TY - GEN A1 - Freitag, Nils A1 - Weber, Pia Deborah A1 - Sanders, Tanja Christiane A1 - Schulz, Holger A1 - Bloch, Wilhelm A1 - Schumann, Moritz T1 - High-intensity interval training and hyperoxia during chemotherapy BT - A case report about the feasibility, safety and physical functioning in a colorectal cancer patient T2 - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe N2 - Introduction: We conducted a case study to examine the feasibility and safety of high-intensity interval training (HIIT) with increased inspired oxygen content in a colon cancer patient undergoing chemotherapy. A secondary purpose was to investigate the effects of such training regimen on physical functioning. Case presentation: A female patient (51 years; 49.1 kg; 1.65 m; tumor stage: pT3, pN2a (5/29), pM1a (HEP), L0, V0, R0) performed 8 sessions of HIIT (5 × 3 minutes at 90% of Wmax, separated by 2 minutes at 45% Wmax) with an increased inspired oxygen fraction of 30%. Patient safety, training adherence, cardiorespiratory fitness (peak oxygen uptake and maximal power output during an incremental cycle ergometer test), autonomous nervous function (i.e., heart rate variability during an orthostatic test) as well as questionnaire-assessed quality of life (EORTC QLQ-C30) were evaluated before and after the intervention. No adverse events were reported throughout the training intervention and a 3 months follow-up. While the patient attended all sessions, adherence to total training time was only 51% (102 of 200 minutes; mean training time per session 12:44 min:sec). VO2peak and Wmax increased by 13% (from 23.0 to 26.1 mL min kg−1) and 21% (from 83 to 100 W), respectively. Heart rate variability represented by the root mean squares of successive differences both in supine and upright positions were increased after the training by 143 and 100%, respectively. The EORTC QLQ-C30 score for physical functioning (7.5%) as well as the global health score (10.7%) improved, while social function decreased (17%). Conclusions: Our results show that a already short period of HIIT with concomitant hyperoxia was safe and feasible for a patient undergoing chemotherapy for colon cancer. Furthermore, the low overall training adherence of only 51% and an overall low training time per session (∼13 minutes) was sufficient to induce clinically meaningful improvements in physical functioning. However, this case also underlines that intensity and/or length of the HIIT-bouts might need further adjustments to increase training compliance. T3 - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 453 KW - carcinoma KW - chemo-toxicity KW - exercise therapy KW - fatigue KW - gastrointestinal cancer KW - heart rate variability KW - high-intensity interval training KW - solid tumor Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-414112 IS - 453 ER - TY - JOUR A1 - Freitag, Nils A1 - Weber, Pia Deborah A1 - Sanders, Tanja Christiane A1 - Schulz, Holger A1 - Bloch, Wilhelm A1 - Schumann, Moritz T1 - High-intensity interval training and hyperoxia during chemotherapy BT - A case report about the feasibility, safety and physical functioning in a colorectal cancer patient JF - Medicine N2 - Introduction: We conducted a case study to examine the feasibility and safety of high-intensity interval training (HIIT) with increased inspired oxygen content in a colon cancer patient undergoing chemotherapy. A secondary purpose was to investigate the effects of such training regimen on physical functioning. Case presentation: A female patient (51 years; 49.1 kg; 1.65 m; tumor stage: pT3, pN2a (5/29), pM1a (HEP), L0, V0, R0) performed 8 sessions of HIIT (5 × 3 minutes at 90% of Wmax, separated by 2 minutes at 45% Wmax) with an increased inspired oxygen fraction of 30%. Patient safety, training adherence, cardiorespiratory fitness (peak oxygen uptake and maximal power output during an incremental cycle ergometer test), autonomous nervous function (i.e., heart rate variability during an orthostatic test) as well as questionnaire-assessed quality of life (EORTC QLQ-C30) were evaluated before and after the intervention. No adverse events were reported throughout the training intervention and a 3 months follow-up. While the patient attended all sessions, adherence to total training time was only 51% (102 of 200 minutes; mean training time per session 12:44 min:sec). VO2peak and Wmax increased by 13% (from 23.0 to 26.1 mL min kg−1) and 21% (from 83 to 100 W), respectively. Heart rate variability represented by the root mean squares of successive differences both in supine and upright positions were increased after the training by 143 and 100%, respectively. The EORTC QLQ-C30 score for physical functioning (7.5%) as well as the global health score (10.7%) improved, while social function decreased (17%). Conclusions: Our results show that a already short period of HIIT with concomitant hyperoxia was safe and feasible for a patient undergoing chemotherapy for colon cancer. Furthermore, the low overall training adherence of only 51% and an overall low training time per session (∼13 minutes) was sufficient to induce clinically meaningful improvements in physical functioning. However, this case also underlines that intensity and/or length of the HIIT-bouts might need further adjustments to increase training compliance. KW - carcinoma KW - chemo-toxicity KW - exercise therapy KW - fatigue KW - gastrointestinal cancer KW - heart rate variability KW - high-intensity interval training KW - solid tumor Y1 - 2018 U6 - https://doi.org/10.1097/MD.0000000000011068 SN - 1536-5964 SN - 0025-7974 VL - 97 IS - 24 SP - 1 EP - 7 PB - Lippincott Williams & Wilkins CY - Baltimore, Md. ER - TY - JOUR A1 - Keller, Sebastian A1 - Notbohm, Hannah Lisa A1 - Bloch, Wilhelm A1 - Schumann, Moritz T1 - Reduced serum concentrations of reactive oxygen and nitrogen species following strenuous exercise in the heat are not associated with an upregulation in serum antioxidative capacity JF - Baltic Journal of Health and Physical Activity N2 - Introduction: Reactive oxygen and nitrogen species (RONS) are produced as a response to exercise and play a part in guiding the adaptive response to physical training. Exercise in the heat has been shown to further increase accumulation of RONS in systemic circulation; however, a high antioxidative response or heat acclimatization mechanisms could attenuate this response. In a previous study, we found reduced RONS concentrations in trained athletes following strenuous cycling in the heat. Therefore, this secondary analysis assessed whether these reduced RONS serum concentrations are induced by an increased serum antioxidant capacity. Methods: Twelve male cyclists (V?O2peak: 60 +/- 4 ml center dot kg-1 center dot min-1) completed a 60-minute constant workload trial (55% peak power output, ambient temperature 30.4 +/- 0.6 degrees C) with and without ice vest in a randomized order. The core body temperature (Tcore) was measured by an ingestible capsule. Blood samples were collected before and after each trial to determine superoxide dismutase (SOD) and catalase (CAT) activity, total antioxidant capacity (TAC) and RONS. Due to the absence of between-group differences, data of both conditions were pooled. Results: Tcore statistically increased (p < 0.001) over the experimental trials (+6.0 +/- 1.6%, effect size (ES) = 5.6). Concentrations of RONS (-17.2 +/- 15.5%, p < 0.001, ES = 1.0) and TAC (-8.9 +/- 22.9%, p = 0.04, ES = 0.7) statistically decreased, while the activity of CAT (+15.5 +/- 84.0%, p = 0.90, ES = 0.04) and SOD (+9.2 +/- 58.7%, p = 0.98, ES = 0.01) remained unchanged. Conclusions: Reduced serum RONS concentrations after strenuous cycling in the heat were not associated with upregulation of serum antioxidant capacity in trained athletes. The prooxidant-antioxidant balance may rather be regulated at a myocellular level and should be further assessed in future studies. KW - total antioxidant KW - capacity KW - antioxidants KW - catalase KW - reactive oxygen KW - species KW - superoxide dismutase KW - sports medicine Y1 - 2022 U6 - https://doi.org/10.29359/BJHPA.14.4.03 SN - 2080-9999 VL - 14 IS - 4 PB - Gda`nsk Academy; Versita, Warsaw CY - Gdansk ER -