TY  - JOUR
A1  - Nguyen, Hung M.
A1  - Schippers, Jos H. M.
A1  - Goni-Ramos, Oscar
A1  - Christoph, Mathias P.
A1  - Dortay, Hakan
A1  - van der Hoorn, Renier A. L.
A1  - Müller-Röber, Bernd
T1  - An upstream regulator of the 26S proteasome modulates organ size in Arabidopsis thaliana
JF  - The plant journal
N2  - In both animal and plant kingdoms, body size is a fundamental but still poorly understood attribute of biological systems. Here we report that the Arabidopsis NAC transcription factor Regulator of Proteasomal Gene Expression' (RPX) controls leaf size by positively modulating proteasome activity. We further show that the cis-element recognized by RPX is evolutionarily conserved between higher plant species. Upon over-expression of RPX, plants exhibit reduced growth, which may be reversed by a low concentration of the pharmacological proteasome inhibitor MG132. These data suggest that the rate of protein turnover during growth is a critical parameter for determining final organ size.
KW  - Arabidopsis thaliana
KW  - organ size
KW  - evolution
KW  - leaf development
KW  - proteasome
KW  - gene regulatory network
Y1  - 2013
U6  - https://doi.org/10.1111/tpj.12097
SN  - 0960-7412
VL  - 74
IS  - 1
SP  - 25
EP  - 36
PB  - Wiley-Blackwell
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Schippers, Jos H. M.
A1  - Nguyen, Hung M.
A1  - Lu, Dandan
A1  - Schmidt, Romy
A1  - Müller-Röber, Bernd
T1  - ROS homeostasis during development: an evolutionary conserved strategy
JF  - Cellular and molecular life sciences
N2  - The balance between cellular proliferation and differentiation is a key aspect of development in multicellular organisms. Recent studies on Arabidopsis roots revealed distinct roles for different reactive oxygen species (ROS) in these processes. Modulation of the balance between ROS in proliferating cells and elongating cells is controlled at least in part at the transcriptional level. The effect of ROS on proliferation and differentiation is not specific for plants but appears to be conserved between prokaryotic and eukaryotic life forms. The ways in which ROS is received and how it affects cellular functioning is discussed from an evolutionary point of view. The different redox-sensing mechanisms that evolved ultimately result in the activation of gene regulatory networks that control cellular fate and decision-making. This review highlights the potential common origin of ROS sensing, indicating that organisms evolved similar strategies for utilizing ROS during development, and discusses ROS as an ancient universal developmental regulator.
KW  - Evolution
KW  - Reactive oxygen species
KW  - Development
Y1  - 2012
U6  - https://doi.org/10.1007/s00018-012-1092-4
SN  - 1420-682X
VL  - 69
IS  - 19
SP  - 3245
EP  - 3257
PB  - Springer
CY  - Basel
ER  -