TY  - JOUR
A1  - Müller, Stefan
A1  - Machicao y Priemer, Antonio
T1  - Head-Driven Phrase Structure Grammar
JF  - Current Approaches to Syntax : a comparative handbook
N2  - Head-Driven Phrase Structure Grammar is a constraint-based theory. It uses features and values to model linguistic objects. Values may be complex, e. g. consist of feature values pairs themselves. The paper shows that such feature value pairs together with identity of values and relations between feature values are sufficient to develop a complete linguistic theory including all linguistic levels of description. The paper explains the goals of researchers working in the framework and the way they deal with data and motivate their analyses. The framework is explained with respect to an example sentence that involves the following phenomena: valence, constituent structure, adjunction/modification, raising, case assignment, nonlocal dependencies, relative clauses.
Y1  - 2019
SN  - 978-3-11-054025-3
SN  - 978-3-11-053821-2
U6  - https://doi.org/10.1515/9783110540253-012
VL  - 3
SP  - 317
EP  - 359
PB  - De Gruyter Mouton
CY  - Berlin
ER  - 
TY  - JOUR
A1  - Carpinteiro, Alexander
A1  - Becker, Katrin Anne
A1  - Japtok, Lukasz
A1  - Hessler, Gabriele
A1  - Keitsch, Simone
A1  - Pozgajova, Miroslava
A1  - Schmid, Kurt W.
A1  - Adams, Constantin
A1  - Müller, Stefan
A1  - Kleuser, Burkhard
A1  - Edwards, Michael J.
A1  - Grassme, Heike
A1  - Helfrich, Iris
A1  - Gulbins, Erich
T1  - Regulation of hematogenous tumor metastasis by acid sphingomyelinase
JF  - EMBO molecular medicine
N2  - Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread. Transplanting wild-type platelets into Asm-deficient mice reinstated tumor metastasis. Likewise, Asm-deficient mice were protected from hematogenous MT/ret melanoma metastasis to the spleen in a mouse model of spontaneous tumor metastasis. Human and mouse melanoma cells triggered activation and release of platelet secretory Asm, in turn leading to ceramide formation, clustering, and activation of 51 integrins on melanoma cells finally leading to adhesion of the tumor cells. Clustering of integrins by applying purified Asm or C-16 ceramide to B16F10 melanoma cells before intravenous injection restored trapping of tumor cells in the lung in Asm-deficient mice. This effect was revertable by arginine-glycine-aspartic acid peptides, which are known inhibitors of integrins, and by antibodies neutralizing 1 integrins. These findings indicate that melanoma cells employ platelet-derived Asm for adhesion and metastasis.
KW  - acid sphingomyelinase
KW  - ceramide
KW  - integrins
KW  - platelets
KW  - tumor-metastasis
Y1  - 2015
SN  - 1757-4676
SN  - 1757-4684
VL  - 7
IS  - 6
SP  - 714
EP  - 734
PB  - Wiley-Blackwell
CY  - Hoboken
ER  -