TY  - JOUR
A1  - Derese, Solomon
A1  - Barasa, Leonard
A1  - Akala, Hoseah M.
A1  - Yusuf, Amir O.
A1  - Kamau, Edwin
A1  - Heydenreich, Matthias
A1  - Yenesew, Abiy
T1  - 4 '-Prenyloxyderrone from the stem bark of Millettia oblata ssp  teitensis and the antiplasmodial activities of isoflavones from some Millettia species
JF  - Phytochemistry letters
N2  - The CH2Cl2/MeOH (1: 1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC50 = 10-12 mu g/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new isoflavone, 4'-prenyloxyderrone (1), together with known isoflavones (8-O-methylretusin, durmillone, maximaisoflavone B, maximaisoflavone H and maximaisoflavone J), a rotenoid (tephrosin) and a triterpene (lupeol). Similar investigation of Millettia leucantha resulted in the identification of the isoflavones afrormosin and wistin, and the flavone chrysin. The identification of these compounds was based on their spectroscopic data. Five of the isoflavones isolated from these plants as well as 11 previously reported compounds from Millettia dura were tested and showed good to moderate antiplasmodial activities (IC50 = 13-53 mu M), with the new compound, 4'-prenyloxyderrone, being the most active (IC50 = 13-15 mu M).
KW  - Millettia oblata ssp teitensis
KW  - Millettia leucantha
KW  - Millettia dura;
Y1  - 2014
U6  - https://doi.org/10.1016/j.phytol.2014.02.001
SN  - 1874-3900
SN  - 1876-7486
VL  - 8
SP  - 69
EP  - 72
PB  - Elsevier
CY  - Amsterdam
ER  -