TY - JOUR A1 - Ehrlichmann, Frank A1 - Krumrein, Frieder A1 - Kugler, Brigitte A1 - Meincke, Rolf A1 - Raum, Bernd A1 - Schröder, Ulrich A1 - Uhlenwinkel, Anke A1 - Zimmermann, Bernd A1 - Zoska, Marianne T1 - Terra Erdkunde : Arbeitsheft für Berlin 5 / 6 ; Lehrerheft Y1 - 1996 PB - Perthes CY - Gotha ER - TY - JOUR A1 - Ehrlichmann, Frank A1 - Krumrein, Frieder A1 - Kugler, Brigitte A1 - Meincke, Rolf A1 - Raum, Bernd A1 - Schröder, Ulrich A1 - Uhlenwinkel, Anke A1 - Zimmermann, Bernd T1 - Terra Erdkunde : Arbeitsheft für Berlin 5 / 6 Y1 - 1995 PB - Perthes CY - Gotha ER - TY - JOUR A1 - Gaeckle, Maren A1 - Domahs, Frank A1 - Kartmann, Angelika A1 - Tomandl, Bernd A1 - Frank, Ulrike T1 - Predictors of Penetration-Aspiration in Parkinson’s Disease Patients With Dysphagia BT - a retrospective analysis JF - Annals of Otology, Rhinology and Laryngology N2 - Methods: The data of 89 PD patients with dysphagia who underwent routinely conducted videofluoroscopic studies of swallowing (VFSS) were included in this retrospective study. The occurrence of penetration-aspiration was defined as scores >= 3 on the Penetration-Aspiration Scale (PAS). Four commonly reported signs of dysphagia in PD patients were evaluated as possible predictors. Furthermore, the relationships between the occurrence of penetration-aspiration and liquid bolus volume as well as clinical severity of PD (modified Hoehn and Yahr scale) were examined. Results: Logistic regression showed that a delayed initiation of the pharyngeal swallow (odds ratio [OR] = 7.47, P = .008) and a reduced hyolaryngeal excursion (OR = 5.13, P = .012) were predictors of penetration-aspiration. Moreover, there was a strong, positive correlation between increasing liquid bolus volume and penetration-aspiration (gamma = 0.71, P < .001). No correlation was found between severity of PD and penetration-aspiration (gamma = 0.077, P = .783). Conclusion: Results of the present study allow for a better understanding of penetration-aspiration risk in PD patients. They are useful for treatment planning in order to improve safe oral intake and adequate nutrition. KW - pneumonia KW - videofluoroscopy Y1 - 2019 U6 - https://doi.org/10.1177/0003489419841398 SN - 0003-4894 SN - 1943-572X VL - 128 IS - 8 SP - 728 EP - 735 PB - Sage Publ. CY - Thousand Oaks ER - TY - JOUR A1 - Danquah, Ina A1 - Dobrucky, C. Lydia A1 - Frank, Laura K. A1 - Henze, Andrea A1 - Amoako, Yaw A. A1 - Bedu-Addo, George A1 - Raila, Jens A1 - Schulze, Matthias Bernd A1 - Mockenhaupt, Frank P. A1 - Schweigert, Florian J. T1 - Vitamin A: potential misclassification of vitamin A status among patients with type 2 diabetes and hypertension in urban Ghana JF - The American journal of clinical nutrition : a publication of the American Society for Nutrition, Inc. N2 - Background: Sub-Saharan Africa is facing a double burden of malnutrition: vitamin A deficiency (VAD) prevails, whereas the nutrition-related chronic conditions type 2 diabetes (T2D) and hypertension are emerging. Serum retinol a VAD marker increases in kidney disease and decreases in inflammation, which can partly be attributed to alterations in the vitamin A transport proteins retinol-binding protein 4 (RBP4) and prealbumin. Kidney dysfunction and inflammation commonly accompany T2D and hypertension. Objective: Among urban Ghanaians, we investigated the associations of T2D and hypertension with serum retinol as well as the importance of kidney function and inflammation in this regard. Design: A hospital-based, case-control study in individuals for risk factors of T2D, hypertension, or both was conducted in Kumasi, Ghana (328 controls, 197 with T2D, 354 with hypertension, and 340 with T2D plus hypertension). In 1219 blood samples, serum retinol, RBP4, and prealbumin were measured. Urinary albumin and estimated glomerular filtration rate (eGFR) defined kidney function. C-reactive protein (CRP) >5 mg/L indicated inflammation. We identified associations of T2D and hypertension with retinol by linear regression and calculated the contribution of RBP4, prealbumin, urinary albumin, eGFR, and CRP to these associations as the percentages of the explained variance of retinol. Results: VAD (retinol <1.05 mu mol/L) was present in 10% of this predominantly female, middle-aged, overweight, and deprived population. Hypertension, but not T2D, was positively associated with retinol (beta: 0.12; 95% CI: 0.08, 0,17), adjusted for age, sex, socioeconomic factors, anthropometric measurements, and lifestyle. In addition to RBP4 (72%) and prealbumin (22%), the effect of increased retinol on individuals with hypertension was mainly attributed to impaired kidney function (eGFR: 30%; urinary albumin: 5%) but not to inflammation. Conclusions: In patients with hypertension, VAD might be underestimated because of increased serum retinol in the context of kidney dysfunction. Thus, the interpretation of serum retinol in sub-Saharan Africa should account for hypertension status. KW - hypertension KW - inflammation KW - kidney dysfunction KW - type 2 diabetes KW - vitamin A deficiency Y1 - 2015 U6 - https://doi.org/10.3945/ajcn.114.101345 SN - 0002-9165 SN - 1938-3207 VL - 102 IS - 1 SP - 207 EP - 214 PB - American Society for Nutrition, Inc. CY - Bethesda ER - TY - JOUR A1 - Kempf, Sascha A1 - Srama, Ralf A1 - Grün, Eberhard A1 - Mocker, Anna A1 - Postberg, Frank A1 - Hillier, Jon K. A1 - Horanyi, Mihaly A1 - Sternovsky, Zoltan A1 - Abel, Bernd A1 - Beinsen, Alexander A1 - Thissen, Roland A1 - Schmidt, Jürgen A1 - Spahn, Frank A1 - Altobelli, Nicolas T1 - Linear high resolution dust mass spectrometer for a mission to the Galilean satellites JF - Planetary and space science N2 - The discovery of volcanic activity on Enceladus stands out amongst the long list of findings by the Cassini mission to Saturn. In particular the compositional analysis of Enceladus ice particles by Cassini's Cosmic Dust Analyser (CDA) (Srama et al., 2004) has proven to be a powerful technique for obtaining information about processes below the moon's ice crust. Small amounts of sodium salts embedded in the particles' ice matrices provide direct evidence for a subsurface liquid water reservoir, which is, or has been, in contact with the moon's rocky core (Postberg et al., 2009, 2011b). Jupiter's Galilean satellites Ganymede, Europa, and Callisto are also believed to have subsurface oceans and are therefore prime targets for future NASA and ESA outer Solar System missions. The Galilean moons are engulfed in tenuous dust clouds consisting of tiny pieces of the moons' surfaces (Kruger et al., 1999), released by hypervelocity impacts of micrometeoroids, which steadily bombard the surfaces of the moons. In situ chemical analysis of these grains by a high resolution dust spectrometer will provide spatially resolved mapping of the surface composition of Europa. Ganymede, and Callisto, meeting key scientific objectives of the planned missions. However, novel high-resolution reflectron-type dust mass spectrometers (Sternovsky et al., 2007; Srama et al., 2007) developed for dust astronomy missions (Gran et al., 2009) are probably not robust enough to be operated in the energetic radiation environment of the inner Jovian system. In contrast, CDA's linear spectrometer is much less affected by harsh radiation conditions because its ion detector is not directly facing out into space. The instrument has been continuously operated on Cassini for 11 years. In this paper we investigate the possibility of operating a CDA-like instrument as a high resolution impact mass spectrometer. We show that such an instrument is capable of reliably identifying traces of organic and inorganic materials in the ice matrix of ejecta expected to be generated from the surfaces of the Galilean moons. These measurements are complementary, and in some cases superior, compared to other traditional techniques such as infrared remote sensing or in situ ion or neutral mass spectrometers. KW - Europa KW - Ganymede KW - Callisto KW - Surface composition KW - Mass spectroscopy KW - Dust Y1 - 2012 U6 - https://doi.org/10.1016/j.pss.2011.12.019 SN - 0032-0633 VL - 65 IS - 1 SP - 10 EP - 20 PB - Elsevier CY - Oxford ER - TY - CHAP A1 - Kurbel, Karl A1 - Nowak, Dawid A1 - Azodi, Amir A1 - Jaeger, David A1 - Meinel, Christoph A1 - Cheng, Feng A1 - Sapegin, Andrey A1 - Gawron, Marian A1 - Morelli, Frank A1 - Stahl, Lukas A1 - Kerl, Stefan A1 - Janz, Mariska A1 - Hadaya, Abdulmasih A1 - Ivanov, Ivaylo A1 - Wiese, Lena A1 - Neves, Mariana A1 - Schapranow, Matthieu-Patrick A1 - Fähnrich, Cindy A1 - Feinbube, Frank A1 - Eberhardt, Felix A1 - Hagen, Wieland A1 - Plauth, Max A1 - Herscheid, Lena A1 - Polze, Andreas A1 - Barkowsky, Matthias A1 - Dinger, Henriette A1 - Faber, Lukas A1 - Montenegro, Felix A1 - Czachórski, Tadeusz A1 - Nycz, Monika A1 - Nycz, Tomasz A1 - Baader, Galina A1 - Besner, Veronika A1 - Hecht, Sonja A1 - Schermann, Michael A1 - Krcmar, Helmut A1 - Wiradarma, Timur Pratama A1 - Hentschel, Christian A1 - Sack, Harald A1 - Abramowicz, Witold A1 - Sokolowska, Wioletta A1 - Hossa, Tymoteusz A1 - Opalka, Jakub A1 - Fabisz, Karol A1 - Kubaczyk, Mateusz A1 - Cmil, Milena A1 - Meng, Tianhui A1 - Dadashnia, Sharam A1 - Niesen, Tim A1 - Fettke, Peter A1 - Loos, Peter A1 - Perscheid, Cindy A1 - Schwarz, Christian A1 - Schmidt, Christopher A1 - Scholz, Matthias A1 - Bock, Nikolai A1 - Piller, Gunther A1 - Böhm, Klaus A1 - Norkus, Oliver A1 - Clark, Brian A1 - Friedrich, Björn A1 - Izadpanah, Babak A1 - Merkel, Florian A1 - Schweer, Ilias A1 - Zimak, Alexander A1 - Sauer, Jürgen A1 - Fabian, Benjamin A1 - Tilch, Georg A1 - Müller, David A1 - Plöger, Sabrina A1 - Friedrich, Christoph M. A1 - Engels, Christoph A1 - Amirkhanyan, Aragats A1 - van der Walt, Estée A1 - Eloff, J. H. P. A1 - Scheuermann, Bernd A1 - Weinknecht, Elisa ED - Meinel, Christoph ED - Polze, Andreas ED - Oswald, Gerhard ED - Strotmann, Rolf ED - Seibold, Ulrich ED - Schulzki, Bernhard T1 - HPI Future SOC Lab BT - Proceedings 2015 N2 - Das Future SOC Lab am HPI ist eine Kooperation des Hasso-Plattner-Instituts mit verschiedenen Industriepartnern. Seine Aufgabe ist die Ermöglichung und Förderung des Austausches zwischen Forschungsgemeinschaft und Industrie. Am Lab wird interessierten Wissenschaftlern eine Infrastruktur von neuester Hard- und Software kostenfrei für Forschungszwecke zur Verfügung gestellt. Dazu zählen teilweise noch nicht am Markt verfügbare Technologien, die im normalen Hochschulbereich in der Regel nicht zu finanzieren wären, bspw. Server mit bis zu 64 Cores und 2 TB Hauptspeicher. Diese Angebote richten sich insbesondere an Wissenschaftler in den Gebieten Informatik und Wirtschaftsinformatik. Einige der Schwerpunkte sind Cloud Computing, Parallelisierung und In-Memory Technologien. In diesem Technischen Bericht werden die Ergebnisse der Forschungsprojekte des Jahres 2015 vorgestellt. Ausgewählte Projekte stellten ihre Ergebnisse am 15. April 2015 und 4. November 2015 im Rahmen der Future SOC Lab Tag Veranstaltungen vor. KW - Future SOC Lab KW - Forschungsprojekte KW - Multicore Architekturen KW - In-Memory Technologie KW - Cloud Computing KW - maschinelles Lernen KW - künstliche Intelligenz Y1 - 2017 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-102516 ER - TY - JOUR A1 - Förstner, Bernd Rainer A1 - Böttger, Sarah Jane A1 - Moldavski, Alexander A1 - Bajbouj, Malek A1 - Pfennig, Andrea A1 - Manook, Andre A1 - Ising, Marcus A1 - Pittig, Andre A1 - Heinig, Ingmar A1 - Heinz, Andreas A1 - Mathiak, Klaus A1 - Schulze, Thomas G. A1 - Schneider, Frank A1 - Kamp-Becker, Inge A1 - Meyer-Lindenberg, Andreas A1 - Padberg, Frank A1 - Banaschewski, Tobias A1 - Bauer, Michael A1 - Rupprecht, Rainer A1 - Wittchen, Hans-Ulrich A1 - Rapp, Michael A. A1 - Tschorn, Mira T1 - The associations of positive and negative valence systems, cognitive systems and social processes on disease severity in anxiety and depressive disorders JF - Frontiers in psychiatry N2 - Background Anxiety and depressive disorders share common features of mood dysfunctions. This has stimulated interest in transdiagnostic dimensional research as proposed by the Research Domain Criteria (RDoC) approach by the National Institute of Mental Health (NIMH) aiming to improve the understanding of underlying disease mechanisms. The purpose of this study was to investigate the processing of RDoC domains in relation to disease severity in order to identify latent disorder-specific as well as transdiagnostic indicators of disease severity in patients with anxiety and depressive disorders. Methods Within the German research network for mental disorders, 895 participants (n = 476 female, n = 602 anxiety disorder, n = 257 depressive disorder) were recruited for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) and included in this cross-sectional study. We performed incremental regression models to investigate the association of four RDoC domains on disease severity in patients with affective disorders: Positive (PVS) and Negative Valance System (NVS), Cognitive Systems (CS) and Social Processes (SP). Results The results confirmed a transdiagnostic relationship for all four domains, as we found significant main effects on disease severity within domain-specific models (PVS: & beta; = -0.35; NVS: & beta; = 0.39; CS: & beta; = -0.12; SP: & beta; = -0.32). We also found three significant interaction effects with main diagnosis showing a disease-specific association. Limitations The cross-sectional study design prevents causal conclusions. Further limitations include possible outliers and heteroskedasticity in all regression models which we appropriately controlled for. Conclusion Our key results show that symptom burden in anxiety and depressive disorders is associated with latent RDoC indicators in transdiagnostic and disease-specific ways. KW - Research Domain Criteria KW - depression KW - anxiety disoders KW - disease severity KW - transdiagnostic KW - RDoC Y1 - 2023 U6 - https://doi.org/10.3389/fpsyt.2023.1161097 SN - 1664-0640 VL - 14 PB - Frontiers Research Foundation CY - Lausanne ER - TY - JOUR A1 - Förstner, Bernd R. A1 - Tschorn, Mira A1 - Reinoso-Schiller, Nicolas A1 - Maričić, Lea Mascarell A1 - Röcher, Erik A1 - Kalman, Janos L. A1 - Stroth, Sanna A1 - Mayer, Annalina V. A1 - Schwarz, Kristina A1 - Kaiser, Anna A1 - Pfennig, Andrea A1 - Manook, André A1 - Ising, Marcus A1 - Heinig, Ingmar A1 - Pittig, Andre A1 - Heinz, Andreas A1 - Mathiak, Klaus A1 - Schulze, Thomas G. A1 - Schneider, Frank A1 - Kamp-Becker, Inge A1 - Meyer-Lindenberg, Andreas A1 - Padberg, Frank A1 - Banaschewski, Tobias A1 - Bauer, Michael A1 - Rupprecht, Rainer A1 - Wittchen, Hans-Ulrich A1 - Rapp, Michael A. T1 - Mapping research domain criteria using a transdiagnostic mini-RDoC assessment in mental disorders: a confirmatory factor analysis JF - European archives of psychiatry and clinical neuroscience N2 - This study aimed to build on the relationship of well-established self-report and behavioral assessments to the latent constructs positive (PVS) and negative valence systems (NVS), cognitive systems (CS), and social processes (SP) of the Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred and thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% from depressive, 7.9% from schizophrenia spectrum, 7.5% from bipolar, 3.4% from autism spectrum, 2.2% from other disorders, 18.4% healthy controls, and 0.2% with no diagnosis specified) recruited in studies within the German research network for mental disorders for the Phenotypic, Diagnostic and Clinical Domain Assessment Network Germany (PD-CAN) were examined with a Mini-RDoC-Assessment including behavioral and self-report measures. The respective data was analyzed with confirmatory factor analysis (CFA) to delineate the underlying latent RDoC-structure. A revised four-factor model reflecting the core domains positive and negative valence systems as well as cognitive systems and social processes showed a good fit across this sample and showed significantly better fit compared to a one factor solution. The connections between the domains PVS, NVS and SP could be substantiated, indicating a universal latent structure spanning across known nosological entities. This study is the first to give an impression on the latent structure and intercorrelations between four core Research Domain Criteria in a transnosological sample. We emphasize the possibility of using already existing and well validated self-report and behavioral measurements to capture aspects of the latent structure informed by the RDoC matrix. KW - Diagnosis and classification KW - Research Domain Criteria KW - PD-CAN KW - Confirmatory factor analysis CFA KW - RDoC KW - Transdiagnostic Y1 - 2022 U6 - https://doi.org/10.1007/s00406-022-01440-6 SN - 0940-1334 SN - 1433-8491 VL - 273 IS - 3 SP - 527 EP - 539 PB - Springer Nature CY - Heidelberg ER - TY - JOUR A1 - Warken, Sophie Friederike A1 - Fohlmeister, Jens Bernd A1 - Schröder-Ritzrauh, Andrea A1 - Constantin, Silviu A1 - Spötl, Christoph A1 - Gerdes, Axel A1 - Esper, Jan A1 - Frank, Norbert A1 - Arps, Jennifer A1 - Terente, Mihai A1 - Riechelmann, Dana Felicitas Christine A1 - Mangini, Augusto A1 - Scholz, Denis T1 - Reconstruction of late Holocene autumn/winter precipitation variability in SW Romania from a high-resolution speleothem trace element record JF - Earth & planetary science letters N2 - We present the first high-resolution trace element (Mg/Ca, Sr/Ca, Ba/Ca) record from a stalagmite in southwestern Romania covering the last 3.6 ka, which provides the potential for quantitative climate reconstruction. Precise age control is based on three independent dating methods, in particular for the last 250 yr, where chemical lamina counting is combined with the identification of the 20th century radiocarbon bomb peak and Th-230/U dating. Long-term cave monitoring and model simulations of drip water and speleothem elemental variability indicate that precipitation-related processes are the main drivers of speleothem Mg/Ca ratios. Calibration against instrumental climate data shows a significant anti-correlation of speleothem Mg/Ca ratios with autumn/winter (October to March) precipitation (r = -0.61, p < 0.01), which is statistically robust when considering age uncertainties and auto-correlation. This relationship is used to develop a quantitative reconstruction of autumn/winter precipitation. During the late Holocene, our data suggest a heterogeneous pattern of past regional winter hydroclimate in the Carpathian/Balkan realm, along with intermittent weakening of the dominant influence of North Atlantic forcing. In agreement with other regional paleo-hydrological reconstructions, the observed variability reveals periodically occurring strong NW-SE hydro-climate gradients. We hypothesize, that this pattern is caused by shifts of the eastern edge of the area of influence of the NAO across central eastern Europe due to the confluence of North Atlantic forcing, and other climatic features such as the East Atlantic/Western Russia (EAWR) pattern. (C) 2018 Elsevier B.V. All rights reserved. KW - speleothem KW - trace elements KW - proxy calibration KW - precipitation reconstruction KW - Romania KW - North Atlantic forcing Y1 - 2018 U6 - https://doi.org/10.1016/j.epsl.2018.07.027 SN - 0012-821X SN - 1385-013X VL - 499 SP - 122 EP - 133 PB - Elsevier CY - Amsterdam ER - TY - JOUR A1 - Pauly, Maren A1 - Helle, Gerhard A1 - Miramont, Cecile A1 - Buentgen, Ulf A1 - Treydte, Kerstin A1 - Reinig, Frederick A1 - Guibal, Frederic A1 - Sivan, Olivier A1 - Heinrich, Ingo A1 - Riedel, Frank A1 - Kromer, Bernd A1 - Balanzategui, Daniel A1 - Wacker, Lukas A1 - Sookdeo, Adam A1 - Brauer, Achim T1 - Subfossil trees suggest enhanced Mediterranean hydroclimate variability at the onset of the Younger Dryas JF - Scientific reports N2 - Nearly 13,000 years ago, the warming trend into the Holocene was sharply interrupted by a reversal to near glacial conditions. Climatic causes and ecological consequences of the Younger Dryas (YD) have been extensively studied, however proxy archives from the Mediterranean basin capturing this period are scarce and do not provide annual resolution. Here, we report a hydroclimatic reconstruction from stable isotopes (delta O-18, delta C-13) in subfossil pines from southern France. Growing before and during the transition period into the YD (12 900-12 600 cal BP), the trees provide an annually resolved, continuous sequence of atmospheric change. Isotopic signature of tree sourcewater (delta O-18(sw)) and estimates of relative air humidity were reconstructed as a proxy for variations in air mass origin and precipitation regime. We find a distinct increase in inter-annual variability of sourcewater isotopes (delta O-18(sw)), with three major downturn phases of increasing magnitude beginning at 12 740 cal BP. The observed variation most likely results from an amplified intensity of North Atlantic (low delta O-18(sw)) versus Mediterranean (high delta O-18(sw)) precipitation. This marked pattern of climate variability is not seen in records from higher latitudes and is likely a consequence of atmospheric circulation oscillations at the margin of the southward moving polar front. Y1 - 2018 U6 - https://doi.org/10.1038/s41598-018-32251-2 SN - 2045-2322 VL - 8 PB - Nature Publ. Group CY - London ER - TY - JOUR A1 - Pittarello, Lidia A1 - Goderis, Steven A1 - Soens, Bastien A1 - McKibbin, Seann J. A1 - Giuli, Gabriele A1 - Bariselli, Federico A1 - Dias, Bruno A1 - Helber, Bernd A1 - Lepore, Giovanni Orazio A1 - Vanhaecke, Frank A1 - Köberl, Christian A1 - Magin, Thierry E. A1 - Claeys, Philippe T1 - Meteoroid atmospheric entry investigated with plasma flow experiments: Petrography and geochemistry of the recovered material JF - Icarus : international journal of solar system studies N2 - Melting experiments attempting to reproduce some of the processes affecting asteroidal and cometary material during atmospheric entry have been performed in a high enthalpy facility. For the first time with the specific experimental setup, the resulting material has been recovered, studied, and compared with natural analogues, focusing on the thermal and redox reactions triggered by interaction between the melt and the atmospheric gases under high temperature and low pressure conditions. Experimental conditions were tested across a range of parameters, such as heat flux, experiment duration, and pressure, using two types of sample holders materials, namely cork and graphite. A basalt served as asteroidal analog and to calibrate the experiments, before melting a H5 ordinary chondrite meteorite. The quenched melt recovered after the experiments has been analyzed by mu-XRF, EDS-SEM, EMPA, LA-ICP-MS, and XANES spectroscopy. The glass formed from the basalt is fairly homogeneous, depleted in highly volatile elements (e.g., Na, K), relatively enriched in moderately siderophile elements (e.g., Co, Ni), and has reached an equilibrium redox state with a lower Fe3+/Fe-tot ratio than that in the starting material. Spherical objects, enriched in SiO2, Na2O and K2O, were observed, inferring condensation from the vaporized material. Despite instantaneous quenching, the melt formed from the ordinary chondrite shows extensive crystallization of mostly olivine and magnetite, the latter indicative of oxygen fugacity compatible with presence of both Fe2+ and Fe3+. Similar features have been observed in natural meteorite fusion crusts and in micrometeorites, implying that, at least in terms of maximum temperature reached and chemical reactions, the experiments have successfully reproduced the conditions likely encountered by extraterrestrial material following atmospheric entry. KW - Melting experiments KW - Atmospheric entry KW - Meteorites KW - Fusion crust KW - Redox Y1 - 2019 U6 - https://doi.org/10.1016/j.icarus.2019.04.033 SN - 0019-1035 SN - 1090-2643 VL - 331 SP - 170 EP - 178 PB - Elsevier CY - San Diego ER - TY - JOUR A1 - Stinnesbeck, Wolfgang A1 - Becker, Julia A1 - Hering, Fabio A1 - Frey, Eberhard A1 - Gonzalez Gonzalez, Arturo A1 - Fohlmeister, Jens Bernd A1 - Stinnesbeck, Sarah A1 - Frank, Norbert A1 - Terrazas Mata, Alejandro A1 - Elena Benavente, Martha A1 - Aviles Olguin, Jeronimo A1 - Aceves Nunez, Eugenio A1 - Zell, Patrick A1 - Deininger, Michael T1 - The earliest settlers of Mesoamerica date back to the late Pleistocene JF - PLoS one N2 - Preceramic human skeletal remains preserved in submerged caves near Tulum in the Mexican state of Quintana Roo, Mexico, reveal conflicting results regarding C-14 dating. Here we use U-series techniques for dating a stalagmite overgrowing the pelvis of a human skeleton discovered in the submerged Chan Hol cave. The oldest closed system U/Th age comes from around 21 mm above the pelvis defining the terminus ante quem for the pelvis to 11311 +/- 370 y BP. However, the skeleton might be considerable older, probably as old as 13 ky BP as indicated by the speleothem stable isotope data. The Chan Hol individual confirms a late Pleistocene settling of Mesoamerica and represents one of the oldest human osteological remains in America. Y1 - 2017 U6 - https://doi.org/10.1371/journal.pone.0183345 SN - 1932-6203 VL - 12 PB - PLoS CY - San Fransisco ER - TY - GEN A1 - Pauly, Maren A1 - Helle, Gerhard A1 - Miramont, Cécile A1 - Büntgen, Ulf A1 - Treydte, Kerstin A1 - Reinig, Frederick A1 - Guibal, Frédéric A1 - Sivan, Olivier A1 - Heinrich, Ingo A1 - Riedel, Frank A1 - Kromer, Bernd A1 - Balanzategui, Daniel A1 - Wacker, Lukas A1 - Sookdeo, Adam Sookdeo A1 - Brauer, Achim T1 - Subfossil trees suggest enhanced Mediterranean hydroclimate variability at the onset of the Younger Dryas T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - Nearly 13,000 years ago, the warming trend into the Holocene was sharply interrupted by a reversal to near glacial conditions. Climatic causes and ecological consequences of the Younger Dryas (YD) have been extensively studied, however proxy archives from the Mediterranean basin capturing this period are scarce and do not provide annual resolution. Here, we report a hydroclimatic reconstruction from stable isotopes (delta O-18, delta C-13) in subfossil pines from southern France. Growing before and during the transition period into the YD (12 900-12 600 cal BP), the trees provide an annually resolved, continuous sequence of atmospheric change. Isotopic signature of tree sourcewater (delta O-18(sw)) and estimates of relative air humidity were reconstructed as a proxy for variations in air mass origin and precipitation regime. We find a distinct increase in inter-annual variability of sourcewater isotopes (delta O-18(sw)), with three major downturn phases of increasing magnitude beginning at 12 740 cal BP. The observed variation most likely results from an amplified intensity of North Atlantic (low delta O-18(sw)) versus Mediterranean (high delta O-18(sw)) precipitation. This marked pattern of climate variability is not seen in records from higher latitudes and is likely a consequence of atmospheric circulation oscillations at the margin of the southward moving polar front. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1135 KW - annually laminated sediments KW - lake Meerfelder Maar KW - isotopic composition KW - oxygen isotope KW - climate KW - cellulose KW - radiocarbon KW - temperature KW - record KW - model Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-459169 SN - 1866-8372 IS - 1135 ER - TY - JOUR A1 - Thulin, Mirjam A1 - Krah, Markus A1 - Gausemeier, Bernd A1 - Mecklenburg, Frank A1 - Oehme, Annegret A1 - Tamás, Máté A1 - Gerlach, Lisa A1 - Gräbe, Viktoria A1 - Wermke, Michael A1 - Oleshkevich, Ekaterina A1 - Arnold, Rafael D. A1 - Wendehorst, Stephan A1 - Talabardon, Susanne A1 - Mays, Devi A1 - Müller, Judith A1 - Herskovitz, Yaakov A1 - Garloff, Katja A1 - Kellenbach, Katharina von A1 - Held, Marcus A1 - Grözinger, Karl Erich ED - Thulin, Mirjam ED - Krah, Markus ED - Pick, Bianca T1 - PaRDeS : Journal of the Association for Jewish Studies in Germany = Jewish Families and Kinship in the Early Modern and Modern Eras T2 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien T2 - PaRDeS : Journal of the Association for Jewish Studies in Germany N2 - The Jewish family has been the subject of much admiration and analysis, criticism and myth-making, not just but especially in modern times. As a field of inquiry, its place is at the intersection – or in the shadow – of the great topics in Jewish Studies and its contributing disciplines. Among them are the modernization and privatization of Judaism and Jewish life; integration and distinctiveness of Jews as individuals and as a group; gender roles and education. These and related questions have been the focus of modern Jewish family research, which took shape as a discipline in the 1910s. This issue of PaRDeS traces the origins of academic Jewish family research and takes stock of its development over a century, with its ruptures that have added to the importance of familial roots and continuities. A special section retrieves the founder of the field, Arthur Czellitzer (1871–1943), his biography and work from oblivion and places him in the context of early 20th-century science and Jewish life. The articles on current questions of Jewish family history reflect the topic’s potential for shedding new light on key questions in Jewish Studies past and present. Their thematic range – from 13th-century Yiddish Arthurian romances via family-based business practices in 19th-century Hungary and Germany, to concepts of Jewish parenthood in Imperial Russia – illustrates the broad interest in Jewish family research as a paradigm for early modern and modern Jewish Studies. T3 - PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. - 26 KW - Modern Jewish history KW - family history KW - early modern history KW - Jewish Studies KW - genealogy KW - Moderne Jüdische Geschichte KW - Familiengeschichte KW - Frühe Neuzeit KW - Jüdische Studien KW - Genealogie Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-473654 SN - 978-3-86956-493-7 SN - 1614-6492 SN - 1862-7684 IS - 26 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Riechelman, Dana F. C. A1 - Fohlmeister, Jens Bernd A1 - Kluge, Tobias A1 - Jochum, Klaus Peter A1 - Richter, Detlev K. A1 - Deininger, Michael A1 - Friedrich, Ronny A1 - Frank, Norbert A1 - Scholz, Denis T1 - Evaluating the potential of tree-ring methodology for cross-dating of three annually laminated stalagmites from Zoolithencave (SE Germany) JF - Quaternary geochronology : the international research and review journal on advances in quaternary dating techniques N2 - Three small stalagmites from Zoolithencave (southern Germany) show visible laminae, which consist of a clear and a brownish, pigmented layer pair. This potentially provides the opportunity to construct precise chronologies by counting annual laminae. The growth period of the three stalagmites was constrained by the C-14 bomb peak in the youngest part of all three stalagmites and C-14-dating of a piece of charcoal in the consolidated base part of stalagmite Zoo-rez-2. These data suggest an age of AD 1970 for the top laminae and a lower age limit of AD 1973-1682 or AD 1735-1778. Laminae were counted and their thickness determined on scanned thin sections of all stalagmites. On stalagmites Zoo-rez-1 and -2, three tracks were measured near the growth axes, each separated into three sections at prominent anchor laminae (I, II, III). Each section was replicated three times (a, b, c). For Zoo-rez-3, only one track was measured. The total number of laminae counted for Zoo-rez-1 ranges from 138 to 177, for Zoo-rez-2 from 119 to 145, and for Zoo-rez-3 from 159 to 166. The numbers agree well with the range constrained by the bomb peak and the age of the charcoal, which supports the annual origin of the laminae. The replicated measurements of the different tracks as well as the three different tracks on the stalagmites Zoo-rez-1 and-2 were cross-dated using the TSAP-Win (R) tree-ring software. This software is very useful for cross-dating because it enables to insert or delete missing or false laminae as well as identifying common pattern by shifting the series back and forth in time. However, visual inspection of the thin sections was necessary to confirm detection of missing or false laminae by TSAP-Win (R). For all three Zoo-rez speleothems, crossdating of the mean lamina thickness series was not possible due to a missing common pattern. The cross-dating procedure results in three refined chronologies for the three Zoo-rez stalagmites of ranging from AD 1821-1970 (Zoo-rez-1), AD 1835-1970 (Zoo-rez-2), and AD 1808-1970 (Zoo-rez-3). KW - Speleothems KW - Annual laminae KW - Lamina thickness KW - C-14 bomb peak KW - Tree-ring software KW - Cross-dating Y1 - 2019 U6 - https://doi.org/10.1016/j.quageo.2019.04.001 SN - 1871-1014 SN - 1878-0350 VL - 52 SP - 37 EP - 50 PB - Elsevier CY - Oxford ER - TY - BOOK A1 - Schubarth, Wilfried A1 - Zylla, Birgitta A1 - Niproschke, Saskia A1 - Guder, Petra A1 - Sonnen, Bernd-Rüdeger A1 - Kahl, Wolfgang A1 - Groeger-Roth, Frederick A1 - Kaeding, Peer A1 - Böhm, Christian A1 - Voigt, Jana A1 - Sturzbecher, Dietmar A1 - Kohlstruck, Michael A1 - Möller, Kurt A1 - Rolfes, Manfred A1 - Winter, Frank A1 - Breitschwerdt, Michael A1 - Kopp, Andrea A1 - Hinze, Klaus A1 - Lösel, Friedrich A1 - Klindworth-Mohr, Antje A1 - Madl, Martina A1 - Dunand, Annelie A1 - Schanzenbächer, Stefan A1 - Rump-Räuber, Michael A1 - Roos, Alfred A1 - Seidel, Andreas A1 - Gröger, Ulli A1 - Ulbricht, Juliane A1 - Martin, Christian A1 - Behrendt, Daniel ED - Schubarth, Wilfried T1 - Nachhaltige Prävention von Kriminalität, Gewalt und Rechtsextremismus BT - Beiträge aus Wissenschaft und Praxis N2 - Was wird unter „nachhaltiger Prävention“ in der Präventionsforschung verstanden? Welche guten Beispiele für nachhaltige Prävention gibt es in der Praxis? Und v. a.: Wie lässt sich Prävention in den verschiedenen Bereichen wie Kriminalität, Gewalt und Rechtsextremismus nachhaltig gestalten? Diesen Fragen will der vorliegende Sammelband nachgehen und damit der Präventionsdebatte neue Impulse verleihen. Der Band will insbesondere die nationale sowie internationale Fachdebatte konstruktiv aufgreifen, Theorie und Praxis verbinden, „good practice“ Beispiele darstellen sowie Perspektiven nachhaltiger Prävention aufzeigen. Mit diesem Themenspektrum richtet er sich sowohl an die Wissenschaft als auch an die Praxis sowie insgesamt an eine interessierte Öffentlichkeit. N2 - What is meant by „sustainable prevention“ in prevention research? What are good examples for sustainable prevention? And above all: How can prevention in fields like crime, violence and right-wing extremism be arranged sustainably? This miscellany is focused on these questions and it is intend to give new inputs for the current discussion on sustainable prevention. Especially, the miscellany is meant to connect the national and international trade debate, to combine theory and practice, to describe examples of “good practice” as well as to show prospects of sustainable prevention. These range of topics focus on science and practice as well as an interested public in general. KW - Prävention KW - Nachhaltigkeit KW - Gewalt KW - Kriminalität KW - Rechtsextremismus KW - prevention KW - sustainability KW - violence KW - crime KW - right-wing extremism Y1 - 2014 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-70537 SN - 978-3-86956-014-4 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Hüttl, Christine A1 - Hettrich, Cornelia A1 - Miller, Reinhard A1 - Paulke, Bernd-Reiner A1 - Henklein, Petra A1 - Rawel, Harshadrai Manilal A1 - Bier, Frank Fabian T1 - Self-assembled peptide amphiphiles function as multivalent binder with increased hemagglutinin affinity JF - BMC biotechnology N2 - Background: A promising way in diagnostic and therapeutic applications is the development of peptide amphiphiles (PAs). Peptides with a palmitic acid alkylchain were designed and characterized to study the effect of the structure modifications on self-assembling capabilities and the multiple binding capacity to hemagglutinin (HA), the surface protein of influenza virus type A. The peptide amphiphiles consists of a hydrophilic headgroup with a biological functionality of the peptide sequence and a chemically conjugated hydrophobic tail. In solution they self-assemble easily to micelles with a hydrophobic core surrounded by a closely packed peptide-shell. Results: In this study the effect of a multiple peptide binding partner to the receptor binding site of HA could be determined with surface plasmon resonance measurements. The applied modification of the peptides causes signal amplification in relationship to the unmodified peptide wherein the high constant specificity persists. The molecular assembly of the peptides was characterized by the determination of critical micelle concentration (CMC) with concentration of 10(-5) M and the colloidal size distribution. Conclusion: The modification of the physico-chemical parameters by producing peptide amphiphiles form monomeric structures which enhances the binding affinity and allows a better examination of the interaction with the virus surface protein hemagglutinin. KW - CMC KW - Influenza virus detection KW - Micelle KW - PAs KW - Surface plasmon resonance Y1 - 2013 U6 - https://doi.org/10.1186/1472-6750-13-51 SN - 1472-6750 VL - 13 IS - 22 PB - BioMed Central CY - London ER - TY - JOUR A1 - Tobie, Gabriel A1 - Giese, Bernd A1 - Hurford, Terry Anthony A1 - Lopes, Rosaly M. A1 - Nimmo, Francis A1 - Postberg, Frank A1 - Retherford, Kurt D. A1 - Schmidt, Jürgen A1 - Spencer, John R. A1 - Tokano, Tetsuya A1 - Turtle, Elizabeth P. T1 - Surface, subsurface and atmosphere exchanges on the satellites of the outer solar system N2 - The surface morphology of icy moons is affected by several processes implicating exchanges between their subsurfaces and atmospheres (if any). The possible exchange of material between the subsurface and the surface is mainly determined by the mechanical properties of the lithosphere, which isolates the deep, warm and ductile ice material from the cold surface conditions. Exchanges through this layer occur only if it is sufficiently thin and/or if it is fractured owing to tectonic stresses, melt intrusion or impact cratering. If such conditions are met, cryomagma can be released, erupting fresh volatile-rich materials onto the surface. For a very few icy moons (Titan, Triton, Enceladus), the emission of gas associated with cryovolcanic activity is sufficiently large to generate an atmosphere, either long- lived or transient. For those moons, atmosphere-driven processes such as cryovolcanic plume deposition, phase transitions of condensable materials and wind interactions continuously re-shape their surfaces, and are able to transport cryovolcanically generated materials on a global scale. In this chapter, we discuss the physics of these different exchange processes and how they affect the evolution of the satellites' surfaces. Y1 - 2010 UR - http://www.springerlink.com/content/102996 U6 - https://doi.org/10.1007/s11214-010-9641-3 SN - 0038-6308 ER - TY - JOUR A1 - Schmidt, Bernd A1 - Elizarov, Nelli A1 - Berger, René A1 - Hölter, Frank T1 - Scope and limitations of the Heck-Matsuda-coupling of phenol diazonium salts and styrenes: a protecting-group economic synthesis of phenolic stilbenes N2 - 4-Phenol diazonium salts undergo Pd-catalyzed Heck reactions with various styrenes to 4ï-hydroxy stilbenes. In almost all cases higher yields and fewer side products were observed, compared to the analogous 4-methoxy benzene diazonium salts. In contrast, the reaction fails completely with 2- and 3-phenol diazonium salts. For these substitution patterns the methoxy-substituted derivatives are superior. Y1 - 2014 UR - http://pubs.rsc.org/en/content/articlepdf/2013/ob/c3ob40420j U6 - https://doi.org/10.1039/C3OB40420J SN - 1477-0520 ER - TY - JOUR A1 - Just, Frank A1 - Walz, Bernd T1 - The effects of serotonin and dopamine on salivary secretion by isolated cockroach salivary glands Y1 - 1996 ER -