TY  - JOUR
A1  - Schaper, Katrin
A1  - Dickhaut, Jeannette
A1  - Japtok, Lukasz
A1  - Kietzmann, Manfred
A1  - Mischke, Reinhard
A1  - Kleuser, Burkhard
A1  - Bäumer, Wolfgang
T1  - Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis
JF  - Journal of dermatological scienc
N2  - Background: It has been indicated that the sphingolipid sphingosine-1-phosphate (SIP) restrains the ability of dendritic cells to migrate to lymph nodes. Furthermore SIP has been demonstrated to inhibit cell growth in human keratinocytes. However, only little is known about the effect of S1P in hyperproliferative and inflammatory in vivo models.
 Objective: In this study, locally acting SIP was explored in different experimental mouse models of psoriasis vulgaris.
 Methods: S1P and FTY720 were tested in the imiquimod-induced psoriasis mouse model, the mouse tail assay and a pilot study of the severe combined immunodeficiency mice (SCID).
 Results: In the imiquimod model the positive control diflorasone diacetate and S1P, but not FTY720 reduced the imiquimod-induced epidermal hyperproliferation of the ear skin. This effect was confirmed in the SCID model, where S1P treated skin from patients suffering from psoriasis showed a decrease in epidermal thickness compared to vehicle. In the imiquimod model, there was also significant inhibition of ear swelling and a moderate reduction of inflammatory cell influx and oedema formation in ear skin by SIP treatment. The inflammatory response on the back skin was, however, only reduced by diflorasone diacetate. In the mouse tail assay, the influence of S1P and FTY720 in stratum granulosum formation was tested compared to the positive control calcipotriol. Whereas topical administration of calcipotriol led to a low but significant increase of stratum granulosum, S1P and FTY720 lacked such an effect.
 Conclusion: Taken together, these results imply that topical administration of SIP might be a new option for the treatment of mild to moderate psoriasis lesions.
KW  - Imiquimod
KW  - Psoriasis
KW  - SCID mice
KW  - Sphingosine-1-phosphate
Y1  - 2013
U6  - https://doi.org/10.1016/j.jdermsci.2013.03.006
SN  - 0923-1811
VL  - 71
IS  - 1
SP  - 29
EP  - 36
PB  - Elsevier
CY  - Clare
ER  -