TY  - JOUR
A1  - Schmiedchen, Bettina
A1  - Longardt, Ann Carolin
A1  - Loui, Andrea
A1  - Buehrer, Christoph
A1  - Raila, Jens
A1  - Schweigert, Florian J.
T1  - Effect of vitamin A supplementation on the urinary retinol excretion in very low birth weight infants
JF  - European journal of pediatrics : official organ of the Belgian Pediatric Association
N2  - Despite high-dose vitamin A supplementation of very low birth weight infants (VLBW, <1500 g), their vitamin A status does not improve substantially. Unknown is the impact of urinary retinol excretion on the serum retinol concentration in these infants. Therefore, the effect of high-dose vitamin A supplementation on the urinary vitamin A excretion in VLBW infants was investigated. Sixty-three VLBW infants were treated with vitamin A (5000 IU intramuscular, 3 times/week for 4 weeks); 38 untreated infants were classified as control group. On days 3 and 28 of life, retinol, retinol-binding protein 4 (RBP4), glomerular filtration rate, proteinuria, and Tamm-Horsfall protein were quantified in urine. On day 3 of life, substantial retinol and RBP4 losses were found in both groups, which significantly decreased until day 28. Notwithstanding, the retinol excretion was higher (P<0.01) under vitamin A supplementation as compared to infants of the control group. On day 28 of life, the urinary retinol concentrations were predictive for serum retinol concentrations in the vitamin A treated (P<0.01), but not in the control group (P=0.570). Conclusion: High urinary retinol excretion may limit the vitamin A supplementation efficacy in VLBW infants. Advanced age and thus postnatal kidney maturation seems to be an important contributor in the prevention of urinary retinol losses.
KW  - Vitamin A supplementation
KW  - RBP4
KW  - Very low birth weight infant
KW  - Urine excretion
Y1  - 2016
U6  - https://doi.org/10.1007/s00431-015-2647-9
SN  - 0340-6199
SN  - 1432-1076
VL  - 175
SP  - 365
EP  - 372
PB  - Springer
CY  - New York
ER  - 
TY  - JOUR
A1  - Schmiedchen, Bettina
A1  - Longardt, Ann Carolin
A1  - Buehrer, Christoph
A1  - Raila, Jens
A1  - Loui, Andrea
A1  - Schweigert, Florian J.
T1  - The relative dose response test based on retinol-binding protein 4 is not suitable to assess vitamin A status in very low birth weight infants
JF  - Neonatology : fetal and neonatal research
KW  - Relative dose response test
KW  - Vitamin A
KW  - Preterm infant
Y1  - 2014
U6  - https://doi.org/10.1159/000356773
SN  - 1661-7800
SN  - 1661-7819
VL  - 105
IS  - 2
SP  - 155
EP  - 160
PB  - Karger
CY  - Basel
ER  -