TY - JOUR A1 - Wittig, Kirsten A1 - Esser, Günter T1 - Erstgespräche mit Kindern und Jugendlichen Y1 - 2010 SN - 978-3-456-84781-8 ER - TY - JOUR A1 - Holtmann, Martin A1 - Buchmann, Arlette F. A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - The child behavior checklist-dysregulation profile predicts substance use, suicidality, and functional impairment : a longitudinal analysis N2 - Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods: We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results: Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions: Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior. Y1 - 2011 ER - TY - JOUR A1 - Esser, Günter A1 - Dinter-Jörg, Monika A1 - Schmidt, Martin H. A1 - Herrle, Johannes A1 - Yantorno-Villalba, P. A1 - Rose, Frauke A1 - Laucht, Manfred T1 - Bedeutung der Blickvermeidung im Säuglingsalter für den Entwicklungsstand des Kindes mit zwei und viereinhalb Jahren Y1 - 1996 ER - TY - JOUR A1 - Esser, Günter T1 - Erscheinungsformen und Häufigkeiten von Teilleistungsstörungen Y1 - 1996 ER - TY - JOUR A1 - Lange, Sabine A1 - Esser, Günter T1 - Ausbildung zum Kinder- und Jugendlichenpsychotherapeuten Y1 - 2008 SN - 978-3-13-126083-3 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Frenzel, Tom A1 - Esser, Günter T1 - Entwicklungspsychopathologie und Entwicklungsepidemiologie Y1 - 2008 SN - 978-3-13-126083-3 ER - TY - JOUR A1 - Esser, Günter A1 - Ihle, Wolfgang T1 - Abhängigkeit von legalen und illegalen psychotropen Substanzen Y1 - 2008 ER - TY - JOUR A1 - Esser, Günter A1 - Lange, Sabine T1 - Verhaltensdiagnostik in der Verhaltenstherapie Y1 - 2006 SN - 978-3-932096-43-3 ER - TY - JOUR A1 - Esser, Günter A1 - Fischer, Sascha A1 - Wyschkon, Anne A1 - Laucht, Manfred A1 - Schmidt, Martin H. T1 - Vorboten hyperkinetischer Störungen : Früherkennung im Kleinkindalter N2 - Objectives: The prospective longitudinal Mannheim Study of Children at Risk followed the development of children from the age of 2 years up to the age of 8 years. Are there differences between the developmental risk load in toddlers (psychopathology, cognition, motor or neurological development. and educational differences) who suffer from a hyperactive disorder at age 8 and that of undisturbed children of the same age? Are there specific harbingers of hyperkinetic disorders for the group concerned? Methods: In terms of their developmental risk load at the age of 2 years, 26 primary school children with hyperkinetic disorders were compared to 241 healthy primary school children, as well as to 25 children of the same age with emotional disturbances and 30 children of the same age with socially disruptive behavior. Results: A significant combination of predictors of later hyperkinetic disorders at primary school age proved to be increased fidgetiness and irritability, as well as a reduced language comprehension, at the age of two. Conclusions: The predictive value of symptoms in early childhood for later hyperkinetic disorder in children of primaryschool age is higher than that of symptoms assessed in infancy, which although expected is without relevant specificity. Y1 - 2007 UR - http://psycontent.metapress.com/content/1422-4917 U6 - https://doi.org/10.1024/1422-4917.35.2.127 SN - 1422-4917 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Lehmann, K. A1 - Esser, Günter T1 - Frühes Einstiegsalter und problematischer Gebrauch von legalen und illegalen Substanzen im Jugendalter : Ergebnisse einer Studie in Sachsen-Anhalt Y1 - 2007 SN - 978-3-939069-37-9 ER - TY - JOUR A1 - Laucht, Michael A1 - Schmidt, Martin H. A1 - Esser, Günter T1 - Problems of behavioral and emotional regulation in early infancy : precursors of psychiatric disorders in later childhood? Y1 - 2007 SN - 978-1-934019-17-7 ER - TY - JOUR A1 - Hohm, E. A1 - Blomeyer, Dorothea A1 - Esser, Günter A1 - Laucht, Manfred T1 - Jugendliche, die frühzeitig rauchen und trinken - eine Risikogruppe? Y1 - 2008 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter T1 - Psychische Störungen bei Kindern und Jugendlichen : Häufigkeit, Versorgungslage und Prävention Y1 - 2007 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter T1 - Psychische Störungen im Kindes- und Jugendalter : Gesundheitliche Lage, gesundheitliche Versorgung und Empfehlungen für die Politik Y1 - 2007 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter T1 - Tagesbetreuung für Kinder bis 3 Jahre aus psychologischer Sicht Y1 - 2007 SN - 1436-9559 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter A1 - Laucht, Manfred A1 - Schmidt, Martin H. T1 - Geschlechtsunterschiede in der Entwicklung psychischer Störungen Y1 - 2007 SN - 978-3-540-71627-3 ER - TY - JOUR A1 - Esser, Günter A1 - Fischer, Sascha A1 - Wyschkon, Anne A1 - Laucht, Manfred A1 - Schmidt, Martin H. T1 - Vorboten hyperkinetischer Störungen : Früherkennung bereits im Säuglingsalter möglich? N2 - Objectives: Are there any differences (organic, psychosocial, psychopathological, cognitive or educational, respectively differences in the motor or neurological development) between infants who later on at the age of 8 years suffer from a hyperactive disorder and those who later on at the same age are undisturbed? Are there specific harbingers for hyperactive disorders in the group concerned? Methods: With regard to their developmental risk load at the age of 3 months, 26 primary school children with hyperactive disorders were compared with 241 healthy children, 25 children with emotional disturbances, and 30 children with socially disruptive behaviour, all of the same age. Results: Identified as the most important predictors for the onset of hyperactive disorders were a reduced birth weight, the mother's origin from a shattered family, early contact impairments on the part of the child, and the mother's neglect of the infant. Conclusions: Altogether, however, the prediction of later hyperactivity in primary school children on the basis of salient features in the infant children remains unsatisfactory and unspecific. Y1 - 2007 UR - http://psycontent.metapress.com/content/1422-4917 U6 - https://doi.org/10.1024/1422-4917.35.3.179 SN - 1422-4917 ER - TY - JOUR A1 - Becker, Katja A1 - El-Faddagh, Mahha A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Laucht, Manfred T1 - Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms N2 - Objective To demonstrate that children homozygous for the 10-repeat allele of the common dopamine transporter (DAT1) polymorphism who were exposed to maternal prenatal smoke exhibited significantly higher hyperactivity-impulsivity than children without these environmental or genetic risks. Study design We performed a prospective longitudinal study from birth into early adulthood monitoring the long-term outcome of early risk factors. Maternal prenatal smoking was determined during a standardized interview with the mother when the child was 3 months old. At age 15 years, 305 adolescents participated in genotyping for the DAT1 40 base pair variable number of tandem repeats polymorphism and assessment of inattention, hyperactivity-impulsivity, and oppositional defiant/conduct disorder symptoms with die Kiddie- Sads-Present and Lifetime Version. Results There was no bivariate association between DAT1 genotype, prenatal smoke exposure and symptoms of attention deficit hyperactivity disorder. However, a significant interaction between DAT1 genotype and prenatal smoke exposure emerged (P =.012), indicating that males with prenatal smoke exposure who were homozygous for the DAT1 10r allele had higher hyperactivity-impulsivity than males from all other groups. In females, no significant main effects of DAT1 genotype or prenatal smoke exposure or interaction effects on any symptoms were evident (all P >.25). Conclusions This study provides further evidence for the multifactorial nature of attention deficit hyperactivity disorder and the importance of studying both genetic and environmental factors and their interaction. Y1 - 2008 SN - 0022-3476 ER - TY - JOUR A1 - Esser, Günter A1 - Mattejat, Fritz T1 - Evidenzbasierte Prävention und Therapie psychischer Störungen des Kindes- und Jugendalters Y1 - 2008 SN - 978-3-940793-34-8 ER - TY - JOUR A1 - Hohmann, Sarah A1 - Becker, Katja A1 - Fellinger, Johannes A1 - Banaschewski, Tobias A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Laucht, Manfred T1 - Evidence for epistasis between the 5-HTTLPR and the dopamine D4 receptor polymorphisms in externalizing behavior among 15-year-olds N2 - The present study aimed to clarify the functional role of genes in the dopamine and serotonin systems by examining whether polymorphisms in these genes are related to adolescent externalizing behavior either alone or in interaction with each other. Participants were selected from an ongoing prospective study of the outcome of early risk factors. At age 15 years, 298 adolescents (144 males, 154 females) completed the Youth Self Report, 296 primary caregivers the Child Behavior Checklist and 253 teachers the Teacher Report Form. DNA was genotyped for the DRD4 exon III VNTR and the 5-HTTLPR polymorphisms. Results revealed that individuals with the DRD4 7r allele reported significantly more externalizing behavior than carriers of other variants. In addition, a significant interaction emerged, indicating that adolescents carrying two copies of the 5-HTTLPR short allele and the DRD4 7r variant scored highest on aggressive and/or delinquent behavior compared to other genotypes. This result suggests an effect of 5-HTTLPR on externalizing behavior in the presence of DRD4 7r but no effect in its absence. Y1 - 2009 UR - http://www.springerlink.com/content/101493 U6 - https://doi.org/10.1007/s00702-009-0290-1 SN - 0300-9564 ER - TY - JOUR A1 - Schmid, Brigitte A1 - Hohm, Erika A1 - Blomeyer, Dorothea A1 - Zimmermann, Ulrich S. A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Laucht, Manfred T1 - Concurrent alcohol and tobacco use during early adolescence characterizes a group at risk N2 - Aims: To investigate whether concurrent alcohol and tobacco use during early adolescence characterizes a subgroup that differs from users of one substance only regarding several risk factors for later substance use problems. Methods: Participants were from a prospective longitudinal cohort study of 384 children at risk for later psychopathology, with the majority being born with obstetric complications and psychosocial adversities. Assessments of adolescent drug consumption and related intrapersonal characteristics were obtained at age 15. Results: Compared to consumers of alcohol only, 15-year-olds drinking and smoking during the same time period (past 4 weeks) had significantly higher levels of consumption and more excessive use of alcohol, started drinking at an earlier age, had higher scores on the Fagerstrom Test for Nicotine Dependence, and more cannabis use. This group could be distinguished from users of alcohol only by higher novelty seeking and more positive alcohol effect expectancies. Compared to consumers of tobacco only, concurrent users reported higher nicotine dependence and more cannabis use. No significant differences were observed regarding frequency and age at initiation of tobacco use, tobacco-related sensitivity, self- efficacy and instrumentality as well as novelty seeking. Conclusions: Concurrent alcohol and tobacco use during early adolescence is associated with characteristics that are well known as risk factors for later alcohol use problems and dependence and that should be targeted by prevention programs. Y1 - 2007 UR - http://alcalc.oxfordjournals.org/ U6 - https://doi.org/10.1093/alcalc/agm024 SN - 0735-0414 ER - TY - JOUR A1 - Dinter-Jörg, Monika A1 - Polowczyk, M. A1 - Herrle, Johannes A1 - Esser, Günter A1 - Laucht, Manfred T1 - Mannheimer Beurteilungsskalen zur Analyse der Mutter-Kind-Interaktion im Kleinkindalter Y1 - 1997 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Genese und Verlauf von emotionalen Störungen von der KIndheit bis ins Erwachsenenalter Y1 - 1997 ER - TY - JOUR A1 - Laucht, Manfred A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Wovor schützen Schutzfaktoren? : Anmerkungen zu einem populären Konzept der modernen Gesundheitsforschung Y1 - 1997 ER - TY - JOUR A1 - Laucht, Manfred A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Developmental outcome of infants born with biological and psychosocial risks Y1 - 1997 ER - TY - JOUR A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Laucht, Manfred T1 - Die Entwicklung nach biologischen und psychsozialen Risiken in der frühen Kindheit Y1 - 1997 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Lebensereignisse : Ursache oder Folge von psychischen Störungen. Y1 - 1997 ER - TY - JOUR A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Psychische Probleme des Jugendalters : Ergebnisse einer prospektiven epidemiologischer Längsschnittsstudie von 8-18 Jahren Y1 - 1997 ER - TY - JOUR A1 - Esser, Günter T1 - Teilleistungsstörungen Y1 - 1997 ER - TY - JOUR A1 - Esser, Günter A1 - Wyschkon, Anne T1 - Diagnostik bei Kindern und Jugendlichen Y1 - 2004 SN - 978-3-932096-43-3 ER - TY - JOUR A1 - Esser, Günter A1 - Wyschkon, Anne A1 - Schmidt, Martin H. A1 - Blanz, Bernhard A1 - Ihle, Wolfgang T1 - Ein Entwicklungsmodell des Substanzmissbrauchs im frühen Erwachsenenalter Y1 - 2008 UR - http://psycontent.metapress.com/content/0942-5403 U6 - https://doi.org/10.1026/0942-5403.17.1.31 SN - 0942-5403 ER - TY - JOUR A1 - Kohn, Juliane A1 - Esser, Günter T1 - ADHS im Jugend- und Erwachsenenalter Y1 - 2008 UR - http://www.springerlink.com/content/100478/ U6 - https://doi.org/10.1007/s00112-008-1731-x SN - 0026-9298 ER - TY - JOUR A1 - Göggerle, Stephanie A1 - Esser, Günter T1 - Entspannungsverfahren Y1 - 2008 SN - 978-3-13-126083-3 ER - TY - JOUR A1 - Hom, Erika A1 - Blomeyer, Dorothea A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Laucht, Manfred T1 - Jugendliche die frühzeitig rauchen und trinken : eine Risikogruppe? N2 - Epidemiological studies have reported elevated rates of legal drug consumption among adolescents in Germany. The aim of this study was to ascertain patterns and parameters of smoking and drinking in early-users as well as to examine possible determinants of risky patterns of use. Participants were from a longitudinal study of a birth cohort of 384 children at risk. Assessments of adolescent drug consumption as well as of individual and social determinants were obtained at age 15. Adolescents drinking and smoking during the same period (past four weeks) were characterized by more excessive and impulsive consumption and by higher rates of cannabis use. No specific determinants of concurrent use could be found. These findings suggest that adolescents displaying early concurrent tobacco and alcohol use may be at higher risk for substance use problems and should be targeted by prevention programs. Y1 - 2007 UR - http://psycontent.metapress.com/content/1661-4747 U6 - https://doi.org/10.1024/1661-4747.55.3.155 SN - 1661-4747 ER - TY - JOUR A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Ihle, Wolfgang A1 - Lay, Barbara T1 - Die Bedeutung psychischer und familiärer Faktoren für die Delinquenzentwicklung bis ins Erwachsenenalter N2 - Es werden Befunde aus einer prospektiven Laengsschnittstudie praesentiert, in der 321 Probanden im Alter von 8, 13, 18 und 25 Jahren untersucht werden konnten; ihre Dunkelfelddelinquenz wurde mit 18 und 25 Jahren erfasst. Wir suchten nach Assoziationen zur Delinquenzentwicklung und erwarteten Unterschiede zwischen auf das Jugendalter beschraenkter gegenueber ins fruehe Erwachsenenalter fortgesetzter sowie spaet, d.h. nach dem Alter von 18 Jahren, beginnender Delinquenz. Wir fanden gemeinsame Risikofaktoren und fuer die drei Verlaufstypen spezifische Risikokonstellationen, die eher im Jugendalter als in der Kindheit identifiziert wurden. Widrige familiaere Bedingungen, Entwicklungsverzoegerungen und psychische Stoerungen scheinen mit Delinquenz als eher persistentem Verhalten assoziiert. Y1 - 2009 SN - 0026-9301 ER - TY - JOUR A1 - Pitzer, Martina A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Laucht, Manfred T1 - Temperamental predictors of externalizing problems among boys and girls : a longitudinal study in a high-risk sample from ages 3 months to 15 years N2 - In a high-risk community sample, we examined the role of regulative temperament and emotionality as well as the extent of gender specificity in the development of externalizing problems. 151 boys and 157 girls born at differing degrees of obstetric and psychosocial risk were followed from birth into adolescence. In infancy and childhood, NYLS- derived temperamental characteristics were assessed by a highly structured parent interview and standardized behavioral observations. At age 15 years, externalizing problems were measured by the Child Behavior Checklist. As revealed by multiple linear regression and logistic regression, low regulative abilities predicted adolescent behavioral and attentional problems over and above obstetric and psychosocial risks. Gender specificity was found in the strength of the association rather than in the kind with a stronger long-term prediction from infant and toddler temperament in girls. Compared to regulative abilities, temperament factors describing aspects of mood and fear/withdrawal versus approach tendencies played a minor role in the development of externalizing problems. Findings are discussed in terms of gender-specific risk factors and possible differential developmental trajectories to subtypes of disruptive behavior. Y1 - 2009 UR - http://www.springerlink.com/content/101492 U6 - https://doi.org/10.1007/s00406-009-0009-1 SN - 0940-1334 ER - TY - JOUR A1 - Schmid, Brigitte A1 - Blomeyer, Dorothea A1 - Becker, Katja A1 - Treutlein, Jens A1 - Zimmermann, Ulrich S. A1 - Buchmann, Arlette F. A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Rietschel, Marcella A1 - Laucht, Manfred T1 - The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds N2 - Recent evidence suggests that heterogeneity in the age at onset could explain the inconsistent findings of association studies relating the dopamine transporter (DAT1) gene with alcohol and nicotine consumption. The aim of this study was to examine interactions between two DAT1 polymorphisms and different initiation ages with regard to alcohol and tobacco consumption levels and dependence. Two hundred and ninety-one young adults (135 males, 156 females) participating in the Mannheim Study of Children at Risk were genotyped for the 40-bp variable number of tandem repeats (VNTR) and rs27072 polymorphisms of DAT1. Age at initiation was assessed at age 15 and 19 years. Information about current alcohol and tobacco consumption was obtained at age 19 years using self-report measures and structured interviews. Results suggest that age at onset of intensive consumption moderated the association of the DAT1 gene with early adult substance use and dependence, revealing a DAT1 effect only among individuals homozygous for the 10r allele of the 40-bp VNTR who had started daily smoking or being intoxicated early in life. Equally, carriers of the T allele of the rs27072 polymorphism reporting an early age at first intoxication showed higher current alcohol consumption at age 19 years. In contrast, no interaction between rs27072 and the age at first cigarette with regard to later smoking was observed. These findings provide evidence that the DAT1 gene interacts with an early heavy or regular drug exposure of the maturing adolescent brain to predict substance (ab)use in young adulthood. Further studies are required to confirm these findings. Y1 - 2009 UR - http://www3.interscience.wiley.com/cgi-bin/issn?DESCRIPTOR=PRINTISSN&VALUE=1355-6215 U6 - https://doi.org/10.1111/j.1369-1600.2009.00171.x SN - 1355-6215 ER - TY - JOUR A1 - Buchmann, Arlette F. A1 - Blomeyer, Dorothea A1 - Jennen-Steinmetz, Christine A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Early smoking onset may promise initial pleasurable sensations and later addiction JF - Addiction biology N2 - There is converging evidence suggesting a particular susceptibility to the addictive properties of nicotine among adolescents. The aim of the current study was to prospectively ascertain the relationship between age at first cigarette and initial smoking experiences, and to examine the combined effects of these characteristics of adolescent smoking behavior on adult smoking. It was hypothesized that the association between earlier age at first cigarette and later development of nicotine dependence may, at least in part, be attributable to differences in experiencing pleasurable early smoking sensations. Data were drawn from the participants of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study from birth to adulthood. Structured interviews at age 15, 19 and 22 years were conducted to assess the age at first cigarette, early smoking experiences and current smoking behavior in 213 young adults. In addition, the participants completed the Fagerstrom Test for Nicotine Dependence. Adolescents who smoked their first cigarette at an earlier age reported more pleasurable sensations from the cigarette, and they were more likely to be regular smokers at age 22. The age at first cigarette also predicted the number of cigarettes smoked and dependence at age 22. Thus, both the age of first cigarette and the pleasure experienced from the cigarette independently predicted aspects of smoking at age 22. KW - Adolescence KW - age at first cigarette KW - dependence KW - early smoking experiences KW - longitudinal study KW - pleasurable smoking sensations Y1 - 2013 U6 - https://doi.org/10.1111/j.1369-1600.2011.00377.x SN - 1369-1600 VL - 18 IS - 6 SP - 947 EP - 954 PB - Wiley-Blackwell CY - Hoboken ER - TY - JOUR A1 - Fätkenheuer, Brigitte A1 - Esser, Günter T1 - Generationstransfer seelischer Gesundheit in Rostock und Mannheim Y1 - 1996 ER - TY - JOUR A1 - Laucht, Manfred A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Stöhr, R.-M. A1 - Weindrich, D. A1 - Ihle, Wolfgang A1 - Marcus, A. T1 - Viereinhalb Jahre danach : Mannheimer Risikokinder im Vorschulalter Y1 - 1996 ER - TY - JOUR A1 - Ihle, Wolfgang A1 - Esser, Günter A1 - Blanz, Bernhard T1 - Dichte und Struktur von Lebensereignissen in Mannheim und Rostock in der Nachwendezeit 1989 - 1995 Y1 - 1996 ER - TY - JOUR A1 - Esser, Günter A1 - Schmidt, Martin H. T1 - Prevalence, course and risk factors for mental disorders Y1 - 1996 ER - TY - JOUR A1 - Esser, Günter A1 - Laucht, Manfred A1 - Schmidt, Martin H. T1 - The Significance of Biological and Psychosocial Risks for Behaviour Problems of Children at Preschool age Y1 - 1996 ER - TY - JOUR A1 - Herrle, Johannes A1 - Laucht, Manfred A1 - Esser, Günter T1 - Interaktionsverhalten psychisch auffälliger Mütter und ihrer Kinder : typische Muster im Kleinkindalter und Bedeutung für die kindliche Entwicklung Y1 - 1996 ER - TY - JOUR A1 - Wyschkon, Anne A1 - Esser, Günter T1 - Enuresis N2 - Die meisten Kinder werden mit 2 bis 4 Jahren am Tage und in der Nacht trocken. Gemäß den klinisch- diagnostischen Leitlinien der ICD-10 (WHO 1993) spricht man von einer Enuresis, wenn es am Tag oder in der Nacht zu einem Entleeren der Blase in die Kleidung bzw. das Bett kommt, die relativ zum geistigen Entwicklungsstand der Person abnorm ist und nicht auf organische Ursachen zurückgeführt werden kann. Die Störungen der Blasenkontrolle dürfen nicht als Folge einer neurologischen Erkrankung, epileptischer Anfälle oder einer strukturellen Anomalie der ableitenden Harnwege auftreten. Gemäß den Forschungskriterien der ICD-10 (WHO 1994) muss das einnässende Kind nach seinem Lebens- und geistigen Alter mindestens 5 Jahre alt sein, um von einer nichtorganischen Enuresis (F 98.0) zu sprechen (in den klinisch-diagnostischen Leitlinien wird ein geistiger Entwicklungsstand gefordert, der mindestens dem eines Vierjährigen entspricht). Um die Diagnose zu erhalten, müssen Kinder unter 7 Jahren zumindest 2mal monatlich, 7-jährige oder ältere Kinder wenigstens einmal im Monat einnässen. Die Symptomdauer sollte mindestens 3 Monate betragen. In der Literatur wird synonym zum Begriff der "nichtorganischen Enuresis" häufig die Bezeichnung "funktionelle Enuresis" verwendet. Auch nach dem DSM-IV (Saß et al. 1996) sollten die Kinder für die Diagnose einer Enuresis (307.6) zumindest ein Entwicklungsalter von 5 Jahren aufweisen und die Symptomatik muss wenigstens seit 3 Monaten bestehen. Im Unterschied zur ICD-10 wird das Einnässen erst dann als klinisch bedeutsam beurteilt, wenn es mindestens 2mal wöchentlich auftritt. Ist dies nicht gegeben, kann die Diagnose dennoch gestellt werden, wenn durch das Einnässen klinisch bedeutsames Leiden hervorgerufen wird oder Beeintraechtigungen in sozialen, schulischen (beruflichen) oder anderen wichtigen Funktionsbereichen entstehen. Die Forderung eines 2mal wöchentlichen Einnässens erscheint deutlich zu streng, während das ein- bzw. 2malige Einnässen pro Monat ein sehr weiches Kriterium darstellt. V. Gontard (1998b) empfiehlt, Einnässen dann als klinisch bedeutsam einzuschätzen, wenn dies mindestens einmal wöchentlich auftritt. Y1 - 2008 SN - 978-3-13-126083-3 ER - TY - JOUR A1 - Buchmann, Arlette F. A1 - Kopf, Daniel A1 - Westphal, Sabine A1 - Lederbogen, Florian A1 - Banaschewski, Tobias A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Zimmermann, Ulrich S. A1 - Laucht, Manfred A1 - Deuschle, Michael T1 - Impact of early parental child-rearing behavior on young adults' cardiometabolic risk profile : a prospective study N2 - Objective: To examine prospectively whether early parental child-rearing behavior is a predictor of cardiometabolic outcome in young adulthood when other potential risk factors are controlled. Metabolic factors associated with increased risk for cardiovascular disease have been found to vary, depending on lifestyle as well as genetic predisposition. Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile. Methods: Participants were drawn from a prospective, epidemiological, cohort study followed up from birth into young adulthood. Parent interviews and behavioral observations at the age of 3 months were conducted to assess child-rearing practices and mother-infant interaction in the home setting and in the laboratory. In 279 participants, anthropometric characteristics, low-density lipoprotein and high-density lipoprotein cholesterol, apolipoproteins, and triglycerides were recorded at age 19 years. In addition, structured interviews were administered to the young adults to assess indicators of current lifestyle and education. Results: Adverse early-life interaction experiences were significantly associated with lower levels of high- density lipoprotein cholesterol and apolipoprotein A1 in young adulthood. Current lifestyle variables and level of education did not account for this effect, although habitual smoking and alcohol consumption also contributed significantly to cardiometabolic outcomes. Conclusions: These findings suggest that early parental child-rearing behavior may predict health outcome in later life through its impact on metabolic parameters in adulthood. Y1 - 2010 UR - http://www.psychosomaticmedicine.org/ U6 - https://doi.org/10.1097/Psy.0b013e3181c88343 SN - 0033-3174 ER - TY - JOUR A1 - Buchmann, Arlette F. A1 - Schmid, Brigitte A1 - Blomeyer, Dorothea A1 - Zimmermann, Ulrich S. A1 - Jennen-Steinmetz, Christine A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Mann, Karl F. A1 - Laucht, Manfred T1 - Drinking against unpleasant emotions : possible outcome of early onset of alcohol use? N2 - Background: Recent animal and human studies indicate that the exposure to alcohol during early adolescence increases the risk for heavy alcohol use in response to stress. The purpose of this study was to examine whether this effect may be the consequence of a higher susceptibility to develop "drinking to cope" motives among early initiators. Methods: Data from 320 participants were collected as part of the Mannheim Study of Children at Risk, an ongoing epidemiological cohort study. Structured interviews at age 15 and 19 were used to assess age at first alcohol experience and drunkenness. The young adults completed questionnaires to obtain information about the occurrence of stressful life events during the past 4 years and current drinking habits. In addition, alcohol use under conditions of negative states was assessed with the Inventory of Drinking Situations. Results: The probability of young adults' alcohol use in situations characterized by unpleasant emotions was significantly increased the earlier they had initiated the use of alcohol, even when controlling for current drinking habits and stressful life events. Similar results were obtained for the age at first drunkenness. Conclusions: The findings strengthen the hypothesis that alcohol experiences during early adolescence facilitate drinking to regulate negative affect as an adverse coping strategy which may represent the starting point of a vicious circle comprising drinking to relieve stress and increased stress as a consequence of drinking. Y1 - 2010 UR - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1530-0277 U6 - https://doi.org/10.1111/j.1530-0277.2010.01180.x SN - 0145-6008 ER - TY - JOUR A1 - Becker, Katja A1 - Blomeyer, Dorothea A1 - El-Faddagh, Mahha A1 - Esser, Günter A1 - Schmidt, Martin H. A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - From regulatory problems in infancy to attention-deficit/hyperactivity disorder in childhood : a moderating role for the dopamine D4 receptor gene? N2 - To examine whether the dopamine receptor D4 gene (DRD4) exon III VNTR moderates the risk of infants with regulatory disorders for developing attention-deficit/hyperactivity disorder (ADHD) later in childhood. In a prospective longitudinal study of children at risk for later psychopathology, 300 participants were assessed for regulatory problems in infancy, DRD4 genotype, and ADHD symptoms and diagnoses from childhood to adolescence. To examine a potential moderating effect on ADHD measures, linear and logistic regressions were computed. Models were fit for the main effects of the DRD4 genotype (presence or absence of the 7r allele) and regulatory problems (presence or absence), with the addition of the interaction term. All models were controlled for sex, family adversity, and obstetric risk status. In children without the DRD4-7r allele, a history of regulatory problems in infancy was unrelated to later ADHD. But in children with regulatory problems in infancy, the additional presence of the DRD4-7r allele increased the risk for ADHD in childhood. The DRD4 genotype seems to moderate the association between regulatory problems in infancy and later ADHD. A replication study is needed before further conclusions can be drawn, however. Y1 - 2010 UR - http://www.sciencedirect.com/science/journal/00223476 U6 - https://doi.org/10.1016/j.jpeds.2009.12.005 SN - 0022-3476 ER - TY - JOUR A1 - Schmid, Brigitte A1 - Buchmann, Arlette F. A1 - Trautmann-Villalba, Patricia A1 - Blomeyer, Dorothea A1 - Zimmermann, Ulrich S. A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Laucht, Manfred T1 - Maternal stimulation in infancy predicts hypothalamic-pituitary-adrenal axis reactivity in young men JF - Journal of neural transmission N2 - Evidence from animal research has demonstrated the effect of early maternal care on the offspring's endocrine and behavioral stress response in adulthood. The present prospective study investigates, in humans, the long-term impact of maternal responsiveness and stimulation during early mother-child interaction on adrenocorticotropic hormone (ACTH) and cortisol response to a psychosocial laboratory stressor in adulthood. The data are from an epidemiological cohort study of the long-term outcome of early risk factors assessed at birth. At age 3 months, mothers and infants were videotaped during a 10-min standardized nursing and playing situation and evaluated by trained raters for maternal stimulation and infant and maternal responsiveness. At age 19 years, 270 participants (146 females, 124 males) completed the Trier Social Stress Test. The results indicated that less maternal stimulation during early interaction at age 3 months predicted diminished plasma ACTH and cortisol increase in response to acute psychosocial stress in male, but not female offspring. In contrast, maternal responsiveness was found to be unrelated to hypothalamic-pituitary-adrenal (HPA) reactivity. In accordance with the findings from animal research, the present study provides prospective evidence in humans of a long-term association between early maternal interaction behavior and the offspring's hormonal stress response in young adulthood, suggesting that poor maternal stimulation in early infancy may result in reduced HPA axis reactivity to an acute psychosocial stressor in males. KW - ACTH KW - Cortisol KW - HPA axis KW - Mother-infant interaction Y1 - 2013 U6 - https://doi.org/10.1007/s00702-013-0970-8 SN - 0300-9564 VL - 120 IS - 8 SP - 1247 EP - 1257 PB - Springer CY - Wien ER - TY - JOUR A1 - Buchmann, Arlette F. A1 - Hellweg, Rainer A1 - Rietschel, Marcella A1 - Treutlein, Jens A1 - Witt, Stephanie H. A1 - Zimmermann, Ulrich S. A1 - Schmidt, Martin H. A1 - Esser, Günter A1 - Banaschewski, Tobias A1 - Laucht, Manfred A1 - Deuschle, Michael T1 - BDNF Val 66 Met and 5-HTTLPR genotype moderate the impact of early psychosocial adversity on plasma brain-derived neurotrophic factor and depressive symptoms - a prospective study JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology N2 - Recent studies have emphasized an important role for neurotrophins, such as brain-derived neurotrophic factor (BDNF), in regulating the plasticity of neural circuits involved in the pathophysiology of stress-related diseases. The aim of the present study was to examine the interplay of the BDNF Val(66)Met and the serotonin transporter promoter (5-HTTLPR) polymorphisms in moderating the impact of early-life adversity on BDNF plasma concentration and depressive symptoms. Participants were taken from an epidemiological cohort study following the long-term outcome of early risk factors from birth into young adulthood. In 259 individuals (119 males, 140 females), genotyped for the BDNF Val(66)Met and the 5-HTTLPR polymorphisms, plasma BDNF was assessed at the age of 19 years. In addition, participants completed the Beck Depression Inventory (BDI). Early adversity was determined according to a family adversity index assessed at 3 months of age. Results indicated that individuals homozygous for both the BDNF Val and the 5-HTTLPR L allele showed significantly reduced BDNF levels following exposure to high adversity. In contrast, BDNF levels appeared to be unaffected by early psychosocial adversity in carriers of the BDNF Met or the 5-HTTLPR S allele. While the former group appeared to be most susceptible to depressive symptoms, the impact of early adversity was less pronounced in the latter group. This is the first preliminary evidence indicating that early-life adverse experiences may have lasting sequelae for plasma BDNF levels in humans, highlighting that the susceptibility to this effect is moderated by BDNF Val(66)Met and 5-HTTLPR genotype. KW - BDNF KW - 5-HTTLPR KW - Human KW - Early psychosocial adversity KW - Longitudinal study KW - Depression Y1 - 2013 U6 - https://doi.org/10.1016/j.euroneuro.2012.09.003 SN - 0924-977X VL - 23 IS - 8 SP - 902 EP - 909 PB - Elsevier CY - Amsterdam ER -