TY  - JOUR
A1  - Zakharova, Anna
A1  - Kurths, Jürgen
A1  - Vadivasova, Tatyana
A1  - Koseska, Aneta
T1  - Analysing dynamical behavior of cellular networks via stochastic bifurcations
JF  - PLoS one
N2  - The dynamical structure of genetic networks determines the occurrence of various biological mechanisms, such as cellular differentiation. However, the question of how cellular diversity evolves in relation to the inherent stochasticity and intercellular communication remains still to be understood. Here, we define a concept of stochastic bifurcations suitable to investigate the dynamical structure of genetic networks, and show that under stochastic influence, the expression of given proteins of interest is defined via the probability distribution of the phase variable, representing one of the genes constituting the system. Moreover, we show that under changing stochastic conditions, the probabilities of expressing certain concentration values are different, leading to different functionality of the cells, and thus to differentiation of the cells in the various types.
Y1  - 2011
U6  - https://doi.org/10.1371/journal.pone.0019696
SN  - 1932-6203
VL  - 6
IS  - 5
PB  - PLoS
CY  - San Fransisco
ER  -