TY  - JOUR
A1  - Gilles, Maria
A1  - Otto, Henrike
A1  - Wolf, Isabell A. C.
A1  - Scharnholz, Barbara
A1  - Peus, Verena
A1  - Schredl, Michael
A1  - Suetterlin, Marc W.
A1  - Witt, Stephanie H.
A1  - Rietschel, Marcella
A1  - Laucht, Manfred
A1  - Deuschle, Michael
T1  - Maternal hypothalamus-pituitary-adrenal (HPA) system activity and stress measures at birth
JF  - Psychoneuroendocrinology
N2  - Background: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome. Methods: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36.8 +/- 1.9 weeks of gestational age) and their singleton neonates were studied. We investigated the impact of different prenatal stress indices derived from six stress variables (perceived stress, specific prenatal worries, negative life events, symptoms of depression, trait anxiety, neuroticism) and diurnal maternal saliva cortisol secretion on gestational age and anthropometric measures at birth.
KW  - Early life stress
KW  - Gestational age
KW  - Anthropometric measures at birth
KW  - Cortisol
KW  - Prenatal distress
KW  - Pregnancy
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.04.022
SN  - 0306-4530
VL  - 94
SP  - 152
EP  - 161
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Send, Tabea Sarah
A1  - Bardtke, Svenja
A1  - Gilles, Maria
A1  - Wolf, Isabella Germaine
A1  - Sütterlin, Marc W.
A1  - Kirschbaum, Clemens
A1  - Laucht, Manfred
A1  - Witt, Stephanie H.
A1  - Rietschel, Marcella
A1  - Streit, Fabian
A1  - Deuschle, Michael
T1  - Stress reactivity in preschool-aged children
BT  - Evaluation of a social stress paradigm and investigation of the impact of prenatal maternal stress
JF  - Psychoneuroendocrinology
N2  - Prenatal maternal stress is an established risk factor for somatic and psychological health of the offspring. A dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in offspring has been suggested as an important mechanism. However, the impact of prenatal stress on stress reactivity in preschool-aged children is not yet well understood. This is partly due to the fact that for this age group there is no stress test as well established as for older children and adults. In the present work a previously published stress test (Kryski et al., 2011) was evaluated in a large sample of 45-month-old children (n = 339). Furthermore, the relation between measures of prenatal maternal stress and cortisol reactivity was investigated. Prenatal stress was defined as psychopathology (self-report available for n = 339; expert-rating available for a subsample of n = 246) and perceived stress (n = 244) during pregnancy. The stress paradigm elicited significant increases in salivary cortisol 30 and 40 min after the test, and 60.8% of the children were classified as responders. Lower cortisol levels after the stress test were observed in the group of children with prenatal stress defined as maternal psychopathology (both self-reported and expert-rated). Maternal perceived stress as a continuous measure was not significantly associated with cortisol levels. However, when comparing children in the highest quartile of maternal perceived stress to all other children, significantly lower cortisol values were observed in the prenatally stressed group. The present study confirms the paradigm by Kryski et al. as an effective stress test for preschool-aged children. Moreover, it provides further evidence that prenatal stress impacts HPA axis reactivity. Future studies should target the timing, nature, and intensity of prenatal stressors and their effect on the stress response in offspring at different developmental stages.
KW  - Stress test
KW  - Children
KW  - Prenatal stress
KW  - Cortisol
KW  - HPA axis reactivity
KW  - Psychopathology
Y1  - 2018
U6  - https://doi.org/10.1016/j.psyneuen.2018.11.002
SN  - 0306-4530
VL  - 101
SP  - 223
EP  - 231
PB  - Elsevier
CY  - Oxford
ER  -