TY - JOUR A1 - Haase, Tobias T1 - Rückfallvorsorge, Lebensqualität und Sprech(un)flüssigkeit BT - Die Bedeutung der Stotterer-Selbsthilfe als posttherapeutische Maßnahme JF - Spektrum Patholinguistik Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-469515 IS - 12 SP - 93 EP - 99 PB - Universitätsverlag Potsdam CY - Potsdam ER - TY - JOUR A1 - Haase, Tobias A1 - Krost, Annalena A1 - Sauter, Tilman A1 - Kratz, Karl A1 - Peter, Jan A1 - Kamann, Stefanie A1 - Jung, Friedrich A1 - Lendlein, Andreas A1 - Zohlnhöfer, Dietlind A1 - Rüder, Constantin T1 - In vivo biocompatibility assessment of poly (ether imide) electrospun scaffolds JF - Journal of Tissue Engineering and Regenerative Medicine N2 - Poly(ether imide) (PEI), which can be chemically functionalized with biologically active ligands, has emerged as a potential biomaterial for medical implants. Electrospun PEI scaffolds have shown advantageous properties, such as enhanced endothelial cell adherence, proliferation and low platelet adhesion in in vitro experiments. In this study, the in vivo behaviour of electrospun PEI scaffolds and PEI films was examined in a murine subcutaneous implantation model. Electrospun PEI scaffolds and films were surgically implanted subcutaneously in the dorsae of mice. The surrounding subcutaneous tissue response was examined via histopathological examination at 7 and 28days after implantation. No serious adverse events were observed for both types of PEI implants. The presence of macrophages or foreign body giant cells in the vicinity of the implants and the formation of a fibrous capsule indicated a normal foreign body reaction towards PEI films and scaffolds. Capsule thickness and inflammatory infiltration cells significantly decreased for PEI scaffolds during days 7-28 while remaining unchanged for PEI films. The infiltration of cells into the implant was observed for PEI scaffolds 7days after implantation and remained stable until 28days of implantation. Additionally some, but not all, PEI scaffold implants induced the formation of functional blood vessels in the vicinity of the implants. Conclusively, this study demonstrates the in vivo biocompatibility of PEI implants, with favourable properties of electrospun PEI scaffolds regarding tissue integration and wound healing. KW - poly(ether imide) KW - in vivo study KW - electrospun scaffold KW - capsule formation KW - foreign body giant cells KW - vascularization Y1 - 2017 U6 - https://doi.org/10.1002/term.2002 SN - 1932-6254 SN - 1932-7005 VL - 11 IS - 4 SP - 1034 EP - 1044 PB - Wiley CY - Hoboken ER - TY - JOUR A1 - Rüder, Constantin A1 - Sauter, Tilman A1 - Kratz, Karl A1 - Haase, Tobias A1 - Peter, Jan A1 - Jung, Friedrich A1 - Lendlein, Andreas A1 - Zohlnhöfer, Dietlind T1 - Influence of fibre diameter and orientation of electrospun copolyetheresterurethanes on smooth muscle and endothelial cell behaviour JF - Clinical hemorheology and microcirculation : blood flow and vessels N2 - Polymers exhibiting cell-selective effects represent an extensive research field with high relevance for biomedical applications e.g. in the cardiovascular field supporting re-endothelialization while suppressing smooth muscle cell overgrowth. Such an endothelial cell-selective effect could be recently demonstrated for a copolyetheresterurethane (PDC) containing biodegradable poly(p-dioxanone) and poly(epsilon-caprolactone) segments, which selectively enhanced the adhesion of human umbilical vein endothelial cells (HUVEC) while suppressing the attachment of smooth muscle cells (SMC). In this study we investigated the influence of the fibre orientation (random and aligned) and fibre diameter (2 mu m and 500 nm) of electrospun PDC scaffolds on the adhesion, proliferation and apoptosis of HUVEC and SMC. Adhesion, viability and proliferation of HUVEC was diminished when the fibre diameter was reduced to a submicron scale, while the orientation of the microfibres did only slightly influence the cellular behaviour. In contrast, a submicron fibre diameter improved SMC viability. In conclusion, PDC scaffolds with micron-sized single fibres could be promising candidate materials for cell-selective stent coatings. KW - Endothelialization KW - drug eluting stent KW - degradable polymer KW - electrospinning KW - cell selectivity Y1 - 2013 U6 - https://doi.org/10.3233/CH-131787 SN - 1386-0291 SN - 1875-8622 VL - 55 IS - 4 SP - 513 EP - 522 PB - IOS Press CY - Amsterdam ER - TY - JOUR A1 - Iven, Claudia A1 - Hansen, Bernd A1 - Anders, Kristina A1 - Starke, Andreas A1 - Richardt, Kirsten A1 - Prüß, Holger A1 - El Meskioui, Martina A1 - Haase, Tobias A1 - Mahlberg, Lea A1 - Wiehe, Lea A1 - de Beer, Carola A1 - Niepelt Karampamapa, Rebekka A1 - Hofmann, Andrea A1 - Stadie, Nicole A1 - Hanne, Sandra A1 - Thomson, Jenny A1 - Schäfer, Blanca A1 - Huttenlauch, Clara A1 - Wartenburger, Isabell A1 - Weiland, Katharina A1 - Wirsam, Anke A1 - Hartung, Julia A1 - Wahl, Michael A1 - Unger, Julia A1 - Buschmann, Anke A1 - Seefeld, Martin A1 - Bethge, Anita A1 - Fieder, Nora A1 - Rahman, Rasha Abdel A1 - Nousair, Iman A1 - Klassert, Annegret A1 - Wellmann, Caroline A1 - Verbree, Rahel A1 - van Rij, Jacolien A1 - Sprenger, Simone A1 - Mähl, Anna Luisa A1 - Schneider, Kathleen A1 - Kutz, Anne A1 - Kaps, Hella A1 - Frank, Ulrike A1 - Brekeller, Sophie A1 - Ryll, Katja ED - Breitenstein, Sarah ED - Burmester, Juliane ED - Yetim, Özlem ED - Fritzsche, Tom T1 - Spektrum Patholinguistik Band 12. Schwerpunktthema: Weg(e) mit dem Stottern: Therapie und Selbsthilfe für Kinder und Erwachsene T2 - Spektrum Patholinguistik N2 - Das 12. Herbsttreffen Patholinguistik mit dem Schwerpunktthema »Weg(e) mit dem Stottern: Therapie und Selbsthilfe für Kinder und Erwachsene« fand am 24.11.2018 in Potsdam statt. Das Herbsttreffen wird seit 2007 jährlich vom Verband für Patholinguistik e.V. (vpl) durchgeführt. Der vorliegende Tagungsband beinhaltet die Vorträge zum Schwerpunktthema sowie Beiträge der Posterpräsentationen zu weiteren Themen aus der sprachtherapeutischen Forschung und Praxis. N2 - The Twelfth Autumn Meeting Patholinguistics (Herbsttreffen Patholinguistik) with its main topic »Away/A way with stuttering: Therapy and self-help for children and adults« took place in Potsdam on November 24 2018. This annual meeting has been organised since 2007 by the Association for Patholinguistics (Verband für Patholinguistik e.V./vpl). The present proceedings contain all talks on the main topic as well as contributions from the poster session covering a broad range of areas in speech/language therapy research and practice. T3 - Spektrum Patholinguistik - 12 KW - Patholinguistik KW - Sprachtherapie KW - Stottern KW - Redeflussstörungen KW - Selbsthilfe KW - patholinguistics KW - speech/language therapy KW - stuttering KW - fluency disorder KW - self-help Y1 - 2020 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-437002 SN - 978-3-86956-479-1 SN - 1866-9085 SN - 1866-9433 IS - 12 PB - Universitätsverlag Potsdam CY - Potsdam ER -