TY  - JOUR
A1  - Jeon, Jae-Hyung
A1  - Monne, Hector Martinez-Seara
A1  - Javanainen, Matti
A1  - Metzler, Ralf
T1  - Anomalous diffusion of phospholipids and cholesterols in a lipid bilayer and its origins
JF  - Physical review letters
N2  - Combining extensive molecular dynamics simulations of lipid bilayer systems of varying chemical compositions with single-trajectory analyses, we systematically elucidate the stochastic nature of the lipid motion. We observe subdiffusion over more than 4 orders of magnitude in time, clearly stretching into the submicrosecond domain. The lipid motion depends on the lipid chemistry, the lipid phase, and especially the presence of cholesterol. We demonstrate that fractional Langevin equation motion universally describes the lipid motion in all phases, including the gel phase, and in the presence of cholesterol. The results underline the relevance of anomalous diffusion in lipid bilayers and the strong effects of the membrane composition.
Y1  - 2012
U6  - https://doi.org/10.1103/PhysRevLett.109.188103
SN  - 0031-9007
VL  - 109
IS  - 18
PB  - American Physical Society
CY  - College Park
ER  -