TY  - GEN
A1  - Andorf, Sandra
A1  - Gärtner, Tanja
A1  - Steinfath, Matthias
A1  - Witucka-Wall, Hanna
A1  - Altmann, Thomas
A1  - Repsilber, Dirk
T1  - Towards systems biology of heterosis
BT  - a hypothesis about molecular network structure applied for the Arabidopsis metabolome
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - We propose a network structure-based model for heterosis, and investigate it relying on metabolite profiles from Arabidopsis. A simple feed-forward two-layer network model (the Steinbuch matrix) is used in our conceptual approach. It allows for directly relating structural network properties with biological function. Interpreting heterosis as increased adaptability, our model predicts that the biological networks involved show increasing connectivity of regulatory interactions. A detailed analysis of metabolite profile data reveals that the increasing-connectivity prediction is true for graphical Gaussian models in our data from early development. This mirrors properties of observed heterotic Arabidopsis phenotypes. Furthermore, the model predicts a limit for increasing hybrid vigor with increasing heterozygosity—a known phenomenon in the literature.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 949 
KW  - partial correlation
KW  - biological network
KW  - metabolite profile
KW  - molecular network
KW  - significant edge
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-436274
SN  - 1866-8372
IS  - 949
ER  -