TY  - JOUR
A1  - Yenesew, Abiy
A1  - Induli, M.
A1  - Derese, Solomon
A1  - Midiwo, Jacob O.
A1  - Heydenreich, Matthias
A1  - Peter, Martin G.
A1  - Akala, Hoseah M.
A1  - Wangui, Julia
A1  - Liyala, Pamela
A1  - Waters, Norman C.
T1  - Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica
N2  - The ethyl acetate extract of the stem bark of Erythrina abyssinica showed anti-plasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 7.9 +/- 1.1 and 5.3 +/- 0.7 mug/ml, respectively. From this extract, a new chalcone, 2,3,4,4'-tetrahydroxy-5- prenylchalcone (trivial name 5-prenylbutein) and a new flavanone, 4',7-dihydroxy-3'-methoxy-5'- prenylflavanone (trivial name, 5-deoxyabyssinin II) along with known flavonoids have been isolated as the anti- plasmodial principles. The structures were determined on the basis of spectroscopic evidence. (C) 2004 Elsevier Ltd. All rights reserved
Y1  - 2004
SN  - 0031-9422
ER  - 
TY  - JOUR
A1  - Andayi, Andrew W.
A1  - Yenesew, Abiy
A1  - Derese, Solomon
A1  - Midiwo, Jacob O.
A1  - Gitu, Peter M.
A1  - Jondiko, Ogoche J. I.
A1  - Akala, Hoseah M.
A1  - Liyala, Pamela
A1  - Wangui, Julia
A1  - Waters, Norman C.
A1  - Heydenreich, Matthias
A1  - Peter, Martin G.
T1  - Antiplasmodial flavonoids from Erythrina sacleuxii
N2  - The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the acetone extract of the root bark afforded a new isoflavone, 7-hydroxy-4 -methoxy-3'- prenylisoflavone (trivial name 5-deoxy-3' - prenylbiochanin A) along with known isoflavonoids as the antiplasmodial principles. Flavonoids and isoflavonoids isolated from the stem bark of E. sucleuxii were also tested and showed antiplasmodial activities. The structures were determined on the basis of spectroscopic evidence
Y1  - 2006
UR  - http://www.thieme-connect.com/ejournals/toc/plantamedica
U6  - https://doi.org/10.1055/s-2005-873200
SN  - 0032-0943
ER  -