TY  - JOUR
A1  - Frodl, Thomas
A1  - Janowitz, Deborah
A1  - Schmaal, Lianne
A1  - Tozzi, Leonardo
A1  - Dobrowolny, Henrik
A1  - Stein, Dan J.
A1  - Veltman, Dick J.
A1  - Wittfeld, Katharina
A1  - van Erp, Theo G. M.
A1  - Jahanshad, Neda
A1  - Block, Andrea
A1  - Hegenscheid, Katrin
A1  - Voelzke, Henry
A1  - Lagopoulos, Jim
A1  - Hatton, Sean N.
A1  - Hickie, Ian B.
A1  - Frey, Eva Maria
A1  - Carballedo, Angela
A1  - Brooks, Samantha J.
A1  - Vuletic, Daniella
A1  - Uhlmann, Anne
A1  - Veer, Ilya M.
A1  - Walter, Henrik
A1  - Schnell, Knut
A1  - Grotegerd, Dominik
A1  - Arolt, Volker
A1  - Kugel, Harald
A1  - Schramm, Elisabeth
A1  - Konrad, Carsten
A1  - Zurowski, Bartosz
A1  - Baune, Bernhard T.
A1  - van der Wee, Nic J. A.
A1  - van Tol, Marie-Jose
A1  - Penninx, Brenda W. J. H.
A1  - Thompson, Paul M.
A1  - Hibar, Derrek P.
A1  - Dannlowski, Udo
A1  - Grabe, Hans J.
T1  - Childhood adversity impacts on brain subcortical structures relevant to depression
JF  - Journal of psychiatric research
N2  - Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis. In this largest effort world-wide to identify subcortical brain structure differences related to childhood adversity, 3036 participants were analyzed for subcortical brain volumes using FreeSurfer. A significant interaction was evident between childhood adversity, MDD diagnosis, sex, and region. Increased exposure to childhood adversity was associated with smaller caudate volumes in females independent of MDD. All subcategories of childhood adversity were negatively associated with caudate volumes in females - in particular emotional neglect and physical neglect (independently from age, ICV, imaging site and MDD diagnosis). There was no interaction effect between childhood adversity and MDD diagnosis on subcortical brain volumes. Childhood adversity is one of the contributors to brain structural abnormalities. It is associated with subcortical brain abnormalities that are relevant to psychiatric disorders such as depression. (C) 2016 Published by Elsevier Ltd.
KW  - Depression
KW  - Childhood adversity
KW  - MRI
KW  - Caudate
KW  - Hippocampus
KW  - ENIGMA
Y1  - 2016
U6  - https://doi.org/10.1016/j.jpsychires.2016.11.010
SN  - 0022-3956
SN  - 1879-1379
VL  - 86
SP  - 58
EP  - 65
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Renteria, Miguel E.
A1  - Schmaal, L.
A1  - Hibar, D. P.
A1  - Couvy-Duchesne, B.
A1  - Strike, L. T.
A1  - Mills, N. T.
A1  - de Zubicaray, Greig. I.
A1  - McMahon, Katie. L.
A1  - Medland, Sarah E.
A1  - Gillespie, N. A.
A1  - Hatton, S. N.
A1  - Lagopoulos, J.
A1  - Veltman, D. J.
A1  - van der Wee, N.
A1  - van Erp, T. G. M.
A1  - Wittfeld, K.
A1  - Grabe, H. J.
A1  - Block, Andrea
A1  - Hegenscheid, K.
A1  - Voelzke, H.
A1  - Veer, I. M.
A1  - Walter, H.
A1  - Schnell, K.
A1  - Schramm, E.
A1  - Normann, C.
A1  - Schoepf, Dieter
A1  - Konrad, C.
A1  - Zurowski, B.
A1  - Godlewska, B. R.
A1  - Cowen, P. J.
A1  - Penninx, B. W. J. H.
A1  - Jahanshad, N.
A1  - Thompson, Paul M.
A1  - Wright, M. J.
A1  - Martin, N. G.
A1  - Christensen, H.
A1  - Hickie, I. B.
T1  - Subcortical brain structure and suicidal behaviour in major depressive disorder: a meta-analysis from the ENIGMA-MDD working group
JF  - Translational Psychiatry
Y1  - 2017
U6  - https://doi.org/10.1038/tp.2017.84
SN  - 2158-3188
VL  - 7
SP  - 2301
EP  - 2320
PB  - Nature Publ. Group
CY  - New York
ER  -