genomic stability in mice are studied. Methods and results: Male mice receive reduced or adequate amounts of TEs for 9 weeks. The TE status is analyzed mass‐spectrometrically in serum and different tissues. Furthermore, gene and protein expression of TE biomarkers are assessed with focus on liver. Iron concentrations are most sensitive toward a reduced supply indicated by increased serum transferrin levels and altered hepatic expression of iron‐related genes. Reduced TE supply results in smaller weight gain but higher spleen and heart weights. Additionally, inflammatory mediators in serum and liver are increased together with hepatic genomic instability. However, global DNA (hydroxy)methylation is unaffected by the TE modulation. Conclusion: Despite homeostatic regulation of most TEs in response to a low intake, this condition still has substantial effects on health parameters. It appears that the liver and immune system react particularly sensitive toward changes in TE intake. The reduced Fe status might be the primary driver for the observed effects.
Y1  - 2020
U6  - https://doi.org/10.1002/mnfr.202000325
SN  - 1613-4125
VL  - 64
IS  - 16
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - CHAP
A1  - Wandt, Viktoria Klara Veronika
A1  - Winkelbeiner, Nicola
A1  - Loßow, Kristina
A1  - Kopp, Johannes
A1  - Simon, Luise
A1  - Ebert, Franziska
A1  - Kipp, Anna Patricia
A1  - Schwerdtle, Tanja
T1  - Trace elements, ageing, and sex. Impact on genome stability
BT  - Abstracts of the 87th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT) with contribution of the Arbeitsgemeinschaft für Angewandte Humanpharmakologie e. V. (AGAH)
T2  - Naunyn-Schmiedeberg's archives of pharmacology
Y1  - 2021
U6  - https://doi.org/10.1007/s00210-021-02066-6
SN  - 0028-1298
SN  - 1432-1912
VL  - 394
IS  - Suppl. 1
SP  - S13
EP  - S13
PB  - Springer
CY  - Berlin ; Heidelberg
ER  - 
TY  - JOUR
A1  - Müller, S. M.
A1  - Finke, Hannah
A1  - Ebert, Franziska
A1  - Kopp, Johannes Florian
A1  - Schumacher, Fabian
A1  - Kleuser, Burkhard
A1  - Francesconi, Kevin A.
A1  - Raber, G.
A1  - Schwerdtle, Tanja
T1  - Arsenic-containing hydrocarbons
BT  - effects on gene expression, epigenetics, and biotransformation in HepG2 cells
JF  - Archives of toxicology : official journal of EUROTOX
N2  - Arsenic-containing hydrocarbons (AsHCs), a subgroup of arsenolipids found in fish and algae, elicit substantial toxic effects in various human cell lines and have a considerable impact on cellular energy levels. The underlying mode of action, however, is still unknown. The present study analyzes the effects of two AsHCs (AsHC 332 and AsHC 360) on the expression of 44 genes covering DNA repair, stress response, cell death, autophagy, and epigenetics via RT-qPCR in human liver (HepG2) cells. Both AsHCs affected the gene expression, but to different extents. After treatment with AsHC 360, flap structure-specific endonuclease 1 (FEN1) as well as xeroderma pigmentosum group A complementing protein (XPA) and (cytosine-5)-methyltransferase 3A (DNMT3A) showed time- and concentration-dependent alterations in gene expression, thereby indicating an impact on genomic stability. In the subsequent analysis of epigenetic markers, within 72 h, neither AsHC 332 nor AsHC 360 showed an impact on the global DNA methylation level, whereas incubation with AsHC 360 increased the global DNA hydroxymethylation level. Analysis of cell extracts and cell media by HPLC-mass spectrometry revealed that both AsHCs were considerably biotransformed. The identified metabolites include not only the respective thioxo-analogs of the two AsHCs, but also several arsenic-containing fatty acids and fatty alcohols, contributing to our knowledge of biotransformation mechanisms of arsenolipids.
KW  - Arsenolipids
KW  - Gene expression
KW  - Arsenic-containing hydrocarbons
KW  - Global DNA methylation
KW  - Arsenic speciation
KW  - Metabolism
Y1  - 2018
U6  - https://doi.org/10.1007/s00204-018-2194-z
SN  - 0340-5761
SN  - 1432-0738
VL  - 92
IS  - 5
SP  - 1751
EP  - 1765
PB  - Springer
CY  - Heidelberg
ER  -