TY - THES A1 - Müller, Frank J. T1 - Integrative Grundschulen aus Sicht der Eltern - auf dem Weg zur Inklusion? : eine qualitative/quantitative Erhebung zur Elternzufriedenheit Y1 - 2013 SN - 978-3-7815-1935-0 PB - Klinkhardt CY - Bad Heilbrunn ER - TY - GEN A1 - Müller, Frank Ernst A1 - Selting, Margret T1 - Kontextualisierung von Sprache : Bericht und Kommentar zum Workshop „Interpretive Sociolinguistics III: 'Contextualization of language'" N2 - Inhalt: - 'Master talkers' und 'bumblers' - Kontextualisierung - Theoretische Beiträge - Empirische Beiträge - Gestik - Prosodie - Schluß T3 - Zweitveröffentlichungen der Universität Potsdam : Philosophische Reihe - 52 Y1 - 1989 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus-41977 ER - TY - JOUR A1 - Schlickewei, Ole A1 - Nienstedt, Julie Cläre A1 - Frank, Ulrike A1 - Fründt, Odette A1 - Pötter-Nerger, Monika A1 - Gerloff, Christian A1 - Buhmann, Carsten A1 - Müller, Frank A1 - Lezius, Susanne A1 - Koseki, Jana-Christiane A1 - Pflug, Christina T1 - The ability of the eating assessment tool‑10 to detect penetration and aspiration in Parkinson’s disease JF - European archives of oto-rhino-laryngology and head & neck N2 - Purpose: Dysphagia is common in patients with Parkinson's disease (PD) and often leads to pneumonia, malnutrition, and reduced quality of life. This study investigates the ability of the Eating Assessment Tool-10 (EAT-10), an established, easy self-administered screening tool, to detect aspiration in PD patients. This study aims to validate the ability of the EAT-10 to detect FEES-proven aspiration in patients with PD. Methods: In a controlled prospective cross-sectional study, a total of 50 PD patients completed the EAT-10 and, subsequently, were examined by Flexible Endoscopic Evaluation of Swallowing (FEES) to determine the swallowing status. The results were rated through the Penetration-Aspiration Scale (PAS) and data were analyzed retrospectively. Results: PAS and EAT-10 did not correlate significantly. Selected items of the EAT-10 could not predict aspiration or residues. 19 (38%) out of 50 patients with either penetration or aspiration were not detected by the EAT-10. The diagnostic accuracy was established at only a sufficient level (AUC 0.65). An optimal cut-off value of >= 6 presented a sensitivity of 58% and specificity of 82%. Conclusions: The EAT-10 is not suited for the detection of penetration and aspiration in PD patients. Therefore, it cannot be used as a screening method in this patient population. There is still a need for a valid, simple, and efficient screening tool to assist physicians in their daily diagnostics and to avoid clinical complications. KW - Parkinson's disease KW - dysphagia KW - questionnaire KW - screening Y1 - 2020 U6 - https://doi.org/10.1007/s00405-020-06377-x SN - 0937-4477 SN - 1434-4726 VL - 278 IS - 5 SP - 1661 EP - 1668 PB - Springer CY - Berlin ER - TY - JOUR A1 - Neffe, Axel T. A1 - Loebus, Axel A1 - Zaupa, Alessandro A1 - Stötzel, Christian A1 - Müller, Frank A. A1 - Lendlein, Andreas T1 - Gelatin functionalization with tyrosine derived moieties to increase the interaction with hydroxyapatite fillers JF - Acta biomaterialia N2 - Combining gelatins functionalized with the tyrosine-derived groups desaminotyrosine or desaminotyrosyl tyrosine with hydroxyapatite (HAp) led to the formation of composite materials with much lower swelling ratios than those of the pure matrices. Shifts of the infra-red (IR) bands related to the free carboxyl groups could be observed in the presence of HAp, which suggested a direct interaction of matrix and filler that formed additional physical cross-links in the material. In tensile tests and rheological measurements the composites equilibrated in water had increased Young's moduli (from 200 kPa up to 2 MPa) and tensile strengths (from 57 kPa up to 1.1 MPa) compared with the matrix polymers without affecting the elongation at break. Furthermore, an increased thermal stability of the networks from 40 to 85 degrees C could be demonstrated. The differences in the behaviour of the functionalized gelatins compared with pure gelatin as a matrix suggested an additional stabilizing bond between the incorporated aromatic groups and the HAp as supported by the IR results. The composites can potentially be applied as bone fillers. KW - Gelatin KW - Hydroxyapatite KW - Composite KW - Hydrogel KW - Biomaterial Y1 - 2011 U6 - https://doi.org/10.1016/j.actbio.2010.11.025 SN - 1742-7061 VL - 7 IS - 4 SP - 1693 EP - 1701 PB - Elsevier CY - Oxford ER - TY - GEN A1 - Sas, Claudia A1 - Müller, Frank A1 - Kappel, Christian A1 - Kent, Tyler V. A1 - Wright, Stephen I. A1 - Hilker, Monika A1 - Lenhard, Michael T1 - Repeated inactivation of the first committed enzyme underlies the loss of benzaldehyde emission after the selfing transition in Capsella T2 - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe N2 - The enormous species richness of flowering plants is at least partly due to floral diversification driven by interactions between plants and their animal pollinators [1, 2]. Specific pollinator attraction relies on visual and olfactory floral cues [3-5]; floral scent can not only attract pollinators but also attract or repel herbivorous insects [6-8]. However, despite its central role for plant-animal interactions, the genetic control of floral scent production and its evolutionary modification remain incompletely understood [9-13]. Benzenoids are an important class of floral scent compounds that are generated from phenylalanine via several enzymatic pathways [14-17]. Here we address the genetic basis of the loss of floral scent associated with the transition from outbreeding to selfing in the genus Capsella. While the outbreeding C. grandiflora emits benzaldehyde as a major constituent of its floral scent, this has been lost in the selfing C. rubella. We identify the Capsella CNL1 gene encoding cinnamate: CoA ligase as responsible for this variation. Population genetic analysis indicates that CNL1 has been inactivated twice independently in C. rubella via different novel mutations to its coding sequence. Together with a recent study in Petunia [18], this identifies cinnamate: CoA ligase as an evolutionary hotspot for mutations causing the loss of benzenoid scent compounds in association with a shift in the reproductive strategy of Capsella from pollination by insects to self-fertilization. T3 - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 904 KW - benzyl alcohol-dehydrogenase KW - floral scent KW - recent speciation KW - petunia flowers KW - genus capsella KW - evolution KW - biosynthesis KW - fragrance KW - purification KW - pollinators KW - benzaldehyde KW - selfing syndrome KW - shepherd’s purse KW - cinnamate:CoA ligase Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-438018 SN - 1866-8372 IS - 904 SP - 3313 EP - 3319 ER -