TY  - JOUR
A1  - Chen, Hao
A1  - Nebe, Stephan
A1  - Mojtahedzadeh, Negin
A1  - Kuitunen-Paul, Soren
A1  - Garbusow, Maria
A1  - Schad, Daniel
A1  - Rapp, Michael Armin
A1  - Huys, Quentin J. M.
A1  - Heinz, Andreas
A1  - Smolka, Michael N.
T1  - Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use
JF  - Addiction biology
N2  - Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community sample of 18-year-old male adults. Participants (N = 191) were instructed to 'collect good shells' and 'leave bad shells' during the presentation of appetitive (monetary reward), aversive (monetary loss) or neutral Pavlovian stimuli. We compared instrumental error rates (ER) and functional magnetic resonance imaging (fMRI) brain responses between the congruent and incongruent conditions, as well as among high-risk and low-risk drinking groups. On average, individuals showed a substantial PIT effect, that is, increased ER when Pavlovian cues and instrumental stimuli were in conflict compared with congruent trials. Neural PIT correlates were found in the ventral striatum and the dorsomedial and lateral prefrontal cortices (lPFC). Importantly, high-risk drinking was associated with a stronger behavioural PIT effect, a decreased lPFC response and an increased neural response in the ventral striatum on the trend level. Moreover, high-risk drinkers showed weaker connectivity from the ventral striatum to the lPFC during incongruent trials. Our study links interference during PIT to drinking behaviour in healthy, young adults. High-risk drinkers showed higher susceptibility to Pavlovian cues, especially when they conflicted with instrumental behaviour, indicating lower interference control abilities. Increased activity in the ventral striatum (bottom-up), decreased lPFC response (top-down), and their altered interplay may contribute to poor interference control in the high-risk drinkers.
KW  - high‐risk drinking
KW  - interference control
KW  - Pavlovian‐to‐instrumental transfer
Y1  - 2020
U6  - https://doi.org/10.1111/adb.12983
SN  - 1355-6215
SN  - 1369-1600
VL  - 26
IS  - 4
SP  - 1
EP  - 14
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Chen, Hao
A1  - Nebe, Stephan
A1  - Mojtahedzadeh, Negin
A1  - Kuitunen-Paul, Soren
A1  - Garbusow, Maria
A1  - Schad, Daniel
A1  - Rapp, Michael Armin
A1  - Huys, Quentin J. M.
A1  - Heinz, Andreas
A1  - Smolka, Michael N.
T1  - Susceptibility to interference between Pavlovian and instrumental control is associated with early hazardous alcohol use
T2  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - Pavlovian-to-instrumental transfer (PIT) tasks examine the influence of Pavlovian stimuli on ongoing instrumental behaviour. Previous studies reported associations between a strong PIT effect, high-risk drinking and alcohol use disorder. This study investigated whether susceptibility to interference between Pavlovian and instrumental control is linked to risky alcohol use in a community sample of 18-year-old male adults. Participants (N = 191) were instructed to 'collect good shells' and 'leave bad shells' during the presentation of appetitive (monetary reward), aversive (monetary loss) or neutral Pavlovian stimuli. We compared instrumental error rates (ER) and functional magnetic resonance imaging (fMRI) brain responses between the congruent and incongruent conditions, as well as among high-risk and low-risk drinking groups. On average, individuals showed a substantial PIT effect, that is, increased ER when Pavlovian cues and instrumental stimuli were in conflict compared with congruent trials. Neural PIT correlates were found in the ventral striatum and the dorsomedial and lateral prefrontal cortices (lPFC). Importantly, high-risk drinking was associated with a stronger behavioural PIT effect, a decreased lPFC response and an increased neural response in the ventral striatum on the trend level. Moreover, high-risk drinkers showed weaker connectivity from the ventral striatum to the lPFC during incongruent trials. Our study links interference during PIT to drinking behaviour in healthy, young adults. High-risk drinkers showed higher susceptibility to Pavlovian cues, especially when they conflicted with instrumental behaviour, indicating lower interference control abilities. Increased activity in the ventral striatum (bottom-up), decreased lPFC response (top-down), and their altered interplay may contribute to poor interference control in the high-risk drinkers.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 855 
KW  - high‐risk drinking
KW  - interference control
KW  - Pavlovian‐to‐instrumental transfer
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-569609
SN  - 1866-8364
IS  - 4
ER  -