TY  - JOUR
A1  - Rüder, Constantin
A1  - Sauter, Tilman
A1  - Kratz, Karl
A1  - Haase, Tobias
A1  - Peter, Jan
A1  - Jung, Friedrich
A1  - Lendlein, Andreas
A1  - Zohlnhöfer, Dietlind
T1  - Influence of fibre diameter and orientation of electrospun copolyetheresterurethanes on smooth muscle and endothelial cell behaviour
JF  - Clinical hemorheology and microcirculation : blood flow and vessels
N2  - Polymers exhibiting cell-selective effects represent an extensive research field with high relevance for biomedical applications e.g. in the cardiovascular field supporting re-endothelialization while suppressing smooth muscle cell overgrowth. Such an endothelial cell-selective effect could be recently demonstrated for a copolyetheresterurethane (PDC) containing biodegradable poly(p-dioxanone) and poly(epsilon-caprolactone) segments, which selectively enhanced the adhesion of human umbilical vein endothelial cells (HUVEC) while suppressing the attachment of smooth muscle cells (SMC).
 In this study we investigated the influence of the fibre orientation (random and aligned) and fibre diameter (2 mu m and 500 nm) of electrospun PDC scaffolds on the adhesion, proliferation and apoptosis of HUVEC and SMC.
 Adhesion, viability and proliferation of HUVEC was diminished when the fibre diameter was reduced to a submicron scale, while the orientation of the microfibres did only slightly influence the cellular behaviour. In contrast, a submicron fibre diameter improved SMC viability. In conclusion, PDC scaffolds with micron-sized single fibres could be promising candidate materials for cell-selective stent coatings.
KW  - Endothelialization
KW  - drug eluting stent
KW  - degradable polymer
KW  - electrospinning
KW  - cell selectivity
Y1  - 2013
U6  - https://doi.org/10.3233/CH-131787
SN  - 1386-0291
SN  - 1875-8622
VL  - 55
IS  - 4
SP  - 513
EP  - 522
PB  - IOS Press
CY  - Amsterdam
ER  -