TY  - JOUR
A1  - Kastl, Johanna
A1  - Braun, Joachim
A1  - Prestel, Andreas
A1  - Möller, Heiko Michael
A1  - Huhn, Thomas
A1  - Mayer, Thomas U.
T1  - Mad2 Inhibitor-1 (M2I-1): A Small Molecule Protein-Protein Interaction Inhibitor Targeting the Mitotic Spindle Assembly Checkpoint
JF  - ACS chemical biology
N2  - The genetic integrity of each organism depends on the faithful segregation of its genome during mitosis. To meet this challenge, a cellular surveillance mechanism, termed the spindle assembly checkpoint (SAC), evolved that monitors the correct attachment of chromosomes and blocks progression through mitosis if corrections are needed. While the central role of the SAC for genome integrity is well established, its functional dissection has been hampered by the limited availability of appropriate small molecule inhibitors. Using a fluorescence polarization-based screen, we identify Mad2 inhibitor-1 (M2I-1), the first small molecule inhibitor targeting the binding of Mad2 to Cdc20, an essential protein-protein interaction (PPI) within the SAC. Based on computational and biochemical analyses, we propose that M2I-1 disturbs conformational dynamics of Mad2 critical for complex formation with Cdc20. Cellular studies revealed that M2I-1 weakens the SAC response, indicating that the compound might be active in cells. Thus, our study identifies the SAC specific complex formation between Mad2 and Cdc20 as a protein-protein interaction that can be targeted by small molecules.
Y1  - 2015
U6  - https://doi.org/10.1021/acschembio.5b00121
SN  - 1554-8929
SN  - 1554-8937
VL  - 10
IS  - 7
SP  - 1661
EP  - 1666
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - BOOK
A1  - Zimmermann, Andreas
A1  - Freiburg-Braun, Elisa
T1  - Aggression under the Rome Statute
BT  - an introduction
N2  - Das Werk analysiert umfassend das Verbrechen der Aggression im Sinne des Römischen Statuts. Ausgehend von der Rechtsgeschichte, werde die einschlägigen Artikel 8bis, 15bis und 15ter des Römischen Statuts, also die Definition des Verbrechens der Aggression, analysiert.
Ebenso behandelt das Buch weiterführende Entwicklungen des Verbrechens der Aggression über das Jahr 2017 hinaus – das Jahr, in dem es, wahrscheinlich, zu einer Entscheidung über die Aktivierung der Gerichtsbarkeit kommt
Y1  - 2019
SN  - 978-3-8487-4678-1
PB  - Nomos
CY  - Baden-Baden
ER  - 
TY  - BOOK
A1  - Adelhelm, Silvia
A1  - Braun, Andreas
A1  - Gronau, Norbert
A1  - Müller, E.
A1  - Vladova, Gergana
T1  - Open Innovation : Methodologische Präzisierung und praktische Umsetzung im Projekt Open Innovation in Life Sciences
Y1  - 2010
SN  - 978-3-8396-0141-9
ER  - 
TY  - CHAP
A1  - Zimmermann, Andreas
A1  - Freiburg-Braun, Elisa
ED  - Ambos, Kai
T1  - Article 15ter Exercise of jurisdiction over the crime of aggression (Security Council referral)
T2  - Rome statute of the International Criminal Court
Y1  - 2022
SN  - 978-3-406-77926-8
SN  - 978-3-406-74384-9
SN  - 978-1-5099-4405-7
SN  - 978-3-8487-7648-1
U6  - https://doi.org/10.17104/9783406779268-927
SP  - 927
EP  - 932
PB  - Beck
CY  - München
ET  - Fourth
ER  - 
TY  - CHAP
A1  - Zimmermann, Andreas
A1  - Freiburg-Braun, Elisa
ED  - Ambos, Kai
T1  - Article 8bis Crime of aggression
T2  - Rome statute of the International Criminal Court
Y1  - 2022
SN  - 978-3-406-77926-8
SN  - 978-3-406-74384-9
SN  - 978-1-5099-4405-7
SN  - 978-3-8487-7648-1
U6  - https://doi.org/10.17104/9783406779268-686
SP  - 686
EP  - 726
PB  - Beck
CY  - München
ET  - Fourth
ER  - 
TY  - JOUR
A1  - Pinkernelle, Josephine
A1  - Abraham, Andreas
A1  - Seidel, Katja
A1  - Braun, Katharina
T1  - Paternal deprivation induces dendritic and synaptic changes and hemispheric asymmetry of pyramidal neurons in the somatosensory cortex
N2  - Similar to maternal care, paternal care is a source of neonatal sensory stimulation, which in primates and rodents has been shown to be essential for developing structure and function of sensory cortices. The aim of our study in the biparental rodent Octodon degus was to assess the impact of paternal deprivation on dendritic and synaptic development in the somatosensory cortex. We (i) quantified the amount of paternal care in relation to total parental investment and (ii) compared dendritic and synaptic development of pyramidal neurons in the somatosensory cortex of animals raised by a single mother or by both parents. On the behavioral level we show that paternal care comprises 37% of total parent-offspring interactions, and that the somatosensory stimulation provided by the fathers primarily consists of huddling, licking/grooming, and playing. On the morphological level we found that, compared with offspring raised by both parents (mother and father), the father-deprived animals displayed significantly reduced spine numbers on the basal dendrites of pyramidal neurons. Furthermore, paternal deprivation induces hemispheric asymmetry of the dendritic morphology of somatosensory pyramidal neurons. Father-deprived animals show shorter and less complex basal dendrites in the left somatosensory cortex compared with the right hemisphere. These findings indicate that paternal deprivation results in delayed or retarded dendritic and synaptic development of somatosensory circuits.
Y1  - 2009
UR  - http://www3.interscience.wiley.com/cgi-bin/jhome/114030483
U6  - https://doi.org/10.1002/Dneu.20726
SN  - 1932-8451
ER  - 
TY  - JOUR
A1  - Reger, Guido
A1  - Adelhelm, Silvia
A1  - Braun, Andreas
T1  - Lead User : von der Kundenorientierung zur Kundenintegration
Y1  - 2009
SN  - 978-3-428-13238-6
ER  - 
TY  - JOUR
A1  - Braun, Andreas
A1  - Reger, Guido
T1  - Innovation, science and institutional change : a research handbook
Y1  - 2009
UR  - http://onlinelibrary.wiley.com/journal/10.1111/%28ISSN%291467-9310
U6  - https://doi.org/10.1111/j.1467-9310.2008.00543_1.x
SN  - 0033-6807
ER  - 
TY  - THES
A1  - Braun, Andreas
T1  - Open innovation - an analysis of the individual level
Y1  - 2014
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Braun, Andreas
A1  - Bockelmann, Laura
T1  - An individual perspective on open innovation capabilities in the context of haute cuisine
JF  - International journal of innovation in management
N2  - Previous research on open innovation (OI) has primarily focused on the organisational level of R&D intensive industries. With this paper, we contribute to research on the individual level of analysis by analysing specific perspectives in the context of creative industries. Our study is based on 36 interviews with Haute cuisine chefs in France, Germany, Great Britain, Italy, Spain, Sweden, and Switzerland listed in the 2012 Michelin Guide. Building on the OI capability concept, our results demonstrate that chefs use absorptive and desorptive capacity (AC, DC) as means to generate and market culinary innovations, respectively. Moreover, we found that chefs almost exclusively rely on their own inventive and innovative capabilities in the early stages of the culinary innovation process. In subsequent phases, however, chefs increasingly integrate other sources such as employees, suppliers, and guests. Our study contributes to the literature in two ways. First, we research the individual level within the OI process, and second, we provide insight into OI practices in the creative industries.
KW  - Open innovation
KW  - open innovation capabilities
KW  - Haute cuisine
KW  - creative industries
Y1  - 2016
U6  - https://doi.org/10.1142/S136391961650002X
SN  - 1363-9196
SN  - 1757-5877
VL  - 20
SP  - 480
EP  - 499
PB  - World Scientific
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Volk, Christin
A1  - Brandsch, Corinna
A1  - Schlegelmilch, Ulf
A1  - Wensch-Dorendorf, Monika
A1  - Hirche, Frank
A1  - Simm, Andreas
A1  - Gargum, Osama
A1  - Wiacek, Claudia
A1  - Braun, Peggy G.
A1  - Kopp, Johannes F.
A1  - Schwerdtle, Tanja
A1  - Treede, Hendrik
A1  - Stangl, Gabriele I.
T1  - Postprandial metabolic response to rapeseed protein in healthy subjects
JF  - Nutrients
N2  - Plant proteins have become increasingly important for ecological reasons. Rapeseed is a novel source of plant proteins with high biological value, but its metabolic impact in humans is largely unknown. A randomized, controlled intervention study including 20 healthy subjects was conducted in a crossover design. All participants received a test meal without additional protein or with 28 g of rapeseed protein isolate or soy protein isolate (control). Venous blood samples were collected over a 360-min period to analyze metabolites; satiety was assessed using a visual analog scale. Postprandial levels of lipids, urea, and amino acids increased following the intake of both protein isolates. The postprandial insulin response was lower after consumption of the rapeseed protein than after intake of the soy protein (p< 0.05), whereas the postmeal responses of glucose, lipids, interleukin-6, minerals, and urea were comparable between the two protein isolates. Interestingly, the rapeseed protein exerted stronger effects on postprandial satiety than the soy protein (p< 0.05). The postmeal metabolism following rapeseed protein intake is comparable with that of soy protein. The favorable effect of rapeseed protein on postprandial insulin and satiety makes it a valuable plant protein for human nutrition.
KW  - rapeseed protein
KW  - soy protein
KW  - postprandial study
KW  - metabolic response
KW  - healthy subjects
Y1  - 2020
U6  - https://doi.org/10.3390/nu12082270
SN  - 2072-6643
VL  - 12
IS  - 8
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Schulze, Michael
A1  - Utecht, Manuel Martin
A1  - Hebert, Andreas
A1  - Rück-Braun, Karola
A1  - Saalfrank, Peter
A1  - Tegeder, Petra
T1  - Reversible Photoswitching of the Interfacial Nonlinear Optical Response
JF  - The journal of physical chemistry letters
N2  - Incorporating photochromic molecules into organic/inorganic hybrid materials may lead to photoresponsive systems. In such systems, the second-order nonlinear properties can be controlled via external stimulation with light at an appropriate wavelength. By creating photochromic molecular switches containing self-assembled monolayers on Si(111), we can demonstrate efficient reversible switching, which is accompanied by a pronounced modulation of the nonlinear optical (NLO) response of the system. The concept of utilizing functionalized photoswitchable Si surfaces could be a way for the generation of two-dimensional NLO switching materials, which are promising for applications in photonic and optoelectronic devices.
Y1  - 2015
U6  - https://doi.org/10.1021/jz502477m
SN  - 1948-7185
VL  - 6
IS  - 3
SP  - 505
EP  - 509
PB  - American Chemical Society
CY  - Washington
ER  - 
TY  - BOOK
A1  - Adelhelm, Silvia
A1  - Braun, Andreas
A1  - Müller, Elisabeth
A1  - Vladova, Gergana
T1  - Philo : PharmaInnovationsLotse ; ihr Weg zum erfolgreichen Open Innovation Management
N2  - Vorliegender Leitfaden ist eines der Ergebnisse des Forschungsprojekts „Open Innovation in Life Sciences“ (OIL), das von Mai 2008 bis April 2011 an der Universität Potsdam durchgeführt wurde. Er nimmt für sich in Anspruch, gerade Innovationsmanager in kleinen und mittleren Unternehmen (KMU) der Pharmaindustrie bei der Einführung des Open Innovation Managements zu unterstützen. Zielsetzung des Forschungsprojekts war es, (1) die Chancen und Risiken von Open Innovation unter besonderer Berücksichtigung der Anforderungen von Pharma-KMU zu analysieren und (2) daraus abgeleitet ein Konzept zur Implementierung von Open Innovation bei Pharma-KMU zu entwickeln. Der Ausgangspunkt des Projektes war die Erkenntnis, dass die Life Sciences-Branche im Allgemeinen und die Pharmaindustrie im Besonderen durch eine steigende Komplexität der Innovationsprozesse und eine zunehmende Tendenz zu Kooperationen gekennzeichnet ist. Vor diesem Hintergrund eröffnet gerade der Open Innovation-Ansatz für die Pharmabranche neue Gestaltungs- und damit Wachstumsmöglichkeiten. Open Innovation – definiert als die planvolle Öffnung der Innovationsprozesse und die strategische Einbindung des Unternehmensumfelds – wird dabei als zentraler Erfolgsfaktor für die Innovationsfähigkeit beschrieben.
N2  - The job title of innovation manager is a comparatively new phenomenon in innovation management. The field of responsibility spans the entire innovation process, from fundamental research, development and production, until the market launch. The competencies include technology, product, service and market orientation, and an innovation manager should have skills in both the strategic as well as the operational sphere. They direct the innovation process, cultivate both internal and external contacts and organise the communication of all persons involved. It is self-evident that these tasks – particularly in the pharmaceutical industry with its complex and long-term processes – present a considerable challenge for every innovation manager. With this in view, the following guidelines are directed primarily at innovation managers in medium sized pharmaceutical companies. The guidelines convey the knowledge and tools that enable the development of market and customer oriented products and services in the pharmaceutical industry from the very start. By means of images and descriptions it demonstrates which steps should be followed from idea generation, to project realization, until the market launch. The centerpiece is formed by the division of the innovation process into manageable, clearly defined phases, specifically tailored for the pharmaceutical industry. The guidelines particularly focus on the question of how customers, suppliers, competitors, etc. can be integrated into this process. This approach – termed open innovation in innovation management – when applied as a deliberate strategy, has the potential to reduce the costs of development and to raise the speed of passage of projects.
KW  - Innovation
KW  - Open Innovation
KW  - pharmazeutische Industrie
KW  - kleine und mittlere Unternehmen
KW  - KMU
KW  - Innovationsprozess
KW  - Innovation
KW  - open innovation
KW  - pharmaceutical industry
KW  - small and medium-sized enterprises
KW  - SME
KW  - innovation process
Y1  - 2011
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-50895
SN  - 978-3-86956-103-5
PB  - Universitätsverlag Potsdam
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Lohwaßer, Roswitha
A1  - Braun, Claudia
A1  - Musil, Andreas
A1  - Kludt, Steffen
A1  - Schroeder, Christoph
A1  - Jostes, Brigitte
A1  - Kortenkamp, Ulrich
A1  - Goetz, Ilka
A1  - Rüdiger, Marie
A1  - Hackel, Manuela
A1  - Brzezinski, Jan
A1  - Polziehn, Tabea
A1  - Faulian, Ariane
A1  - Goral, Johanna
A1  - Wendland, Mirko
A1  - Zurek, Peter Paul
A1  - Nyagolova, Maya
T1  - Kentron : Journal zur Lehrerbildung = Durchstarten
T3  - Kentron : Journal zur Lehrerbildung - 32 
Y1  - 2018
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-590394
SN  - 1867-4720
SN  - 1867-4747
IS  - 32
PB  - Universität Potsdam, Zentrum für Lehrerbildung
CY  - Potsdam
ER  - 
TY  - JOUR
A1  - Adelhelm, Silvia
A1  - Braun, Andreas
A1  - Gronau, Norbert
A1  - Lürig, Detlef
A1  - Müller, Elisabeth
A1  - Vladova, Gergana
A1  - Wagner, Dieter
T1  - Mit Open Innovation zum Erfolg
BT  - So verbessern mittelständische Pharmaunternehmen ihre Innovationsprozesse
JF  - Handbuch prozessorientiertes Wissensmanagment
Y1  - 2014
SN  - 978-3-95545-026-7
SP  - 211
EP  - 226
PB  - GITO
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Ullrich, André
A1  - Vladova, Gergana
A1  - Marquart, Danny
A1  - Braun, Andreas
A1  - Gronau, Norbert
T1  - An overwiew of benefits and risks in open innovation projects and the influence of intermediary participation, decision-making authority, experience, and position on their perception
JF  - International journal of innovation management : IJIM
N2  - This paper presents an exploratory study investigating the influence of the factors (1) intermediary participation, (2) decision-making authority, (3) position in the enterprise, and (4) experience in open innovation on the perception and assessment of the benefits and risks expected from participating in open innovation projects. For this purpose, an online survey was conducted in Germany, Austria and Switzerland. The result of this paper is an empirical evidence showing whether and how these factors affect the perception of potential benefits and risks expected within the context of open innovation project participation. Furthermore, the identified effects are discussed against the theory. Existing theory regarding the benefits and risks of open innovation is expanded by (1) finding that they are perceived mostly independently of the factors, (2) confirming the practical relevance of benefits and risks, and (3) enabling a finer distinction between their degrees of relevance according to respective contextual specifics.
KW  - Open innovation
KW  - intermediaries
KW  - benefits
KW  - decision-making
KW  - experience;
KW  - risks
Y1  - 2022
U6  - https://doi.org/10.1142/S1363919622500128
SN  - 1363-9196
SN  - 1757-5877
VL  - 26
IS  - 02
PB  - World Scientific Publ.
CY  - Singapore
ER  - 
TY  - JOUR
A1  - Hilscher, Martin
A1  - Braun, Michael
A1  - Richter, Michael
A1  - Leininger, Andreas
A1  - Gössel, Michael
T1  - X-tolerant test data compaction with accelerated shift registers
N2  - Using the timing flexibility of modern automatic test equipment (ATE) test response data can be compacted without the need for additional X-masking logic. In this article the test response is compacted by several multiple input shift registers without feedback (NF-MISR). The shift registers are running on a k-times higher clock frequency than the test clock. For each test clock cycle only one out of the k outputs of each shift register is evaluated by the ATE. The impact of consecutive X values within the scan chains is reduced by a periodic permutation of the NF-MISR inputs. As a result, no additional external control signals or test set dependent control logic is required. The benefits of the proposed method are shown by the example of an implementation on a Verigy ATE. Experiments on three industrial circuits demonstrate the effectiveness of the proposed approach in comparison to a commercial DFT solution.
Y1  - 2009
UR  - http://www.springerlink.com/content/100286
U6  - https://doi.org/10.1007/s10836-009-5107-5
SN  - 0923-8174
ER  -