TY - JOUR
A1 - van der Valk, Ralf J. P.
A1 - Kreiner-Moller, Eskil
A1 - Kooijman, Marjolein N.
A1 - Guxens, Monica
A1 - Stergiakouli, Evangelia
A1 - Saaf, Annika
A1 - Bradfield, Jonathan P.
A1 - Geller, Frank
A1 - Hayes, M. Geoffrey
A1 - Cousminer, Diana L.
A1 - Koerner, Antje
A1 - Thiering, Elisabeth
A1 - Curtin, John A.
A1 - Myhre, Ronny
A1 - Huikari, Ville
A1 - Joro, Raimo
A1 - Kerkhof, Marjan
A1 - Warrington, Nicole M.
A1 - Pitkanen, Niina
A1 - Ntalla, Ioanna
A1 - Horikoshi, Momoko
A1 - Veijola, Riitta
A1 - Freathy, Rachel M.
A1 - Teo, Yik-Ying
A1 - Barton, Sheila J.
A1 - Evans, David M.
A1 - Kemp, John P.
A1 - St Pourcain, Beate
A1 - Ring, Susan M.
A1 - Smith, George Davey
A1 - Bergstrom, Anna
A1 - Kull, Inger
A1 - Hakonarson, Hakon
A1 - Mentch, Frank D.
A1 - Bisgaard, Hans
A1 - Chawes, Bo
A1 - Stokholm, Jakob
A1 - Waage, Johannes
A1 - Eriksen, Patrick
A1 - Sevelsted, Astrid
A1 - Melbye, Mads
A1 - van Duijn, Cornelia M.
A1 - Medina-Gomez, Carolina
A1 - Hofman, Albert
A1 - de Jongste, Johan C.
A1 - Taal, H. Rob
A1 - Uitterlinden, Andre G.
A1 - Armstrong, Loren L.
A1 - Eriksson, Johan
A1 - Palotie, Aarno
A1 - Bustamante, Mariona
A1 - Estivill, Xavier
A1 - Gonzalez, Juan R.
A1 - Llop, Sabrina
A1 - Kiess, Wieland
A1 - Mahajan, Anubha
A1 - Flexeder, Claudia
A1 - Tiesler, Carla M. T.
A1 - Murray, Clare S.
A1 - Simpson, Angela
A1 - Magnus, Per
A1 - Sengpiel, Verena
A1 - Hartikainen, Anna-Liisa
A1 - Keinanen-Kiukaanniemi, Sirkka
A1 - Lewin, Alexandra
A1 - Alves, Alexessander Da Silva Couto
A1 - Blakemore, Alexandra I.
A1 - Buxton, Jessica L.
A1 - Kaakinen, Marika
A1 - Rodriguez, Alina
A1 - Sebert, Sylvain
A1 - Vaarasmaki, Marja
A1 - Lakka, Timo
A1 - Lindi, Virpi
A1 - Gehring, Ulrike
A1 - Postma, Dirkje S.
A1 - Ang, Wei
A1 - Newnham, John P.
A1 - Lyytikainen, Leo-Pekka
A1 - Pahkala, Katja
A1 - Raitakari, Olli T.
A1 - Panoutsopoulou, Kalliope
A1 - Zeggini, Eleftheria
A1 - Boomsma, Dorret I.
A1 - Groen-Blokhuis, Maria
A1 - Ilonen, Jorma
A1 - Franke, Lude
A1 - Hirschhorn, Joel N.
A1 - Pers, Tune H.
A1 - Liang, Liming
A1 - Huang, Jinyan
A1 - Hocher, Berthold
A1 - Knip, Mikael
A1 - Saw, Seang-Mei
A1 - Holloway, John W.
A1 - Melen, Erik
A1 - Grant, Struan F. A.
A1 - Feenstra, Bjarke
A1 - Lowe, William L.
A1 - Widen, Elisabeth
A1 - Sergeyev, Elena
A1 - Grallert, Harald
A1 - Custovic, Adnan
A1 - Jacobsson, Bo
A1 - Jarvelin, Marjo-Riitta
A1 - Atalay, Mustafa
A1 - Koppelman, Gerard H.
A1 - Pennell, Craig E.
A1 - Niinikoski, Harri
A1 - Dedoussis, George V.
A1 - Mccarthy, Mark I.
A1 - Frayling, Timothy M.
A1 - Sunyer, Jordi
A1 - Timpson, Nicholas J.
A1 - Rivadeneira, Fernando
A1 - Bonnelykke, Klaus
A1 - Jaddoe, Vincent W. V.
T1 - A novel common variant in DCST2 is associated with length in early life and height in adulthood
JF - Human molecular genetics
N2 - Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide association studies (Stage 1; N = 28 459). We identified seven independent top single nucleotide polymorphisms (SNPs) (P < 1 x 10(-6)) for birth length, of which three were novel and four were in or near loci known to be associated with adult height (LCORL, PTCH1, GPR126 and HMGA2). The three novel SNPs were followed-up in nine replication studies (Stage 2; N = 11 995), with rs905938 in DC-STAMP domain containing 2 (DCST2) genome-wide significantly associated with birth length in a joint analysis (Stages 1 + 2; beta = 0.046, SE = 0.008, P = 2.46 x 10(-8), explained variance = 0.05%). Rs905938 was also associated with infant length (N = 28 228; P = 5.54 x 10(-4)) and adult height (N = 127 513; P = 1.45 x 10(-5)). DCST2 is a DC-STAMP-like protein family member and DC-STAMP is an osteoclast cell-fusion regulator. Polygenic scores based on 180 SNPs previously associated with human adult stature explained 0.13% of variance in birth length. The same SNPs explained 2.95% of the variance of infant length. Of the 180 known adult height loci, 11 were genome-wide significantly associated with infant length (SF3B4, LCORL, SPAG17, C6orf173, PTCH1, GDF5, ZNFX1, HHIP, ACAN, HLA locus and HMGA2). This study highlights that common variation in DCST2 influences variation in early growth and adult height.
Y1 - 2015
U6 - http://dx.doi.org/10.1093/hmg/ddu510
SN - 0964-6906 (print)
SN - 1460-2083 (online)
VL - 24
IS - 4
SP - 1155
EP - 1168
PB - Oxford Univ. Press
CY - Oxford
ER -