TY - JOUR A1 - Kastl, Johanna A1 - Braun, Joachim A1 - Prestel, Andreas A1 - Möller, Heiko Michael A1 - Huhn, Thomas A1 - Mayer, Thomas U. T1 - Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint JF - ACS chemical biology N2 - The genetic integrity of each organism depends on the faithful segregation of its genome during mitosis. To meet this challenge, a cellular surveillance mechanism, termed the spindle assembly checkpoint (SAC), evolved that monitors the correct attachment of chromosomes and blocks progression through mitosis if corrections are needed. While the central role of the SAC for genome integrity is well established, its functional dissection has been hampered by the limited availability of appropriate small molecule inhibitors. Using a fluorescence polarization-based screen, we identify Mad2 inhibitor-1 (M2I-1), the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC. Based on computational and biochemical analyses, we propose that M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells. Thus, our study identifies the SAC specific complex formation between Mad2 and Cdc20 as a protein-protein interaction that can be targeted by small molecules. Y1 - 2015 U6 - https://doi.org/10.1021/acschembio.5b00121 SN - 1554-8929 SN - 1554-8937 VL - 10 IS - 7 SP - 1661 EP - 1666 PB - American Chemical Society CY - Washington ER - TY - BOOK A1 - Zimmermann, Andreas A1 - Freiburg-Braun, Elisa T1 - Aggression under the Rome Statute BT - an introduction N2 - Das Werk analysiert umfassend das Verbrechen der Aggression im Sinne des Römischen Statuts. Ausgehend von der Rechtsgeschichte, werde die einschlägigen Artikel 8bis, 15bis und 15ter des Römischen Statuts, also die Definition des Verbrechens der Aggression, analysiert. Ebenso behandelt das Buch weiterführende Entwicklungen des Verbrechens der Aggression über das Jahr 2017 hinaus – das Jahr, in dem es, wahrscheinlich, zu einer Entscheidung über die Aktivierung der Gerichtsbarkeit kommt Y1 - 2019 SN - 978-3-8487-4678-1 PB - Nomos CY - Baden-Baden ER - TY - BOOK A1 - Adelhelm, Silvia A1 - Braun, Andreas A1 - Gronau, Norbert A1 - Müller, E. A1 - Vladova, Gergana T1 - Open Innovation : Methodologische Präzisierung und praktische Umsetzung im Projekt Open Innovation in Life Sciences Y1 - 2010 SN - 978-3-8396-0141-9 ER - TY - CHAP A1 - Zimmermann, Andreas A1 - Freiburg-Braun, Elisa ED - Ambos, Kai T1 - Article 15ter Exercise of jurisdiction over the crime of aggression (Security Council referral) T2 - Rome statute of the International Criminal Court Y1 - 2022 SN - 978-3-406-77926-8 SN - 978-3-406-74384-9 SN - 978-1-5099-4405-7 SN - 978-3-8487-7648-1 U6 - https://doi.org/10.17104/9783406779268-927 SP - 927 EP - 932 PB - Beck CY - München ET - Fourth ER - TY - CHAP A1 - Zimmermann, Andreas A1 - Freiburg-Braun, Elisa ED - Ambos, Kai T1 - Article 8bis Crime of aggression T2 - Rome statute of the International Criminal Court Y1 - 2022 SN - 978-3-406-77926-8 SN - 978-3-406-74384-9 SN - 978-1-5099-4405-7 SN - 978-3-8487-7648-1 U6 - https://doi.org/10.17104/9783406779268-686 SP - 686 EP - 726 PB - Beck CY - München ET - Fourth ER - TY - JOUR A1 - Pinkernelle, Josephine A1 - Abraham, Andreas A1 - Seidel, Katja A1 - Braun, Katharina T1 - Paternal deprivation induces dendritic and synaptic changes and hemispheric asymmetry of pyramidal neurons in the somatosensory cortex N2 - Similar to maternal care, paternal care is a source of neonatal sensory stimulation, which in primates and rodents has been shown to be essential for developing structure and function of sensory cortices. The aim of our study in the biparental rodent Octodon degus was to assess the impact of paternal deprivation on dendritic and synaptic development in the somatosensory cortex. We (i) quantified the amount of paternal care in relation to total parental investment and (ii) compared dendritic and synaptic development of pyramidal neurons in the somatosensory cortex of animals raised by a single mother or by both parents. On the behavioral level we show that paternal care comprises 37% of total parent-offspring interactions, and that the somatosensory stimulation provided by the fathers primarily consists of huddling, licking/grooming, and playing. On the morphological level we found that, compared with offspring raised by both parents (mother and father), the father-deprived animals displayed significantly reduced spine numbers on the basal dendrites of pyramidal neurons. Furthermore, paternal deprivation induces hemispheric asymmetry of the dendritic morphology of somatosensory pyramidal neurons. Father-deprived animals show shorter and less complex basal dendrites in the left somatosensory cortex compared with the right hemisphere. These findings indicate that paternal deprivation results in delayed or retarded dendritic and synaptic development of somatosensory circuits. Y1 - 2009 UR - http://www3.interscience.wiley.com/cgi-bin/jhome/114030483 U6 - https://doi.org/10.1002/Dneu.20726 SN - 1932-8451 ER - TY - JOUR A1 - Reger, Guido A1 - Adelhelm, Silvia A1 - Braun, Andreas T1 - Lead User : von der Kundenorientierung zur Kundenintegration Y1 - 2009 SN - 978-3-428-13238-6 ER - TY - JOUR A1 - Braun, Andreas A1 - Reger, Guido T1 - Innovation, science and institutional change : a research handbook Y1 - 2009 UR - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291467-9310 U6 - https://doi.org/10.1111/j.1467-9310.2008.00543_1.x SN - 0033-6807 ER - TY - THES A1 - Braun, Andreas T1 - Open innovation - an analysis of the individual level Y1 - 2014 CY - Potsdam ER - TY - JOUR A1 - Braun, Andreas A1 - Bockelmann, Laura T1 - An individual perspective on open innovation capabilities in the context of haute cuisine JF - International journal of innovation in management N2 - Previous research on open innovation (OI) has primarily focused on the organisational level of R&D intensive industries. With this paper, we contribute to research on the individual level of analysis by analysing specific perspectives in the context of creative industries. Our study is based on 36 interviews with Haute cuisine chefs in France, Germany, Great Britain, Italy, Spain, Sweden, and Switzerland listed in the 2012 Michelin Guide. Building on the OI capability concept, our results demonstrate that chefs use absorptive and desorptive capacity (AC, DC) as means to generate and market culinary innovations, respectively. Moreover, we found that chefs almost exclusively rely on their own inventive and innovative capabilities in the early stages of the culinary innovation process. In subsequent phases, however, chefs increasingly integrate other sources such as employees, suppliers, and guests. Our study contributes to the literature in two ways. First, we research the individual level within the OI process, and second, we provide insight into OI practices in the creative industries. KW - Open innovation KW - open innovation capabilities KW - Haute cuisine KW - creative industries Y1 - 2016 U6 - https://doi.org/10.1142/S136391961650002X SN - 1363-9196 SN - 1757-5877 VL - 20 SP - 480 EP - 499 PB - World Scientific CY - Singapore ER -