TY - GEN A1 - Frieler, Katja A1 - Levermann, Anders A1 - Elliott, J. A1 - Heinke, J. A1 - Arneth, A. A1 - Bierkens, M. F. P. A1 - Ciais, Philippe A1 - Clark, D. B. A1 - Deryng, D. A1 - Doell, P. A1 - Falloon, P. A1 - Fekete, B. A1 - Folberth, Christian A1 - Friend, A. D. A1 - Gellhorn, C. A1 - Gosling, S. N. A1 - Haddeland, I. A1 - Khabarov, N. A1 - Lomas, M. A1 - Masaki, Y. A1 - Nishina, K. A1 - Neumann, K. A1 - Oki, T. A1 - Pavlick, R. A1 - Ruane, A. C. A1 - Schmid, E. A1 - Schmitz, C. A1 - Stacke, T. A1 - Stehfest, E. A1 - Tang, Q. A1 - Wisser, D. A1 - Huber, V. A1 - Piontek, Franziska A1 - Warszawski, L. A1 - Schewe, Jacob A1 - Lotze-Campen, Hermann A1 - Schellnhuber, Hans Joachim T1 - A framework for the cross-sectoral integration of multi-model impact projections BT - land use decisions under climate impacts uncertainties T2 - Earth system dynamics N2 - Climate change and its impacts already pose considerable challenges for societies that will further increase with global warming (IPCC, 2014a, b). Uncertainties of the climatic response to greenhouse gas emissions include the potential passing of large-scale tipping points (e.g. Lenton et al., 2008; Levermann et al., 2012; Schellnhuber, 2010) and changes in extreme meteorological events (Field et al., 2012) with complex impacts on societies (Hallegatte et al., 2013). Thus climate change mitigation is considered a necessary societal response for avoiding uncontrollable impacts (Conference of the Parties, 2010). On the other hand, large-scale climate change mitigation itself implies fundamental changes in, for example, the global energy system. The associated challenges come on top of others that derive from equally important ethical imperatives like the fulfilment of increasing food demand that may draw on the same resources. For example, ensuring food security for a growing population may require an expansion of cropland, thereby reducing natural carbon sinks or the area available for bio-energy production. So far, available studies addressing this problem have relied on individual impact models, ignoring uncertainty in crop model and biome model projections. Here, we propose a probabilistic decision framework that allows for an evaluation of agricultural management and mitigation options in a multi-impact-model setting. Based on simulations generated within the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP), we outline how cross-sectorally consistent multi-model impact simulations could be used to generate the information required for robust decision making. Using an illustrative future land use pattern, we discuss the trade-off between potential gains in crop production and associated losses in natural carbon sinks in the new multiple crop-and biome-model setting. In addition, crop and water model simulations are combined to explore irrigation increases as one possible measure of agricultural intensification that could limit the expansion of cropland required in response to climate change and growing food demand. This example shows that current impact model uncertainties pose an important challenge to long-term mitigation planning and must not be ignored in long-term strategic decision making. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 457 KW - global food demand KW - water availability KW - elevated CO2 KW - future KW - carbon KW - system KW - productivity KW - agriculture KW - emissions KW - scarcity Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-407968 ER - TY - JOUR A1 - Frieler, Katja A1 - Levermann, Anders A1 - Elliott, J. A1 - Heinke, Jens A1 - Arneth, A. A1 - Bierkens, M. F. P. A1 - Ciais, Philippe A1 - Clark, D. B. A1 - Deryng, D. A1 - Doell, P. A1 - Falloon, P. A1 - Fekete, B. A1 - Folberth, Christian A1 - Friend, A. D. A1 - Gellhorn, C. A1 - Gosling, S. N. A1 - Haddeland, I. A1 - Khabarov, N. A1 - Lomas, M. A1 - Masaki, Y. A1 - Nishina, K. A1 - Neumann, K. A1 - Oki, T. A1 - Pavlick, R. A1 - Ruane, A. C. A1 - Schmid, E. A1 - Schmitz, C. A1 - Stacke, T. A1 - Stehfest, E. A1 - Tang, Q. A1 - Wisser, D. A1 - Huber, Veronika A1 - Piontek, Franziska A1 - Warszawski, Lila A1 - Schewe, Jacob A1 - Lotze-Campen, Hermann A1 - Schellnhuber, Hans Joachim T1 - A framework for the cross-sectoral integration of multi-model impact projections BT - land use decisions under climate impacts uncertainties JF - Earth system dynamics N2 - Climate change and its impacts already pose considerable challenges for societies that will further increase with global warming (IPCC, 2014a, b). Uncertainties of the climatic response to greenhouse gas emissions include the potential passing of large-scale tipping points (e.g. Lenton et al., 2008; Levermann et al., 2012; Schellnhuber, 2010) and changes in extreme meteorological events (Field et al., 2012) with complex impacts on societies (Hallegatte et al., 2013). Thus climate change mitigation is considered a necessary societal response for avoiding uncontrollable impacts (Conference of the Parties, 2010). On the other hand, large-scale climate change mitigation itself implies fundamental changes in, for example, the global energy system. The associated challenges come on top of others that derive from equally important ethical imperatives like the fulfilment of increasing food demand that may draw on the same resources. For example, ensuring food security for a growing population may require an expansion of cropland, thereby reducing natural carbon sinks or the area available for bio-energy production. So far, available studies addressing this problem have relied on individual impact models, ignoring uncertainty in crop model and biome model projections. Here, we propose a probabilistic decision framework that allows for an evaluation of agricultural management and mitigation options in a multi-impact-model setting. Based on simulations generated within the Inter-Sectoral Impact Model Intercomparison Project (ISI-MIP), we outline how cross-sectorally consistent multi-model impact simulations could be used to generate the information required for robust decision making. Using an illustrative future land use pattern, we discuss the trade-off between potential gains in crop production and associated losses in natural carbon sinks in the new multiple crop-and biome-model setting. In addition, crop and water model simulations are combined to explore irrigation increases as one possible measure of agricultural intensification that could limit the expansion of cropland required in response to climate change and growing food demand. This example shows that current impact model uncertainties pose an important challenge to long-term mitigation planning and must not be ignored in long-term strategic decision making. Y1 - 2015 U6 - https://doi.org/10.5194/esd-6-447-2015 SN - 2190-4979 SN - 2190-4987 VL - 6 IS - 2 SP - 447 EP - 460 PB - Copernicus CY - Göttingen ER - TY - JOUR A1 - Chipman, Ariel D. A1 - Ferrier, David E. K. A1 - Brena, Carlo A1 - Qu, Jiaxin A1 - Hughes, Daniel S. T. A1 - Schroeder, Reinhard A1 - Torres-Oliva, Montserrat A1 - Znassi, Nadia A1 - Jiang, Huaiyang A1 - Almeida, Francisca C. A1 - Alonso, Claudio R. A1 - Apostolou, Zivkos A1 - Aqrawi, Peshtewani A1 - Arthur, Wallace A1 - Barna, Jennifer C. J. A1 - Blankenburg, Kerstin P. A1 - Brites, Daniela A1 - Capella-Gutierrez, Salvador A1 - Coyle, Marcus A1 - Dearden, Peter K. A1 - Du Pasquier, Louis A1 - Duncan, Elizabeth J. A1 - Ebert, Dieter A1 - Eibner, Cornelius A1 - Erikson, Galina A1 - Evans, Peter D. A1 - Extavour, Cassandra G. A1 - Francisco, Liezl A1 - Gabaldon, Toni A1 - Gillis, William J. A1 - Goodwin-Horn, Elizabeth A. A1 - Green, Jack E. A1 - Griffiths-Jones, Sam A1 - Grimmelikhuijzen, Cornelis J. P. A1 - Gubbala, Sai A1 - Guigo, Roderic A1 - Han, Yi A1 - Hauser, Frank A1 - Havlak, Paul A1 - Hayden, Luke A1 - Helbing, Sophie A1 - Holder, Michael A1 - Hui, Jerome H. L. A1 - Hunn, Julia P. A1 - Hunnekuhl, Vera S. A1 - Jackson, LaRonda A1 - Javaid, Mehwish A1 - Jhangiani, Shalini N. A1 - Jiggins, Francis M. A1 - Jones, Tamsin E. A1 - Kaiser, Tobias S. A1 - Kalra, Divya A1 - Kenny, Nathan J. A1 - Korchina, Viktoriya A1 - Kovar, Christie L. A1 - Kraus, F. Bernhard A1 - Lapraz, Francois A1 - Lee, Sandra L. A1 - Lv, Jie A1 - Mandapat, Christigale A1 - Manning, Gerard A1 - Mariotti, Marco A1 - Mata, Robert A1 - Mathew, Tittu A1 - Neumann, Tobias A1 - Newsham, Irene A1 - Ngo, Dinh N. A1 - Ninova, Maria A1 - Okwuonu, Geoffrey A1 - Ongeri, Fiona A1 - Palmer, William J. A1 - Patil, Shobha A1 - Patraquim, Pedro A1 - Pham, Christopher A1 - Pu, Ling-Ling A1 - Putman, Nicholas H. A1 - Rabouille, Catherine A1 - Ramos, Olivia Mendivil A1 - Rhodes, Adelaide C. A1 - Robertson, Helen E. A1 - Robertson, Hugh M. A1 - Ronshaugen, Matthew A1 - Rozas, Julio A1 - Saada, Nehad A1 - Sanchez-Gracia, Alejandro A1 - Scherer, Steven E. A1 - Schurko, Andrew M. A1 - Siggens, Kenneth W. A1 - Simmons, DeNard A1 - Stief, Anna A1 - Stolle, Eckart A1 - Telford, Maximilian J. A1 - Tessmar-Raible, Kristin A1 - Thornton, Rebecca A1 - van der Zee, Maurijn A1 - von Haeseler, Arndt A1 - Williams, James M. A1 - Willis, Judith H. A1 - Wu, Yuanqing A1 - Zou, Xiaoyan A1 - Lawson, Daniel A1 - Muzny, Donna M. A1 - Worley, Kim C. A1 - Gibbs, Richard A. A1 - Akam, Michael A1 - Richards, Stephen T1 - The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima JF - PLoS biology N2 - Myriapods (e. g., centipedes and millipedes) display a simple homonomous body plan relative to other arthropods. All members of the class are terrestrial, but they attained terrestriality independently of insects. Myriapoda is the only arthropod class not represented by a sequenced genome. We present an analysis of the genome of the centipede Strigamia maritima. It retains a compact genome that has undergone less gene loss and shuffling than previously sequenced arthropods, and many orthologues of genes conserved from the bilaterian ancestor that have been lost in insects. Our analysis locates many genes in conserved macro-synteny contexts, and many small-scale examples of gene clustering. We describe several examples where S. maritima shows different solutions from insects to similar problems. The insect olfactory receptor gene family is absent from S. maritima, and olfaction in air is likely effected by expansion of other receptor gene families. For some genes S. maritima has evolved paralogues to generate coding sequence diversity, where insects use alternate splicing. This is most striking for the Dscam gene, which in Drosophila generates more than 100,000 alternate splice forms, but in S. maritima is encoded by over 100 paralogues. We see an intriguing linkage between the absence of any known photosensory proteins in a blind organism and the additional absence of canonical circadian clock genes. The phylogenetic position of myriapods allows us to identify where in arthropod phylogeny several particular molecular mechanisms and traits emerged. For example, we conclude that juvenile hormone signalling evolved with the emergence of the exoskeleton in the arthropods and that RR-1 containing cuticle proteins evolved in the lineage leading to Mandibulata. We also identify when various gene expansions and losses occurred. The genome of S. maritima offers us a unique glimpse into the ancestral arthropod genome, while also displaying many adaptations to its specific life history. Y1 - 2014 U6 - https://doi.org/10.1371/journal.pbio.1002005 SN - 1545-7885 VL - 12 IS - 11 PB - PLoS CY - San Fransisco ER - TY - JOUR A1 - Scheerer-Neumann, Gerheid A1 - Schnitzler, Carola D. T1 - Die Potsdamer Bilderliste : ein Verfahren zur Ermittlung der Entwicklungsstufen beim Schriftspracherwerb in den Klasse 2 und 3 Y1 - 2007 SN - 978-3-531-15623-1 ER - TY - BOOK A1 - Schnitzler, Carola D. A1 - Scheerer-Neumann, Gerheide A1 - Ritter, Christiane A1 - Prengel, Annedore T1 - Individuelle Lernstandsanalysen (ILeA) 3 - 6 : Lesen ; Lehrerheft Y1 - 2007 PB - Landesinstitut für Schule und Medien Brandenburg CY - Ludwigsfelde ER - TY - BOOK A1 - Scheerer-Neumann, Gerheid A1 - Schnitzler, Carola D. A1 - Ritter, Christiane A1 - Prengel, Annedore T1 - Individuelle Lernstandsanalysen (ILeA) 2 : Rechtschreiben ; Lehrerheft Y1 - 2007 PB - Landesinstitut für Schule und Medien Brandenburg CY - Ludwigsfelde ER - TY - BOOK A1 - Scheerer-Neumann, Gerheid A1 - Hübner, Anita A1 - Mühlbauer, Evelyn A1 - Schnitzler, Carola D. A1 - Prengel, Annedore T1 - Individuelle Lernstandsanalysen (ILeA) 3 - 5 : Rechtschreiben ; Lehrerheft Y1 - 2007 PB - Landesinstitut für Schule und Medien Brandenburg CY - Ludwigsfelde ER - TY - BOOK A1 - Scheerer-Neumann, Gerheid A1 - Schnitzler, Carola D. A1 - Ritter, Christiane A1 - Prengel, Annedore T1 - Individuelle Lernstandsanalysen (ILeA) 2 : Lesen; Lehrerheft Y1 - 2007 PB - Landesinstitut für Schule und Medien Brandenburg CY - Ludwigsfelde ER - TY - BOOK A1 - Scheerer-Neumann, Gerheid A1 - Hübner, Anita A1 - Mühlbauer, Evelyn A1 - Schnitzler, Carola D. A1 - Ritter, Christiane T1 - Individuelle Lernstandsanalysen (ILeA) 5 : Deutsch ; Schülerheft Y1 - 2007 PB - Landesinstitut für Schule und Medien Brandenburg CY - Ludwigsfelde ER - TY - BOOK A1 - Scheerer-Neumann, Gerheid A1 - Schnitzler, Carola D. A1 - Ritter, Christiane T1 - Individuelle Lernstandsanalysen (ILeA) 2 : Deutsch ; Schülerheft Y1 - 2007 PB - Landesinstitut für Schule und Medien Brandenburg CY - Ludwigsfelde ER - TY - BOOK A1 - Scheerer-Neumann, Gerheid A1 - Schnitzler, Carola D. T1 - Café der Tiere : das Buchstabenbuch für Vorschulkinder und Schulanfänger N2 - Mithilfe dieses Buches sollen Kinder ihre Lernvoraussetzungen für den Schriftspracherwerb optimieren, indem sie spielerisch Einsicht in die lautliche Struktur der gesprochenen Sprache gewinnen und erste Buchstaben-Laut- Beziehungen kennen lernen. Y1 - 2005 SN - 3-7800-5226-1 PB - Kallmeyer bei Friedrich CY - Seelze ER - TY - JOUR A1 - Christensen, B. J. A1 - Lentz, R. A1 - Mortensen, D. T. A1 - Neumann, G. R. A1 - Werwatz, A. T1 - On-the-job search and the wage distribution N2 - The article structually estimates an on-the-job search model of job separations. Given each employer pays observably equivalent workers the same but wages are dispersed across employers, an employer's separation flow is the sum of an exogenous outflow unrelated to the wage and a job-to-job flow that decreases with the employer's wage. Using data from the Danish Integrated Database for Labour Market Research, the empirical results imply, as predicted by theory, that search effort declines with the wage. Furthermore, the estimates explain the employment effect, defined as the horizontal difference between the distribution of wages earned and the wage offer distribution Y1 - 2005 SN - 0734-306X ER - TY - JOUR A1 - Radbruch, Moritz A1 - Pischon, Hannah A1 - Ostrowski, Anja A1 - Volz, Pierre A1 - Brodwolf, Robert A1 - Neumann, Falko A1 - Unbehauen, Michael A1 - Kleuser, Burkhard A1 - Haag, Rainer A1 - Ma, Nan A1 - Alexiev, Ulrike A1 - Mundhenk, Lars A1 - Gruber, Achim D. T1 - Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin JF - Nanoscale Research Letters N2 - Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters, e. g., to facilitate topical therapy in skin diseases. Atopic dermatitis is among the most common inflammatory skin disorders with complex barrier alterations which may affect the efficacy of topical treatment. Here, we tested the penetration behavior and identified target structures of unloaded CMS after topical administration in healthy mice and in mice with oxazolone-induced atopic dermatitis. We further examined whole body distribution and possible systemic side effects after simulating high dosage dermal penetration by subcutaneous injection. Following topical administration, CMS accumulated in the stratum corneum without penetration into deeper viable epidermal layers. The same was observed in atopic dermatitis mice, indicating that barrier alterations in atopic dermatitis had no influence on the penetration of CMS. Following subcutaneous injection, CMS were deposited in the regional lymph nodes as well as in liver, spleen, lung, and kidney. However, in vitro toxicity tests, clinical data, and morphometry-assisted histopathological analyses yielded no evidence of any toxic or otherwise adverse local or systemic effects of CMS, nor did they affect the severity or course of atopic dermatitis. Taken together, CMS accumulate in the stratum corneum in both healthy and inflammatory skin and appear to be highly biocompatible in the mouse even under conditions of atopic dermatitis and thus could potentially serve to create a depot for anti-inflammatory drugs in the skin. KW - CMS KW - Skin KW - Topical treatment KW - Dermal delivery KW - Atopic dermatitis KW - Oxazolone KW - Fluorescence lifetime imaging microscopy KW - Nanomaterials KW - Multi-domain nanoparticles KW - Penetration enhancement Y1 - 2017 U6 - https://doi.org/10.1186/s11671-017-1835-0 SN - 1556-276X VL - 12 IS - 64 PB - Springer CY - New York ER - TY - JOUR A1 - Senarath Nanayakkara, G. L. A1 - Neumann, Klaus D. A1 - Pohlenz, Philipp T1 - Quality assurance in Sri Lankan Teacher Training BT - evaluation procedures for the assessment of the internship period JF - Potsdamer Beiträge zur Lehrevaluation N2 - In 2002 guidelines for the implementation of the internship programme for prospective teachers have been released in a joint venture by the Basic Education Sector Programme(BESP) of the GTZ (Gesellschaft für Technische Zusammenarbeit/German Technical Cooperation) and the Professional Development Centre (Teacher Education) of the National Institute for Education of Sri Lanka (NIE). These guidelines aim at assisting the National Colleges of Education (NCOEs) and internship schools in implementing the internship programme and at improving its efficiency and effectiveness in the local venues of teacher training. The Monitoring & Evaluation activity described in the present article was to assess as to how far the intentions originally associated with the internship programme are being accomplished. Its main task is to bring strengths and weaknesses of the programme to light and to appraise the current status of its implementation. KW - Qualitätssicherung KW - Lehrerbildung KW - Evaluation Y1 - 2006 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-22017 SN - 3-937786-08-2 SN - 1614-0273 SN - 1862-8664 VL - 2 SP - 301 EP - 319 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Grott, Matthias A1 - Knollenberg, J. A1 - Hamm, M. A1 - Ogawa, K. A1 - Jaumann, R. A1 - Otto, Katharina Alexandra A1 - Delbo, M. A1 - Michel, Patrick A1 - Biele, J. A1 - Neumann, Wladimir A1 - Knapmeyer, Martin A1 - Kührt, E. A1 - Senshu, H. A1 - Okada, T. A1 - Helbert, Jorn A1 - Maturilli, A. A1 - Müller, N. A1 - Hagermann, A. A1 - Sakatani, Naoya A1 - Tanaka, S. A1 - Arai, T. A1 - Mottola, Stefano A1 - Tachibana, Shogo A1 - Pelivan, Ivanka A1 - Drube, Line A1 - Vincent, J-B A1 - Yano, Hajime A1 - Pilorget, C. A1 - Matz, K. D. A1 - Schmitz, N. A1 - Koncz, A. A1 - Schröder, Stefan E. A1 - Trauthan, F. A1 - Schlotterer, Markus A1 - Krause, C. A1 - Ho, T-M A1 - Moussi-Soffys, A. T1 - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu JF - Nature astronomy N2 - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7 Y1 - 2019 U6 - https://doi.org/10.1038/s41550-019-0832-x SN - 2397-3366 VL - 3 IS - 11 SP - 971 EP - 976 PB - Nature Publishing Group CY - London ER - TY - JOUR A1 - Grott, Matthias A1 - Knollenberg, J. A1 - Hamm, M. A1 - Ogawa, K. A1 - Jaumann, R. A1 - Otto, Katharina Alexandra A1 - Delbo, M. A1 - Michel, P. A1 - Biele, J. A1 - Neumann, W. A1 - Knapmeyer, M. A1 - Kuehrt, E. A1 - Senshu, H. A1 - Okada, T. A1 - Helbert, J. A1 - Maturilli, A. A1 - Müller, N. A1 - Hagermann, A. A1 - Sakatani, N. A1 - Tanaka, S. A1 - Arai, T. A1 - Mottola, S. A1 - Tachibana, S. A1 - Pelivan, Ivanka A1 - Drube, L. A1 - Vincent, J-B A1 - Yano, H. A1 - Pilorget, C. A1 - Matz, K. D. A1 - Schmitz, N. A1 - Koncz, A. A1 - Schröder, S. E. A1 - Trauthan, F. A1 - Schlotterer, M. A1 - Krause, C. A1 - Ho, T-M A1 - Moussi-Soffys, A. T1 - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu JF - Nature astronomy N2 - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7. Y1 - 2020 U6 - https://doi.org/10.1038/s41550-019-0832-x SN - 2397-3366 VL - 3 IS - 11 SP - 971 EP - 976 PB - Nature Publishing Group CY - London ER - TY - JOUR A1 - Riedel, K. A1 - Beyersdorf-Radeck, Baerbel A1 - Neumann, B. A1 - Scheller, Frieder W. A1 - Schmid, Rolf D. T1 - Microbial sensors for determination of aromatics and their chloro derivatives. Part III: Determination of chlorinated phenols using a biosensor containing Trichosporon beigelii (cutaneum) Y1 - 1995 ER - TY - JOUR A1 - Lattemann, Christoph A1 - Neumann, D. T1 - Clearing und Settlement im Wandel : eine Perspektive für den europäischen Wertpapierhandel Y1 - 2002 ER - TY - GEN A1 - Radbruch, Moritz A1 - Pischon, Hannah A1 - Ostrowski, Anja A1 - Volz, Pierre A1 - Brodwolf, Robert A1 - Neumann, Falko A1 - Unbehauen, Michael A1 - Kleuser, Burkhard A1 - Haag, Rainer A1 - Ma, Nan A1 - Alexiev, Ulrike A1 - Mundhenk, Lars A1 - Gruber, Achim D. T1 - Dendritic core-multishell nanocarriers in murine models of healthy and atopic skin T2 - Postprints der Universität Potsdam Mathematisch-Naturwissenschaftliche Reihe N2 - Dendritic hPG-amid-C18-mPEG core-multishell nanocarriers (CMS) represent a novel class of unimolecular micelles that hold great potential as drug transporters, e. g., to facilitate topical therapy in skin diseases. Atopic dermatitis is among the most common inflammatory skin disorders with complex barrier alterations which may affect the efficacy of topical treatment. Here, we tested the penetration behavior and identified target structures of unloaded CMS after topical administration in healthy mice and in mice with oxazolone-induced atopic dermatitis. We further examined whole body distribution and possible systemic side effects after simulating high dosage dermal penetration by subcutaneous injection. Following topical administration, CMS accumulated in the stratum corneum without penetration into deeper viable epidermal layers. The same was observed in atopic dermatitis mice, indicating that barrier alterations in atopic dermatitis had no influence on the penetration of CMS. Following subcutaneous injection, CMS were deposited in the regional lymph nodes as well as in liver, spleen, lung, and kidney. However, in vitro toxicity tests, clinical data, and morphometry-assisted histopathological analyses yielded no evidence of any toxic or otherwise adverse local or systemic effects of CMS, nor did they affect the severity or course of atopic dermatitis. Taken together, CMS accumulate in the stratum corneum in both healthy and inflammatory skin and appear to be highly biocompatible in the mouse even under conditions of atopic dermatitis and thus could potentially serve to create a depot for anti-inflammatory drugs in the skin. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 724 KW - CMS KW - skin KW - topical treatment KW - dermal delivery KW - atopic dermatitis KW - oxazolone KW - fluorescence lifetime imaging microscopy KW - nanomaterials KW - multi-domain nanoparticles KW - penetration enhancement Y1 - 2019 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-430136 SN - 1866-8372 IS - 724 ER - TY - JOUR A1 - Scheller, Frieder W. A1 - Kleinjung, Frank A1 - Bier, Frank Fabian A1 - Markower, Alexander A1 - Neumann, Barbara A1 - Wollenberger, Ursula A1 - Kurochkin, Iliya N. A1 - Eremenko, Arkadi V. A1 - Barmin, Anatoli V. A1 - Klußmann, Sven A1 - Fürste, Jens-Peter A1 - Erdmann, Volker A. A1 - Mansuy, D. T1 - New recognition elements in biosensing Y1 - 1998 ER - TY - JOUR A1 - Baldermann, Susanne A1 - Blagojevic, Lara A1 - Frede, Katja A1 - Klopsch, R. A1 - Neugart, Susanne A1 - Neumann, A. A1 - Ngwene, Benard A1 - Norkeweit, Jessica A1 - Schroeter, D. A1 - Schroeter, A. A1 - Schweigert, Florian J. A1 - Wiesner, M. A1 - Schreiner, Monika T1 - Are Neglected Plants the Food for the Future? JF - Critical reviews in plant sciences N2 - Malnutrition, poor health, hunger, and even starvation are still the world's greatest challenges. Malnutrition is defined as deficiency of nutrition due to not ingesting the proper amounts of nutrients by simply not eating enough food and/or by consuming nutrient-poor food in respect to the daily nutritional requirements. Moreover, malnutrition and disease are closely associated and incidences of such diet-related diseases increase particularly in low- and middle-income states. While foods of animal origin are often unaffordable to low-income families, various neglected crops can offer an alternative source of micronutrients, vitamins, as well as health-promoting secondary plant metabolites. Therefore, agricultural and horticultural research should develop strategies not only to produce more food, but also to improve access to more nutritious food. In this context, one promising approach is to promote biodiversity in the dietary pattern of low-income people by getting access to nutritional as well as affordable food and providing recommendations for food selection and preparation. Worldwide, a multitude of various plant species are assigned to be consumed as grains, vegetables, and fruits, but only a limited number of these species are used as commercial cash crops. Consequently, numerous neglected and underutilized species offer the potential to diversify not only the human diet, but also increase food production levels, and, thus, enable more sustainable and resilient agro- and horti-food systems. To exploit the potential of neglected plant (NP) species, coordinated approaches on the local, regional, and international level have to be integrated that consequently demand the involvement of numerous multi-stakeholders. Thus, the objective of the present review is to evaluate whether NP species are important as “Future Food” for improving the nutritional status of humans as well as increasing resilience of agro- and horti-food systems. KW - Fruits KW - malnutrition KW - orphan crops KW - underutilized species KW - vegetables Y1 - 2016 U6 - https://doi.org/10.1080/07352689.2016.1201399 SN - 0735-2689 SN - 1549-7836 VL - 35 SP - 106 EP - 119 PB - Institut d'Estudis Catalans CY - Philadelphia ER - TY - JOUR A1 - Luft, Laura A1 - Neumann, C. A1 - Itzerott, S. A1 - Lausch, A. A1 - Doktor, D. A1 - Freude, M. A1 - Blaum, Niels A1 - Jeltsch, Florian T1 - Digital and real-habitat modeling of Hipparchia statilinus based on hyper spectral remote sensing data JF - International journal of environmental science and technology N2 - The abandonment of military areas leads to succession processes affecting valuable open-land habitats and is considered to be a major threat for European butterflies. We assessed the ability of hyper spectral remote sensing data to spatially predict the occurrence of one of the most endangered butterfly species (Hipparchia statilinus) in Brandenburg (Germany) on the basis of habitat characteristics at a former military training area. Presence-absence data were sampled on a total area of 36 km(2), and N = 65 adult individuals of Hipparchia statilinus could be detected. The floristic composition within the study area was modeled in a three-dimensional ordination space. Occurrence probabilities for the target species were predicted as niches between ordinated floristic gradients by using Regression Kriging of Indicators. Habitat variance could be explained by up to 81 % with spectral variables at a spatial resolution of 2 x 2 m by transferring PLSR models to imagery. Ordinated ecological niche of Hipparchia statilinus was tested against environmental predictor variables. N = 6 variables could be detected to be significantly correlated with habitat preferences of Hipparchia statilinus. They show that Hipparchia statilinus can serve as a valuable indicator for the evaluation of the conservation status of Natura 2000 habitat type 2330 (inland dunes with open Corynephorus and Agrostis grasslands) protected by the Habitat Directive (Council Directive 92/43/EEC). The authors of this approach, conducted in August 2013 at Doberitzer Heide Germany, aim to increase the value of remote sensing as an important tool for questions of biodiversity research and conservation. KW - Habitat gradients KW - Military areas KW - Natura 2000 KW - hyper spectral KW - Vegetation continuum KW - Kriging Y1 - 2016 U6 - https://doi.org/10.1007/s13762-015-0859-1 SN - 1735-1472 SN - 1735-2630 VL - 13 SP - 187 EP - 200 PB - Springer CY - New York ER -