TY  - JOUR
A1  - Khider, D.
A1  - Emile-Geay, J.
A1  - McKay, N. P.
A1  - Gil, Y.
A1  - Garijo, D.
A1  - Ratnakar, V
A1  - Alonso-Garcia, M.
A1  - Bertrand, S.
A1  - Bothe, O.
A1  - Brewer, P.
A1  - Bunn, A.
A1  - Chevalier, M.
A1  - Comas-Bru, L.
A1  - Csank, A.
A1  - Dassie, E.
A1  - DeLong, K.
A1  - Felis, T.
A1  - Francus, P.
A1  - Frappier, A.
A1  - Gray, W.
A1  - Goring, S.
A1  - Jonkers, L.
A1  - Kahle, M.
A1  - Kaufman, D.
A1  - Kehrwald, N. M.
A1  - Martrat, B.
A1  - McGregor, H.
A1  - Richey, J.
A1  - Schmittner, A.
A1  - Scroxton, N.
A1  - Sutherland, E.
A1  - Thirumalai, Kaustubh
A1  - Allen, K.
A1  - Arnaud, F.
A1  - Axford, Y.
A1  - Barrows, T.
A1  - Bazin, L.
A1  - Birch, S. E. Pilaar
A1  - Bradley, E.
A1  - Bregy, J.
A1  - Capron, E.
A1  - Cartapanis, O.
A1  - Chiang, H-W
A1  - Cobb, K. M.
A1  - Debret, M.
A1  - Dommain, Réne
A1  - Du, J.
A1  - Dyez, K.
A1  - Emerick, S.
A1  - Erb, M. P.
A1  - Falster, G.
A1  - Finsinger, W.
A1  - Fortier, D.
A1  - Gauthier, Nicolas
A1  - George, S.
A1  - Grimm, E.
A1  - Hertzberg, J.
A1  - Hibbert, F.
A1  - Hillman, A.
A1  - Hobbs, W.
A1  - Huber, M.
A1  - Hughes, A. L. C.
A1  - Jaccard, S.
A1  - Ruan, J.
A1  - Kienast, M.
A1  - Konecky, B.
A1  - Le Roux, G.
A1  - Lyubchich, V
A1  - Novello, V. F.
A1  - Olaka, L.
A1  - Partin, J. W.
A1  - Pearce, C.
A1  - Phipps, S. J.
A1  - Pignol, C.
A1  - Piotrowska, N.
A1  - Poli, M-S
A1  - Prokopenko, A.
A1  - Schwanck, F.
A1  - Stepanek, C.
A1  - Swann, G. E. A.
A1  - Telford, R.
A1  - Thomas, E.
A1  - Thomas, Z.
A1  - Truebe, S.
A1  - von Gunten, L.
A1  - Waite, A.
A1  - Weitzel, N.
A1  - Wilhelm, B.
A1  - Williams, J.
A1  - Winstrup, M.
A1  - Zhao, N.
A1  - Zhou, Y.
T1  - PaCTS 1.0: A Crowdsourced Reporting Standard for Paleoclimate Data
JF  - Paleoceanography and paleoclimatology
N2  - The progress of science is tied to the standardization of measurements, instruments, and data. This is especially true in the Big Data age, where analyzing large data volumes critically hinges on the data being standardized. Accordingly, the lack of community-sanctioned data standards in paleoclimatology has largely precluded the benefits of Big Data advances in the field. Building upon recent efforts to standardize the format and terminology of paleoclimate data, this article describes the Paleoclimate Community reporTing Standard (PaCTS), a crowdsourced reporting standard for such data. PaCTS captures which information should be included when reporting paleoclimate data, with the goal of maximizing the reuse value of paleoclimate data sets, particularly for synthesis work and comparison to climate model simulations. Initiated by the LinkedEarth project, the process to elicit a reporting standard involved an international workshop in 2016, various forms of digital community engagement over the next few years, and grassroots working groups. Participants in this process identified important properties across paleoclimate archives, in addition to the reporting of uncertainties and chronologies; they also identified archive-specific properties and distinguished reporting standards for new versus legacy data sets. This work shows that at least 135 respondents overwhelmingly support a drastic increase in the amount of metadata accompanying paleoclimate data sets. Since such goals are at odds with present practices, we discuss a transparent path toward implementing or revising these recommendations in the near future, using both bottom-up and top-down approaches.
KW  - standards
KW  - FAIR
KW  - paleoclimate
KW  - paleoceanography
KW  - data
KW  - best practices
Y1  - 2019
U6  - https://doi.org/10.1029/2019PA003632
SN  - 2572-4517
SN  - 2572-4525
VL  - 34
IS  - 10
SP  - 1570
EP  - 1596
PB  - American Geophysical Union
CY  - Washington
ER  - 
TY  - JOUR
A1  - Srama, Ralf
A1  - Kempf, S.
A1  - Moragas-Klostermeyer, Georg
A1  - Helfert, S.
A1  - Ahrens, T. J.
A1  - Altobelli, N.
A1  - Auer, S.
A1  - Beckmann, U.
A1  - Bradley, J. G.
A1  - Burton, M.
A1  - Dikarev, V. V.
A1  - Economou, T.
A1  - Fechtig, H.
A1  - Green, S. F.
A1  - Grande, M.
A1  - Havnes, O.
A1  - Hillierf, J.K.
A1  - Horanyii, M.
A1  - Igenbergsj, E.
A1  - Jessberger, E. K.
A1  - Johnson, T. V.
A1  - Krüger, H.
A1  - Matt, G.
A1  - McBride, N.
A1  - Mocker, A.
A1  - Lamy, P.
A1  - Linkert, D.
A1  - Linkert, G.
A1  - Lura, F.
A1  - McDonnell, J.A.M.
A1  - Möhlmann, D.
A1  - Morfill, G. E.
A1  - Postberg, F.
A1  - Roy, M.
A1  - Schwehm, G.H.
A1  - Spahn, Frank
A1  - Svestka, J.
A1  - Tschernjawski, V.
A1  - Tuzzolino, A. J.
A1  - Wäsch, R.
A1  - Grün, E.
T1  - In situ dust measurements in the inner Saturnian system
JF  - Planetary and space science
N2  - In July 2004 the Cassini–Huygens mission reached the Saturnian system and started its orbital tour. A total of 75 orbits will be carried out during the primary mission until August 2008. In these four years Cassini crosses the ring plane 150 times and spends approx. 400 h within Titan's orbit. The Cosmic Dust Analyser (CDA) onboard Cassini characterises the dust environment with its extended E ring and embedded moons. Here, we focus on the CDA results of the first year and we present the Dust Analyser (DA) data within Titan's orbit. This paper does investigate High Rate Detector data and dust composition measurements. The authors focus on the analysis of impact rates, which were strongly variable primarily due to changes of the spacecraft pointing. An overview is given about the ring plane crossings and the DA counter measurements. The DA dust impact rates are compared with the DA boresight configuration around all ring plane crossings between June 2004 and July 2005. Dust impacts were registered at altitudes as high as 100 000 km above the ring plane at distances from Saturn between 4 and 10 Saturn radii. In those regions the dust density of particles bigger than 0.5 can reach values of 0.001m-3.
KW  - Cassini
KW  - dust
KW  - CDA
KW  - E-ring
KW  - water ice
Y1  - 2006
U6  - https://doi.org/10.1016/j.pss.2006.05.021
SN  - 0032-0633
VL  - 54
IS  - 9-10
SP  - 967
EP  - 987
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Srama, Ralf
A1  - Ahrens, Thomas J.
A1  - Altobelli, Nicolas
A1  - Auer, S.
A1  - Bradley, J. G.
A1  - Burton, M.
A1  - Dikarev, V. V.
A1  - Economou, T.
A1  - Fechtig, Hugo
A1  - Görlich, M.
A1  - Grande, M.
A1  - Graps, Amara
A1  - Grün, Eberhard
A1  - Havnes, Ove
A1  - Helfert, Stefan
A1  - Horanyi, Mihaly
A1  - Igenbergs, E.
A1  - Jessberger, Elmar K.
A1  - Johnson, T. V.
A1  - Kempf, Sascha
A1  - Krivov, Alexander v.
A1  - Krüger, Harald
A1  - Mocker-Ahlreep, Anna
A1  - Moragas-Klostermeyer, Georg
A1  - Lamy, Philippe
A1  - Landgraf, Markus
A1  - Linkert, Dietmar
A1  - Linkert, G.
A1  - Lura, F.
A1  - McDonnell, J. A. M.
A1  - Moehlmann, Dirk
A1  - Morfill, Gregory E.
A1  - Muller, M.
A1  - Roy, M.
A1  - Schafer, G.
A1  - Schlotzhauer, G.
A1  - Schwehm, Gerhard H.
A1  - Spahn, Frank
A1  - Stübig, M.
A1  - Svestka, Jiri
A1  - Tschernjawski, V
T1  - The Cassini Cosmic Dust Analyzer
N2  - The Cassini-Huygens Cosmic Dust Analyzer (CDA) is intended to provide direct observations of dust grains with masses between 10(-19) and 10(-9) kg in interplanetary space and in the jovian and saturnian systems, to investigate their physical, chemical and dynamical properties as functions of the distances to the Sun, to Jupiter and to Saturn and its satellites and rings, to study their interaction with the saturnian rings, satellites and magnetosphere. Chemical composition of interplanetary meteoroids will be compared with asteroidal and cometary dust, as well as with Saturn dust, ejecta from rings and satellites. Ring and satellites phenomena which might be effects of meteoroid impacts will be compared with the interplanetary dust environment. Electrical charges of particulate matter in the magnetosphere and its consequences will be studied, e.g. the effects of the ambient plasma and the magnetic held on the trajectories of dust particles as well as fragmentation of particles due to electrostatic disruption. The investigation will be performed with an instrument that measures the mass, composition, electric charge, speed, and flight direction of individual dust particles. It is a highly reliable and versatile instrument with a mass sensitivity 106 times higher than that of the Pioneer 10 and I I dust detectors which measured dust in the saturnian system. The Cosmic Dust Analyzer has significant inheritance from former space instrumentation developed for the VEGA, Giotto, Galileo, and Ulysses missions. It will reliably measure impacts from as low as I impact per month up to 104 impacts per second. The instrument weighs 17 kg and consumes 12 W, the integrated time-of-flight mass spectrometer has a mass resolution of up to 50. The nominal data transmission rate is 524 bits/s and varies between 50 and 4192 bps
Y1  - 2004
SN  - 0038-6308
ER  - 
TY  - JOUR
A1  - Arnison, Paul G.
A1  - Bibb, Mervyn J.
A1  - Bierbaum, Gabriele
A1  - Bowers, Albert A.
A1  - Bugni, Tim S.
A1  - Bulaj, Grzegorz
A1  - Camarero, Julio A.
A1  - Campopiano, Dominic J.
A1  - Challis, Gregory L.
A1  - Clardy, Jon
A1  - Cotter, Paul D.
A1  - Craik, David J.
A1  - Dawson, Michael
A1  - Dittmann-Thünemann, Elke
A1  - Donadio, Stefano
A1  - Dorrestein, Pieter C.
A1  - Entian, Karl-Dieter
A1  - Fischbach, Michael A.
A1  - Garavelli, John S.
A1  - Goeransson, Ulf
A1  - Gruber, Christian W.
A1  - Haft, Daniel H.
A1  - Hemscheidt, Thomas K.
A1  - Hertweck, Christian
A1  - Hill, Colin
A1  - Horswill, Alexander R.
A1  - Jaspars, Marcel
A1  - Kelly, Wendy L.
A1  - Klinman, Judith P.
A1  - Kuipers, Oscar P.
A1  - Link, A. James
A1  - Liu, Wen
A1  - Marahiel, Mohamed A.
A1  - Mitchell, Douglas A.
A1  - Moll, Gert N.
A1  - Moore, Bradley S.
A1  - Mueller, Rolf
A1  - Nair, Satish K.
A1  - Nes, Ingolf F.
A1  - Norris, Gillian E.
A1  - Olivera, Baldomero M.
A1  - Onaka, Hiroyasu
A1  - Patchett, Mark L.
A1  - Piel, Jörn
A1  - Reaney, Martin J. T.
A1  - Rebuffat, Sylvie
A1  - Ross, R. Paul
A1  - Sahl, Hans-Georg
A1  - Schmidt, Eric W.
A1  - Selsted, Michael E.
A1  - Severinov, Konstantin
A1  - Shen, Ben
A1  - Sivonen, Kaarina
A1  - Smith, Leif
A1  - Stein, Torsten
A1  - Suessmuth, Roderich D.
A1  - Tagg, John R.
A1  - Tang, Gong-Li
A1  - Truman, Andrew W.
A1  - Vederas, John C.
A1  - Walsh, Christopher T.
A1  - Walton, Jonathan D.
A1  - Wenzel, Silke C.
A1  - Willey, Joanne M.
A1  - van der Donk, Wilfred A.
T1  - Ribosomally synthesized and post-translationally modified peptide natural products overview and recommendations for a universal nomenclature
JF  - Natural product reports : a journal of current developments in bio-organic chemistry
N2  - This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.
Y1  - 2013
U6  - https://doi.org/10.1039/c2np20085f
SN  - 0265-0568
VL  - 30
IS  - 1
SP  - 108
EP  - 160
PB  - Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Zancolli, Giulia
A1  - Baker, Timothy G.
A1  - Barlow, Axel
A1  - Bradley, Rebecca K.
A1  - Calvete, Juan J.
A1  - Carter, Kimberley C.
A1  - de Jager, Kaylah
A1  - Owens, John Benjamin
A1  - Price, Jenny Forrester
A1  - Sanz, Libia
A1  - Scholes-Higham, Amy
A1  - Shier, Liam
A1  - Wood, Liam
A1  - Wüster, Catharine E.
A1  - Wüster, Wolfgang
T1  - Is hybridization a source of adaptive venom variation in rattlesnakes?
BT  - a test, using a crotalus scutulatus × viridis hybrid zone in southwestern New Mexico
T2  - Toxins
N2  - Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 443 
KW  - adaptation
KW  - Crotalus
KW  - evolution
KW  - hybridization
KW  - introgression
KW  - Mojave toxin
KW  - molecular evolution
KW  - venom
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-407595
ER  - 
TY  - JOUR
A1  - Zancolli, Giulia
A1  - Baker, Timothy G.
A1  - Barlow, Axel
A1  - Bradley, Rebecca K.
A1  - Calvete, Juan J.
A1  - Carter, Kimberley C.
A1  - de Jager, Kaylah
A1  - Owens, John Benjamin
A1  - Price, Jenny Forrester
A1  - Sanz, Libia
A1  - Scholes-Higham, Amy
A1  - Shier, Liam
A1  - Wood, Liam
A1  - Wüster, Catharine E.
A1  - Wüster, Wolfgang
T1  - Is Hybridization a Source of Adaptive Venom Variation in Rattlesnakes? A Test, Using a Crotalus scutulatus x viridis Hybrid Zone in Southwestern New Mexico
JF  - Toxins
N2  - Venomous snakes often display extensive variation in venom composition both between and within species. However, the mechanisms underlying the distribution of different toxins and venom types among populations and taxa remain insufficiently known. Rattlesnakes (Crotalus, Sistrurus) display extreme inter-and intraspecific variation in venom composition, centered particularly on the presence or absence of presynaptically neurotoxic phospholipases A2 such as Mojave toxin (MTX). Interspecific hybridization has been invoked as a mechanism to explain the distribution of these toxins across rattlesnakes, with the implicit assumption that they are adaptively advantageous. Here, we test the potential of adaptive hybridization as a mechanism for venom evolution by assessing the distribution of genes encoding the acidic and basic subunits of Mojave toxin across a hybrid zone between MTX-positive Crotalus scutulatus and MTX-negative C. viridis in southwestern New Mexico, USA. Analyses of morphology, mitochondrial and single copy-nuclear genes document extensive admixture within a narrow hybrid zone. The genes encoding the two MTX subunits are strictly linked, and found in most hybrids and backcrossed individuals, but not in C. viridis away from the hybrid zone. Presence of the genes is invariably associated with presence of the corresponding toxin in the venom. We conclude that introgression of highly lethal neurotoxins through hybridization is not necessarily favored by natural selection in rattlesnakes, and that even extensive hybridization may not lead to introgression of these genes into another species.
KW  - adaptation
KW  - Crotalus
KW  - evolution
KW  - hybridization
KW  - introgression
KW  - Mojave toxin
KW  - molecular evolution
KW  - venom
Y1  - 2016
U6  - https://doi.org/10.3390/toxins8060188
SN  - 2072-6651
VL  - 8
PB  - MDPI
CY  - Basel
ER  -