TY  - JOUR
A1  - Schuch, Felipe B.
A1  - Stubbs, Brendon
A1  - Meyer, Jacob
A1  - Heissel, Andreas
A1  - Zech, Philipp
A1  - Vancampfort, Davy
A1  - Rosenbaum, Simon
A1  - Deenik, Jeroen
A1  - Firth, Joseph
A1  - Ward, Philip B.
A1  - Carvalho, Andre F.
A1  - Hiles, Sarah A.
T1  - Physical activity protects from incident anxiety: A meta-analysis of prospective cohort studies
JF  - Depression and anxiety
N2  - Background Prospective cohorts have suggested that physical activity (PA) can decrease the risk of incident anxiety. However, no meta-analysis has been conducted. Aims To examine the prospective relationship between PA and incident anxiety and explore potential moderators. Methods Searches were conducted on major databases from inception to October 10, 2018 for prospective studies (at least 1 year of follow-up) that calculated the odds ratio (OR) of incident anxiety in people with high PA against people with low PA. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was conducted and heterogeneity was explored using subgroup and meta-regression analysis. Results Across 14 cohorts of 13 unique prospective studies (N = 75,831, median males = 50.1%) followed for 357,424 person-years, people with high self-reported PA (versus low PA) were at reduced odds of developing anxiety (adjusted odds ratio [AOR] = 0.74; 95% confidence level [95% CI] = 0.62, 0.88; crude OR = 0.80; 95% CI = 0.69, 0.92). High self-reported PA was protective against the emergence of agoraphobia (AOR = 0.42; 95% CI = 0.18, 0.98) and posttraumatic stress disorder (AOR = 0.57; 95% CI = 0.39, 0.85). The protective effects for anxiety were evident in Asia (AOR = 0.31; 95% CI = 0.10, 0.96) and Europe (AOR = 0.82; 95% CI = 0.69, 0.97); for children/adolescents (AOR = 0.52; 95% CI = 0.29, 0.90) and adults (AOR = 0.81; 95% CI = 0.69, 0.95). Results remained robust when adjusting for confounding factors. Overall study quality was moderate to high (mean NOS = 6.7 out of 9). Conclusion Evidence supports the notion that self-reported PA can confer protection against the emergence of anxiety regardless of demographic factors. In particular, higher PA levels protects from agoraphobia and posttraumatic disorder.
KW  - agoraphobia
KW  - anxiety
KW  - exercise
KW  - incidence
KW  - meta-analysis
KW  - panic
KW  - physical activity
KW  - posttraumatic stress disorder
KW  - protection
Y1  - 2019
U6  - https://doi.org/10.1002/da.22915
SN  - 1091-4269
SN  - 1520-6394
VL  - 36
IS  - 9
SP  - 846
EP  - 858
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Yenesew, Abiy
A1  - Mushibe, E. K.
A1  - Induli, M.
A1  - Derese, Solomon
A1  - Midiwo, Jacob O.
A1  - Kabaru, Jacques M.
A1  - Heydenreich, Matthias
A1  - Koch, Andreas
A1  - Peter, Martin G.
T1  - 7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoloata
N2  - From the acetone extract of the roots of Derris trifoliata an isollavonoid derivative, named 7a-O- methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isollavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata. (c) 2005 Elsevier Ltd. All rights reserved
Y1  - 2005
SN  - 0031-9422
ER  - 
TY  - JOUR
A1  - Izraylit, Victor
A1  - Hommes-Schattmann, Paul Jacob
A1  - Neffe, Axel T.
A1  - Gould, Oliver E. C.
A1  - Lendlein, Andreas
T1  - Alkynyl-functionalized chain-extended PCL for coupling to biological molecules
JF  - European polymer journal
N2  - Chemical functionalization of poly(epsilon-caprolactone) (PCL) enables a molecular integration of additional function. Here, we report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3 (prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with M-w of 101 to 385 kg.mol(-1) were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine ethyl ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the density of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asymmetric structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material's mechanical properties. The mixed glass transition temperature T-g = - 60 to - 46 degrees C of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiological conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodology was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile molecular unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions.
KW  - copper-catalyzed alkyne-azide cycloaddition
KW  - chain-extended
KW  - polycaprolactone
KW  - RGD-peptide
KW  - side-chains functionalization
Y1  - 2020
U6  - https://doi.org/10.1016/j.eurpolymj.2020.109908
SN  - 0014-3057
SN  - 1873-1945
VL  - 136
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Pingel, Heiko
A1  - Mulch, Andreas
A1  - Alonso, Ricardo N.
A1  - Cottle, John
A1  - Hynek, Scott A.
A1  - Poletti, Jacob
A1  - Rohrmann, Alexander
A1  - Schmitt, Axel K.
A1  - Stockli, Daniel F.
A1  - Strecker, Manfred
T1  - Surface uplift and convective rainfall along the southern Central Andes (Angastaco Basin, NW Argentina)
JF  - Earth & planetary science letters
N2  - Stable-isotopic and sedimentary records from the orogenic Puna Plateau of NW Argentina and adjacent intermontane basins to the east furnish a unique late Cenozoic record of range uplift and ensuing paleoenvironmental change in the south-central Andes. Today, focused precipitation in this region occurs along the eastern, windward flanks of the Eastern Cordillera and Sierras Pampeanas ranges, while the orogen interior constitutes high-elevation regions with increasingly arid conditions in a westward direction. As in many mountain belts, such hydrologic and topographic gradients are commonly mirrored by a systematic relationship between the oxygen and hydrogen stable isotope ratios of meteoric water and elevation. The glass fraction of isotopically datable volcanic ash intercalated in sedimentary sequences constitutes an environmental proxy that retains a signal of the hydrogen-isotopic composition of ancient precipitation. This isotopic composition thus helps to elucidate the combined climatic and tectonic processes associated with topographic growth, which ultimately controls the spatial patterns of precipitation in mountain belts. However, between 25.5 and 27 degrees S present-day river-based hydrogen isotope lapse rates are very low, possibly due to deep-convective seasonal storms that dominate runoff. If not accounted for, the effects of such conditions on moisture availability in the past may lead to misinterpretations of proxy-records of rainfall. Here, we present hydrogen-isotope data of volcanic glass (delta Dg), extracted from 34 volcanic ash layers in different sedimentary basins of the Eastern Cordillera and the Sierras Pampeanas. Combined with previously published delta Dg records and our refined U-Pb and (U-Th)/He zircon geochronology on 17 tuff samples, we demonstrate hydrogen-isotope variations associated with paleoenvironmental change in the Angastaco Basin, which evolved from a contiguous foreland to a fault-bounded intermontane basin during the late Mio-Pliocene. We unravel the environmental impact of Mio-Pliocene topographic growth and associated orographic effects on long-term hydrogen-isotope records of rainfall in the south-central Andes, and potentially identify temporal variations in regional isotopic lapse rates that may also apply to other regions with similar topographic boundary conditions. (C) 2016 Elsevier B.V. All rights reserved.
KW  - hydrogen stable isotopes
KW  - volcanic glass
KW  - paleoaltimetry
KW  - NW-Argentine Andes
KW  - orographic barrier uplift
KW  - convective rainfall
Y1  - 2016
U6  - https://doi.org/10.1016/j.epsl.2016.02.009
SN  - 0012-821X
SN  - 1385-013X
VL  - 440
SP  - 33
EP  - 42
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Tiegs, Scott D.
A1  - Costello, David M.
A1  - Isken, Mark W.
A1  - Woodward, Guy
A1  - McIntyre, Peter B.
A1  - Gessner, Mark O.
A1  - Chauvet, Eric
A1  - Griffiths, Natalie A.
A1  - Flecker, Alex S.
A1  - Acuna, Vicenc
A1  - Albarino, Ricardo
A1  - Allen, Daniel C.
A1  - Alonso, Cecilia
A1  - Andino, Patricio
A1  - Arango, Clay
A1  - Aroviita, Jukka
A1  - Barbosa, Marcus V. M.
A1  - Barmuta, Leon A.
A1  - Baxter, Colden V.
A1  - Bell, Thomas D. C.
A1  - Bellinger, Brent
A1  - Boyero, Luz
A1  - Brown, Lee E.
A1  - Bruder, Andreas
A1  - Bruesewitz, Denise A.
A1  - Burdon, Francis J.
A1  - Callisto, Marcos
A1  - Canhoto, Cristina
A1  - Capps, Krista A.
A1  - Castillo, Maria M.
A1  - Clapcott, Joanne
A1  - Colas, Fanny
A1  - Colon-Gaud, Checo
A1  - Cornut, Julien
A1  - Crespo-Perez, Veronica
A1  - Cross, Wyatt F.
A1  - Culp, Joseph M.
A1  - Danger, Michael
A1  - Dangles, Olivier
A1  - de Eyto, Elvira
A1  - Derry, Alison M.
A1  - Diaz Villanueva, Veronica
A1  - Douglas, Michael M.
A1  - Elosegi, Arturo
A1  - Encalada, Andrea C.
A1  - Entrekin, Sally
A1  - Espinosa, Rodrigo
A1  - Ethaiya, Diana
A1  - Ferreira, Veronica
A1  - Ferriol, Carmen
A1  - Flanagan, Kyla M.
A1  - Fleituch, Tadeusz
A1  - Shah, Jennifer J. Follstad
A1  - Frainer, Andre
A1  - Friberg, Nikolai
A1  - Frost, Paul C.
A1  - Garcia, Erica A.
A1  - Lago, Liliana Garcia
A1  - Garcia Soto, Pavel Ernesto
A1  - Ghate, Sudeep
A1  - Giling, Darren P.
A1  - Gilmer, Alan
A1  - Goncalves, Jose Francisco
A1  - Gonzales, Rosario Karina
A1  - Graca, Manuel A. S.
A1  - Grace, Mike
A1  - Grossart, Hans-Peter
A1  - Guerold, Francois
A1  - Gulis, Vlad
A1  - Hepp, Luiz U.
A1  - Higgins, Scott
A1  - Hishi, Takuo
A1  - Huddart, Joseph
A1  - Hudson, John
A1  - Imberger, Samantha
A1  - Iniguez-Armijos, Carlos
A1  - Iwata, Tomoya
A1  - Janetski, David J.
A1  - Jennings, Eleanor
A1  - Kirkwood, Andrea E.
A1  - Koning, Aaron A.
A1  - Kosten, Sarian
A1  - Kuehn, Kevin A.
A1  - Laudon, Hjalmar
A1  - Leavitt, Peter R.
A1  - Lemes da Silva, Aurea L.
A1  - Leroux, Shawn J.
A1  - Leroy, Carri J.
A1  - Lisi, Peter J.
A1  - MacKenzie, Richard
A1  - Marcarelli, Amy M.
A1  - Masese, Frank O.
A1  - Mckie, Brendan G.
A1  - Oliveira Medeiros, Adriana
A1  - Meissner, Kristian
A1  - Milisa, Marko
A1  - Mishra, Shailendra
A1  - Miyake, Yo
A1  - Moerke, Ashley
A1  - Mombrikotb, Shorok
A1  - Mooney, Rob
A1  - Moulton, Tim
A1  - Muotka, Timo
A1  - Negishi, Junjiro N.
A1  - Neres-Lima, Vinicius
A1  - Nieminen, Mika L.
A1  - Nimptsch, Jorge
A1  - Ondruch, Jakub
A1  - Paavola, Riku
A1  - Pardo, Isabel
A1  - Patrick, Christopher J.
A1  - Peeters, Edwin T. H. M.
A1  - Pozo, Jesus
A1  - Pringle, Catherine
A1  - Prussian, Aaron
A1  - Quenta, Estefania
A1  - Quesada, Antonio
A1  - Reid, Brian
A1  - Richardson, John S.
A1  - Rigosi, Anna
A1  - Rincon, Jose
A1  - Risnoveanu, Geta
A1  - Robinson, Christopher T.
A1  - Rodriguez-Gallego, Lorena
A1  - Royer, Todd V.
A1  - Rusak, James A.
A1  - Santamans, Anna C.
A1  - Selmeczy, Geza B.
A1  - Simiyu, Gelas
A1  - Skuja, Agnija
A1  - Smykla, Jerzy
A1  - Sridhar, Kandikere R.
A1  - Sponseller, Ryan
A1  - Stoler, Aaron
A1  - Swan, Christopher M.
A1  - Szlag, David
A1  - Teixeira-de Mello, Franco
A1  - Tonkin, Jonathan D.
A1  - Uusheimo, Sari
A1  - Veach, Allison M.
A1  - Vilbaste, Sirje
A1  - Vought, Lena B. M.
A1  - Wang, Chiao-Ping
A1  - Webster, Jackson R.
A1  - Wilson, Paul B.
A1  - Woelfl, Stefan
A1  - Xenopoulos, Marguerite A.
A1  - Yates, Adam G.
A1  - Yoshimura, Chihiro
A1  - Yule, Catherine M.
A1  - Zhang, Yixin X.
A1  - Zwart, Jacob A.
T1  - Global patterns and drivers of ecosystem functioning in rivers and riparian zones
JF  - Science Advances
N2  - River ecosystems receive and process vast quantities of terrestrial organic carbon, the fate of which depends strongly on microbial activity. Variation in and controls of processing rates, however, are poorly characterized at the global scale. In response, we used a peer-sourced research network and a highly standardized carbon processing assay to conduct a global-scale field experiment in greater than 1000 river and riparian sites. We found that Earth’s biomes have distinct carbon processing signatures. Slow processing is evident across latitudes, whereas rapid rates are restricted to lower latitudes. Both the mean rate and variability decline with latitude, suggesting temperature constraints toward the poles and greater roles for other environmental drivers (e.g., nutrient loading) toward the equator. These results and data set the stage for unprecedented “next-generation biomonitoring” by establishing baselines to help quantify environmental impacts to the functioning of ecosystems at a global scale.
Y1  - 2019
U6  - https://doi.org/10.1126/sciadv.aav0486
SN  - 2375-2548
VL  - 5
IS  - 1
PB  - American Assoc. for the Advancement of Science
CY  - Washington
ER  - 
TY  - JOUR
A1  - Hellmann, Uwe
A1  - Rettweiler, Udo
A1  - Kramer, Annette
A1  - Zehe, Erwin
A1  - Jacob, Andreas
A1  - Hafner, Johann Evangelist
A1  - Tronicke, Jens
A1  - Mühle, Ralf-Udo
A1  - Klauss, Susanne
A1  - Dietrich, Larissa
A1  - Richter, Norbert
A1  - Schweigl, Kerstin
T1  - Portal = Ressource Wasser: Mehr als ein Elixier des Lebens
BT  - Die Potsdamer Universitätszeitung
N2  - Aus dem Inhalt:
- Ressource Wasser: Mehr als ein Elixier des Lebens
- Dorniges hinter Glas
- Die Profstars 2007
- Technik gegen unerwünschte Mithörer entwickelt
T3  - Portal: Das Potsdamer Universitätsmagazin - 04-05/2007 
Y1  - 2007
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-440051
SN  - 1618-6893
IS  - 04-05/2007
ER  - 
TY  - JOUR
A1  - Tschorn, Mira
A1  - Schulze, Susanne
A1  - Förstner, Bernd Rainer
A1  - Holmberg, Christine
A1  - Spallek, Jacob
A1  - Heinz, Andreas
A1  - Rapp, Michael A.
T1  - Predictors and prevalence of hazardous alcohol use in middle-late to late adulthood in Europe
JF  - Aging & mental health
N2  - Objectives: 
Even low to moderate levels of alcohol consumption can have detrimental health consequences, especially in older adults (OA). Although many studies report an increase in the proportion of drinkers among OA, there are regional variations. Therefore, we examined alcohol consumption and the prevalence of hazardous alcohol use (HAU) among men and women aged 50+ years in four European regions and investigated predictors of HAU. 

Methods: 
We analyzed data of N = 35,042 participants of the European SHARE study. We investigated differences in alcohol consumption (units last week) according to gender, age and EU-region using ANOVAs. Furthermore, logistic regression models were used to examine the effect of income, education, marital status, history of a low-quality parent-child relationship and smoking on HAU, also stratified for gender and EU-region. HAU was operationalized as binge drinking or risky drinking (<12.5 units of 10 ml alcohol/week). 

Results: 
Overall, past week alcohol consumption was 5.0 units (+/- 7.8), prevalence of HAU was 25.4% within our sample of European adults aged 50+ years. Male gender, younger age and living in Western Europe were linked to both higher alcohol consumption and higher risks of HAU. Income, education, smoking, a low-quality parent-child relationship, living in Northern and especially Eastern Europe were positively associated with HAU. Stratified analyses revealed differences by region and gender. 

Conclusions: 
HAU was highly prevalent within this European sample of OA. Alcohol consumption and determinants of HAU differed between EU-regions, hinting to a necessity of risk-stratified population-level strategies to prevent HAU and subsequent alcohol use disorders.
KW  - Hazardous alcohol use
KW  - older adults
KW  - middle-aged adults
KW  - Europe
KW  - alcohol
KW  - drug and alcohol abuse
KW  - cross-national
KW  - international studies
KW  - environmental factors
KW  - housing
KW  - rural-urban factors
KW  - epidemiology (mental health)
Y1  - 2022
U6  - https://doi.org/10.1080/13607863.2022.2076208
SN  - 1360-7863
SN  - 1364-6915
VL  - 27
IS  - 5
SP  - 1001
EP  - 1010
PB  - Routledge, Taylor & Francis Group
CY  - Abingdon
ER  -