TY  - JOUR
A1  - Abdalla, H.
A1  - Adam, R.
A1  - Aharonian, Felix A.
A1  - Benkhali, F. Ait
A1  - Angüner, Ekrem Oǧuzhan
A1  - Arcaro, C.
A1  - Armand, C.
A1  - Armstrong, T.
A1  - Ashkar, H.
A1  - Backes, M.
A1  - Baghmanyan, V.
A1  - Martins, V. Barbosa
A1  - Barnacka, A.
A1  - Barnard, M.
A1  - Becherini, Y.
A1  - Berge, D.
A1  - Bernlohr, K.
A1  - Bi, B.
A1  - Bottcher, M.
A1  - Boisson, C.
A1  - Bolmont, J.
A1  - de Lavergne, M. de Bony
A1  - Bordas, Pol
A1  - Breuhaus, M.
A1  - Brun, F.
A1  - Brun, P.
A1  - Bryan, M.
A1  - Buchele, M.
A1  - Bulik, T.
A1  - Bylund, T.
A1  - Caroff, S.
A1  - Carosi, A.
A1  - Casanova, Sabrina
A1  - Chand, T.
A1  - Chandra, S.
A1  - Chen, A.
A1  - Cotter, G.
A1  - Curylo, M.
A1  - Mbarubucyeye, J. Damascene
A1  - Davids, I. D.
A1  - Davies, J.
A1  - Deil, C.
A1  - Devin, J.
A1  - deWilt, P.
A1  - Dirson, L.
A1  - Djannati-Atai, A.
A1  - Dmytriiev, A.
A1  - Donath, A.
A1  - Doroshenko, V.
A1  - Duffy, C.
A1  - Dyks, J.
A1  - Egberts, Kathrin
A1  - Eichhorn, F.
A1  - Einecke, S.
A1  - Emery, G.
A1  - Ernenwein, J. -P.
A1  - Feijen, K.
A1  - Fegan, S.
A1  - Fiasson, A.
A1  - de Clairfontaine, G. Fichet
A1  - Fontaine, G.
A1  - Funk, S.
A1  - Fussling, Matthias
A1  - Gabici, S.
A1  - Gallant, Y. A.
A1  - Giavitto, G.
A1  - Giunti, L.
A1  - Glawion, D.
A1  - Glicenstein, J. F.
A1  - Gottschall, D.
A1  - Grondin, M. -H.
A1  - Hahn, J.
A1  - Haupt, M.
A1  - Hermann, G.
A1  - Hinton, J. A.
A1  - Hofmann, W.
A1  - Hoischen, Clemens
A1  - Holch, T. L.
A1  - Holler, M.
A1  - Horbe, M.
A1  - Horns, D.
A1  - Huber, D.
A1  - Jamrozy, M.
A1  - Jankowsky, D.
A1  - Jankowsky, F.
A1  - Jardin-Blicq, A.
A1  - Joshi, V.
A1  - Jung-Richardt, I.
A1  - Kasai, E.
A1  - Kastendieck, M. A.
A1  - Katarzynski, K.
A1  - Katz, U.
A1  - Khangulyan, D.
A1  - Khelifi, B.
A1  - Klepser, S.
A1  - Kluzniak, W.
A1  - Komin, Nu.
A1  - Konno, R.
A1  - Kosack, K.
A1  - Kostunin, D.
A1  - Kreter, M.
A1  - Lamanna, G.
A1  - Lemiere, A.
A1  - Lemoine-Goumard, M.
A1  - Lenain, J. -P.
A1  - Levy, C.
A1  - Lohse, T.
A1  - Lypova, I.
A1  - Mackey, J.
A1  - Majumdar, J.
A1  - Malyshev, D.
A1  - Malyshev, D.
A1  - Marandon, V.
A1  - Marchegiani, P.
A1  - Marcowith, Alexandre
A1  - Mares, A.
A1  - Marti-Devesa, G.
A1  - Marx, R.
A1  - Maurin, G.
A1  - Meintjes, P. J.
A1  - Meyer, M.
A1  - Mitchell, A.
A1  - Moderski, R.
A1  - Mohamed, M.
A1  - Mohrmann, L.
A1  - Montanari, A.
A1  - Moore, C.
A1  - Morris, P.
A1  - Moulin, Emmanuel
A1  - Muller, J.
A1  - Murach, T.
A1  - Nakashima, K.
A1  - Nayerhoda, A.
A1  - de Naurois, M.
A1  - Ndiyavala, H.
A1  - Niederwanger, F.
A1  - Niemiec, J.
A1  - Oakes, L.
A1  - O'Brien, Patrick
A1  - Odaka, H.
A1  - Ohm, S.
A1  - Olivera-Nieto, L.
A1  - Wilhelmi, E. de Ona
A1  - Ostrowski, M.
A1  - Oya, I.
A1  - Panter, M.
A1  - Panny, S.
A1  - Parsons, R. D.
A1  - Peron, G.
A1  - Peyaud, B.
A1  - Piel, Q.
A1  - Pita, S.
A1  - Poireau, V.
A1  - Noel, A. Priyana
A1  - Prokhorov, D. A.
A1  - Prokoph, H.
A1  - Puhlhofer, G.
A1  - Punch, M.
A1  - Quirrenbach, A.
A1  - Raab, S.
A1  - Rauth, R.
A1  - Reichherzer, P.
A1  - Reimer, A.
A1  - Reimer, O.
A1  - Remy, Q.
A1  - Renaud, M.
A1  - Rieger, F.
A1  - Rinchiuso, L.
A1  - Romoli, C.
A1  - Rowell, G.
A1  - Rudak, B.
A1  - Ruiz-Velasco, E.
A1  - Sahakian, V.
A1  - Sailer, S.
A1  - Sanchez, D. A.
A1  - Santangelo, Andrea
A1  - Sasaki, M.
A1  - Scalici, M.
A1  - Schussler, F.
A1  - Schutte, H. M.
A1  - Schwanke, U.
A1  - Schwemmer, S.
A1  - Seglar-Arroyo, M.
A1  - Senniappan, M.
A1  - Seyffert, A. S.
A1  - Shafi, N.
A1  - Shiningayamwe, K.
A1  - Simoni, R.
A1  - Sinha, A.
A1  - Sol, H.
A1  - Specovius, A.
A1  - Spencer, S.
A1  - Spir-Jacob, M.
A1  - Stawarz, L.
A1  - Sun, L.
A1  - Steenkamp, R.
A1  - Stegmann, C.
A1  - Steinmassl, S.
A1  - Steppa, C.
A1  - Takahashi, T.
A1  - Tavernier, T.
A1  - Taylor, A. M.
A1  - Terrier, R.
A1  - Tiziani, D.
A1  - Tluczykont, M.
A1  - Tomankova, L.
A1  - Trichard, C.
A1  - Tsirou, M.
A1  - Tuffs, R.
A1  - Uchiyama, Y.
A1  - van der Walt, D. J.
A1  - van Eldik, C.
A1  - van Rensburg, C.
A1  - van Soelen, B.
A1  - Vasileiadis, G.
A1  - Veh, J.
A1  - Venter, C.
A1  - Vincent, P.
A1  - Vink, J.
A1  - Volk, H. J.
A1  - Vuillaume, T.
A1  - Wadiasingh, Z.
A1  - Wagner, S. J.
A1  - Watson, J.
A1  - Werner, F.
A1  - White, R.
A1  - Wierzcholska, A.
A1  - Wong, Yu Wun
A1  - Yusafzai, A.
A1  - Zacharias, M.
A1  - Zanin, R.
A1  - Zargaryan, D.
A1  - Zdziarski, A. A.
A1  - Zech, Alraune
A1  - Zhu, S. J.
A1  - Ziegler, A.
A1  - Zorn, J.
A1  - Zouari, S.
A1  - Zywucka, N.
T1  - An extreme particle accelerator in the Galactic plane
BT  - HESS J1826-130
JF  - Astronomy and astrophysics : an international weekly journal
N2  - The unidentified very-high-energy (VHE; E > 0.1 TeV) gamma -ray source, HESS J1826-130, was discovered with the High Energy Stereoscopic System (HESS) in the Galactic plane. The analysis of 215 h of HESS data has revealed a steady gamma -ray flux from HESS J1826-130, which appears extended with a half-width of 0.21 degrees +/- 0.02 <br /> (stat)degrees <br /> stat degrees +/- 0.05 <br /> (sys)degrees sys degrees . The source spectrum is best fit with either a power-law function with a spectral index Gamma = 1.78 +/- 0.10(stat) +/- 0.20(sys) and an exponential cut-off at 15.2 <br /> (+5.5)(-3.2) -3.2+5.5 TeV, or a broken power-law with Gamma (1) = 1.96 +/- 0.06(stat) +/- 0.20(sys), Gamma (2) = 3.59 +/- 0.69(stat) +/- 0.20(sys) for energies below and above E-br = 11.2 +/- 2.7 TeV, respectively. The VHE flux from HESS J1826-130 is contaminated by the extended emission of the bright, nearby pulsar wind nebula, HESS J1825-137, particularly at the low end of the energy spectrum. Leptonic scenarios for the origin of HESS J1826-130 VHE emission related to PSR J1826-1256 are confronted by our spectral and morphological analysis. In a hadronic framework, taking into account the properties of dense gas regions surrounding HESS J1826-130, the source spectrum would imply an astrophysical object capable of accelerating the parent particle population up to greater than or similar to 200 TeV. Our results are also discussed in a multiwavelength context, accounting for both the presence of nearby supernova remnants, molecular clouds, and counterparts detected in radio, X-rays, and TeV energies.
KW  - ISM: supernova remnants
KW  - ISM: clouds
KW  - gamma rays: general
KW  - gamma rays:
KW  - ISM
Y1  - 2020
U6  - https://doi.org/10.1051/0004-6361/202038851
SN  - 0004-6361
SN  - 1432-0746
VL  - 644
PB  - EDP Sciences
CY  - Les Ulis
ER  - 
TY  - JOUR
A1  - Koenig, Julian
A1  - Abler, Birgit
A1  - Agartz, Ingrid
A1  - akerstedt, Torbjorn
A1  - Andreassen, Ole A.
A1  - Anthony, Mia
A1  - Baer, Karl-Juergen
A1  - Bertsch, Katja
A1  - Brown, Rebecca C.
A1  - Brunner, Romuald
A1  - Carnevali, Luca
A1  - Critchley, Hugo D.
A1  - Cullen, Kathryn R.
A1  - de Geus, Eco J. C.
A1  - de la Cruz, Feliberto
A1  - Dziobek, Isabel
A1  - Ferger, Marc D.
A1  - Fischer, Hakan
A1  - Flor, Herta
A1  - Gaebler, Michael
A1  - Gianaros, Peter J.
A1  - Giummarra, Melita J.
A1  - Greening, Steven G.
A1  - Guendelman, Simon
A1  - Heathers, James A. J.
A1  - Herpertz, Sabine C.
A1  - Hu, Mandy X.
A1  - Jentschke, Sebastian
A1  - Kaess, Michael
A1  - Kaufmann, Tobias
A1  - Klimes-Dougan, Bonnie
A1  - Koelsch, Stefan
A1  - Krauch, Marlene
A1  - Kumral, Deniz
A1  - Lamers, Femke
A1  - Lee, Tae-Ho
A1  - Lekander, Mats
A1  - Lin, Feng
A1  - Lotze, Martin
A1  - Makovac, Elena
A1  - Mancini, Matteo
A1  - Mancke, Falk
A1  - Mansson, Kristoffer N. T.
A1  - Manuck, Stephen B.
A1  - Mather, Mara
A1  - Meeten, Frances
A1  - Min, Jungwon
A1  - Mueller, Bryon
A1  - Muench, Vera
A1  - Nees, Frauke
A1  - Nga, Lin
A1  - Nilsonne, Gustav
A1  - Ordonez Acuna, Daniela
A1  - Osnes, Berge
A1  - Ottaviani, Cristina
A1  - Penninx, Brenda W. J. H.
A1  - Ponzio, Allison
A1  - Poudel, Govinda R.
A1  - Reinelt, Janis
A1  - Ren, Ping
A1  - Sakaki, Michiko
A1  - Schumann, Andy
A1  - Sorensen, Lin
A1  - Specht, Karsten
A1  - Straub, Joana
A1  - Tamm, Sandra
A1  - Thai, Michelle
A1  - Thayer, Julian F.
A1  - Ubani, Benjamin
A1  - van Der Mee, Denise J.
A1  - van Velzen, Laura S.
A1  - Ventura-Bort, Carlos
A1  - Villringer, Arno
A1  - Watson, David R.
A1  - Wei, Luqing
A1  - Wendt, Julia
A1  - Schreiner, Melinda Westlund
A1  - Westlye, Lars T.
A1  - Weymar, Mathias
A1  - Winkelmann, Tobias
A1  - Wu, Guo-Rong
A1  - Yoo, Hyun Joo
A1  - Quintana, Daniel S.
T1  - Cortical thickness and resting-state cardiac function across the lifespan
BT  - a cross-sectional pooled mega-analysis
JF  - Psychophysiology : journal of the Society for Psychophysiological Research
N2  - Understanding the association between autonomic nervous system [ANS] function and brain morphology across the lifespan provides important insights into neurovisceral mechanisms underlying health and disease. Resting-state ANS activity, indexed by measures of heart rate [HR] and its variability [HRV] has been associated with brain morphology, particularly cortical thickness [CT]. While findings have been mixed regarding the anatomical distribution and direction of the associations, these inconsistencies may be due to sex and age differences in HR/HRV and CT. Previous studies have been limited by small sample sizes, which impede the assessment of sex differences and aging effects on the association between ANS function and CT. To overcome these limitations, 20 groups worldwide contributed data collected under similar protocols of CT assessment and HR/HRV recording to be pooled in a mega-analysis (N = 1,218 (50.5% female), mean age 36.7 years (range: 12-87)). Findings suggest a decline in HRV as well as CT with increasing age. CT, particularly in the orbitofrontal cortex, explained additional variance in HRV, beyond the effects of aging. This pattern of results may suggest that the decline in HRV with increasing age is related to a decline in orbitofrontal CT. These effects were independent of sex and specific to HRV; with no significant association between CT and HR. Greater CT across the adult lifespan may be vital for the maintenance of healthy cardiac regulation via the ANS-or greater cardiac vagal activity as indirectly reflected in HRV may slow brain atrophy. Findings reveal an important association between CT and cardiac parasympathetic activity with implications for healthy aging and longevity that should be studied further in longitudinal research.
KW  - aging
KW  - autonomic nervous system
KW  - cortical thickness
KW  - heart rate
KW  - heart
KW  - rate variability
KW  - sex
Y1  - 2020
U6  - https://doi.org/10.1111/psyp.13688
SN  - 0048-5772
SN  - 1469-8986
VL  - 58
IS  - 7
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Herrero, Mario
A1  - Thornton, Philip K.
A1  - Mason-D'Croz, Daniel
A1  - Palmer, Jeda
A1  - Bodirsky, Benjamin Leon
A1  - Pradhan, Prajal
A1  - Barrett, Christopher B.
A1  - Benton, Tim G.
A1  - Hall, Andrew
A1  - Pikaar, Ilje
A1  - Bogard, Jessica R.
A1  - Bonnett, Graham D.
A1  - Bryan, Brett A.
A1  - Campbell, Bruce M.
A1  - Christensen, Svend
A1  - Clark, Michael
A1  - Fanzo, Jessica
A1  - Godde, Cecile M.
A1  - Jarvis, Andy
A1  - Loboguerrero, Ana Maria
A1  - Mathys, Alexander
A1  - McIntyre, C. Lynne
A1  - Naylor, Rosamond L.
A1  - Nelson, Rebecca
A1  - Obersteiner, Michael
A1  - Parodi, Alejandro
A1  - Popp, Alexander
A1  - Ricketts, Katie
A1  - Smith, Pete
A1  - Valin, Hugo
A1  - Vermeulen, Sonja J.
A1  - Vervoort, Joost
A1  - van Wijk, Mark
A1  - van Zanten, Hannah H. E.
A1  - West, Paul C.
A1  - Wood, Stephen A.
A1  - Rockström, Johan
T1  - Articulating the effect of food systems innovation on the Sustainable Development Goals
JF  - The lancet Planetary health
N2  - Food system innovations will be instrumental to achieving multiple Sustainable Development Goals (SDGs). However, major innovation breakthroughs can trigger profound and disruptive changes, leading to simultaneous and interlinked reconfigurations of multiple parts of the global food system. The emergence of new technologies or social solutions, therefore, have very different impact profiles, with favourable consequences for some SDGs and unintended adverse side-effects for others. Stand-alone innovations seldom achieve positive outcomes over multiple sustainability dimensions. Instead, they should be embedded as part of systemic changes that facilitate the implementation of the SDGs. Emerging trade-offs need to be intentionally addressed to achieve true sustainability, particularly those involving social aspects like inequality in its many forms, social justice, and strong institutions, which remain challenging. Trade-offs with undesirable consequences are manageable through the development of well planned transition pathways, careful monitoring of key indicators, and through the implementation of transparent science targets at the local level.
Y1  - 2020
U6  - https://doi.org/10.1016/S2542-5196(20)30277-1
SN  - 2542-5196
VL  - 5
IS  - 1
SP  - E50
EP  - E62
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Christakoudi, Sofa
A1  - Tsilidis, Konstantinos K.
A1  - Muller, David C.
A1  - Freisling, Heinz
A1  - Weiderpass, Elisabete
A1  - Overvad, Kim
A1  - Söderberg, Stefan
A1  - Häggström, Christel
A1  - Pischon, Tobias
A1  - Dahm, Christina C.
A1  - Zhang, Jie
A1  - Tjønneland, Anne
A1  - Schulze, Matthias Bernd
T1  - A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
JF  - Scientific Reports
N2  - Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
KW  - all-cause mortality
KW  - anthropometric measures
KW  - mass index
KW  - overweight
KW  - cancer
KW  - prediction
KW  - adiposity
KW  - size
Y1  - 2020
VL  - 10
IS  - 1
PB  - Springer Nature
CY  - Berlin
ER  - 
TY  - GEN
A1  - Christakoudi, Sofa
A1  - Tsilidis, Konstantinos K.
A1  - Muller, David C.
A1  - Freisling, Heinz
A1  - Weiderpass, Elisabete
A1  - Overvad, Kim
A1  - Söderberg, Stefan
A1  - Häggström, Christel
A1  - Pischon, Tobias
A1  - Dahm, Christina C.
A1  - Zhang, Jie
A1  - Tjønneland, Anne
A1  - Schulze, Matthias Bernd
T1  - A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI<18.5 kg/m(2)) or obese (BMI30 kg/m(2)) categories, while the highest quartile of ABSI separated 18-39% of the individuals within each BMI category, which had 22-55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1200 
KW  - all-cause mortality
KW  - anthropometric measures
KW  - mass index
KW  - overweight
KW  - cancer
KW  - prediction
KW  - adiposity
KW  - size
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-525827
SN  - 1866-8372
IS  - 1
ER  - 
TY  - JOUR
A1  - van Rees, Charles B.
A1  - Waylen, Kerry A.
A1  - Schmidt-Kloiber, Astrid
A1  - Thackeray, Stephen J.
A1  - Kalinkat, Gregor
A1  - Martens, Koen
A1  - Domisch, Sami
A1  - Lillebo, Ana
A1  - Hermoso, Virgilio
A1  - Grossart, Hans-Peter
A1  - Schinegger, Rafaela
A1  - Decleer, Kris
A1  - Adriaens, Tim
A1  - Denys, Luc
A1  - Jaric, Ivan
A1  - Janse, Jan H.
A1  - Monaghan, Michael T.
A1  - De Wever, Aaike
A1  - Geijzendorffer, Ilse
A1  - Adamescu, Mihai C.
A1  - Jähnig, Sonja C.
T1  - Safeguarding freshwater life beyond 2020
BT  - recommendations for the new global biodiversity framework from the European experience
JF  - Conservation letters
N2  - Plans are currently being drafted for the next decade of action on biodiversity-both the post-2020 Global Biodiversity Framework of the Convention on Biological Diversity (CBD) and Biodiversity Strategy of the European Union (EU). Freshwater biodiversity is disproportionately threatened and underprioritized relative to the marine and terrestrial biota, despite supporting a richness of species and ecosystems with their own intrinsic value and providing multiple essential ecosystem services. Future policies and strategies must have a greater focus on the unique ecology of freshwater life and its multiple threats, and now is a critical time to reflect on how this may be achieved. We identify priority topics including environmental flows, water quality, invasive species, integrated water resources management, strategic conservation planning, and emerging technologies for freshwater ecosystem monitoring. We synthesize these topics with decades of first-hand experience and recent literature into 14 special recommendations for global freshwater biodiversity conservation based on the successes and setbacks of European policy, management, and research. Applying and following these recommendations will inform and enhance the ability of global and European post-2020 biodiversity agreements to halt and reverse the rapid global decline of freshwater biodiversity.
KW  - climate change
KW  - conservation
KW  - ecosystem services
KW  - rivers
KW  - sustainable
KW  - development goals
KW  - water resources
KW  - wetlands
Y1  - 2020
U6  - https://doi.org/10.1111/conl.12771
SN  - 1755-263X
VL  - 14
IS  - 1
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Noonan, Michael J.
A1  - Fleming, Christen H.
A1  - Tucker, Marlee A.
A1  - Kays, Roland
A1  - Harrison, Autumn-Lynn
A1  - Crofoot, Margaret C.
A1  - Abrahms, Briana
A1  - Alberts, Susan C.
A1  - Ali, Abdullahi H.
A1  - Blaum, Niels
T1  - Effects of body size on estimation of mammalian area requirements
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Accurately quantifying species' area requirements is a prerequisite for effective area-based conservation. This typically involves collecting tracking data on species of interest and then conducting home-range analyses. Problematically, autocorrelation in tracking data can result in space needs being severely underestimated. Based on the previous work, we hypothesized the magnitude of underestimation varies with body mass, a relationship that could have serious conservation implications. To evaluate this hypothesis for terrestrial mammals, we estimated home-range areas with global positioning system (GPS) locations from 757 individuals across 61 globally distributed mammalian species with body masses ranging from 0.4 to 4000 kg. We then applied block cross-validation to quantify bias in empirical home-range estimates. Area requirements of mammals <10 kg were underestimated by a mean approximately15%, and species weighing approximately100 kg were underestimated by approximately50% on average. Thus, we found area estimation was subject to autocorrelation-induced bias that was worse for large species. Combined with the fact that extinction risk increases as body mass increases, the allometric scaling of bias we observed suggests the most threatened species are also likely to be those with the least accurate home-range estimates. As a correction, we tested whether data thinning or autocorrelation-informed home-range estimation minimized the scaling effect of autocorrelation on area estimates. Data thinning required an approximately93% data loss to achieve statistical independence with 95% confidence and was, therefore, not a viable solution. In contrast, autocorrelation-informed home-range estimation resulted in consistently accurate estimates irrespective of mass. When relating body mass to home range size, we detected that correcting for autocorrelation resulted in a scaling exponent significantly >1, meaning the scaling of the relationship changed substantially at the upper end of the mass spectrum.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1206 
KW  - allometry
KW  - animal movement
KW  - area-based conservation
KW  - autocorrelation
KW  - home range
KW  - kernel density estimation
KW  - reserve design
KW  - scaling
Y1  - 2019
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-526824
SN  - 1866-8372
IS  - 4
ER  - 
TY  - JOUR
A1  - Noonan, Michael J.
A1  - Fleming, Christen H.
A1  - Tucker, Marlee A.
A1  - Kays, Roland
A1  - Harrison, Autumn-Lynn
A1  - Crofoot, Margaret C.
A1  - Abrahms, Briana
A1  - Alberts, Susan C.
A1  - Ali, Abdullahi H.
A1  - Blaum, Niels
T1  - Effects of body size on estimation of mammalian area requirements
JF  - Conservation Biology
N2  - Accurately quantifying species' area requirements is a prerequisite for effective area-based conservation. This typically involves collecting tracking data on species of interest and then conducting home-range analyses. Problematically, autocorrelation in tracking data can result in space needs being severely underestimated. Based on the previous work, we hypothesized the magnitude of underestimation varies with body mass, a relationship that could have serious conservation implications. To evaluate this hypothesis for terrestrial mammals, we estimated home-range areas with global positioning system (GPS) locations from 757 individuals across 61 globally distributed mammalian species with body masses ranging from 0.4 to 4000 kg. We then applied block cross-validation to quantify bias in empirical home-range estimates. Area requirements of mammals <10 kg were underestimated by a mean approximately15%, and species weighing approximately100 kg were underestimated by approximately50% on average. Thus, we found area estimation was subject to autocorrelation-induced bias that was worse for large species. Combined with the fact that extinction risk increases as body mass increases, the allometric scaling of bias we observed suggests the most threatened species are also likely to be those with the least accurate home-range estimates. As a correction, we tested whether data thinning or autocorrelation-informed home-range estimation minimized the scaling effect of autocorrelation on area estimates. Data thinning required an approximately93% data loss to achieve statistical independence with 95% confidence and was, therefore, not a viable solution. In contrast, autocorrelation-informed home-range estimation resulted in consistently accurate estimates irrespective of mass. When relating body mass to home range size, we detected that correcting for autocorrelation resulted in a scaling exponent significantly >1, meaning the scaling of the relationship changed substantially at the upper end of the mass spectrum.
KW  - allometry
KW  - animal movement
KW  - area-based conservation
KW  - autocorrelation
KW  - home range
KW  - kernel density estimation
KW  - reserve design
KW  - scaling
Y1  - 2019
VL  - 34
IS  - 4
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Schenck, Marcia C.
T1  - Small Strangers at the School of Friendship: Memories of Mozambican School Students of The German Democratic Republic
JF  - German Historical Institute Washington Bulletin / Supplement
KW  - migration, school of friendship, German Democratic Repubic, Mozambique
Y1  - 2020
UR  - https://perspectivia.net/servlets/MCRFileNodeServlet/pnet_derivate_00003158/schenk_strangers.pdf
IS  - 15
SP  - 41
EP  - 59
PB  - Max Weber Stiftung – Deutsche Geisteswissenschaftliche Institute im Ausland
ER  - 
TY  - JOUR
A1  - Ryo, Masahiro
A1  - Jeschke, Jonathan M.
A1  - Rillig, Matthias C.
A1  - Heger, Tina
T1  - Machine learning with the hierarchy-of-hypotheses (HoH) approach discovers novel pattern in studies on biological invasions
JF  - Research synthesis methods
N2  - Research synthesis on simple yet general hypotheses and ideas is challenging in scientific disciplines studying highly context-dependent systems such as medical, social, and biological sciences. This study shows that machine learning, equation-free statistical modeling of artificial intelligence, is a promising synthesis tool for discovering novel patterns and the source of controversy in a general hypothesis. We apply a decision tree algorithm, assuming that evidence from various contexts can be adequately integrated in a hierarchically nested structure. As a case study, we analyzed 163 articles that studied a prominent hypothesis in invasion biology, the enemy release hypothesis. We explored if any of the nine attributes that classify each study can differentiate conclusions as classification problem. Results corroborated that machine learning can be useful for research synthesis, as the algorithm could detect patterns that had been already focused in previous narrative reviews. Compared with the previous synthesis study that assessed the same evidence collection based on experts' judgement, the algorithm has newly proposed that the studies focusing on Asian regions mostly supported the hypothesis, suggesting that more detailed investigations in these regions can enhance our understanding of the hypothesis. We suggest that machine learning algorithms can be a promising synthesis tool especially where studies (a) reformulate a general hypothesis from different perspectives, (b) use different methods or variables, or (c) report insufficient information for conducting meta-analyses.
KW  - artificial intelligence
KW  - hierarchy-of-hypotheses approach
KW  - machine learning
KW  - meta-analysis
KW  - synthesis
KW  - systematic review
Y1  - 2019
U6  - https://doi.org/10.1002/jrsm.1363
SN  - 1759-2879
SN  - 1759-2887
VL  - 11
IS  - 1
SP  - 66
EP  - 73
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - JOUR
A1  - Coesfeld, Jacqueline
A1  - Kuester, Theres
A1  - Kuechly, Helga U.
A1  - Kyba, Christopher C. M.
T1  - Reducing variability and removing natural light from nighttime satellite imagery: A case study using the VIIRS DNB
JF  - Sensors
N2  - Temporal variation of natural light sources such as airglow limits the ability of night light sensors to detect changes in small sources of artificial light (such as villages). This study presents a method for correcting for this effect globally, using the satellite radiance detected from regions without artificial light emissions. We developed a routine to define an approximate grid of locations worldwide that do not have regular light emission. We apply this method with a 5 degree equally spaced global grid (total of 2016 individual locations), using data from the Visible Infrared Imaging Radiometer Suite (VIIRS) Day-Night Band (DNB). This code could easily be adapted for other future global sensors. The correction reduces the standard deviation of data in the Earth Observation Group monthly DNB composites by almost a factor of two. The code and datasets presented here are available under an open license by GFZ Data Services, and are implemented in the Radiance Light Trends web application.
KW  - airglow
KW  - artificial light
KW  - calibration
KW  - VIIRS DNB
KW  - nightlights
KW  - remote sensing
Y1  - 2020
VL  - 20
PB  - MDPI
CY  - Basel
ER  - 
TY  - GEN
A1  - Schenck, Marcia C.
T1  - Africa’s forgotten refugee convention
Africa is a Country
T2  - Histories of Refuge - Geschichten der Zuflucht
Y1  - 2020
UR  - https://africasacountry.com/2020/11/africas-forgotten-refugee-convention
PB  - Forum Transregionale Studien eV
CY  - Berlin
ER  - 
TY  - GEN
A1  - Schenck, Marcia C.
T1  - History without borders
BT  - How historians engage in humanitarian work
T2  - African Refugees Crossroads
Y1  - 2020
UR  - https://networks.h-net.org/node/6630600/blog/history-without-borders-how-historians-engage-humanitarian-work/6929027/history#reply-6929028
PB  - H-Net: Humanities & Social Sciences Online
CY  - East Lansing
ER  - 
TY  - JOUR
A1  - Tesselaar, Max
A1  - Botzen, W. J. Wouter
A1  - Haer, Toon
A1  - Hudson, Paul
A1  - Tiggeloven, Timothy
A1  - Aerts, Jeroen C. J. H.
T1  - Regional inequalities in flood insurance affordability and uptake under climate change
JF  - Sustainability
N2  - Flood insurance coverage can enhance financial resilience of households to changing flood risk caused by climate change. However, income inequalities imply that not all households can afford flood insurance. The uptake of flood insurance in voluntary markets may decline when flood risk increases as a result of climate change. This increase in flood risk may cause substantially higher risk-based insurance premiums, reduce the willingness to purchase flood insurance, and worsen problems with the unaffordability of coverage for low-income households. A socio-economic tipping-point can occur when the functioning of a formal flood insurance system is hampered by diminishing demand for coverage. In this study, we examine whether such a tipping-point can occur in Europe for current flood insurance systems under different trends in future flood risk caused by climate and socio-economic change. This analysis gives insights into regional inequalities concerning the ability to continue to use flood insurance as an instrument to adapt to changing flood risk. For this study, we adapt the "Dynamic Integrated Flood and Insurance" (DIFI) model by integrating new flood risk simulations in the model that enable examining impacts from various scenarios of climate and socio-economic change on flood insurance premiums and consumer demand. Our results show rising unaffordability and declining demand for flood insurance across scenarios towards 2080. Under a high climate change scenario, simulations show the occurrence of a socio-economic tipping-point in several regions, where insurance uptake almost disappears. A tipping-point and related inequalities in the ability to use flood insurance as an adaptation instrument can be mitigated by introducing reforms of flood insurance arrangements.
KW  - climate change
KW  - flood risk management
KW  - insurance
KW  - socio-economic
KW  - tipping-point
KW  - adaptation
KW  - partial equilibrium modeling
Y1  - 2020
U6  - https://doi.org/10.3390/su12208734
SN  - 2071-1050
VL  - 12
IS  - 20
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Liu, Yue
A1  - Gould, Oliver E. C.
A1  - Kratz, Karl
A1  - Lendlein, Andreas
T1  - Shape-memory actuation of individual micro-/nanofibers
JF  - MRS Advances
N2  - Advances in the fabrication and characterization of polymeric nanomaterials has greatly advanced the miniaturization of soft actuators, creating materials capable of replicating the functional physical behavior previously limited to the macroscale. Here, we demonstrate how a reversible shape-memory polymer actuation can be generated in a single micro/nano object, where the shape change during actuation of an individual fiber can be dictated by programming using an AFM-based method. Electrospinning was used to prepare poly(epsilon-caprolactone) micro-/nanofibers, which were fixed and crosslinked on a structured silicon wafer. The programming as well as the observation of recovery and reversible displacement of the fiber were performed by vertical three point bending, using an AFM testing platform introduced here. A plateau tip was utilized to improve the stability of the fiber contact and working distance, enabling larger deformations and greater rbSMPA performance. Values for the reversible elongation of epsilon(rev)= 3.4 +/- 0.1% and 10.5 +/- 0.1% were obtained for a single micro (d = 1.0 +/- 0.2 mu m) and nanofiber (d = 300 +/- 100 nm) in cyclic testing between the temperatures 10 and 60 degrees C. The reversible actuation of the nanofiber was successfully characterized for 10 cycles. The demonstration and characterization of individual shape-memory nano and microfiber actuators represents an important step in the creation of miniaturized robotic devices capable of performing complex physical functions at the length scale of cells and structural component of the extracellular matrix.
Y1  - 2020
U6  - https://doi.org/10.1557/adv.2020.276
SN  - 2059-8521
VL  - 5
IS  - 46-47
SP  - 2391
EP  - 2399
PB  - Cambridge Univ. Press
CY  - New York
ER  - 
TY  - CHAP
A1  - Schenck, Marcia C.
T1  - Wandergesellen des Kalten Krieges
BT  - Arbeits- und Ausbildungsmigration von Angola und Mosambik nach Ostdeutschland und zurück
T2  - Für Respekt und Anerkennung: Die mosambikanischen Vertragsarbeiter und das schwierige Erbe aus der DDR
N2  - Der Umgang mit einem schwierigen Erbe
2019 befasste sich die internationale Tagung »Respekt und Anerkennung« mit der Entwicklungszusammen­arbeit Mosambik-Deutschland unter dem Schwerpunktthema Vertrags­arbeit. Anlass war der 40. Jahrestag des 1979 geschlossenen Staatsvertrages der VR Mosambik mit der DDR. Der nun erscheinende Tagungsband enthält u. a. Beiträge zu den Themen »Die Lebenswege der SchülerInnen der Schule der Freundschaft in Staßfurt«, »DDR-­ExpertInnen in Mosambik«, »Wie aus Vertragsarbeitern Madgermanes wurden« und »Auf dem Weg zu Respekt und Anerkennung: Sind wir für die Versöhnung?«. Ein Dokumentenanhang ergänzt den Band.
Mit Beiträgen von Katrin Baar, António Daniel, Hans-Joachim Döring, António Frangoulis, Rainer Grajek, Adelino Massuvira João, Lázaro Magalhães, Dinis Matsolo, Francisca Raposo, Marcia C. Schenck, Ralf Straßburg, Mathias Tullner und Cesare Zucconi.
KW  - Migration, Deutsche Demokratische Republik, Mosambik
Y1  - 2020
SN  - 978-3-96311-314-7
SP  - 103
EP  - 114
PB  - Mitteldeutscher Verlag
CY  - Halle
ER  - 
TY  - JOUR
A1  - Matthias, Katja
A1  - Rissling, Olesja
A1  - Pieper, Dawid Aleksander
A1  - Morche, Johannes
A1  - Nocon, Marc
A1  - Jacobs, Anja
A1  - Wegewitz, Uta Elke
A1  - Schirm, Jaqueline
A1  - Lorenz, Robert C.
T1  - The methodological quality of systematic reviews on the treatment of adult major depression needs improvement according to AMSTAR 2
BT  - a cross-sectional study
JF  - Heliyon
N2  - Background:
Several standards have been developed to assess methodological quality of systematic reviews (SR). One widely used tool is the AMSTAR. A recent update -AMSTAR 2 -is a 16 item evaluation tool that enables a detailed assessment of SR that include randomised (RCT) or non-randomised studies (NRS) of healthcare interventions. 

Methods:
A cross-sectional study of SR on pharmacological or psychological interventions in major depression in adults was conducted. SR published during 2012-2017 were sampled from MEDLINE, EMBASE and the Cochrane Database of SR. Methodological quality was assessed using AMSTAR 2. Potential predictive factors associated with quality were examined.

Results:
In rating overall confidence in the results of 60 SR four reviews were rated "high", two were "moderate", one was "low" and 53 were "critically low". The mean AMSTAR 2 percentage score was 45.3% (standard deviation 22.6%) in a wide range from 7.1% to 93.8%. Predictors of higher quality were: type of review (higher quality in Cochrane Reviews), SR including only randomized trials and higher journal impact factor.

Limitations:
AMSTAR 2 is not intended to be used for the generation of a percentage score.

Conclusions:
According to AMSTAR 2 the overall methodological quality of SR on the treatment of adult major depression needs improvement. Although there is a high need for summarized information in the field of mental health, this work demonstrates the need to critically assess SR before using their findings. Better adherence to established reporting guidelines for SR is needed.
KW  - public health
KW  - epidemiology
KW  - psychiatry
KW  - depression
KW  - evidence-based
KW  - medicine
KW  - AMSTAR 2
KW  - methodological quality
KW  - risk of bias
KW  - systematic
KW  - review
KW  - major depression
Y1  - 2020
U6  - https://doi.org/10.1016/j.heliyon.2020.e04776
SN  - 2405-8440
VL  - 6
IS  - 9
PB  - Elsevier
CY  - London [u.a.]
ER  - 
TY  - JOUR
A1  - Schenck, Marcia C.
T1  - Small Strangers at the School of Friendship
BT  - Memories of Mozambican School Students to the German Democratic Republic
JF  - German Historical Institute Bulletin: German Historical Institute Washington Bulletin
N2  - “Why,” Francisca Isidro wonders, “did we have to leave our families and move so far away, only to come back as cooks, waitresses, sales assistants, and the like?” And she recalls: “We came back from our time in East Germany with professions that were not held in particu-larly high regard in Mozambique. Nobody understood why we didn’t return as engineers, doctors and teachers. ‘A waitress?,’ they would wonder. ‘Why, they could have become a waitress in Mozambique. Nobody needs to spend so many years in school for that.’”2And with that, Ms. Isidro puts her fi nger right on a misapprehension at the heart of an ambitious state-led education migration program that saw 900 Mozambican children attend the School of Friendship (Schule der Freundschaft  , SdF) in Staßfurt in the district of Magdeburg, in what today is Saxony-Anhalt, in the German Democratic Republic (GDR, or East Germany) from 1982 to 1988.3 Ms. Isidro returned to Mozambique as a trained salesperson for clothing, a profession she neither chose nor ever worked in again subsequently. Like her, these 900 children had to navigate the diverging values that particular environments bestowed upon knowledge. What they learned was interpreted diff  erently in their home communities, at the SdF, and in their German host families
KW  - Migration, Deutsche Demokratische Republik, Mosambik, Schule der Freundschaft
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-494614
UR  - https://perspectivia.net/publikationen/bulletin-of-the-ghi-washington-supplements
VL  - 2020
IS  - 15: Histories of Migrant Knowledge: Transatlantic and Global Perspectives
SP  - 41
EP  - 59
PB  - German Historical Institute
CY  - Washington
ER  - 
TY  - GEN
A1  - Coesfeld, Jacqueline
A1  - Kuester, Theres
A1  - Kuechly, Helga U.
A1  - Kyba, Christopher C. M.
T1  - Reducing variability and removing natural light from nighttime satellite imagery: A case study using the VIIRS DNB
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Temporal variation of natural light sources such as airglow limits the ability of night light sensors to detect changes in small sources of artificial light (such as villages). This study presents a method for correcting for this effect globally, using the satellite radiance detected from regions without artificial light emissions. We developed a routine to define an approximate grid of locations worldwide that do not have regular light emission. We apply this method with a 5 degree equally spaced global grid (total of 2016 individual locations), using data from the Visible Infrared Imaging Radiometer Suite (VIIRS) Day-Night Band (DNB). This code could easily be adapted for other future global sensors. The correction reduces the standard deviation of data in the Earth Observation Group monthly DNB composites by almost a factor of two. The code and datasets presented here are available under an open license by GFZ Data Services, and are implemented in the Radiance Light Trends web application.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1181 
KW  - airglow
KW  - artificial light
KW  - calibration
KW  - VIIRS DNB
KW  - nightlights
KW  - remote sensing
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-524397
SN  - 1866-8372
IS  - 11
ER  - 
TY  - GEN
A1  - Ryo, Masahiro
A1  - Jeschke, Jonathan M.
A1  - Rillig, Matthias C.
A1  - Heger, Tina
T1  - Machine learning with the hierarchy-of-hypotheses (HoH) approach discovers novel pattern in studies on biological invasions
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Research synthesis on simple yet general hypotheses and ideas is challenging in scientific disciplines studying highly context-dependent systems such as medical, social, and biological sciences. This study shows that machine learning, equation-free statistical modeling of artificial intelligence, is a promising synthesis tool for discovering novel patterns and the source of controversy in a general hypothesis. We apply a decision tree algorithm, assuming that evidence from various contexts can be adequately integrated in a hierarchically nested structure. As a case study, we analyzed 163 articles that studied a prominent hypothesis in invasion biology, the enemy release hypothesis. We explored if any of the nine attributes that classify each study can differentiate conclusions as classification problem. Results corroborated that machine learning can be useful for research synthesis, as the algorithm could detect patterns that had been already focused in previous narrative reviews. Compared with the previous synthesis study that assessed the same evidence collection based on experts' judgement, the algorithm has newly proposed that the studies focusing on Asian regions mostly supported the hypothesis, suggesting that more detailed investigations in these regions can enhance our understanding of the hypothesis. We suggest that machine learning algorithms can be a promising synthesis tool especially where studies (a) reformulate a general hypothesis from different perspectives, (b) use different methods or variables, or (c) report insufficient information for conducting meta-analyses.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1171 
KW  - artificial intelligence
KW  - hierarchy-of-hypotheses approach
KW  - machine learning
KW  - meta-analysis
KW  - synthesis
KW  - systematic review
Y1  - 2021
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-517643
SN  - 1866-8372
IS  - 1171
SP  - 66
EP  - 73
ER  - 
TY  - JOUR
A1  - Dennis, Alice B.
A1  - Ballesteros, Gabriel I.
A1  - Robin, Stéphanie
A1  - Schrader, Lukas
A1  - Bast, Jens
A1  - Berghöfer, Jan
A1  - Beukeboom, Leo W.
A1  - Belghazi, Maya
A1  - Bretaudeau, Anthony
A1  - Buellesbach, Jan
A1  - Cash, Elizabeth
A1  - Colinet, Dominique
A1  - Dumas, Zoé
A1  - Errbii, Mohammed
A1  - Falabella, Patrizia
A1  - Gatti, Jean-Luc
A1  - Geuverink, Elzemiek
A1  - Gibson, Joshua D.
A1  - Hertaeg, Corinne
A1  - Hartmann, Stefanie
A1  - Jacquin-Joly, Emmanuelle
A1  - Lammers, Mark
A1  - Lavandero, Blas I.
A1  - Lindenbaum, Ina
A1  - Massardier-Galata, Lauriane
A1  - Meslin, Camille
A1  - Montagné, Nicolas
A1  - Pak, Nina
A1  - Poirié, Marylène
A1  - Salvia, Rosanna
A1  - Smith, Chris R.
A1  - Tagu, Denis
A1  - Tares, Sophie
A1  - Vogel, Heiko
A1  - Schwander, Tanja
A1  - Simon, Jean-Christophe
A1  - Figueroa, Christian C.
A1  - Vorburger, Christoph
A1  - Legeai, Fabrice
A1  - Gadau, Jürgen
T1  - Functional insights from the GC-poor genomes of two aphid parasitoids, Aphidius ervi and Lysiphlebus fabarum
JF  - BMC Genomics
N2  - Background

Parasitoid wasps have fascinating life cycles and play an important role in trophic networks, yet little is known about their genome content and function. Parasitoids that infect aphids are an important group with the potential for biological control. Their success depends on adapting to develop inside aphids and overcoming both host aphid defenses and their protective endosymbionts.

Results

We present the de novo genome assemblies, detailed annotation, and comparative analysis of two closely related parasitoid wasps that target pest aphids: Aphidius ervi and Lysiphlebus fabarum (Hymenoptera: Braconidae: Aphidiinae). The genomes are small (139 and 141 Mbp) and the most AT-rich reported thus far for any arthropod (GC content: 25.8 and 23.8%). This nucleotide bias is accompanied by skewed codon usage and is stronger in genes with adult-biased expression. AT-richness may be the consequence of reduced genome size, a near absence of DNA methylation, and energy efficiency. We identify missing desaturase genes, whose absence may underlie mimicry in the cuticular hydrocarbon profile of L. fabarum. We highlight key gene groups including those underlying venom composition, chemosensory perception, and sex determination, as well as potential losses in immune pathway genes.

Conclusions

These findings are of fundamental interest for insect evolution and biological control applications. They provide a strong foundation for further functional studies into coevolution between parasitoids and their hosts. Both genomes are available at https://bipaa.genouest.org.
KW  - Parasitoid wasp
KW  - Aphid host
KW  - Aphidius ervi
KW  - Lysiphlebus fabarum
KW  - de novo genome assembly
KW  - DNA methylation loss
KW  - Chemosensory genes
KW  - Venom proteins
KW  - GC content
KW  - Toll and Imd pathways
Y1  - 2020
U6  - https://doi.org/10.1186/s12864-020-6764-0
SN  - 1471-2164
VL  - 21
PB  - BioMed Central
CY  - London
ER  - 
TY  - GEN
A1  - Dennis, Alice B.
A1  - Ballesteros, Gabriel I.
A1  - Robin, Stéphanie
A1  - Schrader, Lukas
A1  - Bast, Jens
A1  - Berghöfer, Jan
A1  - Beukeboom, Leo W.
A1  - Belghazi, Maya
A1  - Bretaudeau, Anthony
A1  - Buellesbach, Jan
A1  - Cash, Elizabeth
A1  - Colinet, Dominique
A1  - Dumas, Zoé
A1  - Errbii, Mohammed
A1  - Falabella, Patrizia
A1  - Gatti, Jean-Luc
A1  - Geuverink, Elzemiek
A1  - Gibson, Joshua D.
A1  - Hertaeg, Corinne
A1  - Hartmann, Stefanie
A1  - Jacquin-Joly, Emmanuelle
A1  - Lammers, Mark
A1  - Lavandero, Blas I.
A1  - Lindenbaum, Ina
A1  - Massardier-Galata, Lauriane
A1  - Meslin, Camille
A1  - Montagné, Nicolas
A1  - Pak, Nina
A1  - Poirié, Marylène
A1  - Salvia, Rosanna
A1  - Smith, Chris R.
A1  - Tagu, Denis
A1  - Tares, Sophie
A1  - Vogel, Heiko
A1  - Schwander, Tanja
A1  - Simon, Jean-Christophe
A1  - Figueroa, Christian C.
A1  - Vorburger, Christoph
A1  - Legeai, Fabrice
A1  - Gadau, Jürgen
T1  - Functional insights from the GC-poor genomes of two aphid parasitoids, Aphidius ervi and Lysiphlebus fabarum
T2  - Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Background

Parasitoid wasps have fascinating life cycles and play an important role in trophic networks, yet little is known about their genome content and function. Parasitoids that infect aphids are an important group with the potential for biological control. Their success depends on adapting to develop inside aphids and overcoming both host aphid defenses and their protective endosymbionts.

Results

We present the de novo genome assemblies, detailed annotation, and comparative analysis of two closely related parasitoid wasps that target pest aphids: Aphidius ervi and Lysiphlebus fabarum (Hymenoptera: Braconidae: Aphidiinae). The genomes are small (139 and 141 Mbp) and the most AT-rich reported thus far for any arthropod (GC content: 25.8 and 23.8%). This nucleotide bias is accompanied by skewed codon usage and is stronger in genes with adult-biased expression. AT-richness may be the consequence of reduced genome size, a near absence of DNA methylation, and energy efficiency. We identify missing desaturase genes, whose absence may underlie mimicry in the cuticular hydrocarbon profile of L. fabarum. We highlight key gene groups including those underlying venom composition, chemosensory perception, and sex determination, as well as potential losses in immune pathway genes.

Conclusions

These findings are of fundamental interest for insect evolution and biological control applications. They provide a strong foundation for further functional studies into coevolution between parasitoids and their hosts. Both genomes are available at https://bipaa.genouest.org.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 989 
KW  - Parasitoid wasp
KW  - Aphid host
KW  - Aphidius ervi
KW  - GC content
KW  - de novo genome assembly
KW  - DNA methylation loss
KW  - Chemosensory genes
KW  - Toll and Imd pathways
KW  - Venom proteins
KW  - Lysiphlebus fabarum
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-476129
SN  - 1866-8372
IS  - 989
ER  - 
TY  - JOUR
A1  - Izraylit, Victor
A1  - Gould, Oliver E. C.
A1  - Kratz, Karl
A1  - Lendlein, Andreas
T1  - Investigating the phase-morphology of PLLA-PCL multiblock copolymer/PDLA blends cross-linked using stereocomplexation
JF  - MRS advances
N2  - The macroscale function of multicomponent polymeric materials is dependent on their phase-morphology. Here, we investigate the morphological structure of a multiblock copolymer consisting of poly(L-lactide) and poly(epsilon-caprolactone) segments (PLLA-PCL), physically cross-linked by stereocomplexation with a low molecular weight poly(D-lactide) oligomer (PDLA). The effects of blend composition and PLLA-PCL molecular structure on the morphology are elucidated by AFM, TEM and SAXS. We identify the formation of a lattice pattern, composed of PLA domains within a PCL matrix, with an average domain spacing d0 = 12 - 19 nm. The size of the PLA domains were found to be proportional to the block length of the PCL segment of the copolymer and inversely proportional to the PDLA content of the blend. Changing the PLLA-PCL / PDLA ratio caused a shift in the melt transition Tm attributed to the PLA stereocomplex crystallites, indicating partial amorphous phase dilution of the PLA and PCL components within the semicrystalline material. By elucidating the phase structure and thermal character of multifunctional PLLA-PCL / PDLA blends, we illustrate how composition affects the internal structure and thermal properties of multicomponent polymeric materials. This study should facilitate the more effective incorporation of a variety of polymeric structural units capable of stimuli responsive phase transitions, where an understanding the phase-morphology of each component will enable the production of multifunctional soft-actuators with enhanced performance.
KW  - polymer
KW  - blend
KW  - nanostructure
KW  - morphology
Y1  - 2020
U6  - https://doi.org/10.1557/adv.2019.465
SN  - 2059-8521
VL  - 5
IS  - 14-15
SP  - 699
EP  - 707
PB  - Cambridge Univ. Press
CY  - New York
ER  - 
TY  - JOUR
A1  - Izraylit, Victor
A1  - Hommes-Schattmann, Paul Jacob
A1  - Neffe, Axel T.
A1  - Gould, Oliver E. C.
A1  - Lendlein, Andreas
T1  - Alkynyl-functionalized chain-extended PCL for coupling to biological molecules
JF  - European polymer journal
N2  - Chemical functionalization of poly(epsilon-caprolactone) (PCL) enables a molecular integration of additional function. Here, we report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3 (prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with M-w of 101 to 385 kg.mol(-1) were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine ethyl ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the density of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asymmetric structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material's mechanical properties. The mixed glass transition temperature T-g = - 60 to - 46 degrees C of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiological conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodology was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile molecular unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions.
KW  - copper-catalyzed alkyne-azide cycloaddition
KW  - chain-extended
KW  - polycaprolactone
KW  - RGD-peptide
KW  - side-chains functionalization
Y1  - 2020
U6  - https://doi.org/10.1016/j.eurpolymj.2020.109908
SN  - 0014-3057
SN  - 1873-1945
VL  - 136
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Izraylit, Victor
A1  - Hommes-Schattmann, Paul J.
A1  - Neffe, Axel T.
A1  - Gould, Oliver E. C.
A1  - Lendlein, Andreas
T1  - Polyester urethane functionalizable through maleimide side-chains and cross-linkable by polylactide stereocomplexes
JF  - European polymer journal
N2  - Sustainable multifunctional alternatives to fossil-derived materials, which can be functionalized and are degradable, can be envisioned by combining naturally derived starting materials with an established polymer design concept. Modularity and chemical flexibility of polyester urethanes (PEU) enable the combination of segments bearing functionalizable moieties and the tailoring of the mechanical and thermal properties. In this work, a PEU multiblock structure was synthesized from naturally derived L-lysine diisocyanate ethyl ester (LDI), poly(L-lactide) diol (PLLA) and N-(2,3-dihydroxypropyl)-maleimide (MID) in a one-step reaction. A maleimide side-chain (MID) provided a reactive site for the catalyst-free coupling of thiols shown for L-cysteine with a yield of 94%. Physical cross-links were generated by blending the PEU with poly(D-lactide) (PDLA), upon which the PLLA segments of the PEU and the PDLA formed stereocomplexes. Stereocomplexation occurred spontaneously during solution casting and was investigated with WAXS and DSC. Stereocomplex crystallites were observed in the blends, while isotactic PLA crystallization was not observed. The presented material platform with tailorable mechanical properties by blending is of specific interest for engineering biointerfaces of implants or carrier systems for bioactive molecules.
KW  - Functionalization
KW  - Polylactide stereocomplex
KW  - Biomolecules coupling
Y1  - 2020
U6  - https://doi.org/10.1016/j.eurpolymj.2020.109916
SN  - 0014-3057
SN  - 1873-1945
VL  - 137
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Halilbasic, Emina
A1  - Fuerst, Elisabeth
A1  - Heiden, Denise
A1  - Japtok, Lukasz
A1  - Diesner, Susanne C.
A1  - Trauner, Michael
A1  - Kulu, Askin
A1  - Jaksch, Peter
A1  - Hoetzenecker, Konrad
A1  - Kleuser, Burkhard
A1  - Kazemi-Shirazi, Lili
A1  - Untersmayr, Eva
T1  - Plasma levels of the bioactive sphingolipid metabolite S1P in adult cystic fibrosis patients
BT  - potential target for immunonutrition?
JF  - Nutrients
N2  - Recent research has linked sphingolipid (SL) metabolism with cystic fibrosis transmembrane conductance regulator (CFTR) activity, affecting bioactive lipid mediator sphingosine-1-phosphate (S1P). We hypothesize that loss of CFTR function in cystic fibrosis (CF) patients influenced plasma S1P levels. Total and unbound plasma S1P levels were measured in 20 lung-transplanted adult CF patients and 20 healthy controls by mass spectrometry and enzyme-linked immunosorbent assay (ELISA). S1P levels were correlated with CFTR genotype, routine laboratory parameters, lung function and pathogen colonization, and clinical symptoms. Compared to controls, CF patients showed lower unbound plasma S1P, whereas total S1P levels did not differ. A positive correlation of total and unbound S1P levels was found in healthy controls, but not in CF patients. Higher unbound S1P levels were measured in Delta F508-homozygous compared to Delta F508-heterozygous CF patients (p = 0.038), accompanied by higher levels of HDL in Delta F508-heterozygous patients. Gastrointestinal symptoms were more common in Delta F508 heterozygotes compared to Delta F508 homozygotes. This is the first clinical study linking plasma S1P levels with CFTR function and clinical presentation in adult CF patients. Given the emerging role of immunonutrition in CF, our study might pave the way for using S1P as a novel biomarker and nutritional target in CF.
KW  - sphingolipids
KW  - sphingosine-1-phosphate
KW  - intestine
KW  - high density
KW  - lipoproteins
KW  - cystic fibrosis
KW  - Delta F508 mutation
KW  - immunonutrition
Y1  - 2020
U6  - https://doi.org/10.3390/nu12030765
SN  - 2072-6643
VL  - 12
IS  - 3
PB  - MDPI
CY  - Basel
ER  - 
TY  - JOUR
A1  - Liu, Yue
A1  - Gould, Oliver E. C.
A1  - Rudolph, Tobias
A1  - Fang, Liang
A1  - Kratz, Karl
A1  - Lendlein, Andreas
T1  - Polymeric microcuboids programmable for temperature-memory
JF  - Macromolecular materials and engineering
N2  - Microobjects with programmable mechanical functionality are highly desirable for the creation of flexible electronics, sensors, and microfluidic systems, where fabrication/programming and quantification methods are required to fully control and implement dynamic physical behavior. Here, programmable microcuboids with defined geometries are prepared by a template-based method from crosslinked poly[ethylene-co-(vinyl acetate)] elastomers. These microobjects could be programmed to exhibit a temperature-memory effect or a shape-memory polymer actuation capability. Switching temperaturesT(sw)during shape recovery of 55 +/- 2, 68 +/- 2, 80 +/- 2, and 86 +/- 2 degrees C are achieved by tuning programming temperatures to 55, 70, 85, and 100 degrees C, respectively. Actuation is achieved with a reversible strain of 2.9 +/- 0.2% to 6.7 +/- 0.1%, whereby greater compression ratios and higher separation temperatures induce a more pronounced actuation. Micro-geometry change is quantified using optical microscopy and atomic force microscopy. The realization and quantification of microparticles, capable of a tunable temperature responsive shape-change or reversible actuation, represent a key development in the creation of soft microscale devices for drug delivery or microrobotics.
KW  - actuation
KW  - atomic force microscopy
KW  - biomaterials
KW  - microparticles
KW  - shape-memory polymers
Y1  - 2020
U6  - https://doi.org/10.1002/mame.202000333
SN  - 1438-7492
SN  - 1439-2054
VL  - 305
IS  - 10
PB  - Wiley-VCH
CY  - Weinheim
ER  - 
TY  - JOUR
A1  - Dolcos, Florin
A1  - Katsumi, Yuta
A1  - Bogdan, Paul C.
A1  - Shen, Chen
A1  - Jun, Suhnyoung
A1  - Buetti, Simona
A1  - Lleras, Alejandro
A1  - Bost, Kelly Freeman
A1  - Weymar, Mathias
A1  - Dolcos, Sanda
T1  - The impact of focused attention on subsequent emotional recollection
BT  - a functional MRI investigation
JF  - Neuropsychologia : an international journal in behavioural and cognitive neuroscience
N2  - In his seminal works, Endel Tulving argued that functionally distinct memory systems give rise to subjective experiences of remembering and knowing (i.e., recollection- vs. familiarity-based memory, respectively). Evidence shows that emotion specifically enhances recollection, and this effect is subserved by a synergistic mechanism involving the amygdala (AMY) and hippocampus (HC). In extreme circumstances, however, uncontrolled recollection of highly distressing memories may lead to symptoms of affective disorders. Therefore, it is important to understand the factors that can diminish such detrimental effects. Here, we investigated the effects of Focused Attention (FA) on emotional recollection. FA is an emotion regulation strategy that has been proven quite effective in reducing the impact of emotional responses associated with the recollection of distressing autobiographical memories, but its impact during emotional memory encoding is not known. Functional MRI and eye-tracking data were recorded while participants viewed a series of composite negative and neutral images with distinguishable foreground (FG) and background (BG) areas. Participants were instructed to focus either on the FG or BG content of the images and to rate their emotional responses. About 4 days later, participants' memory was assessed using the R/K procedure, to indicate whether they Recollected specific contextual details about the encoded images or the images were just familiar to them - i.e., participants only Knew that they saw the pictures without being able to remember specific contextual details. First, results revealed that FA was successful in decreasing memory for emotional pictures viewed in BG Focus condition, and this effect was driven by recollection-based retrieval. Second, the BG Focus condition was associated with decreased activity in the AMY, HC, and anterior parahippocampal gyrus for subsequently recollected emotional items. Moreover, correlation analyses also showed that reduced activity in these regions predicted greater reduction in emotional recollection following FA. These results demonstrate the effectiveness of FA in mitigating emotional experiences and emotional recollection associated with unpleasant emotional events.
KW  - affect
KW  - emotion control
KW  - emotional memory
KW  - MTL
KW  - emotion-cognition
KW  - interaction
KW  - functional magnetic resonance imaging
Y1  - 2020
U6  - https://doi.org/10.1016/j.neuropsychologia.2020.107338
SN  - 0028-3932
SN  - 1873-3514
VL  - 138
PB  - Elsevier
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Seroussi, Helene
A1  - Nowicki, Sophie
A1  - Payne, Antony J.
A1  - Goelzer, Heiko
A1  - Lipscomb, William H.
A1  - Abe-Ouchi, Ayako
A1  - Agosta, Cecile
A1  - Albrecht, Torsten
A1  - Asay-Davis, Xylar
A1  - Barthel, Alice
A1  - Calov, Reinhard
A1  - Cullather, Richard
A1  - Dumas, Christophe
A1  - Galton-Fenzi, Benjamin K.
A1  - Gladstone, Rupert
A1  - Golledge, Nicholas R.
A1  - Gregory, Jonathan M.
A1  - Greve, Ralf
A1  - Hattermann, Tore
A1  - Hoffman, Matthew J.
A1  - Humbert, Angelika
A1  - Huybrechts, Philippe
A1  - Jourdain, Nicolas C.
A1  - Kleiner, Thomas
A1  - Larour, Eric
A1  - Leguy, Gunter R.
A1  - Lowry, Daniel P.
A1  - Little, Chistopher M.
A1  - Morlighem, Mathieu
A1  - Pattyn, Frank
A1  - Pelle, Tyler
A1  - Price, Stephen F.
A1  - Quiquet, Aurelien
A1  - Reese, Ronja
A1  - Schlegel, Nicole-Jeanne
A1  - Shepherd, Andrew
A1  - Simon, Erika
A1  - Smith, Robin S.
A1  - Straneo, Fiammetta
A1  - Sun, Sainan
A1  - Trusel, Luke D.
A1  - Van Breedam, Jonas
A1  - van de Wal, Roderik S. W.
A1  - Winkelmann, Ricarda
A1  - Zhao, Chen
A1  - Zhang, Tong
A1  - Zwinger, Thomas
T1  - ISMIP6 Antarctica
BT  - a multi-model ensemble of the Antarctic ice sheet evolution over the 21st century
JF  - The Cryosphere : TC ; an interactive open access journal of the European Geosciences Union
N2  - Ice flow models of the Antarctic ice sheet are commonly used to simulate its future evolution in response to different climate scenarios and assess the mass loss that would contribute to future sea level rise. However, there is currently no consensus on estimates of the future mass balance of the ice sheet, primarily because of differences in the representation of physical processes, forcings employed and initial states of ice sheet models. This study presents results from ice flow model simulations from 13 international groups focusing on the evolution of the Antarctic ice sheet during the period 2015-2100 as part of the Ice Sheet Model Intercomparison for CMIP6 (ISMIP6). They are forced with outputs from a subset of models from the Coupled Model Intercomparison Project Phase 5 (CMIP5), representative of the spread in climate model results. Simulations of the Antarctic ice sheet contribution to sea level rise in response to increased warming during this period varies between 7:8 and 30.0 cm of sea level equivalent (SLE) under Representative Concentration Pathway (RCP) 8.5 scenario forcing. These numbers are relative to a control experiment with constant climate conditions and should therefore be added to the mass loss contribution under climate conditions similar to present-day conditions over the same period. The simulated evolution of the West Antarctic ice sheet varies widely among models, with an overall mass loss, up to 18.0 cm SLE, in response to changes in oceanic conditions. East Antarctica mass change varies between 6 :1 and 8.3 cm SLE in the simulations, with a significant increase in surface mass balance outweighing the increased ice discharge under most RCP 8.5 scenario forcings. The inclusion of ice shelf collapse, here assumed to be caused by large amounts of liquid water ponding at the surface of ice shelves, yields an additional simulated mass loss of 28mm compared to simulations without ice shelf collapse. The largest sources of uncertainty come from the climate forcing, the ocean-induced melt rates, the calibration of these melt rates based on oceanic conditions taken outside of ice shelf cavities and the ice sheet dynamic response to these oceanic changes. Results under RCP 2.6 scenario based on two CMIP5 climate models show an additional mass loss of 0 and 3 cm of SLE on average compared to simulations done under present-day conditions for the two CMIP5 forcings used and display limited mass gain in East Antarctica.
Y1  - 2020
U6  - https://doi.org/10.5194/tc-14-3033-2020
SN  - 1994-0416
SN  - 1994-0424
VL  - 14
IS  - 9
SP  - 3033
EP  - 3070
PB  - Copernicus
CY  - Göttingen
ER  - 
TY  - JOUR
A1  - Zhou, Renjie
A1  - Aitchison, Jonathan C.
A1  - Lokho, Kapesa
A1  - Sobel, Edward
A1  - Feng, Yuexing
A1  - Zhao, Jian-xin
T1  - Unroofing the Ladakh Batholith: constraints from autochthonous molasse of the Indus Basin, NW Himalaya
JF  - Journal of the Geological Society
N2  - The Indus Molasse records orogenic sedimentation associated with uplift and erosion of the southern margin of Asia in the course of ongoing India-Eurasia collision. Detailed field investigation clarifies the nature and extent of the depositional contact between this molasse and the underlying basement units. We report the first dataset on detrital zircon U-Pb ages, Hf isotopes and apatite U-Pb ages for the autochthonous molasse in the Indus Suture Zone. A latest Oligocene depositional age is proposed on the basis of the youngest detrital zircon U-Pb age peak and is consistent with published biostratigraphic data. Multiple provenance indicators suggest exclusively northerly derivation with no input from India in the lowermost parts of the section. The results provide constraints on the uplift and erosion history of the Ladakh Range following the initial India-Asia collision.
Y1  - 2020
U6  - https://doi.org/10.1144/jgs2019-188
SN  - 0016-7649
SN  - 2041-479X
VL  - 177
IS  - 4
SP  - 818
EP  - 825
PB  - Geological Society (London)
CY  - London
ER  - 
TY  - GEN
A1  - Ramirez-Campillo, Rodrigo
A1  - Andrade, David C.
A1  - Nikolaidis, Pantelis T.
A1  - Moran, Jason
A1  - Clemente, Filipe Manuel
A1  - Chaabene, Helmi
A1  - Comfort, Paul
T1  - Effects of plyometric jump training on vertical jump height of volleyball players: a systematic review with meta-analysis of randomized-controlled trial
T2  - Postprints der Universität Potsdam : Humanwissenschaftliche Reihe
N2  - This meta-analysis aimed to assess the effects of plyometric jump training (PJT) on volleyball players’ vertical jump height (VJH), comparing changes with those observed in a matched control group. A literature search in the databases of PubMed, MEDLINE, Web of Science, and SCOPUS was conducted. Only randomized-controlled trials and studies that included a pre-to-post intervention assessment of VJH were included. They involved only healthy volleyball players with no restrictions on age or sex. Data were independently extracted from the included studies by two authors. The Physiotherapy Evidence Database scale was used to assess the risk of bias, and methodological quality, of eligible studies included in the review. From 7,081 records, 14 studies were meta-analysed. A moderate Cohen’s d effect size (ES = 0.82, p <0.001) was observed for VJH, with moderate heterogeneity (I2 = 34.4%, p = 0.09) and no publication bias (Egger’s test, p = 0.59). Analyses of moderator variables revealed no significant differences for PJT program duration (≤8 vs. >8 weeks, ES = 0.79 vs. 0.87, respectively), frequency (≤2 vs. >2 sessions/week, ES = 0.83 vs. 0.78, respectively), total number of sessions (≤16 vs. >16 sessions, ES = 0.73 vs. 0.92, respectively), sex (female vs. male, ES = 1.3 vs. 0.5, respectively), age (≥19 vs. <19 years of age, ES = 0.89 vs. 0.70, respectively), and volume (>2,000 vs. <2,000 jumps, ES = 0.76 vs. 0.79, respectively). In conclusion, PJT appears to be effective in inducing improvements in volleyball players’ VJH. Improvements in VJH may be achieved by both male and female volleyball players, in different age groups, with programs of relatively low volume and frequency. Though PJT seems to be safe for volleyball players, it is recommended that an individualized approach, according to player position, is adopted with some players (e.g. libero) less prepared to sustain PJT loads.
T3  - Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe - 729 
KW  - human physical conditioning
KW  - resistance training
KW  - stretch-shortening cycle
KW  - physical fitness
KW  - exercise therapy
KW  - team sports
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-525898
SN  - 1866-8364
ER  - 
TY  - JOUR
A1  - Ramirez-Campillo, Rodrigo
A1  - Andrade, David C.
A1  - Nikolaidis, Pantelis T.
A1  - Moran, Jason
A1  - Clemente, Filipe Manuel
A1  - Chaabene, Helmi
A1  - Comfort, Paul
T1  - Effects of plyometric jump training on vertical jump height of volleyball players: a systematic review with meta-analysis of randomized-controlled trial
JF  - Journal of Sports Science and Medicine
N2  - This meta-analysis aimed to assess the effects of plyometric jump training (PJT) on volleyball players’ vertical jump height (VJH), comparing changes with those observed in a matched control group. A literature search in the databases of PubMed, MEDLINE, Web of Science, and SCOPUS was conducted. Only randomized-controlled trials and studies that included a pre-to-post intervention assessment of VJH were included. They involved only healthy volleyball players with no restrictions on age or sex. Data were independently extracted from the included studies by two authors. The Physiotherapy Evidence Database scale was used to assess the risk of bias, and methodological quality, of eligible studies included in the review. From 7,081 records, 14 studies were meta-analysed. A moderate Cohen’s d effect size (ES = 0.82, p <0.001) was observed for VJH, with moderate heterogeneity (I2 = 34.4%, p = 0.09) and no publication bias (Egger’s test, p = 0.59). Analyses of moderator variables revealed no significant differences for PJT program duration (≤8 vs. >8 weeks, ES = 0.79 vs. 0.87, respectively), frequency (≤2 vs. >2 sessions/week, ES = 0.83 vs. 0.78, respectively), total number of sessions (≤16 vs. >16 sessions, ES = 0.73 vs. 0.92, respectively), sex (female vs. male, ES = 1.3 vs. 0.5, respectively), age (≥19 vs. <19 years of age, ES = 0.89 vs. 0.70, respectively), and volume (>2,000 vs. <2,000 jumps, ES = 0.76 vs. 0.79, respectively). In conclusion, PJT appears to be effective in inducing improvements in volleyball players’ VJH. Improvements in VJH may be achieved by both male and female volleyball players, in different age groups, with programs of relatively low volume and frequency. Though PJT seems to be safe for volleyball players, it is recommended that an individualized approach, according to player position, is adopted with some players (e.g. libero) less prepared to sustain PJT loads.
KW  - human physical conditioning
KW  - resistance training
KW  - stretch-shortening cycle
KW  - physical fitness
KW  - exercise therapy
KW  - team sports
Y1  - 2020
VL  - 19
PB  - Wiley-Blackwell
CY  - Oxford
ER  - 
TY  - JOUR
A1  - Lehmann, Anika
A1  - Zheng, Weishuang
A1  - Ryo, Masahiro
A1  - Soutschek, Katharina
A1  - Roy, Julien
A1  - Rongstock, Rebecca
A1  - Maaß, Stefanie
A1  - Rillig, Matthias C.
T1  - Fungal traits important for soil aggregation
JF  - Frontiers in microbiology
N2  - Soil structure, the complex arrangement of soil into aggregates and pore spaces, is a key feature of soils and soil biota. Among them, filamentous saprobic fungi have well-documented effects on soil aggregation. However, it is unclear what properties, or traits, determine the overall positive effect of fungi on soil aggregation. To achieve progress, it would be helpful to systematically investigate a broad suite of fungal species for their trait expression and the relation of these traits to soil aggregation. Here, we apply a trait-based approach to a set of 15 traits measured under standardized conditions on 31 fungal strains including Ascomycota, Basidiomycota, and Mucoromycota, all isolated from the same soil. We find large differences among these fungi in their ability to aggregate soil, including neutral to positive effects, and we document large differences in trait expression among strains. We identify biomass density, i.e., the density with which a mycelium grows (positive effects), leucine aminopeptidase activity (negative effects) and phylogeny as important factors explaining differences in soil aggregate formation (SAF) among fungal strains; importantly, growth rate was not among the important traits. Our results point to a typical suite of traits characterizing fungi that are good soil aggregators, and our findings illustrate the power of employing a trait-based approach to unravel biological mechanisms underpinning soil aggregation. Such an approach could now be extended also to other soil biota groups. In an applied context of restoration and agriculture, such trait information can inform management, for example to prioritize practices that favor the expression of more desirable fungal traits.
KW  - soil aggregation
KW  - traits
KW  - saprobic fungi
KW  - random forest
KW  - biomass
KW  - density
KW  - leucine amino peptidases
Y1  - 2020
U6  - https://doi.org/10.3389/fmicb.2019.02904
SN  - 1664-302X
VL  - 10
PB  - Frontiers Media
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Rillig, Matthias C.
A1  - Bielcik, Milos
A1  - Chaudhary, Veer Bala
A1  - Grünfeld, Leonie
A1  - Maass, Stefanie
A1  - Mansour, India
A1  - Ryo, Masahiro
A1  - Veresoglou, Stavros D.
T1  - Ten simple rules for increased lab resilience
JF  - PLoS Computational Biology : a new community journal
N2  - When running a lab we do not think about calamities, since they are rare events for which we cannot plan while we are busy with the day-to-day management and intellectual challenges of a research lab. No lab team can be prepared for something like a pandemic such as COVID-19, which has led to shuttered labs around the globe. But many other types of crises can also arise that labs may have to weather during their lifetime. What can researchers do to make a lab more resilient in the face of such exterior forces? What systems or behaviors could we adjust in 'normal' times that promote lab success, and increase the chances that the lab will stay on its trajectory? We offer 10 rules, based on our current experiences as a lab group adapting to crisis.
Y1  - 2020
U6  - https://doi.org/10.1371/journal.pcbi.1008313
SN  - 1553-734X
SN  - 1553-7358
VL  - 16
IS  - 11
PB  - PLoS
CY  - San Fransisco
ER  - 
TY  - JOUR
A1  - Qiu, Xunlin
A1  - Benjamin, Aravindan Joseph
A1  - Raman Venkatesan, Thulasinath
A1  - Schmidt, Georg C.
A1  - Soler, Ricardo Alonso Quintana
A1  - Panicker, Pramul Muraleedhara
A1  - Gerhard, Reimund
A1  - Hübler, Arved Carl
T1  - Dielectric and electroacoustic assessment of screen-printed piezoelectric polymer layers as flexible transducers
BT  - influence of the electrode material
JF  - IEEE transactions on dielectrics and electrical insulation
N2  - Here, piezoelectric transducers consisting of a P(VDF-TrFE) layer with either silver or PEDOT:PSS screen-printed electrodes are studied. The influence of electrodes on the dielectric and electroacoustic properties are studied in dielectric-spectroscopy and ferroelectric-hysteresis measurements. Only when both the bottom and the top electrodes are made of silver, the typical dielectric relaxation of the P(VDF-TrFE) layer is clearly observed. When one or two of the electrodes are of PEDOT:PSS, a Debye-like relaxation is present. Compared with silver electrodes, PEDOT:PSS electrodes allow for moderate self-healing. Consequently, samples with bottom and top PEDOT:PSS electrodes can be poled to saturation, while samples with silver electrodes can hardly be poled to saturation due to destructive electric breakdown. Acoustic transducer measurements show that silver electrodes facilitate higher and broader frequency operation, while PEDOT:PSS electrodes bring slightly lower total harmonic distortion. Overall, the acoustic performance shows no significant deviations between differently electroded samples so that silver electrodes do not offer any advantages for the transducers studied here due to their much higher tendency for destructive electric breakdown.
KW  - poly(vinylidenefluoride-trifluoroethylene) P(VDF-TrFE)
KW  - dielectric
KW  - spectroscopy
KW  - ferroelectricity and piezoelectricity in polymers
KW  - screen
KW  - printing
KW  - printed electroacoustic thin-film transducers
Y1  - 2020
U6  - https://doi.org/10.1109/TDEI.2020.008864
SN  - 1070-9878
SN  - 1558-4135
SN  - 0018-9367
VL  - 27
IS  - 5
SP  - 1683
EP  - 1690
PB  - Institute of Electrical and Electronics Engineers
CY  - New York, NY
ER  - 
TY  - GEN
A1  - Griscom, Bronson W.
A1  - Busch, Jonah
A1  - Cook-Patton, Susan C.
A1  - Ellis, Peter W.
A1  - Funk, Jason
A1  - Leavitt, Sara M.
A1  - Lomax, Guy
A1  - Turner, Will R.
A1  - Chapman, Melissa
A1  - Streck, Charlotte
T1  - National mitigation potential from natural climate solutions in the tropics
T2  - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe
N2  - Better land stewardship is needed to achieve the Paris Agreement's temperature goal, particularly in the tropics, where greenhouse gas emissions from the destruction of ecosystems are largest, and where the potential for additional land carbon storage is greatest. As countries enhance their nationally determined contributions (NDCs) to the Paris Agreement, confusion persists about the potential contribution of better land stewardship to meeting the Agreement's goal to hold global warming below 2 degrees C. We assess cost-effective tropical country-level potential of natural climate solutions (NCS)-protection, improved management and restoration of ecosystems-to deliver climate mitigation linked with sustainable development goals (SDGs). We identify groups of countries with distinctive NCS portfolios, and we explore factors (governance, financial capacity) influencing the feasibility of unlocking national NCS potential. Cost-effective tropical NCS offers globally significant climate mitigation in the coming decades (6.56 Pg CO(2)e yr(-1) at less than 100 US$ per Mg CO(2)e). In half of the tropical countries, cost-effective NCS could mitigate over half of national emissions. In more than a quarter of tropical countries, cost-effective NCS potential is greater than national emissions. We identify countries where, with international financing and political will, NCS can cost-effectively deliver the majority of enhanced NDCs while transforming national economies and contributing to SDGs. This article is part of the theme issue 'Climate change and ecosystems: threats, opportunities and solutions'.
T3  - Zweitveröffentlichungen der Universität Potsdam : Wirtschafts- und Sozialwissenschaftliche Reihe - 195 
KW  - natural climate solutions
KW  - climate mitigation
KW  - protection
KW  - land management
KW  - restoration
KW  - Paris Agreement
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-513692
SN  - 1867-5808
IS  - 1794
ER  - 
TY  - GEN
A1  - Foster, William J.
A1  - Garvie, Christopher L.
A1  - Weiss, Anna M.
A1  - Muscente, A. Drew
A1  - Aberhan, Martin
A1  - Counts, John W.
A1  - Martindale, Rowan C.
T1  - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1410 
KW  - eocene thermal maximum
KW  - gulf coastal plain
KW  - climate-change
KW  - ocean acidification
KW  - extinction event
KW  - carbon-cycle
KW  - heat-stress
KW  - origination
KW  - ecosystems
KW  - diversity
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516011
SN  - 1866-8372
IS  - 1
ER  - 
TY  - JOUR
A1  - Foster, William J.
A1  - Garvie, Christopher L.
A1  - Weiss, Anna M.
A1  - Muscente, A. Drew
A1  - Aberhan, Martin
A1  - Counts, John W.
A1  - Martindale, Rowan C.
T1  - Resilience of marine invertebrate communities during the early Cenozoic hyperthermals
JF  - Scientific Reports
N2  - The hyperthermal events of the Cenozoic, including the Paleocene-Eocene Thermal Maximum, provide an opportunity to investigate the potential effects of climate warming on marine ecosystems. Here, we examine the shallow benthic marine communities preserved in the late Cretaceous to Eocene strata on the Gulf Coastal Plain (United States). In stark contrast to the ecological shifts following the end-Cretaceous mass extinction, our data show that the early Cenozoic hyperthermals did not have a long-term impact on the generic diversity nor composition of the Gulf Coastal Plain molluscan communities. We propose that these communities were resilient to climate change because molluscs are better adapted to high temperatures than other taxa, as demonstrated by their physiology and evolutionary history. In terms of resilience, these communities differ from other shallow-water carbonate ecosystems, such as reef communities, which record significant changes during the early Cenozoic hyperthermals. These data highlight the strikingly different responses of community types, i.e., the almost imperceptible response of molluscs versus the marked turnover of foraminifera and reef faunas. The impact on molluscan communities may have been low because detrimental conditions did not devastate the entire Gulf Coastal Plain, allowing molluscs to rapidly recolonise vacated areas once harsh environmental conditions ameliorated.
KW  - eocene thermal maximum
KW  - gulf coastal plain
KW  - climate-change
KW  - ocean acidification
KW  - extinction event
KW  - carbon-cycle
KW  - heat-stress
KW  - origination
KW  - ecosystems
KW  - diversity
Y1  - 2020
U6  - https://doi.org/10.1038/s41598-020-58986-5
SN  - 2045-2322
VL  - 10
IS  - 1
SP  - 1
EP  - 11
PB  - Springer Nature
CY  - London
ER  - 
TY  - JOUR
A1  - McNulty, Margaret A.
A1  - Goupil, Brad A.
A1  - Albarado, Diana C.
A1  - Castaño-Martinez, Teresa
A1  - Ambrosi, Thomas H.
A1  - Puh, Spela
A1  - Schulz, Tim Julius
A1  - Schürmann, Annette
A1  - Morrison, Christopher D.
A1  - Laeger, Thomas
T1  - FGF21, not GCN2, influences bone morphology due to dietary protein restrictions
JF  - Bone Reports
N2  - Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone.

Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass.

Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.

Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21.
KW  - dietary restriction
KW  - protein restriction
KW  - FGF21
KW  - GCN2
KW  - microcomputed tomography
Y1  - 2020
U6  - https://doi.org/10.1016/j.bonr.2019.100241
SN  - 2352-1872
VL  - 12
SP  - 1
EP  - 10
PB  - Elsevier
CY  - Amsterdam
ER  - 
TY  - JOUR
A1  - Horton, Benjamin P.
A1  - Khan, Nicole S.
A1  - Cahill, Niamh
A1  - Lee, Janice S. H.
A1  - Shaw, Timothy A.
A1  - Garner, Andra J.
A1  - Kemp, Andrew C.
A1  - Engelhart, Simon E.
A1  - Rahmstorf, Stefan
T1  - Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey
JF  - npj Climate and Atmospheric Science
N2  - Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet.
KW  - projections
KW  - Greenland
KW  - consequences
KW  - climate
Y1  - 2020
U6  - https://doi.org/10.1038/s41612-020-0121-5
SN  - 2397-3722
VL  - 3
IS  - 1
SP  - 1
EP  - 8
PB  - Springer Nature
CY  - London
ER  - 
TY  - GEN
A1  - McNulty, Margaret A.
A1  - Goupil, Brad A.
A1  - Albarado, Diana C.
A1  - Castaño-Martinez, Teresa
A1  - Ambrosi, Thomas H.
A1  - Puh, Spela
A1  - Schulz, Tim Julius
A1  - Schürmann, Annette
A1  - Morrison, Christopher D.
A1  - Laeger, Thomas
T1  - FGF21, not GCN2, influences bone morphology due to dietary protein restrictions
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Background: Dietary protein restriction is emerging as an alternative approach to treat obesity and glucose intolerance because it markedly increases plasma fibroblast growth factor 21 (FGF21) concentrations. Similarly, dietary restriction of methionine is known to mimic metabolic effects of energy and protein restriction with FGF21 as a required mechanism. However, dietary protein has been shown to be required for normal bone growth, though there is conflicting evidence as to the influence of dietary protein restriction on bone remodeling. The purpose of the current study was to evaluate the effect of dietary protein and methionine restriction on bone in lean and obese mice, and clarify whether FGF21 and general control nonderepressible 2 (GCN2) kinase, that are part of a novel endocrine pathway implicated in the detection of protein restriction, influence the effect of dietary protein restriction on bone.

Methods: Adult wild-type (WT) or Fgf21 KO mice were fed a normal protein (18 kcal%; CON) or low protein (4 kcal%; LP) diet for 2 or 27 weeks. In addition, adult WT or Gcn2 KO mice were fed a CON or LP diet for 27 weeks. Young New Zealand obese (NZO) mice were placed on high-fat diets that provided protein at control (16 kcal%; CON), low levels (4 kcal%) in a high-carbohydrate (LP/HC) or high-fat (LP/HF) regimen, or on high-fat diets (protein, 16 kcal%) that provided methionine at control (0.86%; CON-MR) or low levels (0.17%; MR) for up to 9 weeks. Long bones from the hind limbs of these mice were collected and evaluated with micro-computed tomography (mu CT) for changes in trabecular and cortical architecture and mass.

Results: In WT mice the 27-week LP diet significantly reduced cortical bone, and this effect was enhanced by deletion of Fgf21 but not Gcn2. This decrease in bone did not appear after 2 weeks on the LP diet. In addition, Fgf21 KO mice had significantly less bone than their WT counterparts. In obese NZO mice dietary protein and methionine restriction altered bone architecture. The changes were mediated by FGF21 due to methionine restriction in the presence of cystine, which did not increase plasma FGF21 levels and did not affect bone architecture.

Conclusions: This study provides direct evidence of a reduction in bone following long-term dietary protein restriction in a mouse model, effects that appear to be mediated by FGF21.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1406 
KW  - dietary restriction
KW  - protein restriction
KW  - FGF21
KW  - GCN2
KW  - microcomputed tomography
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516297
SN  - 1866-8372
ER  - 
TY  - GEN
A1  - Deng, Zijun
A1  - Wang, Weiwei
A1  - Xua, Xun
A1  - Gould, Oliver E. C.
A1  - Kratz, Karl
A1  - Ma, Nan
A1  - Lendlein, Andreas
T1  - Polymeric sheet actuators with programmable bioinstructivity
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Stem cells are capable of sensing and processing environmental inputs, converting this information to output a specific cell lineage through signaling cascades. Despite the combinatorial nature of mechanical, thermal, and biochemical signals, these stimuli have typically been decoupled and applied independently, requiring continuous regulation by controlling units. We employ a programmable polymer actuator sheet to autonomously synchronize thermal and mechanical signals applied to mesenchymal stem cells (MSC5). Using a grid on its underside, the shape change of polymer sheet, as well as cell morphology, calcium (Ca2+) influx, and focal adhesion assembly, could be visualized and quantified. This paper gives compelling evidence that the temperature sensing and mechanosensing of MSC5 are interconnected via intracellular Ca2+. Up-regulated Ca2+ levels lead to a remarkable alteration of histone H3K9 acetylation and activation of osteogenic related genes. The interplay of physical, thermal, and biochemical signaling was utilized to accelerate the cell differentiation toward osteogenic lineage. The approach of programmable bioinstructivity provides a fundamental principle for functional biomaterials exhibiting multifaceted stimuli on differentiation programs. Technological impact is expected in the tissue engineering of periosteum for treating bone defects.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1441 
KW  - reversible shape-memory actuator
KW  - mesenchymal stem cells
KW  - calcium influx
KW  - HDAC1
KW  - RUNX2
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-515490
SN  - 1866-8372
IS  - 4
ER  - 
TY  - GEN
A1  - Horton, Benjamin P.
A1  - Khan, Nicole S.
A1  - Cahill, Niamh
A1  - Lee, Janice S. H.
A1  - Shaw, Timothy A.
A1  - Garner, Andra J.
A1  - Kemp, Andrew C.
A1  - Engelhart, Simon E.
A1  - Rahmstorf, Stefan
T1  - Estimating global mean sea-level rise and its uncertainties by 2100 and 2300 from an expert survey
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Sea-level rise projections and knowledge of their uncertainties are vital to make informed mitigation and adaptation decisions. To elicit projections from members of the scientific community regarding future global mean sea-level (GMSL) rise, we repeated a survey originally conducted five years ago. Under Representative Concentration Pathway (RCP) 2.6, 106 experts projected a likely (central 66% probability) GMSL rise of 0.30-0.65 m by 2100, and 0.54-2.15 m by 2300, relative to 1986-2005. Under RCP 8.5, the same experts projected a likely GMSL rise of 0.63-1.32 m by 2100, and 1.67-5.61 m by 2300. Expert projections for 2100 are similar to those from the original survey, although the projection for 2300 has extended tails and is higher than the original survey. Experts give a likelihood of 42% (original survey) and 45% (current survey) that under the high-emissions scenario GMSL rise will exceed the upper bound (0.98 m) of the likely range estimated by the Fifth Assessment Report of the Intergovernmental Panel on Climate Change, which is considered to have an exceedance likelihood of 17%. Responses to open-ended questions suggest that the increases in upper-end estimates and uncertainties arose from recent influential studies about the impact of marine ice cliff instability on the meltwater contribution to GMSL rise from the Antarctic Ice Sheet.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1437 
KW  - projections
KW  - Greenland
KW  - consequences
KW  - climate
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-516788
SN  - 1866-8372
IS  - 1
ER  - 
TY  - JOUR
A1  - Zouita, Sghaier
A1  - Zouhal, Hassane
A1  - Ferchichi, Habiba
A1  - Paillard, Thierry
A1  - Dziri, Catherine
A1  - Hackney, Anthony C.
A1  - Laher, Ismail
A1  - Granacher, Urs
A1  - Ben Moussa Zouita, Amira
T1  - Effects of Combined Balance and Strength Training on Measures of Balance and Muscle Strength in Older Women With a History of Falls
JF  - Frontiers in Physiology
N2  - Objective: We investigated the effects of combined balance and strength training on measures of balance and muscle strength in older women with a history of falls.

Methods: Twenty-seven older women aged 70.4 ± 4.1 years (age range: 65 to 75 years) were randomly allocated to either an intervention (IG, n = 12) or an active control (CG, n = 15) group. The IG completed 8 weeks combined balance and strength training program with three sessions per week including visual biofeedback using force plates. The CG received physical therapy and gait training at a rehabilitation center. Training volumes were similar between the groups. Pre and post training, tests were applied for the assessment of muscle strength (weight-bearing squat [WBS] by measuring the percentage of body mass borne by each leg at different knee flexions [0°, 30°, 60°, and 90°], sit-to-stand test [STS]), and balance. Balance tests used the modified clinical test of sensory interaction (mCTSIB) with eyes closed (EC) and opened (EO), on stable (firm) and unstable (foam) surfaces as well as spatial parameters of gait such as step width and length (cm) and walking speed (cm/s).

Results: Significant group × time interactions were found for different degrees of knee flexion during WBS (0.0001 < p < 0.013, 0.441 < d < 0.762). Post hoc tests revealed significant pre-to-post improvements for both legs and for all degrees of flexion (0.0001 < p < 0.002, 0.697 < d < 1.875) for IG compared to CG. Significant group × time interactions were found for firm EO, foam EO, firm EC, and foam EC (0.006 < p < 0.029; 0.302 < d < 0.518). Post hoc tests showed significant pre-to-post improvements for both legs and for all degrees of oscillations (0.0001 < p < 0.004, 0.753 < d < 2.097) for IG compared to CG. This study indicates that combined balance and strength training improved percentage distribution of body weight between legs at different conditions of knee flexion (0°, 30°, 60°, and 90°) and also decreased the sway oscillation on a firm surface with eyes closed, and on foam surface (with eyes opened or closed) in the IG.

Conclusion: The higher positive effects of training seen in standing balance tests, compared with dynamic tests, suggests that balance training exercises including lateral, forward, and backward exercises improved static balance to a greater extent in older women.
KW  - aging
KW  - exercise
KW  - postural sway
KW  - force
KW  - tasks
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.619016
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Wiedmer, Petra
A1  - Jung, Tobias
A1  - Castro, Jose Pedro
A1  - Pomatto, Laura C. D.
A1  - Sun, Patrick Y.
A1  - Davies, Kelvin J. A.
A1  - Grune, Tilman
T1  - Sarcopenia
BT  - molecular mechanisms and open questions
JF  - Ageing research reviews : ARR
N2  - Sarcopenia represents a muscle-wasting syndrome characterized by progressive and generalized degenerative loss of skeletal muscle mass, quality, and strength occurring during normal aging. Sarcopenia patients are mainly suffering from the loss in muscle strength and are faced with mobility disorders reducing their quality of life and are, therefore, at higher risk for morbidity (falls, bone fracture, metabolic diseases) and mortality. <br /> Several molecular mechanisms have been described as causes for sarcopenia that refer to very different levels of muscle physiology. These mechanisms cover e. g. function of hormones (e. g. IGF-1 and Insulin), muscle fiber composition and neuromuscular drive, myo-satellite cell potential to differentiate and proliferate, inflammatory pathways as well as intracellular mechanisms in the processes of proteostasis and mitochondrial function. <br /> In this review, we describe sarcopenia as a muscle-wasting syndrome distinct from other atrophic diseases and summarize the current view on molecular causes of sarcopenia development as well as open questions provoking further research efforts for establishing efficient lifestyle and therapeutic interventions.
KW  - molecular pathways
KW  - proteostasis
KW  - proteasome
KW  - autophagy
KW  - mitochondria,
KW  - muscle fibre composition
Y1  - 2020
U6  - https://doi.org/10.1016/j.arr.2020.101200
SN  - 1568-1637
SN  - 1872-9649
VL  - 65
PB  - Elsevier
CY  - Clare
ER  - 
TY  - JOUR
A1  - Ravé, Guillaume
A1  - Granacher, Urs
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Zouhal, Hassane
T1  - How to Use Global Positioning Systems (GPS) Data to Monitor Training Load in the “Real World” of Elite Soccer
JF  - Frontiers in Physiology
KW  - acute chronic workload ratio
KW  - injury risk
KW  - physical performance
KW  - monitoring
KW  - external training load
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00944
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Arazi, Hamid
A1  - Asadi, Abbas
A1  - Khalkhali, Farhood
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players
BT  - A Preliminary Study
N2  - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r²) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
KW  - training load
KW  - rate of perceived exertion
KW  - rolling averages
KW  - weighted moving averages
KW  - football
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00608
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Arazi, Hamid
A1  - Asadi, Abbas
A1  - Khalkhali, Farhood
A1  - Boullosa, Daniel
A1  - Hackney, Anthony C.
A1  - Granacher, Urs
A1  - Zouhal, Hassane
T1  - Association Between the Acute to Chronic Workload Ratio and Injury Occurrence in Young Male Team Soccer Players
BT  - A Preliminary Study
JF  - Frontiers in Physiology
N2  - This study aimed to investigate the relationship between the acute to chronic workload ratio (ACWR), based upon participant session rating of perceived exertion (sRPE), using two models [(1) rolling averages (ACWRRA); and (2) exponentially weighted moving averages (ACWREWMA)] and the injury rate in young male team soccer players aged 17.1 ± 0.7 years during a competitive mesocycle. Twenty-two players were enrolled in this study and performed four training sessions per week with 2 days of recovery and 1 match day per week. During each training session and each weekly match, training time and sRPE were recorded. In addition, training impulse (TRIMP), monotony, and strain were subsequently calculated. The rate of injury was recorded for each soccer player over a period of 4 weeks (i.e., 28 days) using a daily questionnaire. The results showed that over the course of the study, the number of non-contact injuries was significantly higher than that for contact injuries (2.5 vs. 0.5, p = 0.01). There were also significant positive correlations between sRPE and training time (r = 0.411, p = 0.039), ACWRRA (r = 0.47, p = 0.049), and ACWREWMA (r = 0.51, p = 0.038). In addition, small-to-medium correlations were detected between ACWR and non-contact injury occurrence (ACWRRA, r = 0.31, p = 0.05; ACWREWMA, r = 0.53, p = 0.03). Explained variance (r 2) for non-contact injury was significantly greater using the ACWREWMA model (ranging between 21 and 52%) compared with ACWRRA (ranging between 17 and 39%). In conclusion, the results of this study showed that the ACWREWMA model is more sensitive than ACWRRA to identify non-contact injury occurrence in male team soccer players during a short period in the competitive season.
KW  - training load
KW  - rate of perceived exertion
KW  - rolling averages
KW  - weighted moving averages
KW  - football
Y1  - 2020
U6  - https://doi.org/10.3389/fphys.2020.00995
SN  - 1664-042X
VL  - 11
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  - 
TY  - JOUR
A1  - Christakoudi, Sofia
A1  - Pagoni, Panagiota
A1  - Ferrari, Pietro
A1  - Cross, Amanda J.
A1  - Tzoulaki, Ioanna
A1  - Muller, David C.
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Murphy, Neil
A1  - Dossus, Laure
A1  - Turzanski Fortner, Renee
A1  - Agudo, Antonio
A1  - Overvad, Kim
A1  - Perez-Cornago, Aurora
A1  - Key, Timothy J.
A1  - Brennan, Paul
A1  - Johansson, Mattias
A1  - Tjonneland, Anne
A1  - Halkjaer, Jytte
A1  - Boutron-Ruault, Marie-Christine
A1  - Artaud, Fanny
A1  - Severi, Gianluca
A1  - Kaaks, Rudolf
A1  - Schulze, Matthias Bernd
A1  - Bergmann, Manuela M.
A1  - Masala, Giovanna
A1  - Grioni, Sara
A1  - Simeon, Vittorio
A1  - Tumino, Rosario
A1  - Sacerdote, Carlotta
A1  - Skeie, Guri
A1  - Rylander, Charlotta
A1  - Borch, Kristin Benjaminsen
A1  - Quiros, J. Ramon
A1  - Rodriguez-Barranco, Miguel
A1  - Chirlaque, Maria-Dolores
A1  - Ardanaz, Eva
A1  - Amiano, Pilar
A1  - Drake, Isabel
A1  - Stocks, Tanja
A1  - Häggström, Christel
A1  - Harlid, Sophia
A1  - Ellingjord-Dale, Merete
A1  - Riboli, Elio
A1  - Tsilidis, Konstantinos K.
T1  - Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
JF  - International journal of cancer
N2  - Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
KW  - BMI change
KW  - cancer
KW  - middle adulthood
KW  - weight gain
KW  - weight loss
Y1  - 2020
U6  - https://doi.org/10.1002/ijc.33339
SN  - 0020-7136
SN  - 1097-0215
VL  - 148
IS  - 7
SP  - 1637
EP  - 1651
PB  - Wiley
CY  - Hoboken
ER  - 
TY  - GEN
A1  - Christakoudi, Sofia
A1  - Pagoni, Panagiota
A1  - Ferrari, Pietro
A1  - Cross, Amanda J.
A1  - Tzoulaki, Ioanna
A1  - Muller, David C.
A1  - Weiderpass, Elisabete
A1  - Freisling, Heinz
A1  - Murphy, Neil
A1  - Dossus, Laure
A1  - Turzanski Fortner, Renee
A1  - Agudo, Antonio
A1  - Overvad, Kim
A1  - Perez-Cornago, Aurora
A1  - Key, Timothy J.
A1  - Brennan, Paul
A1  - Johansson, Mattias
A1  - Tjonneland, Anne
A1  - Halkjaer, Jytte
A1  - Boutron-Ruault, Marie-Christine
A1  - Artaud, Fanny
A1  - Severi, Gianluca
A1  - Kaaks, Rudolf
A1  - Schulze, Matthias Bernd
A1  - Bergmann, Manuela M.
A1  - Masala, Giovanna
A1  - Grioni, Sara
A1  - Simeon, Vittorio
A1  - Tumino, Rosario
A1  - Sacerdote, Carlotta
A1  - Skeie, Guri
A1  - Rylander, Charlotta
A1  - Borch, Kristin Benjaminsen
A1  - Quiros, J. Ramon
A1  - Rodriguez-Barranco, Miguel
A1  - Chirlaque, Maria-Dolores
A1  - Ardanaz, Eva
A1  - Amiano, Pilar
A1  - Drake, Isabel
A1  - Stocks, Tanja
A1  - Haggstrom, Christel
A1  - Harlid, Sophia
A1  - Ellingjord-Dale, Merete
A1  - Riboli, Elio
A1  - Tsilidis, Konstantinos K.
T1  - Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
T2  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe
N2  - Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241 323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20 960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio [HR] = 1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/- 0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR = 1.41; 1.01-1.96), postmenopausal breast (HR = 1.08; 1.00-1.16) and thyroid (HR = 1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organisation categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the postmenopausal breast (HR = 1.19; 1.06-1.33), ovary (HR = 1.40; 1.04-1.91), corpus uteri (HR = 1.42; 1.06-1.91), kidney (HR = 1.80; 1.20-2.68) and pancreas in men (HR = 1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR = 0.40; 0.23-0.69) and colon (HR = 0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
T3  - Zweitveröffentlichungen der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe - 1373 
KW  - BMI change
KW  - cancer
KW  - middle adulthood
KW  - weight gain
KW  - weight loss
Y1  - 2020
U6  - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:517-opus4-573609
SN  - 1866-8372
IS  - 7
ER  -