TY  - JOUR
A1  - Stoessel, Daniel
A1  - Schulte, Claudia
A1  - dos Santos, Marcia C. Teixeira
A1  - Scheller, Dieter
A1  - Rebollo-Mesa, Irene
A1  - Deuschle, Christian
A1  - Walther, Dirk
A1  - Schauer, Nicolas
A1  - Berg, Daniela
A1  - da Costa, Andre Nogueira
A1  - Maetzler, Walter
T1  - Promising Metabolite Profiles in the Plasma and CSF of Early Clinical
JF  - Frontiers in Aging Neuroscience
N2  - Parkinson's disease (PD) shows high heterogeneity with regard to the underlying molecular pathogenesis involving multiple pathways and mechanisms. Diagnosis is still challenging and rests entirely on clinical features. Thus, there is an urgent need for robust diagnostic biofluid markers. Untargeted metabolomics allows establishing low-molecular compound biomarkers in a wide range of complex diseases by the measurement of various molecular classes in biofluids such as blood plasma, serum, and cerebrospinal fluid (CSF). Here, we applied untargeted high-resolution mass spectrometry to determine plasma and CSF metabolite profiles. We semiquantitatively determined small-molecule levels (<= 1.5 kDa) in the plasma and CSF from early PD patients (disease duration 0-4 years; n = 80 and 40, respectively), and sex-and age-matched controls (n = 76 and 38, respectively). We performed statistical analyses utilizing partial least square and random forest analysis with a 70/30 training and testing split approach, leading to the identification of 20 promising plasma and 14 CSF metabolites. The semetabolites differentiated the test set with an AUC of 0.8 (plasma) and 0.9 (CSF). Characteristics of the metabolites indicate perturbations in the glycerophospholipid, sphingolipid, and amino acid metabolism in PD, which underscores the high power of metabolomic approaches. Further studies will enable to develop a potential metabolite-based biomarker panel specific for PD
KW  - biomarker
KW  - untargeted metabolomics
KW  - neurodegeneration
KW  - plasma
KW  - CSF
KW  - machinelearning
Y1  - 2018
U6  - https://doi.org/10.3389/fnagi.2018.00051
SN  - 1663-4365
VL  - 10
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - GEN
A1  - Ferenz, Hans-Jürgen
A1  - Peter, Martin G.
A1  - Berg, Dieter
T1  - Inhibition of farnesoic acid methyltransferase by sinefungin
N2  - Sinefungin inhibited the S-adenosylmethionine-dependent farnesoic acid methyltransferase in a cell-free system containing a homogenate of corpora allata from female locusts, Locusta migratoria. The enzyme catalyzed the penultimate step of juvenile hormone biosynthesis in the insects. Culturing corpora allata in the presence of sinefungin greatly suppressed juvenile hormone production. The following in vivo effects were visible after injection of the inhibitor: increase in mortality and reduction of total haemolymph protein liter and ovary fresh weight, as well as length of terminal oocytes. Attempts to reverse these effects by topical application of the juvenile hormone analog ZR-515 (methoprene) were only partly successful. Therefore, the in vivo effects may be due to a general inhibition of methyltransferase enzymes in the insect. Sinefungin appeared to be of potential interest as the first representative of a new class of insect growth regulators.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - paper 077 
KW  - Juvenile hormone analogue
KW  - Orthoptera
KW  - Juvenile hormone
KW  - Biosynthesis
KW  - Enzyme
KW  - Corpora allata
KW  - In vitro
KW  - Biological activity
KW  - Enzyme inhibitor
Y1  - 1983
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-17016
ER  - 
TY  - CHAP
A1  - Heinisch, Isabelle
A1  - Romeike, Ralf
A1  - Knobelsdorf, Maria
A1  - Kreitz, Christoph
A1  - Nylén, Aletta
A1  - Dörge, Christina
A1  - Göttel, Timo
A1  - Holz, Jan
A1  - Bergner, Nadine
A1  - Schroeder, Ulrik
A1  - Metzger, Christiane
A1  - Haag, Johann
A1  - Abke, Jörg
A1  - Schwirtlich, Vincent
A1  - Sedelmaier, Yvonne
A1  - Müller, Dorothee
A1  - Frommer, Andreas
A1  - Humbert, Ludger
A1  - Berges, Marc
A1  - Mühling, Andreas
A1  - Hubwieser, Peter
A1  - Steuer, Horst
A1  - Engbring, Dieter
A1  - Selke, Harald
A1  - Drews, Paul
A1  - Schirmer, Ingrid
A1  - Morisse, Marcel
A1  - Sagawe, Arno
A1  - Rolf, Arno
A1  - Friedemann, Stefan
A1  - Gröger, Stefan
A1  - Schumann, Matthias
A1  - Klinger, Melanie
A1  - Polutina, Olena
A1  - Bibel, Ariane
A1  - Götz, Christian
A1  - Brinda, Torsten
A1  - Apel, Rebecca
A1  - Berg, Tobias
A1  - Bergner, Nadine
A1  - Chatti, Mohamed Amine
A1  - Leicht-Scholten, Carmen
A1  - Schroeder, Ulrik
A1  - Al-Saffar, Loay Talib
A1  - Petre, Marian
A1  - Schirmer, Ingrid
A1  - Rick, Detlef
ED  - Forbrig, Peter
ED  - Rick, Detlef
ED  - Schmolitzky, Axel
T1  - HDI 2012 – Informatik für eine nachhaltige Zukunft : 5. Fachtagung Hochschuldidaktik der Informatik ; 06.–07. November 2012, Universität Hamburg
N2  - Die Tagungsreihe zur Hochschuldidaktik der Informatik HDI wird vom Fachbereich Informatik und Ausbildung / Didaktik der Informatik (IAD) in der Gesellschaft für Informatik e. V. (GI) organisiert. Sie dient den Lehrenden der Informatik in Studiengängen an Hochschulen als Forum der Information und des Austauschs über neue didaktische Ansätze und bildungspolitische Themen im Bereich der Hochschulausbildung aus der fachlichen Perspektive der Informatik. Diese fünfte HDI 2012 wurde an der Universität Hamburg organisiert. Für sie wurde das spezielle Motto „Informatik für eine nachhaltige Zukunft“ gewählt, um insbesondere Fragen der Bildungsrelevanz informatischer Inhalte, der Kompetenzen für Studierende informatisch geprägter Studiengänge und der Rolle der Informatik in der Hochschulentwicklung zu diskutieren.
T3  - Commentarii informaticae didacticae (CID) - 5 
Y1  - 2013
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-62891
SN  - 978-3-86956-220-9
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  -