TY  - GEN
A1  - Schwarze, Thomas
A1  - Müller, Holger
A1  - Ast, Sandra
A1  - Steinbrück, Dörte
A1  - Eidner, Sascha
A1  - Geißler, Felix
A1  - Kumke, Michael Uwe
A1  - Holdt, Hans-Jürgen
T1  - Fluorescence lifetime-based sensing of sodium by an optode
N2  - We report a 1,2,3-triazol fluoroionophore for detecting Na+ that shows in vitro enhancement in the Na+-induced fluorescence intensity and decay time. The Na+-selective molecule 1 was incorporated into a hydrogel as a part of a fiber optical sensor. This sensor allows the direct determination of Na+ in the range of 1–10 mM by measuring reversible fluorescence decay time changes.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 182 
KW  - ion optodes
KW  - sensors
KW  - indicators
KW  - chromoionophore
KW  - ionophore
KW  - membrane
KW  - switches
KW  - systems
KW  - samples
KW  - green
Y1  - 2014
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-76785
SP  - 14167
EP  - 14170
PB  - The Royal Society of Chemistry
CY  - Cambridge
ER  - 
TY  - GEN
A1  - Schwarze, Thomas
A1  - Riemer, Janine
A1  - Müller, Holger
A1  - John, Leonard
A1  - Holdt, Hans‐Jürgen
A1  - Wessig, Pablo
T1  - Na+ Selective Fluorescent Tools Based on Fluorescence Intensity Enhancements, Lifetime Changes, and on a Ratiometric Response
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Over the years, we developed highly selective fluorescent probes for K+ in water, which show K+-induced fluorescence intensity enhancements, lifetime changes, or a ratiometric behavior at two emission wavelengths (cf. Scheme 1, K1-K4). In this paper, we introduce selective fluorescent probes for Na+ in water, which also show Na+ induced signal changes, which are analyzed by diverse fluorescence techniques. Initially, we synthesized the fluorescent probes 2, 4, 5, 6 and 10 for a fluorescence analysis by intensity enhancements at one wavelength by varying the Na+ responsive ionophore unit and the fluorophore moiety to adjust different K-d values for an intra- or extracellular Na+ analysis. Thus, we found that 2, 4 and 5 are Na+ selective fluorescent tools, which are able to measure physiologically important Na+ levels at wavelengths higher than 500 nm. Secondly, we developed the fluorescent probes 7 and 8 to analyze precise Na+ levels by fluorescence lifetime changes. Herein, only 8 (K-d=106 mm) is a capable fluorescent tool to measure Na+ levels in blood samples by lifetime changes. Finally, the fluorescent probe 9 was designed to show a Na+ induced ratiometric fluorescence behavior at two emission wavelengths. As desired, 9 (K-d=78 mm) showed a ratiometric fluorescence response towards Na+ ions and is a suitable tool to measure physiologically relevant Na+ levels by the intensity change of two emission wavelengths at 404 nm and 492 nm.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1136 
KW  - crown compounds
KW  - fluorescence lifetime
KW  - fluorescent probes
KW  - ratiometric
KW  - sodium
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437482
SN  - 1866-8372
IS  - 1136
ER  -