TY  - JOUR
A1  - Abdalla, H.
A1  - Adam, R.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Armstrong, T.
A1  - Ashkar, H.
A1  - Backes, M.
A1  - Baghmanyan, V.
A1  - Martins, V. Barbosa
A1  - Barnacka, A.
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Berge, D.
A1  - Bernlohr, K.
A1  - Bi, B.
A1  - Bottcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - de Lavergne, M. de Bony
A1  - Bordas, Pol
A1  - Breuhaus, M.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Buchele, M.
A1  - Bulik, T.
A1  - Bylund, T.
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Chand, T.
A1  - Chandra, S.
A1  - Chen, A.
A1  - Cotter, G.
A1  - Curylo, M.
A1  - Mbarubucyeye, J. Damascene
A1  - Davids, I. D.
A1  - Davies, J.
A1  - Deil, C.
A1  - Devin, J.
A1  - deWilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, A.
A1  - Doroshenko, V.
A1  - Duffy, C.
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Eichhorn, F.
A1  - Einecke, S.
A1  - Emery, G.
A1  - Ernenwein, J. -P.
A1  - Feijen, K.
A1  - Fegan, S.
A1  - Fiasson, A.
A1  - de Clairfontaine, G. Fichet
A1  - Fontaine, G.
A1  - Funk, S.
A1  - Fussling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Giavitto, G.
A1  - Giunti, L.
A1  - Glawion, D.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M. -H.
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Hermann, G.
A1  - Hinton, J. A.
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, T. L.
A1  - Holler, M.
A1  - Horbe, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Jamrozy, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jardin-Blicq, A.
A1  - Joshi, V.
A1  - Jung-Richardt, I.
A1  - Kasai, E.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu.
A1  - Konno, R.
A1  - Kosack, K.
A1  - Kostunin, D.
A1  - Kreter, M.
A1  - Lamanna, G.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Levy, C.
A1  - Lohse, T.
A1  - Lypova, I.
A1  - Mackey, J.
A1  - Majumdar, J.
A1  - Malyshev, D.
A1  - Malyshev, D.
A1  - Marandon, V.
A1  - Marchegiani, P.
A1  - Marcowith, Alexandre
A1  - Mares, A.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Meyer, M.
A1  - Mitchell, A.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Montanari, A.
A1  - Moore, C.
A1  - Morris, P.
A1  - Moulin, Emmanuel
A1  - Muller, J.
A1  - Murach, T.
A1  - Nakashima, K.
A1  - Nayerhoda, A.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - O'Brien, Patrick
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Olivera-Nieto, L.
A1  - Wilhelmi, E. de Ona
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Panny, S.
A1  - Parsons, R. D.
A1  - Peron, G.
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V.
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puhlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reichherzer, P.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Remy, Q.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V.
A1  - Sailer, S.
A1  - Sanchez, D. A.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Scalici, M.
A1  - Schussler, F.
A1  - Schutte, H. M.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Specovius, A.
A1  - Spencer, S.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Sun, L.
A1  - Steenkamp, R.
A1  - Stegmann, C.
A1  - Steinmassl, S.
A1  - Steppa, C.
A1  - Takahashi, T.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Tomankova, L.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Volk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Watson, J.
A1  - Werner, F.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wong, Yu Wun
A1  - Yusafzai, A.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zargaryan, D.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zhu, S. J.
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zouari, S.
A1  - Zywucka, N.
T1  - An extreme particle accelerator in the Galactic plane
BT  - HESS J1826-130
JF  - Astronomy and astrophysics : an international weekly journal
N2  - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02 <br /> (stat)degrees <br /> stat degrees +/- 0.05 <br /> (sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2 <br /> (+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW  - ISM: supernova remnants
KW  - ISM: clouds
KW  - gamma rays: general
KW  - gamma rays:
KW  - ISM
Y1  - 2020
U6  - https://doi.org/10.1051/0004-6361/202038851
SN  - 0004-6361
SN  - 1432-0746
VL  - 644
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Anguener, E. O.
A1  - Arakawa, M.
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Ashkar, H.
A1  - Backes, M.
A1  - Martins, V. Barbosa
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Berge, D.
A1  - Bernloehr, K.
A1  - Blackwell, R.
A1  - Boettcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - Bonnefoy, S.
A1  - Bregeon, J.
A1  - Breuhaus, M.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Buechele, M.
A1  - Bulik, T.
A1  - Bylund, T.
A1  - Capasso, M.
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Cerruti, M.
A1  - Chakraborty, N.
A1  - Chand, T.
A1  - Chandra, S.
A1  - Chaves, R. C. G.
A1  - Chen, A.
A1  - Colafrancesco, S.
A1  - Curylo, M.
A1  - Davids, I. D.
A1  - Deil, C.
A1  - Devin, J.
A1  - de Wilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, A.
A1  - Doroshenko, V
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Emery, G.
A1  - Ernenwein, J-p
A1  - Eschbach, S.
A1  - Feijen, K.
A1  - Fegan, S.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Funk, S.
A1  - Fuessling, M.
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Gate, F.
A1  - Giavitto, G.
A1  - Glawion, D.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M-H
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, Tim Lukas
A1  - Holler, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Iwasaki, H.
A1  - Jamrozy, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jung-Richardt, I
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - King, J.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu
A1  - Kosack, K.
A1  - Kostunin, D.
A1  - Kraus, M.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J-P
A1  - Leser, Eva
A1  - Levy, C.
A1  - Lohse, T.
A1  - Lopez-Coto, R.
A1  - Lypova, I
A1  - Mackey, J.
A1  - Majumdar, J.
A1  - Malyshev, D.
A1  - Marandon, V
A1  - Marcowith, Alexandre
A1  - Mares, A.
A1  - Mariaud, C.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Muller, J.
A1  - Moore, C.
A1  - Moulin, Emmanuel
A1  - Murach, T.
A1  - Nakashima, S.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Wilhelmi, E. de Ona
A1  - Ostrowski, M.
A1  - Oya, I
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Perennes, C.
A1  - Petrucci, P-O
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Remy, Q.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V
A1  - Saito, S.
A1  - Sanchez, David M.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schussler, F.
A1  - Schulz, A.
A1  - Schutte, H.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Specovius, A.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steppa, Constantin Beverly
A1  - Takahashi, T.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Yang, R.
A1  - Yoneda, H.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zywucka, N.
A1  - Maxted, N.
T1  - Upper limits on very-high-energy gamma-ray emission from core-collapse supernovae observed with H.E.S.S.
JF  - Astronomy and astrophysics : an international weekly journal
N2  - Young core-collapse supernovae with dense-wind progenitors may be able to accelerate cosmic-ray hadrons beyond the knee of the cosmic-ray spectrum, and this may result in measurable gamma-ray emission. We searched for gamma-ray emission from ten super- novae observed with the High Energy Stereoscopic System (H.E.S.S.) within a year of the supernova event. Nine supernovae were observed serendipitously in the H.E.S.S. data collected between December 2003 and December 2014, with exposure times ranging from 1.4 to 53 h. In addition we observed SN 2016adj as a target of opportunity in February 2016 for 13 h. No significant gamma-ray emission has been detected for any of the objects, and upper limits on the >1 TeV gamma-ray flux of the order of similar to 10(-13) cm(-)(2)s(-1) are established, corresponding to upper limits on the luminosities in the range similar to 2 x 10(39) to similar to 1 x 10(42) erg s(-1). These values are used to place model-dependent constraints on the mass-loss rates of the progenitor stars, implying upper limits between similar to 2 x 10(-5) and similar to 2 x 10(-3) M-circle dot yr(-1) under reasonable assumptions on the particle acceleration parameters.
KW  - gamma rays: general
KW  - supernovae: general
KW  - cosmic rays
Y1  - 2019
U6  - https://doi.org/10.1051/0004-6361/201935242
SN  - 1432-0746
VL  - 626
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Adam, R.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, M.
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Ashkar, H.
A1  - Backes, M.
A1  - Martins, V. Barbosa
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Berge, D.
A1  - Bernloehr, K.
A1  - Bissaldi, E.
A1  - Blackwell, R.
A1  - Boettcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - Bonnefoy, S.
A1  - Bregeon, J.
A1  - Breuhaus, M.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Buechele, M.
A1  - Bulik, T.
A1  - Bylund, T.
A1  - Capasso, M.
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Cerruti, M.
A1  - Chand, T.
A1  - Chandra, S.
A1  - Chen, A.
A1  - Colafrancesco, S.
A1  - Curylo, M.
A1  - Davids, I. D.
A1  - Deil, C.
A1  - Devin, J.
A1  - deWilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, A.
A1  - Doroshenko, V
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Emery, G.
A1  - Ernenwein, J-P
A1  - Eschbach, S.
A1  - Feijen, K.
A1  - Fegan, S.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Funk, S.
A1  - Fussling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Gate, F.
A1  - Giavitto, G.
A1  - Giunti, L.
A1  - Glawion, D.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M-H
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hinton, J. A.
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, T. L.
A1  - Holler, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Iwasaki, H.
A1  - Jamrozy, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jardin-Blicq, A.
A1  - Jung-Richardt, I
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - King, J.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu
A1  - Kosack, K.
A1  - Kostunin, D.
A1  - Kreter, M.
A1  - Lamanna, G.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J-P
A1  - Leser, Eva
A1  - Levy, C.
A1  - Lohse, T.
A1  - Lypova, I
A1  - Mackey, J.
A1  - Majumdar, J.
A1  - Malyshev, D.
A1  - Marandon, V
A1  - Marcowith, Alexandre
A1  - Mares, A.
A1  - Mariaud, C.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Moore, C.
A1  - Moulin, Emmanuel
A1  - Muller, J.
A1  - Murach, T.
A1  - Nakashima, S.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Wilhelmi, E. de Ona
A1  - Ostrowski, M.
A1  - Oya, I
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Perennes, C.
A1  - Petrucci, P-O
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puehlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Remy, Q.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V
A1  - Sailer, S.
A1  - Saito, S.
A1  - Sanchez, D. A.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schussler, F.
A1  - Schulz, A.
A1  - Schutte, H. M.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Specovius, A.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steppa, Constantin Beverly
A1  - Takahashi, T.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Yang, R.
A1  - Yoneda, H.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zywucka, N.
A1  - de Palma, F.
A1  - Axelsson, M.
A1  - Roberts, O. J.
T1  - A very-high-energy component deep in the gamma-ray burst afterglow
JF  - Nature : the international weekly journal of science
N2  - Gamma-ray bursts (GRBs) are brief flashes of gamma-rays and are considered to be the most energetic explosive phenomena in the Universe(1). The emission from GRBs comprises a short (typically tens of seconds) and bright prompt emission, followed by a much longer afterglow phase. During the afterglow phase, the shocked outflow-produced by the interaction between the ejected matter and the circumburst medium-slows down, and a gradual decrease in brightness is observed(2). GRBs typically emit most of their energy via.-rays with energies in the kiloelectronvolt-to-megaelectronvolt range, but a few photons with energies of tens of gigaelectronvolts have been detected by space-based instruments(3). However, the origins of such high-energy (above one gigaelectronvolt) photons and the presence of very-high-energy (more than 100 gigaelectronvolts) emission have remained elusive(4). Here we report observations of very-high-energy emission in the bright GRB 180720B deep in the GRB afterglow-ten hours after the end of the prompt emission phase, when the X-ray flux had already decayed by four orders of magnitude. Two possible explanations exist for the observed radiation: inverse Compton emission and synchrotron emission of ultrarelativistic electrons. Our observations show that the energy fluxes in the X-ray and gamma-ray range and their photon indices remain comparable to each other throughout the afterglow. This discovery places distinct constraints on the GRB environment for both emission mechanisms, with the inverse Compton explanation alleviating the particle energy requirements for the emission observed at late times. The late timing of this detection has consequences for the future observations of GRBs at the highest energies.
Y1  - 2019
U6  - https://doi.org/10.1038/s41586-019-1743-9
SN  - 0028-0836
SN  - 1476-4687
VL  - 575
IS  - 7783
SP  - 464
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Abdalla, Hassan E.
A1  - Adam, R.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arakawa, M.
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Ashkar, H.
A1  - Backes, M.
A1  - Martins, V. Barbosa
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Berge, D.
A1  - Bernloehr, K.
A1  - Blackwell, R.
A1  - Böttcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - Bonnefoy, S.
A1  - Bregeon, J.
A1  - Breuhaus, M.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Büchele, M.
A1  - Bulik, T.
A1  - Bylund, T.
A1  - Capasso, M.
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Cerruti, M.
A1  - Chand, T.
A1  - Chandra, S.
A1  - Chen, A.
A1  - Colafrancesco, S.
A1  - Curylo, M.
A1  - Davids, I. D.
A1  - Deil, C.
A1  - Devin, J.
A1  - DeWilt, P.
A1  - Dirson, L.
A1  - Djannati-Ata, A.
A1  - Dmytriiev, A.
A1  - Donath, A.
A1  - Doroshenko, V
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Emery, G.
A1  - Ernenwein, J-P
A1  - Eschbach, S.
A1  - Feijen, K.
A1  - Fegan, S.
A1  - Fiasson, A.
A1  - Fontaine, G.
A1  - Funk, S.
A1  - Füßling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Gate, F.
A1  - Giavitto, G.
A1  - Glawion, D.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M-H
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Heinzelmann, G.
A1  - Henri, G.
A1  - Hermann, G.
A1  - Hinton, James Anthony
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, Tim Lukas
A1  - Holler, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Iwasaki, H.
A1  - Jamrozy, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jardin-Blicq, A.
A1  - Jung-Richardt, I
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katsuragawa, M.
A1  - Katz, U.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - King, J.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu
A1  - Kosack, K.
A1  - Kostunin, D.
A1  - Kraus, M.
A1  - Lamanna, G.
A1  - Lau, J.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J-P
A1  - Leser, Eva
A1  - Levy, C.
A1  - Lohse, T.
A1  - Lypova, I
A1  - Mackey, J.
A1  - Majumdar, J.
A1  - Malyshev, D.
A1  - Marandon, V
A1  - Marcowith, Alexandre
A1  - Mares, A.
A1  - Mariaud, C.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Mitchell, A. M. W.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Moore, C.
A1  - Moulin, Emmanuel
A1  - Muller, J.
A1  - Murach, T.
A1  - Nakashima, S.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Wilhelmi, E. de Ona
A1  - Ostrowski, M.
A1  - Oya, I
A1  - Panter, M.
A1  - Parsons, R. D.
A1  - Perennes, C.
A1  - Petrucci, P-O
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V
A1  - Priyana Noel, A.
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Pühlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Remy, Q.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V
A1  - Saito, S.
A1  - Sanchez, David M.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Schlickeiser, R.
A1  - Schüssler, F.
A1  - Schulz, A.
A1  - Schutte, H.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Specovius, A.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Steenkamp, R.
A1  - Stegmann, Christian
A1  - Steppa, Constantin Beverly
A1  - Takahashi, T.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tsuji, N.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van Der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Voisin, F.
A1  - Voelk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Yang, R.
A1  - Yoneda, H.
A1  - Zacharias, Michael
A1  - Zanin, R.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zywucka, N.
A1  - Meyer, M.
T1  - Constraints on the emission region of 3C 279 during strong flares in 2014 and 2015 through VHE gamma-ray observations with HESS
JF  - Astronomy and astrophysics : an international weekly journal
N2  - The flat spectrum radio quasar 3C 279 is known to exhibit pronounced variability in the high-energy (100MeV < E < 100 GeV) gamma-ray band, which is continuously monitored with Fermi-LAT. During two periods of high activity in April 2014 and June 2015 target-of-opportunity observations were undertaken with the High Energy Stereoscopic System (H.E.S.S.) in the very-high-energy (VHE, E > 100 GeV) gamma-ray domain. While the observation in 2014 provides an upper limit, the observation in 2015 results in a signal with 8 : 7 sigma significance above an energy threshold of 66 GeV. No VHE variability was detected during the 2015 observations. The VHE photon spectrum is soft and described by a power-law index of 4.2 +/- 0.3. The H.E.S.S. data along with a detailed and contemporaneous multiwavelength data set provide constraints on the physical parameters of the emission region. The minimum distance of the emission region from the central black hole was estimated using two plausible geometries of the broad-line region and three potential intrinsic spectra. The emission region is confidently placed at r greater than or similar to 1 : 7 X 1017 cm from the black hole, that is beyond the assumed distance of the broad-line region. Time-dependent leptonic and lepto-hadronic one-zone models were used to describe the evolution of the 2015 flare. Neither model can fully reproduce the observations, despite testing various parameter sets. Furthermore, the H.E.S.S. data were used to derive constraints on Lorentz invariance violation given the large redshift of 3C 279.
KW  - radiation mechanisms: non-thermal
KW  - quasars: individual: 3C 279
KW  - galaxies: active
KW  - relativistic processes
Y1  - 2019
U6  - https://doi.org/10.1051/0004-6361/201935704
SN  - 1432-0746
VL  - 627
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Warrington, Nicole
A1  - Beaumont, Robin
A1  - Horikoshi, Momoko
A1  - Day, Felix R.
A1  - Helgeland, Øyvind
A1  - Laurin, Charles
A1  - Bacelis, Jonas
A1  - Peng, Shouneng
A1  - Hao, Ke
A1  - Feenstra, Bjarke
A1  - Wood, Andrew R.
A1  - Mahajan, Anubha
A1  - Tyrrell, Jessica
A1  - Robertson, Neil R.
A1  - Rayner, N. William
A1  - Qiao, Zhen
A1  - Moen, Gunn-Helen
A1  - Vaudel, Marc
A1  - Marsit, Carmen
A1  - Chen, Jia
A1  - Nodzenski, Michael
A1  - Schnurr, Theresia M.
A1  - Zafarmand, Mohammad Hadi
A1  - Bradfield, Jonathan P.
A1  - Grarup, Niels
A1  - Kooijman, Marjolein N.
A1  - Li-Gao, Ruifang
A1  - Geller, Frank
A1  - Ahluwalia, Tarunveer Singh
A1  - Paternoster, Lavinia
A1  - Rueedi, Rico
A1  - Huikari, Ville
A1  - Hottenga, Jouke-Jan
A1  - Lyytikäinen, Leo-Pekka
A1  - Cavadino, Alana
A1  - Metrustry, Sarah
A1  - Cousminer, Diana L.
A1  - Wu, Ying
A1  - Thiering, Elisabeth Paula
A1  - Wang, Carol A.
A1  - Have, Christian Theil
A1  - Vilor-Tejedor, Natalia
A1  - Joshi, Peter K.
A1  - Painter, Jodie N.
A1  - Ntalla, Ioanna
A1  - Myhre, Ronny
A1  - Pitkänen, Niina
A1  - van Leeuwen, Elisabeth M.
A1  - Joro, Raimo
A1  - Lagou, Vasiliki
A1  - Richmond, Rebecca C.
A1  - Espinosa, Ana
A1  - Barton, Sheila J.
A1  - Inskip, Hazel M.
A1  - Holloway, John W.
A1  - Santa-Marina, Loreto
A1  - Estivill, Xavier
A1  - Ang, Wei
A1  - Marsh, Julie A.
A1  - Reichetzeder, Christoph
A1  - Marullo, Letizia
A1  - Hocher, Berthold
A1  - Lunetta, Kathryn L.
A1  - Murabito, Joanne M.
A1  - Relton, Caroline L.
A1  - Kogevinas, Manolis
A1  - Chatzi, Leda
A1  - Allard, Catherine
A1  - Bouchard, Luigi
A1  - Hivert, Marie-France
A1  - Zhang, Ge
A1  - Muglia, Louis J.
A1  - Heikkinen, Jani
A1  - Morgen, Camilla S.
A1  - van Kampen, Antoine H. C.
A1  - van Schaik, Barbera D. C.
A1  - Mentch, Frank D.
A1  - Langenberg, Claudia
A1  - Scott, Robert A.
A1  - Zhao, Jing Hua
A1  - Hemani, Gibran
A1  - Ring, Susan M.
A1  - Bennett, Amanda J.
A1  - Gaulton, Kyle J.
A1  - Fernandez-Tajes, Juan
A1  - van Zuydam, Natalie R.
A1  - Medina-Gomez, Carolina
A1  - de Haan, Hugoline G.
A1  - Rosendaal, Frits R.
A1  - Kutalik, Zoltán
A1  - Marques-Vidal, Pedro
A1  - Das, Shikta
A1  - Willemsen, Gonneke
A1  - Mbarek, Hamdi
A1  - Müller-Nurasyid, Martina
A1  - Standl, Marie
A1  - Appel, Emil V. R.
A1  - Fonvig, Cilius Esmann
A1  - Trier, Caecilie
A1  - van Beijsterveldt, Catharina E. M.
A1  - Murcia, Mario
A1  - Bustamante, Mariona
A1  - Bonàs-Guarch, Sílvia
A1  - Hougaard, David M.
A1  - Mercader, Josep M.
A1  - Linneberg, Allan
A1  - Schraut, Katharina E.
A1  - Lind, Penelope A.
A1  - Medland, Sarah Elizabeth
A1  - Shields, Beverley M.
A1  - Knight, Bridget A.
A1  - Chai, Jin-Fang
A1  - Panoutsopoulou, Kalliope
A1  - Bartels, Meike
A1  - Sánchez, Friman
A1  - Stokholm, Jakob
A1  - Torrents, David
A1  - Vinding, Rebecca K.
A1  - Willems, Sara M.
A1  - Atalay, Mustafa
A1  - Chawes, Bo L.
A1  - Kovacs, Peter
A1  - Prokopenko, Inga
A1  - Tuke, Marcus A.
A1  - Yaghootkar, Hanieh
A1  - Ruth, Katherine S.
A1  - Jones, Samuel E.
A1  - Loh, Po-Ru
A1  - Murray, Anna
A1  - Weedon, Michael N.
A1  - Tönjes, Anke
A1  - Stumvoll, Michael
A1  - Michaelsen, Kim Fleischer
A1  - Eloranta, Aino-Maija
A1  - Lakka, Timo A.
A1  - van Duijn, Cornelia M.
A1  - Kiess, Wieland
A1  - Koerner, Antje
A1  - Niinikoski, Harri
A1  - Pahkala, Katja
A1  - Raitakari, Olli T.
A1  - Jacobsson, Bo
A1  - Zeggini, Eleftheria
A1  - Dedoussis, George V.
A1  - Teo, Yik-Ying
A1  - Saw, Seang-Mei
A1  - Montgomery, Grant W.
A1  - Campbell, Harry
A1  - Wilson, James F.
A1  - Vrijkotte, Tanja G. M.
A1  - Vrijheid, Martine
A1  - de Geus, Eco J. C. N.
A1  - Hayes, M. Geoffrey
A1  - Kadarmideen, Haja N.
A1  - Holm, Jens-Christian
A1  - Beilin, Lawrence J.
A1  - Pennell, Craig E.
A1  - Heinrich, Joachim
A1  - Adair, Linda S.
A1  - Borja, Judith B.
A1  - Mohlke, Karen L.
A1  - Eriksson, Johan G.
A1  - Widen, Elisabeth E.
A1  - Hattersley, Andrew T.
A1  - Spector, Tim D.
A1  - Kaehoenen, Mika
A1  - Viikari, Jorma S.
A1  - Lehtimaeki, Terho
A1  - Boomsma, Dorret I.
A1  - Sebert, Sylvain
A1  - Vollenweider, Peter
A1  - Sorensen, Thorkild I. A.
A1  - Bisgaard, Hans
A1  - Bonnelykke, Klaus
A1  - Murray, Jeffrey C.
A1  - Melbye, Mads
A1  - Nohr, Ellen A.
A1  - Mook-Kanamori, Dennis O.
A1  - Rivadeneira, Fernando
A1  - Hofman, Albert
A1  - Felix, Janine F.
A1  - Jaddoe, Vincent W. V.
A1  - Hansen, Torben
A1  - Pisinger, Charlotta
A1  - Vaag, Allan A.
A1  - Pedersen, Oluf
A1  - Uitterlinden, Andre G.
A1  - Jarvelin, Marjo-Riitta
A1  - Power, Christine
A1  - Hypponen, Elina
A1  - Scholtens, Denise M.
A1  - Lowe, William L.
A1  - Smith, George Davey
A1  - Timpson, Nicholas J.
A1  - Morris, Andrew P.
A1  - Wareham, Nicholas J.
A1  - Hakonarson, Hakon
A1  - Grant, Struan F. A.
A1  - Frayling, Timothy M.
A1  - Lawlor, Debbie A.
A1  - Njolstad, Pal R.
A1  - Johansson, Stefan
A1  - Ong, Ken K.
A1  - McCarthy, Mark I.
A1  - Perry, John R. B.
A1  - Evans, David M.
A1  - Freathy, Rachel M.
T1  - Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
JF  - Nature genetics
N2  - Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effects, then applied Mendelian randomization to illuminate causal pathways. For example, both indirect maternal and direct fetal genetic effects drive the observational relationship between lower birth weight and higher later blood pressure: maternal blood pressure-raising alleles reduce offspring birth weight, but only direct fetal effects of these alleles, once inherited, increase later offspring blood pressure. Using maternal birth weight-lowering genotypes to proxy for an adverse intrauterine environment provided no evidence that it causally raises offspring blood pressure, indicating that the inverse birth weight-blood pressure association is attributable to genetic effects, and not to intrauterine programming.
Y1  - 2019
SN  - 1061-4036
SN  - 1546-1718
VL  - 51
IS  - 5
SP  - 804
EP  - +
PB  - Nature Publ. Group
CY  - New York
ER  - 
TY  - JOUR
A1  - Aarts, Alexander A.
A1  - Anderson, Joanna E.
A1  - Anderson, Christopher J.
A1  - Attridge, Peter R.
A1  - Attwood, Angela
A1  - Axt, Jordan
A1  - Babel, Molly
A1  - Bahnik, Stepan
A1  - Baranski, Erica
A1  - Barnett-Cowan, Michael
A1  - Bartmess, Elizabeth
A1  - Beer, Jennifer
A1  - Bell, Raoul
A1  - Bentley, Heather
A1  - Beyan, Leah
A1  - Binion, Grace
A1  - Borsboom, Denny
A1  - Bosch, Annick
A1  - Bosco, Frank A.
A1  - Bowman, Sara D.
A1  - Brandt, Mark J.
A1  - Braswell, Erin
A1  - Brohmer, Hilmar
A1  - Brown, Benjamin T.
A1  - Brown, Kristina
A1  - Bruening, Jovita
A1  - Calhoun-Sauls, Ann
A1  - Callahan, Shannon P.
A1  - Chagnon, Elizabeth
A1  - Chandler, Jesse
A1  - Chartier, Christopher R.
A1  - Cheung, Felix
A1  - Christopherson, Cody D.
A1  - Cillessen, Linda
A1  - Clay, Russ
A1  - Cleary, Hayley
A1  - Cloud, Mark D.
A1  - Cohn, Michael
A1  - Cohoon, Johanna
A1  - Columbus, Simon
A1  - Cordes, Andreas
A1  - Costantini, Giulio
A1  - Alvarez, Leslie D. Cramblet
A1  - Cremata, Ed
A1  - Crusius, Jan
A1  - DeCoster, Jamie
A1  - DeGaetano, Michelle A.
A1  - Della Penna, Nicolas
A1  - den Bezemer, Bobby
A1  - Deserno, Marie K.
A1  - Devitt, Olivia
A1  - Dewitte, Laura
A1  - Dobolyi, David G.
A1  - Dodson, Geneva T.
A1  - Donnellan, M. Brent
A1  - Donohue, Ryan
A1  - Dore, Rebecca A.
A1  - Dorrough, Angela
A1  - Dreber, Anna
A1  - Dugas, Michelle
A1  - Dunn, Elizabeth W.
A1  - Easey, Kayleigh
A1  - Eboigbe, Sylvia
A1  - Eggleston, Casey
A1  - Embley, Jo
A1  - Epskamp, Sacha
A1  - Errington, Timothy M.
A1  - Estel, Vivien
A1  - Farach, Frank J.
A1  - Feather, Jenelle
A1  - Fedor, Anna
A1  - Fernandez-Castilla, Belen
A1  - Fiedler, Susann
A1  - Field, James G.
A1  - Fitneva, Stanka A.
A1  - Flagan, Taru
A1  - Forest, Amanda L.
A1  - Forsell, Eskil
A1  - Foster, Joshua D.
A1  - Frank, Michael C.
A1  - Frazier, Rebecca S.
A1  - Fuchs, Heather
A1  - Gable, Philip
A1  - Galak, Jeff
A1  - Galliani, Elisa Maria
A1  - Gampa, Anup
A1  - Garcia, Sara
A1  - Gazarian, Douglas
A1  - Gilbert, Elizabeth
A1  - Giner-Sorolla, Roger
A1  - Glöckner, Andreas
A1  - Göllner, Lars
A1  - Goh, Jin X.
A1  - Goldberg, Rebecca
A1  - Goodbourn, Patrick T.
A1  - Gordon-McKeon, Shauna
A1  - Gorges, Bryan
A1  - Gorges, Jessie
A1  - Goss, Justin
A1  - Graham, Jesse
A1  - Grange, James A.
A1  - Gray, Jeremy
A1  - Hartgerink, Chris
A1  - Hartshorne, Joshua
A1  - Hasselman, Fred
A1  - Hayes, Timothy
A1  - Heikensten, Emma
A1  - Henninger, Felix
A1  - Hodsoll, John
A1  - Holubar, Taylor
A1  - Hoogendoorn, Gea
A1  - Humphries, Denise J.
A1  - Hung, Cathy O. -Y.
A1  - Immelman, Nathali
A1  - Irsik, Vanessa C.
A1  - Jahn, Georg
A1  - Jaekel, Frank
A1  - Jekel, Marc
A1  - Johannesson, Magnus
A1  - Johnson, Larissa G.
A1  - Johnson, David J.
A1  - Johnson, Kate M.
A1  - Johnston, William J.
A1  - Jonas, Kai
A1  - Joy-Gaba, Jennifer A.
A1  - Kappes, Heather Barry
A1  - Kelso, Kim
A1  - Kidwell, Mallory C.
A1  - Kim, Seung Kyung
A1  - Kirkhart, Matthew
A1  - Kleinberg, Bennett
A1  - Knezevic, Goran
A1  - Kolorz, Franziska Maria
A1  - Kossakowski, Jolanda J.
A1  - Krause, Robert Wilhelm
A1  - Krijnen, Job
A1  - Kuhlmann, Tim
A1  - Kunkels, Yoram K.
A1  - Kyc, Megan M.
A1  - Lai, Calvin K.
A1  - Laique, Aamir
A1  - Lakens, Daniel
A1  - Lane, Kristin A.
A1  - Lassetter, Bethany
A1  - Lazarevic, Ljiljana B.
A1  - LeBel, Etienne P.
A1  - Lee, Key Jung
A1  - Lee, Minha
A1  - Lemm, Kristi
A1  - Levitan, Carmel A.
A1  - Lewis, Melissa
A1  - Lin, Lin
A1  - Lin, Stephanie
A1  - Lippold, Matthias
A1  - Loureiro, Darren
A1  - Luteijn, Ilse
A1  - Mackinnon, Sean
A1  - Mainard, Heather N.
A1  - Marigold, Denise C.
A1  - Martin, Daniel P.
A1  - Martinez, Tylar
A1  - Masicampo, E. J.
A1  - Matacotta, Josh
A1  - Mathur, Maya
A1  - May, Michael
A1  - Mechin, Nicole
A1  - Mehta, Pranjal
A1  - Meixner, Johannes
A1  - Melinger, Alissa
A1  - Miller, Jeremy K.
A1  - Miller, Mallorie
A1  - Moore, Katherine
A1  - Möschl, Marcus
A1  - Motyl, Matt
A1  - Müller, Stephanie M.
A1  - Munafo, Marcus
A1  - Neijenhuijs, Koen I.
A1  - Nervi, Taylor
A1  - Nicolas, Gandalf
A1  - Nilsonne, Gustav
A1  - Nosek, Brian A.
A1  - Nuijten, Michele B.
A1  - Olsson, Catherine
A1  - Osborne, Colleen
A1  - Ostkamp, Lutz
A1  - Pavel, Misha
A1  - Penton-Voak, Ian S.
A1  - Perna, Olivia
A1  - Pernet, Cyril
A1  - Perugini, Marco
A1  - Pipitone, R. Nathan
A1  - Pitts, Michael
A1  - Plessow, Franziska
A1  - Prenoveau, Jason M.
A1  - Rahal, Rima-Maria
A1  - Ratliff, Kate A.
A1  - Reinhard, David
A1  - Renkewitz, Frank
A1  - Ricker, Ashley A.
A1  - Rigney, Anastasia
A1  - Rivers, Andrew M.
A1  - Roebke, Mark
A1  - Rutchick, Abraham M.
A1  - Ryan, Robert S.
A1  - Sahin, Onur
A1  - Saide, Anondah
A1  - Sandstrom, Gillian M.
A1  - Santos, David
A1  - Saxe, Rebecca
A1  - Schlegelmilch, Rene
A1  - Schmidt, Kathleen
A1  - Scholz, Sabine
A1  - Seibel, Larissa
A1  - Selterman, Dylan Faulkner
A1  - Shaki, Samuel
A1  - Simpson, William B.
A1  - Sinclair, H. Colleen
A1  - Skorinko, Jeanine L. M.
A1  - Slowik, Agnieszka
A1  - Snyder, Joel S.
A1  - Soderberg, Courtney
A1  - Sonnleitner, Carina
A1  - Spencer, Nick
A1  - Spies, Jeffrey R.
A1  - Steegen, Sara
A1  - Stieger, Stefan
A1  - Strohminger, Nina
A1  - Sullivan, Gavin B.
A1  - Talhelm, Thomas
A1  - Tapia, Megan
A1  - te Dorsthorst, Anniek
A1  - Thomae, Manuela
A1  - Thomas, Sarah L.
A1  - Tio, Pia
A1  - Traets, Frits
A1  - Tsang, Steve
A1  - Tuerlinckx, Francis
A1  - Turchan, Paul
A1  - Valasek, Milan
A1  - Van Aert, Robbie
A1  - van Assen, Marcel
A1  - van Bork, Riet
A1  - van de Ven, Mathijs
A1  - van den Bergh, Don
A1  - van der Hulst, Marije
A1  - van Dooren, Roel
A1  - van Doorn, Johnny
A1  - van Renswoude, Daan R.
A1  - van Rijn, Hedderik
A1  - Vanpaemel, Wolf
A1  - Echeverria, Alejandro Vasquez
A1  - Vazquez, Melissa
A1  - Velez, Natalia
A1  - Vermue, Marieke
A1  - Verschoor, Mark
A1  - Vianello, Michelangelo
A1  - Voracek, Martin
A1  - Vuu, Gina
A1  - Wagenmakers, Eric-Jan
A1  - Weerdmeester, Joanneke
A1  - Welsh, Ashlee
A1  - Westgate, Erin C.
A1  - Wissink, Joeri
A1  - Wood, Michael
A1  - Woods, Andy
A1  - Wright, Emily
A1  - Wu, Sining
A1  - Zeelenberg, Marcel
A1  - Zuni, Kellylynn
T1  - Estimating the reproducibility of psychological science
JF  - Science
N2  - Reproducibility is a defining feature of science, but the extent to which it characterizes current research is unknown. We conducted replications of 100 experimental and correlational studies published in three psychology journals using high-powered designs and original materials when available. Replication effects were half the magnitude of original effects, representing a substantial decline. Ninety-seven percent of original studies had statistically significant results. Thirty-six percent of replications had statistically significant results; 47% of original effect sizes were in the 95% confidence interval of the replication effect size; 39% of effects were subjectively rated to have replicated the original result; and if no bias in original results is assumed, combining original and replication results left 68% with statistically significant effects. Correlational tests suggest that replication success was better predicted by the strength of original evidence than by characteristics of the original and replication teams.
Y1  - 2015
U6  - https://doi.org/10.1126/science.aac4716
SN  - 1095-9203
SN  - 0036-8075
VL  - 349
IS  - 6251
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Soliveres, Santiago
A1  - van der Plas, Fons
A1  - Manning, Peter
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Renner, Swen C.
A1  - Alt, Fabian
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Binkenstein, Julia
A1  - Birkhofer, Klaus
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Boch, Steffen
A1  - Böhm, Stefan
A1  - Börschig, Carmen
A1  - Buscot, Francois
A1  - Diekötter, Tim
A1  - Heinze, Johannes
A1  - Hölzel, Norbert
A1  - Jung, Kirsten
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Müller, Jörg
A1  - Oelmann, Yvonne
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Rillig, Matthias C.
A1  - Schaefer, H. Martin
A1  - Schloter, Michael
A1  - Schmitt, Barbara
A1  - Schöning, Ingo
A1  - Schrumpf, Marion
A1  - Sikorski, Johannes
A1  - Socher, Stephanie A.
A1  - Solly, Emily F.
A1  - Sonnemann, Ilja
A1  - Sorkau, Elisabeth
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Stempfhuber, Barbara
A1  - Tschapka, Marco
A1  - Türke, Manfred
A1  - Venter, Paul C.
A1  - Weiner, Christiane N.
A1  - Weisser, Wolfgang W.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wilcke, Wolfgang
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Fischer, Markus
A1  - Allan, Eric
T1  - Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality
JF  - Nature : the international weekly journal of science
Y1  - 2016
U6  - https://doi.org/10.1038/nature19092
SN  - 0028-0836
SN  - 1476-4687
VL  - 536
SP  - 456
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Grott, Matthias
A1  - Knollenberg, J.
A1  - Hamm, M.
A1  - Ogawa, K.
A1  - Jaumann, R.
A1  - Otto, Katharina Alexandra
A1  - Delbo, M.
A1  - Michel, Patrick
A1  - Biele, J.
A1  - Neumann, Wladimir
A1  - Knapmeyer, Martin
A1  - Kührt, E.
A1  - Senshu, H.
A1  - Okada, T.
A1  - Helbert, Jorn
A1  - Maturilli, A.
A1  - Müller, N.
A1  - Hagermann, A.
A1  - Sakatani, Naoya
A1  - Tanaka, S.
A1  - Arai, T.
A1  - Mottola, Stefano
A1  - Tachibana, Shogo
A1  - Pelivan, Ivanka
A1  - Drube, Line
A1  - Vincent, J-B
A1  - Yano, Hajime
A1  - Pilorget, C.
A1  - Matz, K. D.
A1  - Schmitz, N.
A1  - Koncz, A.
A1  - Schröder, Stefan E.
A1  - Trauthan, F.
A1  - Schlotterer, Markus
A1  - Krause, C.
A1  - Ho, T-M
A1  - Moussi-Soffys, A.
T1  - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
JF  - Nature astronomy
N2  - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7
Y1  - 2019
U6  - https://doi.org/10.1038/s41550-019-0832-x
SN  - 2397-3366
VL  - 3
IS  - 11
SP  - 971
EP  - 976
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - JOUR
A1  - Grott, Matthias
A1  - Knollenberg, J.
A1  - Hamm, M.
A1  - Ogawa, K.
A1  - Jaumann, R.
A1  - Otto, Katharina Alexandra
A1  - Delbo, M.
A1  - Michel, P.
A1  - Biele, J.
A1  - Neumann, W.
A1  - Knapmeyer, M.
A1  - Kuehrt, E.
A1  - Senshu, H.
A1  - Okada, T.
A1  - Helbert, J.
A1  - Maturilli, A.
A1  - Müller, N.
A1  - Hagermann, A.
A1  - Sakatani, N.
A1  - Tanaka, S.
A1  - Arai, T.
A1  - Mottola, S.
A1  - Tachibana, S.
A1  - Pelivan, Ivanka
A1  - Drube, L.
A1  - Vincent, J-B
A1  - Yano, H.
A1  - Pilorget, C.
A1  - Matz, K. D.
A1  - Schmitz, N.
A1  - Koncz, A.
A1  - Schröder, S. E.
A1  - Trauthan, F.
A1  - Schlotterer, M.
A1  - Krause, C.
A1  - Ho, T-M
A1  - Moussi-Soffys, A.
T1  - Low thermal conductivity boulder with high porosity identified on C-type asteroid (162173) Ryugu
JF  - Nature astronomy
N2  - C-type asteroids are among the most pristine objects in the Solar System, but little is known about their interior structure and surface properties. Telescopic thermal infrared observations have so far been interpreted in terms of a regolith-covered surface with low thermal conductivity and particle sizes in the centimetre range. This includes observations of C-type asteroid (162173) Ryugu1,2,3. However, on arrival of the Hayabusa2 spacecraft at Ryugu, a regolith cover of sand- to pebble-sized particles was found to be absent4,5 (R.J. et al., manuscript in preparation). Rather, the surface is largely covered by cobbles and boulders, seemingly incompatible with the remote-sensing infrared observations. Here we report on in situ thermal infrared observations of a boulder on the C-type asteroid Ryugu. We found that the boulder’s thermal inertia was much lower than anticipated based on laboratory measurements of meteorites, and that a surface covered by such low-conductivity boulders would be consistent with remote-sensing observations. Our results furthermore indicate high boulder porosities as well as a low tensile strength in the few hundred kilopascal range. The predicted low tensile strength confirms the suspected observational bias6 in our meteorite collections, as such asteroidal material would be too frail to survive atmospheric entry7.
Y1  - 2020
U6  - https://doi.org/10.1038/s41550-019-0832-x
SN  - 2397-3366
VL  - 3
IS  - 11
SP  - 971
EP  - 976
PB  - Nature Publishing Group
CY  - London
ER  - 
TY  - JOUR
A1  - Read, Betsy A.
A1  - Kegel, Jessica
A1  - Klute, Mary J.
A1  - Kuo, Alan
A1  - Lefebvre, Stephane C.
A1  - Maumus, Florian
A1  - Mayer, Christoph
A1  - Miller, John
A1  - Monier, Adam
A1  - Salamov, Asaf
A1  - Young, Jeremy
A1  - Aguilar, Maria
A1  - Claverie, Jean-Michel
A1  - Frickenhaus, Stephan
A1  - Gonzalez, Karina
A1  - Herman, Emily K.
A1  - Lin, Yao-Cheng
A1  - Napier, Johnathan
A1  - Ogata, Hiroyuki
A1  - Sarno, Analissa F.
A1  - Shmutz, Jeremy
A1  - Schroeder, Declan
A1  - de Vargas, Colomban
A1  - Verret, Frederic
A1  - von Dassow, Peter
A1  - Valentin, Klaus
A1  - Van de Peer, Yves
A1  - Wheeler, Glen
A1  - Dacks, Joel B.
A1  - Delwiche, Charles F.
A1  - Dyhrman, Sonya T.
A1  - Glöckner, Gernot
A1  - John, Uwe
A1  - Richards, Thomas
A1  - Worden, Alexandra Z.
A1  - Zhang, Xiaoyu
A1  - Grigoriev, Igor V.
A1  - Allen, Andrew E.
A1  - Bidle, Kay
A1  - Borodovsky, M.
A1  - Bowler, C.
A1  - Brownlee, Colin
A1  - Cock, J. Mark
A1  - Elias, Marek
A1  - Gladyshev, Vadim N.
A1  - Groth, Marco
A1  - Guda, Chittibabu
A1  - Hadaegh, Ahmad
A1  - Iglesias-Rodriguez, Maria Debora
A1  - Jenkins, J.
A1  - Jones, Bethan M.
A1  - Lawson, Tracy
A1  - Leese, Florian
A1  - Lindquist, Erika
A1  - Lobanov, Alexei
A1  - Lomsadze, Alexandre
A1  - Malik, Shehre-Banoo
A1  - Marsh, Mary E.
A1  - Mackinder, Luke
A1  - Mock, Thomas
A1  - Müller-Röber, Bernd
A1  - Pagarete, Antonio
A1  - Parker, Micaela
A1  - Probert, Ian
A1  - Quesneville, Hadi
A1  - Raines, Christine
A1  - Rensing, Stefan A.
A1  - Riano-Pachon, Diego Mauricio
A1  - Richier, Sophie
A1  - Rokitta, Sebastian
A1  - Shiraiwa, Yoshihiro
A1  - Soanes, Darren M.
A1  - van der Giezen, Mark
A1  - Wahlund, Thomas M.
A1  - Williams, Bryony
A1  - Wilson, Willie
A1  - Wolfe, Gordon
A1  - Wurch, Louie L.
T1  - Pan genome of the phytoplankton Emiliania underpins its global distribution
JF  - Nature : the international weekly journal of science
N2  - Coccolithophores have influenced the global climate for over 200 million years(1). These marine phytoplankton can account for 20 per cent of total carbon fixation in some systems(2). They form blooms that can occupy hundreds of thousands of square kilometres and are distinguished by their elegantly sculpted calcium carbonate exoskeletons (coccoliths), rendering them visible from space(3). Although coccolithophores export carbon in the form of organic matter and calcite to the sea floor, they also release CO2 in the calcification process. Hence, they have a complex influence on the carbon cycle, driving either CO2 production or uptake, sequestration and export to the deep ocean(4). Here we report the first haptophyte reference genome, from the coccolithophore Emiliania huxleyi strain CCMP1516, and sequences from 13 additional isolates. Our analyses reveal a pan genome (core genes plus genes distributed variably between strains) probably supported by an atypical complement of repetitive sequence in the genome. Comparisons across strains demonstrate that E. huxleyi, which has long been considered a single species, harbours extensive genome variability reflected in different metabolic repertoires. Genome variability within this species complex seems to underpin its capacity both to thrive in habitats ranging from the equator to the subarctic and to form large-scale episodic blooms under a wide variety of environmental conditions.
Y1  - 2013
U6  - https://doi.org/10.1038/nature12221
SN  - 0028-0836
SN  - 1476-4687
VL  - 499
IS  - 7457
SP  - 209
EP  - 213
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Christakoudi, Sofa
A1  - Tsilidis, Konstantinos K.
A1  - Muller, David C.
A1  - Freisling, Heinz
A1  - Weiderpass, Elisabete
A1  - Overvad, Kim
A1  - Söderberg, Stefan
A1  - Häggström, Christel
A1  - Pischon, Tobias
A1  - Dahm, Christina C.
A1  - Zhang, Jie
A1  - Tjønneland, Anne
A1  - Schulze, Matthias Bernd
T1  - A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
JF  - Scientific Reports
N2  - Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
KW  - all-cause mortality
KW  - anthropometric measures
KW  - mass index
KW  - overweight
KW  - cancer
KW  - prediction
KW  - adiposity
KW  - size
Y1  - 2020
VL  - 10
IS  - 1
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - GEN
A1  - Christakoudi, Sofa
A1  - Tsilidis, Konstantinos K.
A1  - Muller, David C.
A1  - Freisling, Heinz
A1  - Weiderpass, Elisabete
A1  - Overvad, Kim
A1  - Söderberg, Stefan
A1  - Häggström, Christel
A1  - Pischon, Tobias
A1  - Dahm, Christina C.
A1  - Zhang, Jie
A1  - Tjønneland, Anne
A1  - Schulze, Matthias Bernd
T1  - A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1200 
KW  - all-cause mortality
KW  - anthropometric measures
KW  - mass index
KW  - overweight
KW  - cancer
KW  - prediction
KW  - adiposity
KW  - size
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-525827
SN  - 1866-8372
IS  - 1
ER  - 
TY  - JOUR
A1  - Gross, M.
A1  - Müller, David C.
A1  - Nothofer, Heinz-Georg
A1  - Scherf, Ullrich
A1  - Neher, Dieter
A1  - Bräuchler, C.
A1  - Meerholz, Klaus
T1  - Improving the performance of doped p-conjugated polymers for use in organic light-emitting diodes
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Gossner, Martin M.
A1  - Lewinsohn, Thomas M.
A1  - Kahl, Tiemo
A1  - Grassein, Fabrice
A1  - Boch, Steffen
A1  - Prati, Daniel
A1  - Birkhofer, Klaus
A1  - Renner, Swen C.
A1  - Sikorski, Johannes
A1  - Wubet, Tesfaye
A1  - Arndt, Hartmut
A1  - Baumgartner, Vanessa
A1  - Blaser, Stefan
A1  - Blüthgen, Nico
A1  - Börschig, Carmen
A1  - Buscot, Francois
A1  - Diekötter, Tim
A1  - Jorge, Leonardo Re
A1  - Jung, Kirsten
A1  - Keyel, Alexander C.
A1  - Klein, Alexandra-Maria
A1  - Klemmer, Sandra
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Müller, Jörg
A1  - Overmann, Jörg
A1  - Pasalic, Esther
A1  - Penone, Caterina
A1  - Perovic, David J.
A1  - Purschke, Oliver
A1  - Schall, Peter
A1  - Socher, Stephanie A.
A1  - Sonnemann, Ilja
A1  - Tschapka, Marco
A1  - Tscharntke, Teja
A1  - Türke, Manfred
A1  - Venter, Paul Christiaan
A1  - Weiner, Christiane N.
A1  - Werner, Michael
A1  - Wolters, Volkmar
A1  - Wurst, Susanne
A1  - Westphal, Catrin
A1  - Fischer, Markus
A1  - Weisser, Wolfgang W.
A1  - Allan, Eric
T1  - Land-use intensification causes multitrophic homogenization of grassland communities
JF  - Nature : the international weekly journal of science
N2  - Land-use intensification is a major driver of biodiversity loss(1,2). Alongside reductions in local species diversity, biotic homogenization at larger spatial scales is of great concern for conservation. Biotic homogenization means a decrease in beta-diversity (the compositional dissimilarity between sites). Most studies have investigated losses in local (alpha)-diversity(1,3) and neglected biodiversity loss at larger spatial scales. Studies addressing beta-diversity have focused on single or a few organism groups (for example, ref. 4), and it is thus unknown whether land-use intensification homogenizes communities at different trophic levels, above-and belowground. Here we show that even moderate increases in local land-use intensity (LUI) cause biotic homogenization across microbial, plant and animal groups, both above- and belowground, and that this is largely independent of changes in alpha-diversity. We analysed a unique grassland biodiversity dataset, with abundances of more than 4,000 species belonging to 12 trophic groups. LUI, and, in particular, high mowing intensity, had consistent effects on beta-diversity across groups, causing a homogenization of soil microbial, fungal pathogen, plant and arthropod communities. These effects were nonlinear and the strongest declines in beta-diversity occurred in the transition from extensively managed to intermediate intensity grassland. LUI tended to reduce local alpha-diversity in aboveground groups, whereas the alpha-diversity increased in belowground groups. Correlations between the alpha-diversity of different groups, particularly between plants and their consumers, became weaker at high LUI. This suggests a loss of specialist species and is further evidence for biotic homogenization. The consistently negative effects of LUI on landscape-scale biodiversity underscore the high value of extensively managed grasslands for conserving multitrophic biodiversity and ecosystem service provision. Indeed, biotic homogenization rather than local diversity loss could prove to be the most substantial consequence of land-use intensification.
Y1  - 2016
U6  - https://doi.org/10.1038/nature20575
SN  - 0028-0836
SN  - 1476-4687
VL  - 540
SP  - 266
EP  - +
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - JOUR
A1  - Allan, Eric
A1  - Bossdorf, Oliver
A1  - Dormann, Carsten F.
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Tscharntke, Teja
A1  - Blüthgen, Nico
A1  - Bellach, Michaela
A1  - Birkhofer, Klaus
A1  - Boch, Steffen
A1  - Böhm, Stefan
A1  - Börschig, Carmen
A1  - Chatzinotas, Antonis
A1  - Christ, Sabina
A1  - Daniel, Rolf
A1  - Diekötter, Tim
A1  - Fischer, Christiane
A1  - Friedl, Thomas
A1  - Glaser, Karin
A1  - Hallmann, Christine
A1  - Hodac, Ladislav
A1  - Hölzel, Norbert
A1  - Jung, Kirsten
A1  - Klein, Alexandra-Maria
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Krauss, Jochen
A1  - Lange, Markus
A1  - Morris, E. Kathryn
A1  - Müller, Jörg
A1  - Nacke, Heiko
A1  - Pasalic, Esther
A1  - Rillig, Matthias C.
A1  - Rothenwoehrer, Christoph
A1  - Schally, Peter
A1  - Scherber, Christoph
A1  - Schulze, Waltraud X.
A1  - Socher, Stephanie A.
A1  - Steckel, Juliane
A1  - Steffan-Dewenter, Ingolf
A1  - Türke, Manfred
A1  - Weiner, Christiane N.
A1  - Werner, Michael
A1  - Westphal, Catrin
A1  - Wolters, Volkmar
A1  - Wubet, Tesfaye
A1  - Gockel, Sonja
A1  - Gorke, Martin
A1  - Hemp, Andreas
A1  - Renner, Swen C.
A1  - Schöning, Ingo
A1  - Pfeiffer, Simone
A1  - König-Ries, Birgitta
A1  - Buscot, Francois
A1  - Linsenmair, Karl Eduard
A1  - Schulze, Ernst-Detlef
A1  - Weisser, Wolfgang W.
A1  - Fischer, Markus
T1  - Interannual variation in land-use intensity enhances grassland multidiversity
JF  - Proceedings of the National Academy of Sciences of the United States of America
N2  - Although temporal heterogeneity is a well-accepted driver of biodiversity, effects of interannual variation in land-use intensity (LUI) have not been addressed yet. Additionally, responses to land use can differ greatly among different organisms; therefore, overall effects of land-use on total local biodiversity are hardly known. To test for effects of LUI (quantified as the combined intensity of fertilization, grazing, and mowing) and interannual variation in LUI (SD in LUI across time), we introduce a unique measure of whole-ecosystem biodiversity, multidiversity. This synthesizes individual diversity measures across up to 49 taxonomic groups of plants, animals, fungi, and bacteria from 150 grasslands. Multidiversity declined with increasing LUI among grasslands, particularly for rarer species and aboveground organisms, whereas common species and belowground groups were less sensitive. However, a high level of interannual variation in LUI increased overall multidiversity at low LUI and was even more beneficial for rarer species because it slowed the rate at which the multidiversity of rare species declined with increasing LUI. In more intensively managed grasslands, the diversity of rarer species was, on average, 18% of the maximum diversity across all grasslands when LUI was static over time but increased to 31% of the maximum when LUI changed maximally over time. In addition to decreasing overall LUI, we suggest varying LUI across years as a complementary strategy to promote biodiversity conservation.
KW  - biodiversity loss
KW  - agricultural grasslands
KW  - Biodiversity Exploratories
Y1  - 2014
U6  - https://doi.org/10.1073/pnas.1312213111
SN  - 0027-8424
VL  - 111
IS  - 1
SP  - 308
EP  - 313
PB  - National Acad. of Sciences
CY  - Washington
ER  - 
TY  - JOUR
A1  - Müller, C.
A1  - Dibbern, P
T1  - Selbstorganisiertes Wissensmanagement in Unternehmen auf Basis der Wiki-Technologie : ein Anwendungsfall
Y1  - 2006
SN  - 978-3- 89864-384-9
ER  - 
TY  - JOUR
A1  - Müller, C.
A1  - Birn, Lukas
T1  - Wikis for collaborative software documentation
Y1  - 2006
ER  - 
TY  - JOUR
A1  - Meinecke, Frank C.
A1  - Ziehe, Andreas
A1  - Kurths, Jürgen
A1  - Müller, Klaus-Robert
T1  - Measuring phase synchronization of superimposed signals
N2  - Phase synchronization is an important phenomenon that occurs in a wide variety of complex oscillatory processes. Measuring phase synchronization can therefore help to gain fundamental insight into nature. In this Letter we point out that synchronization analysis techniques can detect spurious synchronization, if they are fed with a superposition of signals such as in electroencephalography or magnetoencephalography data. We show how techniques from blind source separation can help to nevertheless measure the true synchronization and avoid such pitfalls
Y1  - 2005
SN  - 0031-9007
ER  - 
TY  - JOUR
A1  - Nolte, Guido
A1  - Meinecke, Frank C.
A1  - Ziehe, Andreas
A1  - Müller, Klaus-Robert
T1  - Identifying interactions in mixed and noisy complex systems
N2  - We present a technique that identifies truly interacting subsystems of a complex system from multichannel data if the recordings are an unknown linear and instantaneous mixture of the true sources. The method is valid for arbitrary noise structure. For this, a blind source separation technique is proposed that diagonalizes antisymmetrized cross- correlation or cross-spectral matrices. The resulting decomposition finds truly interacting subsystems blindly and suppresses any spurious interaction stemming from the mixture. The usefulness of this interacting source analysis is demonstrated in simulations and for real electroencephalography data
Y1  - 2006
UR  - http://pre.aps.org/
U6  - https://doi.org/10.1103/Physreve.73.051913
ER  - 
TY  - JOUR
A1  - Bahrs, Julian
A1  - Müller, C.
T1  - Wissensnachfrage-orientierte Gestaltung von Softwareentwicklungsprozessen
N2  - Die zunehmend dynamische Umwelt erfordert steigende Adaptivität von Softwareentwicklungsprozessen. Dem kann durch eine Prozessgestaltung nach Methoden des geschäftsprozessorientierten Wissensmanagements und dem damit vollzogenen Paradigmenwechsel zur nachfrageorientierten Wissensverteilung begegnet werden. In diesem Beitrag wird die Analyse einer ausgewählten Instanz eines mit der KMDL-SE beschriebenen Softwareentwicklungsprozesses vorgestellt
Y1  - 2005
UR  - http://wi.uni-potsdam.de
ER  - 
TY  - JOUR
A1  - Meinecke, Frank C.
A1  - Harmeling, Stefan
A1  - Müller, Klaus-Robert
T1  - Inlier-based ICA with an application to superimposed images
N2  - This paper proposes a new independent component analysis (ICA) method which is able to unmix overcomplete mixtures of sparce or structured signals like speech, music or images. Furthermore, the method is designed to be robust against outliers, which is a favorable feature for ICA algorithms since most of them are extremely sensitive to outliers. Our approach is based on a simple outlier index. However, instead of robustifying an existing algorithm by some outlier rejection technique we show how this index can be used directly to solve the ICA problem for super-Gaussian sources. The resulting inlier-based ICA (IBICA) is outlier-robust by construction and can be used for standard ICA as well as for overcomplete ICA (i.e. more source signals than observed signals). (c) 2005 Wiley Periodicals, Inc
Y1  - 2005
SN  - 0899-9457
ER  - 
TY  - JOUR
A1  - Harmeling, Stefan
A1  - Meinecke, Frank C.
A1  - Müller, Klaus-Robert
T1  - Injecting noise for analysing the stability of ICA components
N2  - Usually, noise is considered to be destructive. We present a new method that constructively injects noise to assess the reliability and the grouping structure of empirical ICA component estimates. Our method can be viewed as a Monte-Carlo-style approximation of the curvature of some performance measure at the solution. Simulations show that the true root-mean-squared angle distances between the real sources and the source estimates can be approximated well by our method. In a toy experiment, we see that we are also able to reveal the underlying grouping structure of the extracted ICA components. Furthermore, an experiment with fetal ECG data demonstrates that our approach is useful for exploratory data analysis of real-world data. (C) 2003 Elsevier B.V. All rights reserved
Y1  - 2004
SN  - 0165-1684
ER  - 
TY  - JOUR
A1  - Müller, Klaus-Robert
A1  - Vigario, R.
A1  - Meinecke, Frank C.
A1  - Ziehe, Andreas
T1  - Blind source separation techniques for decomposing event-related brain signals
N2  - Recently blind source separation (BSS) methods have been highly successful when applied to biomedical data. This paper reviews the concept of BSS and demonstrates its usefulness in the context of event-related MEG measurements. In a first experiment we apply BSS to artifact identification of raw MEG data and discuss how the quality of the resulting independent component projections can be evaluated. The second part of our study considers averaged data of event-related magnetic fields. Here, it is particularly important to monitor and thus avoid possible overfitting due to limited sample size. A stability assessment of the BSS decomposition allows to solve this task and an additional grouping of the BSS components reveals interesting structure, that could ultimately be used for gaining a better physiological modeling of the data
Y1  - 2004
SN  - 0218-1274
ER  - 
TY  - JOUR
A1  - Simons, Nadja K.
A1  - Lewinsohn, Thomas
A1  - Bluethgen, Nico
A1  - Buscot, Francois
A1  - Boch, Steffen
A1  - Daniel, Rolf
A1  - Gossner, Martin M.
A1  - Jung, Kirsten
A1  - Kaiser, Kristin
A1  - Müller, Jörg
A1  - Prati, Daniel
A1  - Renner, Swen C.
A1  - Socher, Stephanie A.
A1  - Sonnemann, Ilja
A1  - Weiner, Christiane N.
A1  - Werner, Michael
A1  - Wubet, Tesfaye
A1  - Wurst, Susanne
A1  - Weisser, Wolfgang W.
T1  - Contrasting effects of grassland management modes on species-abundance distributions of multiple groups
JF  - Agriculture, ecosystems & environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere
N2  - Intensive land use is a major cause of biodiversity loss, but most studies comparing the response of multiple taxa rely on simple diversity measures while analyses of other community attributes are only recently gaining attention. Species-abundance distributions (SADs) are a community attribute that can be used to study changes in the overall abundance structure of species groups, and whether these changes are driven by abundant or rare species. We evaluated the effect of grassland management intensity for three land-use modes (fertilization, mowing, grazing) and their combination on species richness and SADs for three belowground (arbuscular mycorrhizal fungi, prokaryotes and insect larvae) and seven aboveground groups (vascular plants, bryophytes and lichens; arthropod herbivores; arthropod pollinators; bats and birds). Three descriptors of SADs were evaluated: general shape (abundance decay rate), proportion of rare species (rarity) and proportional abundance of the commonest species (dominance). Across groups, taxonomic richness was largely unaffected by land-use intensity and only decreased with increasing mowing intensity. Of the three SAD descriptors, abundance decay rate became steeper with increasing combined land-use intensity across groups. This reflected a decrease in rarity among plants, herbivores and vertebrates. Effects of fertilization on the three descriptors were similar to the combined land-use intensity effects. Mowing intensity only affected the SAD descriptors of insect larvae and vertebrates, while grazing intensity produced a range of effects on different descriptors in distinct groups. Overall, belowground groups had more even abundance distribtitions than aboveground groups. Strong differences among aboveground groups and between above- and belowground groups indicate that no single taxonomic group can serve as an indicator for effects in other groups. In the past, the use of SADs has been hampered by concerns over theoretical models underlying specific forms of SADs. Our study shows that SAD descriptors that are not connected to a particular model are suitable to assess the effect of land use on community structure.
KW  - Biodiversity
KW  - Cutting frequency
KW  - Management intensity
KW  - Rank-abundance
KW  - Species loss
KW  - Rarity
Y1  - 2017
U6  - https://doi.org/10.1016/j.agee.2016.12.022
SN  - 0167-8809
SN  - 1873-2305
VL  - 237
SP  - 143
EP  - 153
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Schall, Peter
A1  - Gossner, Martin M.
A1  - Heinrichs, Steffi
A1  - Fischer, Markus
A1  - Boch, Steffen
A1  - Prati, Daniel
A1  - Jung, Kirsten
A1  - Baumgartner, Vanessa
A1  - Blaser, Stefan
A1  - Böhm, Stefan
A1  - Buscot, Francois
A1  - Daniel, Rolf
A1  - Goldmann, Kezia
A1  - Kaiser, Kristin
A1  - Kahl, Tiemo
A1  - Lange, Markus
A1  - Müller, Jörg Hans
A1  - Overmann, Jörg
A1  - Renner, Swen C.
A1  - Schulze, Ernst-Detlef
A1  - Sikorski, Johannes
A1  - Tschapka, Marco
A1  - Türke, Manfred
A1  - Weisser, Wolfgang W.
A1  - Wemheuer, Bernd
A1  - Wubet, Tesfaye
A1  - Ammer, Christian
T1  - The impact of even-aged and uneven-aged forest management on regional biodiversity of multiple taxa in European beech forests
JF  - Journal of applied ecology : an official journal of the British Ecological Society
N2  - 1. For managed temperate forests, conservationists and policymakers favour fine-grained uneven-aged (UEA) management over more traditional coarse-grained even-aged (EA) management, based on the assumption that within-stand habitat heterogeneity enhances biodiversity. There is, however, little empirical evidence to support this assumption. We investigated for the first time how differently grained forest management systems affect the biodiversity of multiple above- and below-ground taxa across spatial scales. 2. We sampled 15 taxa of animals, plants, fungi and bacteria within the largest contiguous beech forest landscape of Germany and classified them into functional groups. Selected forest stands have been managed for more than a century at different spatial grains. The EA (coarse-grained management) and UEA (fine-grained) forests are comparable in spatial arrangement, climate and soil conditions. These were compared to forests of a nearby national park that have been unmanaged for at least 20years. We used diversity accumulation curves to compare -diversity for Hill numbers D-0 (species richness), D-1 (Shannon diversity) and D-2 (Simpson diversity) between the management systems. Beta diversity was quantified as multiple-site dissimilarity. 3. Gamma diversity was higher in EA than in UEA forests for at least one of the three Hill numbers for six taxa (up to 77%), while eight showed no difference. Only bacteria showed the opposite pattern. Higher -diversity in EA forests was also found for forest specialists and saproxylic beetles. 4. Between-stand -diversity was higher in EA than in UEA forests for one-third (all species) and half (forest specialists) of all taxa, driven by environmental heterogeneity between age-classes, while -diversity showed no directional response across taxa or for forest specialists. 5. Synthesis and applications. Comparing EA and uneven-aged forest management in Central European beech forests, our results show that a mosaic of different age-classes is more important for regional biodiversity than high within-stand heterogeneity. We suggest reconsidering the current trend of replacing even-aged management in temperate forests. Instead, the variability of stages and stand structures should be increased to promote landscape-scale biodiversity.
KW  - beta diversity
KW  - forest specialists
KW  - gamma diversity
KW  - heterogeneity
KW  - Hill numbers
KW  - saproxylic beetles
KW  - spatial grain
KW  - species accumulation curve
KW  - species richness
KW  - species turnover
Y1  - 2017
U6  - https://doi.org/10.1111/1365-2664.12950
SN  - 0021-8901
SN  - 1365-2664
VL  - 55
IS  - 1
SP  - 267
EP  - 278
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Batsios, Petros
A1  - Ishikawa-Ankerhold, Hellen Christina
A1  - Roth, Heike
A1  - Schleicher, Michael
A1  - Wong, Catherine C. L.
A1  - Müller-Taubenberger, Annette
T1  - Ate1-mediated posttranslational arginylation affects substrate adhesion and cell migration in Dictyostelium discoideum
JF  - Molecular biology of the cell : the official publication of the American Society for Cell Biology
N2  - The highly conserved enzyme arginyl-tRNA-protein transferase (Ate1) mediates arginylation, a posttranslational modification that is only incompletely understood at its molecular level. To investigate whether arginylation affects actin-dependent processes in a simple model organism, Dictyostelium discoideum, we knocked out the gene encoding Ate1 and characterized the phenotype of ate1-null cells. Visualization of actin cytoskeleton dynamics by live-cell microscopy indicated significant changes in comparison to wild-type cells. Ate1-null cells were almost completely lacking focal actin adhesion sites at the substrate-attached surface and were only weakly adhesive. In two-dimensional chemotaxis assays toward folate or cAMP, the motility of ate1-null cells was increased. However, in three-dimensional chemotaxis involving more confined conditions, the motility of ate1-null cells was significantly reduced. Live-cell imaging showed that GFP-tagged Ate1 rapidly relocates to sites of newly formed actin-rich protrusions. By mass spectrometric analysis, we identified four arginylation sites in the most abundant actin isoform of Dictyostelium, in addition to arginylation sites in other actin isoforms and several actin-binding proteins. In vitro polymerization assays with actin purified from ate1-null cells revealed a diminished polymerization capacity in comparison to wild-type actin. Our data indicate that arginylation plays a crucial role in the regulation of cytoskeletal activities.
Y1  - 2019
U6  - https://doi.org/10.1091/mbc.E18-02-0132
SN  - 1059-1524
SN  - 1939-4586
VL  - 30
IS  - 4
SP  - 453
EP  - 466
PB  - American Society for Cell Biology
CY  - Bethesda
ER  - 
TY  - JOUR
A1  - Müller, Katharina
A1  - Foerstendorf, Harald
A1  - Steudtner, Robin
A1  - Tsushima, Satoru
A1  - Kumke, Michael Uwe
A1  - Lefèvre, Grégory
A1  - Rothe, Jörg
A1  - Mason, Harris
A1  - Szabó, Zoltán
A1  - Yang, Ping
A1  - Adam, Christian K. R.
A1  - André, Rémi
A1  - Brennenstuhl, Katlen
A1  - Chiorescu, Ion
A1  - Cho, Herman M.
A1  - Creff, Gaëlle
A1  - Coppin, Frédéric
A1  - Dardenne, Kathy
A1  - Den Auwer, Christophe
A1  - Drobot, Björn
A1  - Eidner, Sascha
A1  - Hess, Nancy J.
A1  - Kaden, Peter
A1  - Kremleva, Alena
A1  - Kretzschmar, Jerome
A1  - Krüger, Sven
A1  - Platts, James A.
A1  - Panak, Petra
A1  - Polly, Robert
A1  - Powell, Brian A.
A1  - Rabung, Thomas
A1  - Redon, Roland
A1  - Reiller, Pascal E.
A1  - Rösch, Notker
A1  - Rossberg, André
A1  - Scheinost, Andreas C.
A1  - Schimmelpfennig, Bernd
A1  - Schreckenbach, Georg
A1  - Skerencak-Frech, Andrej
A1  - Sladkov, Vladimir
A1  - Solari, Pier Lorenzo
A1  - Wang, Zheming
A1  - Washton, Nancy M.
A1  - Zhang, Xiaobin
T1  - Interdisciplinary Round-Robin Test on molecular spectroscopy of the U(VI) Acetate System
JF  - ACS omega / American Chemical Society
N2  - A comprehensive molecular analysis of a simple aqueous complexing system. U(VI) acetate. selected to be independently investigated by various spectroscopic (vibrational, luminescence, X-ray absorption, and nuclear magnetic resonance spectroscopy) and quantum chemical methods was achieved by an international round-robin test (RRT). Twenty laboratories from six different countries with a focus on actinide or geochemical research participated and contributed to this scientific endeavor. The outcomes of this RRT were considered on two levels of complexity: first, within each technical discipline, conformities as well as discrepancies of the results and their sources were evaluated. The raw data from the different experimental approaches were found to be generally consistent. In particular, for complex setups such as accelerator-based X-ray absorption spectroscopy, the agreement between the raw data was high. By contrast, luminescence spectroscopic data turned out to be strongly related to the chosen acquisition parameters. Second, the potentials and limitations of coupling various spectroscopic and theoretical approaches for the comprehensive study of actinide molecular complexes were assessed. Previous spectroscopic data from the literature were revised and the benchmark data on the U(VI) acetate system provided an unambiguous molecular interpretation based on the correlation of spectroscopic and theoretical results. The multimethodologic approach and the conclusions drawn address not only important aspects of actinide spectroscopy but particularly general aspects of modern molecular analytical chemistry.
Y1  - 2019
U6  - https://doi.org/10.1021/acsomega.9b00164
SN  - 2470-1343
VL  - 4
IS  - 5
SP  - 8167
EP  - 8177
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - JOUR
A1  - Müller, B. R.
A1  - Cooper, R. C.
A1  - Lange, A.
A1  - Kupsch, Andreas
A1  - Wheeler, M.
A1  - Hentschel, M. P.
A1  - Staude, A.
A1  - Pandey, A.
A1  - Shyam, A.
A1  - Bruno, Giovanni
T1  - Stress-induced microcrack density evolution in beta-eucryptite ceramics
BT  - experimental observations and possible route to strain hardening
JF  - Acta materialia
N2  - In order to investigate their microcracking behaviour, the microstructures of several beta-eucryptite ceramics, obtained from glass precursor and cerammed to yield different grain sizes and microcrack densities, were characterized by laboratory and synchrotron x-ray refraction and tomography. Results were compared with those obtained from scanning electron microscopy (SEM). In SEM images, the characterized materials appeared fully dense but computed tomography showed the presence of pore clusters. Uniaxial tensile testing was performed on specimens while strain maps were recorded and analyzed by Digital Image Correlation (DIC). X-ray refraction techniques were applied on specimens before and after tensile testing to measure the amount of the internal specific surface (i.e., area per unit volume). X-ray refraction revealed that (a) the small grain size (SGS) material contained a large specific surface, originating from the grain boundaries and the interfaces of TiO2 precipitates; (b) the medium (MGS) and large grain size (LGS) materials possessed higher amounts of specific surface compared to SGS material due to microcracks, which decreased after tensile loading; (c) the precursor glass had negligible internal surface. The unexpected decrease in the internal surface of MGS and LGS after tensile testing is explained by the presence of compressive regions in the DIC strain maps and further by theoretical arguments. It is suggested that while some microcracks merge via propagation, more close mechanically, thereby explaining the observed X-ray refraction results. The mechanisms proposed would allow the development of a strain hardening route in ceramics.
KW  - Beta-eucryptite
KW  - Microcracked ceramics
KW  - X-ray refraction
KW  - Tensile load
KW  - Strain hardening
Y1  - 2017
U6  - https://doi.org/10.1016/j.actamat.2017.10.030
SN  - 1359-6454
SN  - 1873-2453
VL  - 144
SP  - 627
EP  - 641
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Müller, C.
A1  - Weber, Edzard
A1  - Gronau, Norbert
T1  - Requirements for an integration of methods analyzing social issues in knowledge organizations
Y1  - 2006
ER  - 
TY  - JOUR
A1  - Gronau, Norbert
A1  - Müller, C.
T1  - Von der Kommunikationsstrukturanalyse zur Knowledge Modeling and Description Language
Y1  - 2006
SN  - 978-3-540-28906-7
ER  - 
TY  - JOUR
A1  - Gronau, Norbert
A1  - Korf, Roman
A1  - Müller, C.
T1  - KMDL - Capturing, analysing and improving knowledge-intensive business processes
N2  - Existing approaches in the area of knowledge-intensive processes focus on integrated knowledge and process management systems, the support of processes with KM systems, or the analysis of knowledge-intensive activities. For capturing knowledge-intensive business processes well known and established methods do not meet the requirements of a comprehensive and integrated approach of process-oriented knowledge management. These approaches are not able to visualise the decisions, actions and measures which are causing the sequence of the processes in an adequate manner. Parallel to conventional processes knowledge-intensive processes exist. These processes are based on conversions of knowledge within these processes. To fill these gaps in modelling knowledge-intensive business processes the Knowledge Modelling and Description Language (KMDL) got developed. The KMDL is able to represent the development, use, offer and demand of knowledge along business processes. Further it is possible to show the existing knowledge conversions which take place additionally to the normal business processes. The KMDL can be used to formalise knowledgeintensive processes with a focus on certain knowledge-specific characteristics and to identify process improvements in these processes. The KMDL modelling tool K-Modeler is introduced for a computer-aided modelling and analysing. The technical framework and the most important functionalities to support the analysis of the captured processes are introduced in the following contribution.
Y1  - 2005
UR  - http://wi.uni-potsdam.de
ER  - 
TY  - JOUR
A1  - Gronau, Norbert
A1  - Lämmer, Anne
A1  - Müller, C.
T1  - Selbstorganisierte Dienstleistungsnetzwerke im Maschinen- und Anlagenbau
Y1  - 2008
ER  - 
TY  - BOOK
A1  - Hailbronner, Kay
A1  - Magiera, S.
A1  - Klein, Eckart
A1  - Müller-Graf, C.
T1  - Handkommentar zum Vertrag über die Europäische Union : EUV, EGV
Y1  - 1996
SN  - 3-452-22171-7
PB  - Heymanns
CY  - Köln
ER  - 
TY  - JOUR
A1  - Harmeling, Stefan
A1  - Dornhege, Guido
A1  - Tax, David
A1  - Meinecke, Frank C.
A1  - Müller, Klaus-Robert
T1  - From outliers to prototypes : Ordering data
N2  - We propose simple and fast methods based on nearest neighbors that order objects from high-dimensional data sets from typical points to untypical points. On the one hand, we show that these easy-to-compute orderings allow us to detect outliers (i.e. very untypical points) with a performance comparable to or better than other often much more sophisticated methods. On the other hand, we show how to use these orderings to detect prototypes (very typical points) which facilitate exploratory data analysis algorithms such as noisy nonlinear dimensionality reduction and clustering. Comprehensive experiments demonstrate the validity of our approach.
Y1  - 2006
UR  - http://www.sciencedirect.com/science/journal/09252312
U6  - https://doi.org/10.1016/j.neucom.2005.05.015
SN  - 0925-2312
ER  - 
TY  - JOUR
A1  - Klein, Julia
A1  - Darvin, Maxim E.
A1  - Meinke, Martina C.
A1  - Schweigert, Florian J.
A1  - Müller, Kerstin E.
A1  - Lademann, Jürgen
T1  - Analyses of the correlation between dermal and blood carotenoids in female cattle by optical methods
JF  - Journal of biomedical optics
N2  - Herd health programs for the maintenance of welfare and productivity in cattle need efficient tools for monitoring the health of individual animals. Recent reports demonstrate that the oxidative status is related to various stress conditions in dairy cows. Biomarkers, among other carotenoids, could serve as indicators of stress originating from the environment (e.g., heat stress or sun radiation) or from the animal itself (e.g., disease). To date, only invasive in vitro tests are available to assess the oxidative status in cattle. The present study compares the results of optical noninvasive in vivo measurements of dermal carotenoids in cattle udder skin using an LED-based miniaturized spectroscopic system (MSS) with those obtained by photometric analysis of beta carotene in whole blood samples using a portable device. Correlations between the concentrations of dermal and blood carotenoids were calculated under consideration of the nutritional status of the animals. Significant correlation (R = 0.86) was found for cattle with a moderate to obese body condition. Thus, the blood and skin concentrations of the marker substance beta carotene are comparable under stable stress conditions of the cattle. This demonstrates that the MSS is suitable for noninvasive assessment of dermal carotenoid concentrations in cattle.
KW  - Raman spectroscopy
KW  - reflection spectroscopy
KW  - skin
KW  - antioxidants
KW  - free radicals
Y1  - 2013
U6  - https://doi.org/10.1117/1.JBO.18.6.061219
SN  - 1083-3668
VL  - 18
IS  - 6
PB  - SPIE
CY  - Bellingham
ER  - 
TY  - JOUR
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Prati, Daniel
A1  - Gossner, Martin M.
A1  - Alt, Fabian
A1  - Boch, Steffen
A1  - Gockel, Sonja
A1  - Hemp, Andreas
A1  - Lange, Markus
A1  - Müller, Jörg
A1  - Oelmann, Yvonne
A1  - Pasalic, Esther
A1  - Renner, Swen C.
A1  - Socher, Stephanie A.
A1  - Türke, Manfred
A1  - Weisser, Wolfgang W.
A1  - Fischer, Markus
A1  - Hölzel, Norbert
T1  - Does organic grassland farming benefit plant and arthropod diversity at the expense of yield and soil fertility?
JF  - Agriculture, ecosystems & environment : an international journal for scientific research on the relationship of agriculture and food production to the biosphere
N2  - Organic management is one of the most popular strategies to reduce negative environmental impacts of intensive agriculture. However, little is known about benefits for biodiversity and potential worsening of yield under organic grasslands management across different grassland types, i.e. meadow, pasture and mown pasture. Therefore, we studied the diversity of vascular plants and foliage-living arthropods (Coleoptera, Araneae, Heteroptera, Auchenorrhyncha), yield, fodder quality, soil phosphorus concentrations and land-use intensity of organic and conventional grasslands across three study regions in Germany. Furthermore, all variables were related to the time since conversion to organic management in order to assess temporal developments reaching up to 18 years. Arthropod diversity was significantly higher under organic than conventional management, although this was not the case for Araneae, Heteroptera and Auchenorrhyncha when analyzed separately. On the contrary, arthropod abundance, vascular plant diversity and also yield and fodder quality did not considerably differ between organic and conventional grasslands. Analyses did not reveal differences in the effect of organic management among grassland types. None of the recorded abiotic and biotic parameters showed a significant trend with time since transition to organic management, except soil organic phosphorus concentrations which decreased with time. This implies that permanent grasslands respond slower and probably weaker to organic management than crop fields do. However, as land-use intensity and inorganic soil phosphorus concentrations were significantly lower in organic grasslands, overcoming seed and dispersal limitation by re-introducing plant species might be needed to exploit the full ecological potential of organic grassland management. We conclude that although organic management did not automatically increase the diversity of all studied taxa, it is a reasonable and useful way to support agro-biodiversity.
KW  - Agri-environmental schemes
KW  - Fertilization
KW  - Fodder quality
KW  - Land-use intensity
KW  - Nitrogen
KW  - Biomass nutrient concentrations
KW  - Organic farming
KW  - Phosphorus
KW  - Species richness
KW  - Nutrient availability
Y1  - 2013
U6  - https://doi.org/10.1016/j.agee.2013.05.019
SN  - 0167-8809
VL  - 177
IS  - 3
SP  - 1
EP  - 9
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Blüthgen, Nico
A1  - Dormann, Carsten F.
A1  - Prati, Daniel
A1  - Klaus, Valentin H.
A1  - Kleinebecker, Till
A1  - Hoelzel, Norbert
A1  - Alt, Fabian
A1  - Boch, Steffen
A1  - Gockel, Sonja
A1  - Hemp, Andreas
A1  - Müller, Jörg
A1  - Nieschulze, Jens
A1  - Renner, Swen C.
A1  - Schöning, Ingo
A1  - Schumacher, Uta
A1  - Socher, Stephanie A.
A1  - Wells, Konstans
A1  - Birkhofer, Klaus
A1  - Buscot, Francois
A1  - Oelmann, Yvonne
A1  - Rothenwöhrer, Christoph
A1  - Scherber, Christoph
A1  - Tscharntke, Teja
A1  - Weiner, Christiane N.
A1  - Fischer, Markus
A1  - Kalko, Elisabeth K. V.
A1  - Linsenmair, Karl Eduard
A1  - Schulze, Ernst-Detlef
A1  - Weisser, Wolfgang W.
T1  - A quantitative index of land-use intensity in grasslands integrating mowing, grazing and fertilization
JF  - Basic and applied ecology : Journal of the Gesellschaft für Ökologie
N2  - Land use is increasingly recognized as a major driver of biodiversity and ecosystem functioning in many current research projects. In grasslands, land use is often classified by categorical descriptors such as pastures versus meadows or fertilized versus unfertilized sites. However, to account for the quantitative variation of multiple land-use types in heterogeneous landscapes, a quantitative, continuous index of land-use intensity (LUI) is desirable. Here we define such a compound, additive LUI index for managed grasslands including meadows and pastures. The LUI index summarizes the standardized intensity of three components of land use, namely fertilization, mowing, and livestock grazing at each site. We examined the performance of the LUI index to predict selected response variables on up to 150 grassland sites in the Biodiversity Exploratories in three regions in Germany(Alb, Hainich, Schorlheide). We tested the average Ellenberg nitrogen indicator values of the plant community, nitrogen and phosphorus concentration in the aboveground plant biomass, plant-available phosphorus concentration in the top soil, and soil C/N ratio, and the first principle component of these five response variables.
 The LUI index significantly predicted the principal component of all five response variables, as well as some of the individual responses. Moreover, vascular plant diversity decreased significantly with LUI in two regions (Alb and Hainich).
 Inter-annual changes in management practice were pronounced from 2006 to 2008, particularly due to variation in grazing intensity. This rendered the selection of the appropriate reference year(s) an important decision for analyses of land-use effects, whereas details in the standardization of the index were of minor importance. We also tested several alternative calculations of a LUI index, but all are strongly linearly correlated to the proposed index.
 The proposed LUI index reduces the complexity of agricultural practices to a single dimension and may serve as a baseline to test how different groups of organisms and processes respond to land use. In combination with more detailed analyses, this index may help to unravel whether and how land-use intensities, associated disturbance levels or other local or regional influences drive ecological processes.
KW  - Agro-ecosystems
KW  - Biodiversity exploratories
KW  - Grassland management
KW  - Land-use impacts
KW  - Livestock density
KW  - Meadows
KW  - Nitrogen
KW  - Pastures
Y1  - 2012
U6  - https://doi.org/10.1016/j.baae.2012.04.001
SN  - 1439-1791
VL  - 13
IS  - 3
SP  - 207
EP  - 220
PB  - Elsevier
CY  - Jena
ER  - 
TY  - JOUR
A1  - Thulke, Hans-Hermann
A1  - Tischendorf, L.
A1  - Staubach, C.
A1  - Selhorst, T.
A1  - Jeltsch, Florian
A1  - Müller, T.
A1  - Schlüter, H.
A1  - Wissel, Christian
T1  - The spatio-temporal dynamics of a post-vaccination recovery of rabies in foxes and emergency vaccination planning
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Parra, L.
A1  - Spence, C.
A1  - Sajda, P.
A1  - Ziehe, Andreas
A1  - Müller, Klaus-Robert
T1  - Unmixing hyperspectral data
Y1  - 2000
ER  - 
TY  - JOUR
A1  - Gomez-Merino, Fernando Carlos
A1  - Arana-Ceballos, Fernando Alberto
A1  - Trejo-Tellez, L. I.
A1  - Skirycz, Aleksandra
A1  - Brearley, C. A.
A1  - Dormann, P.
A1  - Müller-Röber, Bernd
T1  - Arabidopsis AtDGK7, the smallest member of plant diacylglycerol kinases (DGKs), displays unique biochemical features and saturates at low substrate concentration : the DGK inhibitor R59022 differentially affects AtDGK2 and AtDGK7 activity in vitro and alters plant growth and development
N2  - Diacylglycerol kinase (DGK) regulates the level of the second messenger diacylglycerol and produces phosphatidic acid (PA), another signaling molecule. The Arabidopsis thaliana genome encodes seven putative diacylglycerol kinase isozymes (named AtDGK1 to -7), structurally falling into three major clusters. So far, enzymatic activity has not been reported for any plant Cluster II DGK. Here, we demonstrate that a representative of this cluster, AtDGK7, is biochemically active when expressed as a recombinant protein in Escherichia coli. AtDGK7, encoded by gene locus At4g30340, contains 374 amino acids with an apparent molecular mass of 41.2 kDa. AtDGK7 harbors an N-terminal catalytic domain, but in contrast to various characterized DGKs (including AtDGK2), it lacks a cysteine-rich domain at its N terminus, and, importantly, its C-terminal DGK accessory domain is incomplete. Recombinant AtDGK7 expressed in E. coli exhibits Michaelis-Menten type kinetics with 1,2-dioleoyl-sn-glycerol as substrate. AtDGK7 activity was affected by pH, detergents, and the DGK inhibitor R59022. We demonstrate that both AtDGK2 and AtDGK7 phosphorylate diacylglycerol molecular species that are typically found in plants, indicating that both enzymes convert physiologically relevant substrates. AtDGK7 is expressed throughout the Arabidopsis plant, but expression is strongest in flowers and young seedlings. Expression of AtDGK2 is transiently induced by wounding. R59022 at similar to 80 mu M inhibits root elongation and lateral root formation and reduces plant growth, indicating that DGKs play an important role in plant development
Y1  - 2005
SN  - 0021-9258
ER  - 
TY  - JOUR
A1  - Lin, W. H.
A1  - Wang, Y.
A1  - Müller-Röber, Bernd
A1  - Brearley, C. A.
A1  - Xu, Z. H.
A1  - Xue, H. W.
T1  - At5PTase13 modulates cotyledon vein development through regulating auxin homeostasis
N2  - Phosphatidylinositol signaling pathway and the relevant metabolites are known to be critical to the modulation of different aspects of plant growth, development, and stress responses. Inositol polyphosphate 5-phosphatase is a key enzyme involved in phosphatidylinositol metabolism and is encoded by an At5PTase gene family in Arabidopsis thaliana. A previous study shows that At5PTase11 mediates cotyledon vascular development probably through the regulation of intracellular calcium levels. In this study, we provide evidence that At5PTase13 modulates the development of cotyledon veins through its regulation of auxin homeostasis. A T-DNA insertional knockout mutant, At5pt13-1, showed a defect in development of the cotyledon vein, which was rescued completely by exogenous auxin and in part by brassinolide, a steroid hormone. Furthermore, the mutant had reduced auxin content and altered auxin accumulation in seedlings revealed by the DR5:beta-glucuronidase fusion construct in seedlings. In addition, microarray analysis shows that the transcription of key genes responsible for auxin biosynthesis and transport was altered in At5pt13-1. The At5pt13-1 mutant was also less sensitive to auxin inhibition of root elongation. These results suggest that At5PTase13 regulates the homeostasis of auxin, a key hormone controlling vascular development in plants
Y1  - 2005
SN  - 0032-0889
ER  - 
TY  - JOUR
A1  - Gomez-Merino, Fernando Carlos
A1  - Brearley, C. A.
A1  - Ornatowska, Magdalena
A1  - Abdel-Haliem, Mahmoud E. F.
A1  - Zanor, Maria Ines
A1  - Müller-Röber, Bernd
T1  - AtDGK2, a novel diacylglycerol kinase from Arabidopsis thaliana, phosphorylates 1-stearoyl-2-arachidonoyl-sn- glycerol and 1,2-dioleoyl-sn-glycerol and exhibits cold-inducible gene expression
N2  - Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Both DAG and PA are implicated in signal transduction pathways. DGKs have been widely studied in animals, but their analysis in plants is fragmentary. Here, we report the cloning and biochemical characterization of AtDGK2, encoding DGK from Arabidopsis thaliana. AtDGK2 has a predicted molecular mass of 79.4 kDa and, like AtDGK1 previously reported, harbors two copies of a phorbol ester/DAG-binding domain in its N-terminal region. AtDGK2 belongs to a family of seven DGK genes in A. thaliana. AtDGK3 to AtDGK7 encode similar to55-kDa DGKs that lack a typical phorbol ester/DAG-binding domain. Phylogenetically, plant DGKs fall into three clusters. Members of all three clusters are widely expressed in vascular plants. Recombinant AtDGK2 was expressed in Escherichia coli and biochemically characterized. The enzyme phosphorylated 1,2-dioleoyl-sn-glycerol to yield PA, exhibiting Michaelis-Menten type kinetics. Estimated K-m and V-max values were 125 muM for DAG and 0.25 pmol of PA min(-1) mug(-1), respectively. The enzyme was maximally active at pH 7.2. Its activity was Mg2+-dependent and affected by the presence of detergents, salts, and the DGK inhibitor R59022, but not by Ca2+. AtDGK2 exhibited substrate preference for unsaturated DAG analogues (i.e. 1-stearoyl-2-arachidonoyl-sn-glycerol and 1,2- dioleoyl-sn-glycerol). The AtDGK2 gene is expressed in various tissues of the Arabidopsis plant, including leaves, roots, and flowers, as shown by Northern blot analysis and promoter-reporter gene fusions. We found that AtDGK2 is induced by exposure to low temperature (4degreesC), pointing to a role in cold signal transduction
Y1  - 2004
SN  - 0021-9258
ER  - 
TY  - JOUR
A1  - Xu, J.
A1  - Brearley, C. A.
A1  - Lin, W. H.
A1  - Wang, Y.
A1  - Ye, R.
A1  - Müller-Röber, Bernd
A1  - Xu, Z. H.
A1  - Xue, H. W.
T1  - A role of Arabidopsis inositol polyphosphate kinase, AtIPK2 alpha, in pollen germination and root growth
N2  - Inositol polyphosphates, such as inositol trisphosphate, are pivotal intracellular signaling molecules in eukaryotic cells. In higher plants the mechanism for the regulation of the type and the level of these signaling molecules is poorly understood. In this study we investigate the physiological function of an Arabidopsis (Arabidopsis thaliana) gene encoding inositol polyphosphate kinase (AtIPK2alpha), which phosphorylates inositol 1,4,5-trisphosphate successively at the D-6 and D-3 positions, and inositol 1,3,4,5-tetrakisphosphate at D-6, resulting in the generation of inositol 1,3,4,5,6-pentakisphosphate. Semiquantitative reverse transcription-PCR and promoter-beta-glucuronidase reporter gene analyses showed that AtIPK2alpha is expressed in various tissues, including roots and root hairs, stem, leaf, pollen grains, pollen tubes, the flower stigma, and siliques. Transgenic Arabidopsis plants expressing the AtIPK2alpha antisense gene under its own promoter were generated. Analysis of several independent transformants exhibiting strong reduction in AtIPK2alpha transcript levels showed that both pollen germination and pollen tube growth were enhanced in the antisense lines compared to wild-type plants, especially in the presence of nonoptimal low Ca2+ concentrations in the culture medium. Furthermore, root growth and root hair development were also stimulated in the antisense lines, in the presence of elevated external Ca2+ concentration or upon the addition of EGTA. In addition, seed germination and early seedling growth was stimulated in the antisense lines. These observations suggest a general and important role of AtIPK2alpha, and hence inositol polyphosphate metabolism, in the regulation of plant growth most likely through the regulation of calcium signaling, consistent with the well-known function of inositol trisphosphate in the mobilization of intracellular calcium stores
Y1  - 2005
SN  - 0032-0889
ER  - 
TY  - JOUR
A1  - Diluiso, Francesca
A1  - Walk, Paula
A1  - Manych, Niccolo
A1  - Cerutti, Nicola
A1  - Chipiga, Vladislav
A1  - Workman, Annabelle
A1  - Ayas, Ceren
A1  - Cui, Ryna Yiyun
A1  - Cui, Diyang
A1  - Song, Kaihui
A1  - Banisch, Lucy A.
A1  - Moretti, Nikolaj
A1  - Callaghan, Max W.
A1  - Clarke, Leon
A1  - Creutzig, Felix
A1  - Hilaire, Jerome
A1  - Jotzo, Frank
A1  - Kalkuhl, Matthias
A1  - Lamb, William F.
A1  - Löschel, Andreas
A1  - Müller-Hansen, Finn
A1  - Nemet, Gregory F.
A1  - Oei, Pao-Yu
A1  - Sovacool, Benjamin K.
A1  - Steckel, Jan Christoph
A1  - Thomas, Sebastian
A1  - Wiseman, John
A1  - Minx, Jan C.
T1  - Coal transitions - part 1
BT  - a systematic map and review of case study learnings from regional, national, and local coal phase-out experiences
JF  - Environmental research letters
N2  - A rapid coal phase-out is needed to meet the goals of the Paris Agreement, but is hindered by serious challenges ranging from vested interests to the risks of social disruption. To understand how to organize a global coal phase-out, it is crucial to go beyond cost-effective climate mitigation scenarios and learn from the experience of previous coal transitions. Despite the relevance of the topic, evidence remains fragmented throughout different research fields, and not easily accessible. To address this gap, this paper provides a systematic map and comprehensive review of the literature on historical coal transitions. We use computer-assisted systematic mapping and review methods to chart and evaluate the available evidence on historical declines in coal production and consumption. We extracted a dataset of 278 case studies from 194 publications, covering coal transitions in 44 countries and ranging from the end of the 19th century until 2021. We find a relatively recent and rapidly expanding body of literature reflecting the growing importance of an early coal phase-out in scientific and political debates. Previous evidence has primarily focused on the United Kingdom, the United States, and Germany, while other countries that experienced large coal declines, like those in Eastern Europe, are strongly underrepresented. An increasing number of studies, mostly published in the last 5 years, has been focusing on China. Most of the countries successfully reducing coal dependency have undergone both demand-side and supply-side transitions. This supports the use of policy approaches targeting both demand and supply to achieve a complete coal phase-out. From a political economy perspective, our dataset highlights that most transitions are driven by rising production costs for coal, falling prices for alternative energies, or local environmental concerns, especially regarding air pollution. The main challenges for coal-dependent regions are structural change transformations, in particular for industry and labor. Rising unemployment is the most largely documented outcome in the sample. Policymakers at multiple levels are instrumental in facilitating coal transitions. They rely mainly on regulatory instruments to foster the transitions and compensation schemes or investment plans to deal with their transformative processes. Even though many models suggest that coal phase-outs are among the low-hanging fruits on the way to climate neutrality and meeting the international climate goals, our case studies analysis highlights the intricate political economy at work that needs to be addressed through well-designed and just policies.
KW  - climate change mitigation
KW  - coal transitions
KW  - evidence synthesis
KW  - political economy
KW  - systematic map
Y1  - 2021
U6  - https://doi.org/10.1088/1748-9326/ac1b58
SN  - 1748-9326
VL  - 16
IS  - 11
PB  - Institute of Physics Publishing (IOP)
CY  - Bristol
ER  - 
TY  - JOUR
A1  - Becker, Dirk
A1  - Geiger, D.
A1  - Dunkel, M.
A1  - Roller, A.
A1  - Bertl, Adam
A1  - Latz, A.
A1  - Carpaneto, Armando
A1  - Dietrich, Peter
A1  - Roelfsema, M. R. G.
A1  - Voelker, C.
A1  - Schmidt, D.
A1  - Müller-Röber, Bernd
A1  - Czempinski, Katrin
A1  - Hedrich, R.
T1  - AtTPK4, an Arabidopsis tandem-pore K+ channel, poised to control the pollen membrane voltage in a pH- and Ca2+- dependent manner
N2  - The Arabidopsis tandem-pore K+ (TPK) channels displaying four transmembrane domains and two pore regions share structural homologies with their animal counterparts of the KCNK family. In contrast to the Shaker-like Arabidopsis channels (six transmembrane domains/one pore region), the functional properties and the biological role of plant TPK channels have not been elucidated yet. Here, we show that AtTPK4 (KCO4) localizes to the plasma membrane and is predominantly expressed in pollen. AtTPK4 (KCO4) resembles the electrical properties of a voltage-independent K+ channel after expression in Xenopus oocytes and yeast. Hyperpolarizing as well as depolarizing membrane voltages elicited instantaneous K+ currents, which were blocked by extracellular calcium and cytoplasmic protons. Functional complementation assays using a K+ transport-deficient yeast confirmed the biophysical and pharmacological properties of the AtTPK4 channel. The features of AtTPK4 point toward a role in potassium homeostasis and membrane voltage control of the growing pollen tube. Thus, AtTPK4 represents a member of plant tandem-pore-K+ channels, resembling the characteristics of its animal counterparts as well as plant-specific features with respect to modulation of channel activity by acidosis and calcium
Y1  - 2004
SN  - 0027-8424
ER  - 
TY  - JOUR
A1  - Mehrabi, Pedram
A1  - Schulz, Eike C.
A1  - Dsouza, Raison
A1  - Müller-Werkmeister, Henrike
A1  - Tellkamp, Friedjof
A1  - Miller, R. J. Dwayne
A1  - Pai, Emil F.
T1  - Time-resolved crystallography reveals allosteric communication aligned with molecular breathing
JF  - Science
N2  - A comprehensive understanding of protein function demands correlating structure and dynamic changes. Using time-resolved serial synchrotron crystallography, we visualized half-of-the-sites reactivity and correlated molecular-breathing motions in the enzyme fluoroacetate dehalogenase. Eighteen time points from 30 milliseconds to 30 seconds cover four turnover cycles of the irreversible reaction. They reveal sequential substrate binding, covalent-intermediate formation, setup of a hydrolytic water molecule, and product release. Small structural changes of the protein mold and variations in the number and placement of water molecules accompany the various chemical steps of catalysis. Triggered by enzyme-ligand interactions, these repetitive changes in the protein framework’s dynamics and entropy constitute crucial components of the catalytic machinery.
Y1  - 2019
U6  - https://doi.org/10.1126/science.aaw9904
SN  - 0036-8075
SN  - 1095-9203
VL  - 365
IS  - 6458
SP  - 1167
EP  - 1170
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Schulz, Eike C.
A1  - Mehrabi, Pedram
A1  - Müller-Werkmeister, Henrike
A1  - Tellkamp, Friedjof
A1  - Jha, Ajay
A1  - Stuart, William
A1  - Persch, Elke
A1  - De Gasparo, Raoul
A1  - Diederich, François
A1  - Pai, Emil F.
A1  - Miller, R. J. Dwayne
T1  - The hit-and-return system enables efficient time-resolved serial synchrotron crystallography
JF  - Nature methods : techniques for life scientists and chemists
N2  - We present a ‘hit-and-return’ (HARE) method for time-resolved serial synchrotron crystallography with time resolution from milliseconds to seconds or longer. Timing delays are set mechanically, using the regular pattern in fixed-target crystallography chips and a translation stage system. Optical pump-probe experiments to capture intermediate structures of fluoroacetate dehalogenase binding to its ligand demonstrated that data can be collected at short (30 ms), medium (752 ms) and long (2,052 ms) intervals.
KW  - Biophysical chemistry
KW  - Enzymes
KW  - Molecular biophysics
KW  - X-ray crystallography
Y1  - 2018
U6  - https://doi.org/10.1038/s41592-018-0180-2
SN  - 1548-7091
SN  - 1548-7105
VL  - 15
IS  - 11
SP  - 901
EP  - 904
PB  - Nature Publishing Group (London)
CY  - London
ER  - 
TY  - JOUR
A1  - Wienhold, Sandra-Maria
A1  - Macri, Mario
A1  - Nouailles, Geraldine
A1  - Dietert, Kristina
A1  - Gurtner, Corinne
A1  - Gruber, Achim D.
A1  - Heimesaat, Markus M.
A1  - Lienau, Jasmin
A1  - Schumacher, Fabian
A1  - Kleuser, Burkhard
A1  - Opitz, Bastian
A1  - Suttorp, Norbert
A1  - Witzenrath, Martin
A1  - Müller-Redetzky, Holger C.
T1  - Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice
JF  - Critical Care
N2  - BackgroundAntibiotic exposure alters the microbiota, which can impact the inflammatory immune responses. Critically ill patients frequently receive antibiotic treatment and are often subjected to mechanical ventilation, which may induce local and systemic inflammatory responses and development of ventilator-induced lung injury (VILI). The aim of this study was to investigate whether disruption of the microbiota by antibiotic therapy prior to mechanical ventilation affects pulmonary inflammatory responses and thereby the development of VILI.MethodsMice underwent 6-8weeks of enteral antibiotic combination treatment until absence of cultivable bacteria in fecal samples was confirmed. Control mice were housed equally throughout this period. VILI was induced 3 days after completing the antibiotic treatment protocol, by high tidal volume (HTV) ventilation (34ml/kg; positive end-expiratory pressure=2 cmH(2)O) for 4h. Differences in lung function, oxygenation index, pulmonary vascular leakage, macroscopic assessment of lung injury, and leukocyte and lymphocyte differentiation were assessed. Control groups of mice ventilated with low tidal volume and non-ventilated mice were analyzed accordingly.ResultsAntibiotic-induced microbiota depletion prior to HTV ventilation led to aggravation of VILI, as shown by increased pulmonary permeability, increased oxygenation index, decreased pulmonary compliance, enhanced macroscopic lung injury, and increased cytokine/chemokine levels in lung homogenates.ConclusionsDepletion of the microbiota by broad-spectrum antibiotics prior to HTV ventilation renders mice more susceptible to developing VILI, which could be clinically relevant for critically ill patients frequently receiving broad-spectrum antibiotics.
KW  - Broad-spectrum antibiotic therapy
KW  - Ventilator-induced lung injury
KW  - Microbiota
Y1  - 2018
U6  - https://doi.org/10.1186/s13054-018-2213-8
SN  - 1466-609X
SN  - 1364-8535
VL  - 22
IS  - 282
PB  - BMC
CY  - London
ER  - 
TY  - JOUR
A1  - Gulbins, Anne
A1  - Schumacher, Fabian
A1  - Becker, Katrin Anne
A1  - Wilker, Barbara
A1  - Soddemann, Matthias
A1  - Boldrin, Francesco
A1  - Müller, Christian P.
A1  - Edwards, Michael J.
A1  - Goodman, Michael
A1  - Caldwell, Charles C.
A1  - Kleuser, Burkhard
A1  - Kornhuber, Johannes
A1  - Szabo, Ildiko
A1  - Gulbins, Erich
T1  - Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide
JF  - Molecular psychiatry
N2  - Major depressive disorder (MDD) is a common and severe disease characterized by mood changes, somatic alterations, and often suicide. MDD is treated with antidepressants, but the molecular mechanism of their action is unknown. We found that widely used antidepressants such as amitriptyline and fluoxetine induce autophagy in hippocampal neurons via the slow accumulation of sphingomyelin in lysosomes and Golgi membranes and of ceramide in the endoplasmic reticulum (ER). ER ceramide stimulates phosphatase 2A and thereby the autophagy proteins Ulk, Beclin, Vps34/Phosphatidylinositol 3-kinase, p62, and Lc3B. Although treatment with amitriptyline or fluoxetine requires at least 12 days to achieve sphingomyelin accumulation and the subsequent biochemical and cellular changes, direct inhibition of sphingomyelin synthases with tricyclodecan-9-yl-xanthogenate (D609) results in rapid (within 3 days) accumulation of ceramide in the ER, activation of autophagy, and reversal of biochemical and behavioral signs of stress-induced MDD. Inhibition of Beclin blocks the antidepressive effects of amitriptyline and D609 and induces cellular and behavioral changes typical of MDD. These findings identify sphingolipid-controlled autophagy as an important target for antidepressive treatment methods and provide a rationale for the development of novel antidepressants that act within a few days.
Y1  - 2018
U6  - https://doi.org/10.1038/s41380-018-0090-9
SN  - 1359-4184
SN  - 1476-5578
VL  - 23
IS  - 12
SP  - 2324
EP  - 2346
PB  - Nature Publ. Group
CY  - London
ER  - 
TY  - GEN
A1  - Troll, K.
A1  - Kulkarni, Amit
A1  - Wang, W.
A1  - Darko, C.
A1  - Koumba, A. M. Bivigou
A1  - Laschewsky, André
A1  - Müller-Buschbaum, Peter
A1  - Papadakis, Christine M.
T1  - The collapse transition of poly(styrene-b-(N-isopropyl acrylamide)) diblock copolymers in aqueous solution and in thin films
T2  - Colloid and polymer science : official journal of the Kolloid-Gesellschaft
Y1  - 2011
U6  - https://doi.org/10.1007/s00396-010-2344-1
SN  - 0303-402X
VL  - 289
IS  - 2
SP  - 227
EP  - 227
PB  - Springer
CY  - New York
ER  -