TY  - JOUR
A1  - Fay, Doris
A1  - Bagotyriute, Ruta
A1  - Urbach, Tina
A1  - West, Michael A.
A1  - Dawson, Jeremy
T1  - Differential effects of workplace stressors on innovation
BT  - an integrated perspective of cybernetics and coping
JF  - International Journal of Stress Management
N2  - It is now consensus that engaging in innovative work behaviors is not restricted to traditional innovation jobs (e.g., research and development), but that they can be performed on a discretionary basis in most of today’s jobs. To date, our knowledge on the role of workplace stressors for discretionary innovative behavior, in particular for innovation implementation, is limited. We draw on a cybernetic view as well as on a transactional, coping-based perspective with stress to propose differential effects of stressors on innovation implementation. We propose that work demands have a positive effect on innovation implementation, whereas role-based stressors (i.e., role conflict, role ambiguity, and professional compromise) have a negative effect. We conducted a time-lagged, survey-based study in the health care sector (Study 1, United Kingdom: N = 235 nurses). Innovation implementation was measured 2 years after the assessment of the stressors. Supporting our hypotheses, work demands were positively related to subsequent innovation implementation, whereas role ambiguity and professional compromise were negatively related to subsequent innovation implementation. We also tested organizational commitment as a mediator, but there was only partial support for the mediation. To test the generalizability of the findings, we replicated the study (Study 2, Germany: employees from various professions, N = 138, time lag 2 weeks). Similar results to that in Study 1 were obtained. There was no support for strain as a mediator. Our results suggest differential effects of work demands and role stressors on innovation implementation, for which the underlying mechanism still needs to be uncovered.
KW  - innovation implementation
KW  - stressors
KW  - innovative work behavior
KW  - cybernetic stress theory
Y1  - 2019
U6  - https://doi.org/10.1037/str0000081
SN  - 1072-5245
SN  - 1573-3424
VL  - 26
IS  - 1
SP  - 11
EP  - 24
PB  - American Psychological Association
CY  - Washington
ER  - 
TY  - JOUR
A1  - Morgner, Frank
A1  - Stufler, Stefan
A1  - Geissler, Daniel
A1  - Medintz, Igor L.
A1  - Algar, W. Russ
A1  - Susumu, Kimihiro
A1  - Stewart, Michael H.
A1  - Blanco-Canosa, Juan B.
A1  - Dawson, Philip E.
A1  - Hildebrandt, Niko
T1  - Terbium to quantum dot FRET Bioconjugates for clinical diagnostics  influence of human plasma on optical and assembly properties
JF  - Sensors
N2  - Forster resonance energy transfer (FRET) from luminescent terbium complexes (LTC) as donors to semiconductor quantum dots (QDs) as acceptors allows extraordinary large FRET efficiencies due to the long Forster distances afforded. Moreover, time-gated detection permits an efficient suppression of autofluorescent background leading to sub-picomolar detection limits even within multiplexed detection formats. These characteristics make FRET-systems with LTC and QDs excellent candidates for clinical diagnostics. So far, such proofs of principle for highly sensitive multiplexed biosensing have only been performed under optimized buffer conditions and interactions between real-life clinical media such as human serum or plasma and LTC-QD-FRET-systems have not yet been taken into account. Here we present an extensive spectroscopic analysis of absorption, excitation and emission spectra along with the luminescence decay times of both the single components as well as the assembled FRET-systems in TRIS-buffer, TRIS-buffer with 2% bovine serum albumin, and fresh human plasma. Moreover, we evaluated homogeneous LTC-QD FRET assays in QD conjugates assembled with either the well-known, specific biotin-streptavidin biological interaction or, alternatively, the metal-affinity coordination of histidine to zinc. In the case of conjugates assembled with biotin-streptavidin no significant interference with the optical and binding properties occurs whereas the histidine-zinc system appears to be affected by human plasma.
KW  - FRET
KW  - quantum dots
KW  - terbium
KW  - luminescence lifetime
KW  - blood
KW  - plasma
KW  - clinical diagnostics
KW  - biotin
KW  - streptavidin
KW  - histidin
KW  - immunoassay
Y1  - 2011
U6  - https://doi.org/10.3390/s111009667
SN  - 1424-8220
VL  - 11
IS  - 10
SP  - 9667
EP  - 9684
PB  - MDPI
CY  - Basel
ER  -